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Q9JLI4

- NCOA6_RAT

UniProt

Q9JLI4 - NCOA6_RAT

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Protein

Nuclear receptor coactivator 6

Gene

Ncoa6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivate expression in an agonist- and AF2-dependent manner. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway (By similarity).By similarity

GO - Molecular functioni

  1. ligand-dependent nuclear receptor binding Source: RGD
  2. ligand-dependent nuclear receptor transcription coactivator activity Source: RGD
  3. protein homodimerization activity Source: RGD
  4. thyroid hormone receptor binding Source: UniProtKB

GO - Biological processi

  1. myeloid cell differentiation Source: UniProtKB
  2. positive regulation of transcription, DNA-templated Source: RGD
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 6
Alternative name(s):
Activating signal cointegrator 2
Short name:
ASC-2
Amplified in breast cancer protein 3
Cancer-amplified transcriptional coactivator ASC-2
Nuclear receptor coactivator RAP250
Short name:
NRC
Nuclear receptor-activating protein, 250 kDa
Peroxisome proliferator-activated receptor-interacting protein
Short name:
PPAR-interacting protein
Short name:
PRIP
Thyroid hormone receptor-binding protein
Gene namesi
Name:Ncoa6
Synonyms:Aib3, Rap250, Trbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620111. Ncoa6.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi174 – 1785LVNLL → AVNAA: Abolishes interaction with nuclear receptors. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 418›418Nuclear receptor coactivator 6PRO_0000094415Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JLI4.
PRIDEiQ9JLI4.

PTM databases

PhosphoSiteiQ9JLI4.

Expressioni

Gene expression databases

GenevestigatoriQ9JLI4.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts in vitro with the basal transcription factors GTF2A and TBP, suggesting an autonomous transactivation function. Interacts with NCOA1, CRSP3, RBM14, the histone acetyltransferase proteins EP300 and CREBBP, and with methyltransferase proteins NCOA6IP and PRMT2 (By similarity). Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity). Interacts with ZNF335; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033722EBI-286271,EBI-78473From a different organism.
GHRP109122EBI-286271,EBI-286316From a different organism.
RXRAP197932EBI-286271,EBI-78598From a different organism.
THRAP108272EBI-286271,EBI-286285From a different organism.
VDRP114732EBI-286271,EBI-286357From a different organism.

Protein-protein interaction databases

IntActiQ9JLI4. 9 interactions.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni‹1 – 418›418NCOA1-binding regionBy similarityAdd
BLAST
Regioni‹1 – 352›352CREBBP-binding regionBy similarityAdd
BLAST
Regioni‹1 – 215›215TBP/GTF2A-binding regionBy similarityAdd
BLAST
Regioni60 – 214155NCOA6IP-binding regionBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi174 – 1785LXXLL motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi200 – 2056Poly-Lys
Compositional biasi301 – 3088Poly-Pro
Compositional biasi310 – 32718Poly-GlnAdd
BLAST
Compositional biasi328 – 3347Poly-Met

Domaini

Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which is essential for the association with nuclear receptors.

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000113745.
InParanoidiQ9JLI4.

Family and domain databases

InterProiIPR026638. NCOA6.
[Graphical view]
PANTHERiPTHR15690. PTHR15690. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9JLI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
EQIMTNQMQG NKAQFNSQNQ SNVMPGPAQI MRGPTPNMQG NMVQFTGQMS
60 70 80 90 100
GQMLPQQGPV SNSPSQVMGI QGQVLRPPGP SPHMAQQHTD PATTANNDVN
110 120 130 140 150
LSQMMPDVSM QQTSMVPPHV QSMQGNSASG SHFSGHGVSF NAPFGGAPNG
160 170 180 190 200
TQMSCGQNPG FPVNKDVTLT SPLLVNLLQS DISAGHFGVN NKQNNTNANK
210 220 230 240 250
QKKKKPPRKK KNCHQDLNTP DSRPAGLEEV DQQSLPGEQG INLDNTGPKL
260 270 280 290 300
PDFSNRPPGY PTQPVEQRPL QQMPPQLMQH VAPPPQPPQQ QPQPQLPQQQ
310 320 330 340 350
PQPQPPPPSQ PQSQQQQQQQ QQQQQQQMMM MLMMQQDPKS IRLPVSQNVH
360 370 380 390 400
PPRGPLNPDS QRVPMQQSGN VPVMVSLQGP ASVPPSPDKQ RMPMPVNTPL
410
GSNSRKMVYQ ESPQNSSS
Length:418
Mass (Da):45,574
Last modified:February 12, 2003 - v2
Checksum:iA90D7C4111C67CAE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228043 mRNA. Translation: AAF76422.1.
AF176351 mRNA. Translation: AAF71830.1.
UniGeneiRn.234544.
Rn.9077.

Genome annotation databases

UCSCiRGD:620111. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228043 mRNA. Translation: AAF76422.1 .
AF176351 mRNA. Translation: AAF71830.1 .
UniGenei Rn.234544.
Rn.9077.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JLI4. 9 interactions.

PTM databases

PhosphoSitei Q9JLI4.

Proteomic databases

PaxDbi Q9JLI4.
PRIDEi Q9JLI4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620111. rat.

Organism-specific databases

RGDi 620111. Ncoa6.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000113745.
InParanoidi Q9JLI4.

Miscellaneous databases

PROi Q9JLI4.

Gene expression databases

Genevestigatori Q9JLI4.

Family and domain databases

InterProi IPR026638. NCOA6.
[Graphical view ]
PANTHERi PTHR15690. PTHR15690. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator."
    Ko L., Cardona G.R., Chin W.W.
    Proc. Natl. Acad. Sci. U.S.A. 97:6212-6217(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-285, INTERACTION WITH THRB.
    Tissue: Pituitary.
  2. "A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP."
    Mahajan M.A., Samuels H.H.
    Mol. Cell. Biol. 20:5048-5063(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 135-418, INTERACTION WITH THRA; THRB; RAR; RXR; ESR; VDR; NR3C1, MUTAGENESIS OF 174-LEU--LEU-178.
    Strain: Sprague-Dawley.
    Tissue: Pituitary.

Entry informationi

Entry nameiNCOA6_RAT
AccessioniPrimary (citable) accession number: Q9JLI4
Secondary accession number(s): Q9JIH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3