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Protein

Sperm-associated antigen 6

Gene

Spag6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.2 Publications

GO - Biological processi

  • flagellated sperm motility Source: MGI
  • sperm axoneme assembly Source: MGI
  • ventricular system development Source: MGI

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm-associated antigen 6
Alternative name(s):
Axoneme central apparatus protein
Protein PF16 homolog
Gene namesi
Name:Spag6
Synonyms:Pf16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1354388 Spag6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Microtubule

Pathology & Biotechi

Involvement in diseasei

Defects in Spag6 are a cause of hydrocephalus and of male infertility.1 Publication

Disruption phenotypei

In null embryos the central apparatus is unstable leading to a loss, and presumably degradation of proteins to which SPAG6 normally binds, including SPAG16 AND SPAG17.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720961 – 507Sperm-associated antigen 6Add BLAST507

Proteomic databases

MaxQBiQ9JLI7
PaxDbiQ9JLI7
PRIDEiQ9JLI7

PTM databases

PhosphoSitePlusiQ9JLI7

Expressioni

Tissue specificityi

Highly expressed in testis. Not detected in prostate, ovary, spleen, thymus, small intestine, colon and peripheral blood leukocytes.2 Publications

Gene expression databases

BgeeiENSMUSG00000022783
CleanExiMM_SPAG6
ExpressionAtlasiQ9JLI7 baseline and differential
GenevisibleiQ9JLI7 MM

Interactioni

Subunit structurei

Interacts with SPAG16 AND SPAG17.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Spag17Q5S0033EBI-1783654,EBI-1783665

Protein-protein interaction databases

BioGridi206052, 1 interactor
IntActiQ9JLI7, 1 interactor
STRINGi10090.ENSMUSP00000023468

Structurei

3D structure databases

ProteinModelPortaliQ9JLI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 70ARM 1Add BLAST40
Repeati73 – 112ARM 2Add BLAST40
Repeati115 – 154ARM 3Add BLAST40
Repeati157 – 196ARM 4Add BLAST40
Repeati199 – 238ARM 5Add BLAST40
Repeati241 – 280ARM 6Add BLAST40
Repeati325 – 365ARM 7Add BLAST41
Repeati402 – 441ARM 8Add BLAST40

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0166 Eukaryota
COG5064 LUCA
GeneTreeiENSGT00900000141099
HOGENOMiHOG000257051
HOVERGENiHBG055326
InParanoidiQ9JLI7
OMAiRVENYQP
OrthoDBiEOG091G07CA
PhylomeDBiQ9JLI7
TreeFamiTF328894

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR000357 HEAT
PfamiView protein in Pfam
PF00514 Arm, 4 hits
PF02985 HEAT, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 7 hits
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JLI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRQVLQVF EQYQKARTQF VQMVAELATR PQNIETLQNA GVMSLLRPLL
60 70 80 90 100
LDVVPTIQQT AALALGRLAN YNDDLAEAVV KGDILPQLVY SLAEQNRFYK
110 120 130 140 150
KAAAFVLRAV GKHSPQLAQA IVDCGALDTL VICLEDFDPG VKEAAAWALG
160 170 180 190 200
YIARHNTELS QAVVDAGAIP LLVLCIQEPE IALKRIAASA LSDISKHSPE
210 220 230 240 250
LAQTVVDAGA IAHLAQMILN PDAKLKRQVL SALSQIAKHS VDLAEMVVEA
260 270 280 290 300
EIFPVVLTCL KDKDEYVKKN ACTLIREIAK HTPELSQLIV NAGGVAAVID
310 320 330 340 350
CIGSCKGNIR LPGIMMLGYV AAHSENLAMA VIISKGVPQL SICLSEEPED
360 370 380 390 400
HIKAAAAWAL GQLGRHTPEH ARAVAVTNTL PVLLSLYMSP ESSEDLQLKS
410 420 430 440 450
KKAIKNILQK CTYLPALEPF LYDAPPNILK HVVGQFSKVL PHDSKARRLF
460 470 480 490 500
VTSGGLKKVQ EIKAEPGSLL QEYINSINNC YPEEIVRYYS PGYSDTLLQR

VDSYQPL
Length:507
Mass (Da):55,269
Last modified:October 1, 2000 - v1
Checksum:iEFFAE719EC111285
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173866 mRNA Translation: AAF35831.1
AK005732 mRNA Translation: BAB24211.1
AF486266 Genomic DNA Translation: AAM64149.1
CCDSiCCDS27988.1
RefSeqiNP_056588.1, NM_015773.2
UniGeneiMm.31701

Genome annotation databases

EnsembliENSMUST00000023468; ENSMUSP00000023468; ENSMUSG00000022783
GeneIDi50525
KEGGimmu:50525
UCSCiuc007yjb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSPAG6_MOUSE
AccessioniPrimary (citable) accession number: Q9JLI7
Secondary accession number(s): Q8K461
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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