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Protein
Submitted name:

Collagen type V alpha 3 chain

Gene

Col5a3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: InterPro
  2. heparin binding Source: MGI
  3. structural molecule activity Source: MGI

GO - Biological processi

  1. cell-matrix adhesion Source: MGI
  2. extracellular matrix organization Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_196607. Non-integrin membrane-ECM interactions.
REACT_196644. Syndecan interactions.
REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.
REACT_199055. Collagen degradation.
REACT_206066. Extracellular matrix organization.
REACT_216309. Integrin cell surface interactions.
REACT_236183. NCAM1 interactions.
REACT_263353. Signaling by PDGF.

Names & Taxonomyi

Protein namesi
Submitted name:
Collagen type V alpha 3 chainImported
Submitted name:
Collagen, type V, alpha 3Imported
Submitted name:
Procollagen, type V, alpha 3, isoform CRA_bImported
Submitted name:
Protein Col5a3Imported
Gene namesi
Name:Col5a3Imported
ORF Names:mCG_67925Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1858212. Col5a3.

Subcellular locationi

GO - Cellular componenti

  1. collagen type V trimer Source: MGI
  2. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9JLI2.

Structurei

3D structure databases

ProteinModelPortaliQ9JLI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

CollagenImported

Phylogenomic databases

GeneTreeiENSGT00780000121837.
HOGENOMiHOG000085654.
HOVERGENiHBG004933.
KOiK06236.
OMAiKGDVGQD.
OrthoDBiEOG7XPZ4W.
TreeFamiTF323987.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008160. Collagen.
IPR013320. ConA-like_dom.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 7 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50025. LAM_G_DOMAIN. 1 hit.
PS51461. NC1_FIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JLI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSCRRLDQL QAGLCLLLAS LQLVSWTLAA EPVDVLEAWG VHRDQAGVAE
60 70 80 90 100
GPGFCPLRIP QGDRAFRVGK SSLLSVPTWQ LFPDGHFPEN FSVLLTLRAQ
110 120 130 140 150
PANQSVLLSI YDEKGVRQLG LALGPALGLL GDSFRPLPKQ VNIMDGRWHR
160 170 180 190 200
VAVSISGNKV TLVVDCEPQP PTFGQGPRFI STAGLTVMGT QDTREESFEG
210 220 230 240 250
DIQELLLIPD PQAAFQACES YLPGCETLDS TTTGAPKDDE PETPAPRRRK
260 270 280 290 300
GKGKKKGRGR KGKGRKKNKE TSELSPTPGA PENQTSLHIP ETEKTVPHLP
310 320 330 340 350
LTPTPLAITT TVTIGQNATV SQGLDSGTET EQTTPEVDST EEGEGGGPTM
360 370 380 390 400
GPKFRAAEQS LQTEFQIFPG AGEKGAKGEP ATVEQGQQFE GPAGAPGPRG
410 420 430 440 450
ISGPSGPPGP PGFPGDRGLP GPAGLPGIPG IDGARGLPGT VIMMPFHFAS
460 470 480 490 500
SSMKGPPVSF QQAQAQAVLQ QAQLSMKGPP GPVGLTGRPG PVGLPGYPGL
510 520 530 540 550
KGELGEVGPQ GPRGLQGPPG PPGREGKTGR AGADGARGLP GDTGPKGDRG
560 570 580 590 600
FDGLPGLPGE KGQRGDFGRV GQPGPPGEDG VKGLQGPPGP TGQAGEPGPR
610 620 630 640 650
GLIGPRGLPG PLGRPGVTGS DGAPGAKGNV GPPGEPGPPG QQGNHGSQGI
660 670 680 690 700
PGPQGPIGTP GEKGPPGNPG IPGVPGSEGP PGHPGHEGPT GEKGAQGPPG
710 720 730 740 750
SAGPRGYPGL RGVKGTSGNR GLQGEKGERG EDGFPGFKGD EGPKGDRGNP
760 770 780 790 800
GPPGPRGEDG PEGQKGPGGL PGDEGPPGAA GEKGKLGVPG LPGYPGRPGP
810 820 830 840 850
KGSIGFPGPL GPLGEKGKRG KAGQPGEEGE RGTPGTRGDR GQPGATGQPG
860 870 880 890 900
PKGDVGQNGS PGPPGEKGLP GLQGPPGFPG PKGPPGPQGK DGISGHPGQR
910 920 930 940 950
GELGFQGLTG PPGPAGVLGP QGKVGDVGPL GERGPPGPPG PPGEQGLPGI
960 970 980 990 1000
EGREGAKGEL GPLGSVGKEG PPGPRGFPGP QGAPGDPGPI GLKGDKGPPG
1010 1020 1030 1040 1050
PVGANGSPGE RGPVGPSGGI GLPGQSGGQG PIGPAGEKGS PGERGTPGPT
1060 1070 1080 1090 1100
GKDGIPGPPG LQGPSGAAGP SGEEGDKGEV GMPGHKGSKG DKGDAGPPGP
1110 1120 1130 1140 1150
TGIRGPAGHS GLPGADGAQG RRGPPGLFGQ KGDDGVRGFV GVIGPPGLQG
1160 1170 1180 1190 1200
LPGPPGEKGE VGDVGSMGPH GAPGPRGPPG PSGSEGPPGL PGGVGQPGAV
1210 1220 1230 1240 1250
GEKGEPGDAG DAGPPGIPGI PGPKGEIGEK GDSGPSGAAG PPGKKGPPGE
1260 1270 1280 1290 1300
DGSKGNMGPT GLPGDLGPPG DPGVPGIDGI PGEKGNAGDI GGPGPPGASG
1310 1320 1330 1340 1350
EPGARGLPGK RGSPGRMGPE GREGEKGAKG DAGPDGPPGR TGPIGARGPP
1360 1370 1380 1390 1400
GRIGPDGLPG IPGPVGEPGL LGPPGLIGPP GPLGPPGLPG LKGDAGPKGE
1410 1420 1430 1440 1450
KGHIGLIGLI GPPGEAGEKG DQGLPGVQGP PGLQGDPGLP GPVGSLGHPG
1460 1470 1480 1490 1500
PPGVVGPLGQ KGSKGSPGSL GPRGDPGPAG PPGPPGSPAE VHGLRRRRSV
1510 1520 1530 1540 1550
TDTLEGGLEE VMASLNSLSL ELQQLQRPLG TAESPGLMCR ELHRDHPHLP
1560 1570 1580 1590 1600
DGEYWIDPNQ GCARDAFKVF CNFTAGGETC LYPDKKFETV KLASWSREKP
1610 1620 1630 1640 1650
GGWYSTFRRG KKFSYVDADG SPVNVVQLTF LKLLSAAAHQ RFTYICQNSV
1660 1670 1680 1690 1700
AWLDEAAGDH RHSIRFQGTN WEELSFNQTT AATIKVSHDG CRVRKGQAKT
1710 1720 1730
LFEFSSSVGF LPLWDVAASD FGQTNQKFGF ELGSICFSS
Length:1,739
Mass (Da):171,969
Last modified:October 1, 2000 - v1
Checksum:iEFBDFEBA46E69984
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC166365 Genomic DNA. No translation available.
AF176645 mRNA. Translation: AAF59901.1.
BC138417 mRNA. Translation: AAI38418.1.
BC138419 mRNA. Translation: AAI38420.1.
CH466522 Genomic DNA. Translation: EDL25130.1.
RefSeqiNP_058615.1. NM_016919.2.
UniGeneiMm.334994.

Genome annotation databases

EnsembliENSMUST00000004201; ENSMUSP00000004201; ENSMUSG00000004098.
GeneIDi53867.
KEGGimmu:53867.
UCSCiuc009ojf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC166365 Genomic DNA. No translation available.
AF176645 mRNA. Translation: AAF59901.1.
BC138417 mRNA. Translation: AAI38418.1.
BC138419 mRNA. Translation: AAI38420.1.
CH466522 Genomic DNA. Translation: EDL25130.1.
RefSeqiNP_058615.1. NM_016919.2.
UniGeneiMm.334994.

3D structure databases

ProteinModelPortaliQ9JLI2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004201; ENSMUSP00000004201; ENSMUSG00000004098.
GeneIDi53867.
KEGGimmu:53867.
UCSCiuc009ojf.1. mouse.

Organism-specific databases

CTDi50509.
MGIiMGI:1858212. Col5a3.

Phylogenomic databases

GeneTreeiENSGT00780000121837.
HOGENOMiHOG000085654.
HOVERGENiHBG004933.
KOiK06236.
OMAiKGDVGQD.
OrthoDBiEOG7XPZ4W.
TreeFamiTF323987.

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_196607. Non-integrin membrane-ECM interactions.
REACT_196644. Syndecan interactions.
REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.
REACT_199055. Collagen degradation.
REACT_206066. Extracellular matrix organization.
REACT_216309. Integrin cell surface interactions.
REACT_236183. NCAM1 interactions.
REACT_263353. Signaling by PDGF.

Miscellaneous databases

ChiTaRSiCol5a3. mouse.
NextBioi310709.
PROiQ9JLI2.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ9JLI2.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008160. Collagen.
IPR013320. ConA-like_dom.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 7 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50025. LAM_G_DOMAIN. 1 hit.
PS51461. NC1_FIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The pro-alpha3 (V) collagen chain. Complete primary structure, expression domains in adult and developing tissues, and comparison to the structures and expression domains of the other types V and XI procollagen chains."
    Imamura Y., Scott I.C., Greenspan D.S.
    J. Biol. Chem. 275:8749-8759(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  2. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9JLI2_MOUSE
AccessioniPrimary (citable) accession number: Q9JLI2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.