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Protein

Polycystic kidney disease 2-like 2 protein

Gene

Pkd2l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a subunit of a cation channel and play a role in fertilization.

GO - Molecular functioni

  1. calcium channel activity Source: GO_Central
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. calcium ion transmembrane transport Source: GOC
  2. detection of mechanical stimulus Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Polycystic kidney disease 2-like 2 protein
Alternative name(s):
Polycystin-2L2
Polycystin-L2
Gene namesi
Name:Pkd2l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1858231. Pkd2l2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei32 – 5221HelicalSequence AnalysisAdd
BLAST
Topological domaini53 – 277225ExtracellularSequence AnalysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence AnalysisAdd
BLAST
Topological domaini299 – 31416CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence AnalysisAdd
BLAST
Topological domaini336 – 36025ExtracellularSequence AnalysisAdd
BLAST
Transmembranei361 – 38121HelicalSequence AnalysisAdd
BLAST
Topological domaini382 – 40625CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei407 – 42721HelicalSequence AnalysisAdd
BLAST
Topological domaini428 – 46841ExtracellularSequence AnalysisAdd
BLAST
Transmembranei469 – 48921HelicalSequence AnalysisAdd
BLAST
Topological domaini490 – 621132CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Polycystic kidney disease 2-like 2 proteinPRO_0000164362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9JLG4.

PTM databases

PhosphoSiteiQ9JLG4.

Expressioni

Tissue specificityi

Expressed only in testis and heart.

Gene expression databases

BgeeiQ9JLG4.
CleanExiMM_PKD2L2.
GenevestigatoriQ9JLG4.

Interactioni

Protein-protein interaction databases

MINTiMINT-4998333.

Structurei

3D structure databases

ProteinModelPortaliQ9JLG4.
SMRiQ9JLG4. Positions 408-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili521 – 55131Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi126 – 13813Polycystin motifAdd
BLAST

Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG325704.
GeneTreeiENSGT00700000104221.
HOGENOMiHOG000230858.
HOVERGENiHBG014945.
InParanoidiQ9JLG4.
KOiK04991.
OMAiAQFRIVL.
OrthoDBiEOG7N8ZTW.
TreeFamiTF316484.

Family and domain databases

InterProiIPR013122. PKD1_2_channel.
IPR003915. PKD_2.
[Graphical view]
PfamiPF08016. PKD_channel. 1 hit.
[Graphical view]
PRINTSiPR01433. POLYCYSTIN2.

Sequencei

Sequence statusi: Complete.

Q9JLG4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEATWWYRG GTSKHDLHYR REAEVNTTLE ELLLYFIFLI NLCILTFGMV
60 70 80 90 100
NPHMYYLNKV MSSLFVDTSL PDDERSSFRS IRSITEFWKF MEGPLIDGLY
110 120 130 140 150
WDSWYGNKQL YSVKNSSRIY YENVLLGIPR VRQLRVRNNT CKVYPAFQSL
160 170 180 190 200
VSDCYSKYTV ENEDFSDFGL KRNPEWTHTP SSRTAPWHWG FVGVYRDGGY
210 220 230 240 250
IVTLSKSKSE TKAKFVDLRL NNWISRGTRA VFIDFSLYNA NVNLFCIIRL
260 270 280 290 300
LAEFPATGGL LTSWQFYSVK LLRYVSYYDY FIASCEVIFC IFLFVFIIQE
310 320 330 340 350
LRKVNEFKSA YFRSVWNWLE MLLLLLCFLA VSFYAYCNMQ SFLLLGQLLK
360 370 380 390 400
NTDSYPDFYF LAYWHIYYNN VIAITIFFAW IKIFKFISFN ETMSQLSSTL
410 420 430 440 450
SRCMKDIVGF AIMFFIIFSA YAQLGFLVFG SQVDDFSTFQ NSIFAQFRIV
460 470 480 490 500
LGDFNFAGIQ QANWILGPIY FITFIFFVFF VLLNMFLAII NDTYSEVKAD
510 520 530 540 550
YSIGRRPDFE LGKIIQKSCF NVLEKLRLKK AQAKEEKKMQ TTDLAQRARR
560 570 580 590 600
DGFDESEIQE AEQMKRWKER LEKKYYSTEI QDDYQPVTQQ EFRELFLYAV
610 620
ELEKELHYVS LKLNQLMRKL H
Length:621
Mass (Da):73,683
Last modified:July 27, 2011 - v2
Checksum:iC542425A2C8A7480
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1071N → T in AAF65621. (PubMed:10756092)Curated
Sequence conflicti551 – 5511D → E in AAF65621. (PubMed:10756092)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182033 mRNA. Translation: AAF65621.1.
BC138717 mRNA. Translation: AAI38718.1.
CCDSiCCDS29127.1.
RefSeqiNP_001156476.1. NM_001163004.1.
NP_058623.2. NM_016927.3.
XP_006526157.1. XM_006526094.1.
UniGeneiMm.445792.

Genome annotation databases

EnsembliENSMUST00000014647; ENSMUSP00000014647; ENSMUSG00000014503.
ENSMUST00000166156; ENSMUSP00000127257; ENSMUSG00000014503.
GeneIDi53871.
KEGGimmu:53871.
UCSCiuc008ekm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182033 mRNA. Translation: AAF65621.1.
BC138717 mRNA. Translation: AAI38718.1.
CCDSiCCDS29127.1.
RefSeqiNP_001156476.1. NM_001163004.1.
NP_058623.2. NM_016927.3.
XP_006526157.1. XM_006526094.1.
UniGeneiMm.445792.

3D structure databases

ProteinModelPortaliQ9JLG4.
SMRiQ9JLG4. Positions 408-492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4998333.

PTM databases

PhosphoSiteiQ9JLG4.

Proteomic databases

PRIDEiQ9JLG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014647; ENSMUSP00000014647; ENSMUSG00000014503.
ENSMUST00000166156; ENSMUSP00000127257; ENSMUSG00000014503.
GeneIDi53871.
KEGGimmu:53871.
UCSCiuc008ekm.2. mouse.

Organism-specific databases

CTDi27039.
MGIiMGI:1858231. Pkd2l2.

Phylogenomic databases

eggNOGiNOG325704.
GeneTreeiENSGT00700000104221.
HOGENOMiHOG000230858.
HOVERGENiHBG014945.
InParanoidiQ9JLG4.
KOiK04991.
OMAiAQFRIVL.
OrthoDBiEOG7N8ZTW.
TreeFamiTF316484.

Miscellaneous databases

NextBioi310725.
PROiQ9JLG4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JLG4.
CleanExiMM_PKD2L2.
GenevestigatoriQ9JLG4.

Family and domain databases

InterProiIPR013122. PKD1_2_channel.
IPR003915. PKD_2.
[Graphical view]
PfamiPF08016. PKD_channel. 1 hit.
[Graphical view]
PRINTSiPR01433. POLYCYSTIN2.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization."
    Guo L., Schreiber T.H., Weremowicz S., Morton C.C., Lee C., Zhou J.
    Genomics 64:241-251(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPK2L2_MOUSE
AccessioniPrimary (citable) accession number: Q9JLG4
Secondary accession number(s): B2RS50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.