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Protein

Polycystic kidney disease 2-like 2 protein

Gene

Pkd2l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a subunit of a cation channel and play a role in fertilization.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Polycystic kidney disease 2-like 2 protein
Alternative name(s):
Polycystin-2L2
Polycystin-L2
Gene namesi
Name:Pkd2l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1858231. Pkd2l2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 277ExtracellularSequence analysisAdd BLAST225
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 314CytoplasmicSequence analysisAdd BLAST16
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Topological domaini336 – 360ExtracellularSequence analysisAdd BLAST25
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Topological domaini382 – 406CytoplasmicSequence analysisAdd BLAST25
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 468ExtracellularSequence analysisAdd BLAST41
Transmembranei469 – 489HelicalSequence analysisAdd BLAST21
Topological domaini490 – 621CytoplasmicSequence analysisAdd BLAST132

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001643621 – 621Polycystic kidney disease 2-like 2 proteinAdd BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JLG4.
PRIDEiQ9JLG4.

PTM databases

PhosphoSitePlusiQ9JLG4.

Expressioni

Tissue specificityi

Expressed only in testis and heart.

Gene expression databases

BgeeiENSMUSG00000014503.
CleanExiMM_PKD2L2.
GenevisibleiQ9JLG4. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4998333.
STRINGi10090.ENSMUSP00000014647.

Structurei

3D structure databases

ProteinModelPortaliQ9JLG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili521 – 551Sequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi126 – 138Polycystin motifAdd BLAST13

Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
ENOG410XTGE. LUCA.
GeneTreeiENSGT00700000104221.
HOGENOMiHOG000230858.
HOVERGENiHBG014945.
InParanoidiQ9JLG4.
KOiK04991.
OMAiVWNWLEL.
OrthoDBiEOG091G034F.
TreeFamiTF316484.

Family and domain databases

InterProiIPR013122. PKD1_2_channel.
IPR003915. PKD_2.
[Graphical view]
PfamiPF08016. PKD_channel. 1 hit.
[Graphical view]
PRINTSiPR01433. POLYCYSTIN2.

Sequencei

Sequence statusi: Complete.

Q9JLG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEATWWYRG GTSKHDLHYR REAEVNTTLE ELLLYFIFLI NLCILTFGMV
60 70 80 90 100
NPHMYYLNKV MSSLFVDTSL PDDERSSFRS IRSITEFWKF MEGPLIDGLY
110 120 130 140 150
WDSWYGNKQL YSVKNSSRIY YENVLLGIPR VRQLRVRNNT CKVYPAFQSL
160 170 180 190 200
VSDCYSKYTV ENEDFSDFGL KRNPEWTHTP SSRTAPWHWG FVGVYRDGGY
210 220 230 240 250
IVTLSKSKSE TKAKFVDLRL NNWISRGTRA VFIDFSLYNA NVNLFCIIRL
260 270 280 290 300
LAEFPATGGL LTSWQFYSVK LLRYVSYYDY FIASCEVIFC IFLFVFIIQE
310 320 330 340 350
LRKVNEFKSA YFRSVWNWLE MLLLLLCFLA VSFYAYCNMQ SFLLLGQLLK
360 370 380 390 400
NTDSYPDFYF LAYWHIYYNN VIAITIFFAW IKIFKFISFN ETMSQLSSTL
410 420 430 440 450
SRCMKDIVGF AIMFFIIFSA YAQLGFLVFG SQVDDFSTFQ NSIFAQFRIV
460 470 480 490 500
LGDFNFAGIQ QANWILGPIY FITFIFFVFF VLLNMFLAII NDTYSEVKAD
510 520 530 540 550
YSIGRRPDFE LGKIIQKSCF NVLEKLRLKK AQAKEEKKMQ TTDLAQRARR
560 570 580 590 600
DGFDESEIQE AEQMKRWKER LEKKYYSTEI QDDYQPVTQQ EFRELFLYAV
610 620
ELEKELHYVS LKLNQLMRKL H
Length:621
Mass (Da):73,683
Last modified:July 27, 2011 - v2
Checksum:iC542425A2C8A7480
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107N → T in AAF65621 (PubMed:10756092).Curated1
Sequence conflicti551D → E in AAF65621 (PubMed:10756092).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182033 mRNA. Translation: AAF65621.1.
BC138717 mRNA. Translation: AAI38718.1.
CCDSiCCDS29127.1.
RefSeqiNP_001156476.1. NM_001163004.1.
NP_058623.2. NM_016927.3.
XP_017173434.1. XM_017317945.1.
UniGeneiMm.445792.

Genome annotation databases

EnsembliENSMUST00000014647; ENSMUSP00000014647; ENSMUSG00000014503.
ENSMUST00000166156; ENSMUSP00000127257; ENSMUSG00000014503.
GeneIDi53871.
KEGGimmu:53871.
UCSCiuc008ekm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182033 mRNA. Translation: AAF65621.1.
BC138717 mRNA. Translation: AAI38718.1.
CCDSiCCDS29127.1.
RefSeqiNP_001156476.1. NM_001163004.1.
NP_058623.2. NM_016927.3.
XP_017173434.1. XM_017317945.1.
UniGeneiMm.445792.

3D structure databases

ProteinModelPortaliQ9JLG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4998333.
STRINGi10090.ENSMUSP00000014647.

PTM databases

PhosphoSitePlusiQ9JLG4.

Proteomic databases

PaxDbiQ9JLG4.
PRIDEiQ9JLG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014647; ENSMUSP00000014647; ENSMUSG00000014503.
ENSMUST00000166156; ENSMUSP00000127257; ENSMUSG00000014503.
GeneIDi53871.
KEGGimmu:53871.
UCSCiuc008ekm.2. mouse.

Organism-specific databases

CTDi27039.
MGIiMGI:1858231. Pkd2l2.

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
ENOG410XTGE. LUCA.
GeneTreeiENSGT00700000104221.
HOGENOMiHOG000230858.
HOVERGENiHBG014945.
InParanoidiQ9JLG4.
KOiK04991.
OMAiVWNWLEL.
OrthoDBiEOG091G034F.
TreeFamiTF316484.

Miscellaneous databases

PROiQ9JLG4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014503.
CleanExiMM_PKD2L2.
GenevisibleiQ9JLG4. MM.

Family and domain databases

InterProiIPR013122. PKD1_2_channel.
IPR003915. PKD_2.
[Graphical view]
PfamiPF08016. PKD_channel. 1 hit.
[Graphical view]
PRINTSiPR01433. POLYCYSTIN2.
ProtoNetiSearch...

Entry informationi

Entry nameiPK2L2_MOUSE
AccessioniPrimary (citable) accession number: Q9JLG4
Secondary accession number(s): B2RS50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.