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Q9JLG4

- PK2L2_MOUSE

UniProt

Q9JLG4 - PK2L2_MOUSE

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Protein

Polycystic kidney disease 2-like 2 protein

Gene
Pkd2l2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May function as a subunit of a cation channel and play a role in fertilization.

GO - Molecular functioni

  1. calcium channel activity Source: RefGenome
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. calcium ion transmembrane transport Source: GOC
  2. detection of mechanical stimulus Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Polycystic kidney disease 2-like 2 protein
Alternative name(s):
Polycystin-2L2
Polycystin-L2
Gene namesi
Name:Pkd2l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1858231. Pkd2l2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei32 – 5221Helical; Reviewed predictionAdd
BLAST
Topological domaini53 – 277225Extracellular Reviewed predictionAdd
BLAST
Transmembranei278 – 29821Helical; Reviewed predictionAdd
BLAST
Topological domaini299 – 31416Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei315 – 33521Helical; Reviewed predictionAdd
BLAST
Topological domaini336 – 36025Extracellular Reviewed predictionAdd
BLAST
Transmembranei361 – 38121Helical; Reviewed predictionAdd
BLAST
Topological domaini382 – 40625Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei407 – 42721Helical; Reviewed predictionAdd
BLAST
Topological domaini428 – 46841Extracellular Reviewed predictionAdd
BLAST
Transmembranei469 – 48921Helical; Reviewed predictionAdd
BLAST
Topological domaini490 – 621132Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Polycystic kidney disease 2-like 2 proteinPRO_0000164362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi138 – 1381N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9JLG4.

PTM databases

PhosphoSiteiQ9JLG4.

Expressioni

Tissue specificityi

Expressed only in testis and heart.

Gene expression databases

BgeeiQ9JLG4.
CleanExiMM_PKD2L2.
GenevestigatoriQ9JLG4.

Interactioni

Protein-protein interaction databases

MINTiMINT-4998333.

Structurei

3D structure databases

ProteinModelPortaliQ9JLG4.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili521 – 55131 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi126 – 13813Polycystin motifAdd
BLAST

Sequence similaritiesi

Belongs to the polycystin family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG325704.
GeneTreeiENSGT00700000104221.
HOGENOMiHOG000230858.
HOVERGENiHBG014945.
InParanoidiB2RS50.
KOiK04991.
OMAiTSWQFYS.
OrthoDBiEOG7N8ZTW.
TreeFamiTF316484.

Family and domain databases

InterProiIPR013122. PKD1_2_channel.
IPR003915. PKD_2.
[Graphical view]
PfamiPF08016. PKD_channel. 1 hit.
[Graphical view]
PRINTSiPR01433. POLYCYSTIN2.

Sequencei

Sequence statusi: Complete.

Q9JLG4-1 [UniParc]FASTAAdd to Basket

« Hide

MSEATWWYRG GTSKHDLHYR REAEVNTTLE ELLLYFIFLI NLCILTFGMV    50
NPHMYYLNKV MSSLFVDTSL PDDERSSFRS IRSITEFWKF MEGPLIDGLY 100
WDSWYGNKQL YSVKNSSRIY YENVLLGIPR VRQLRVRNNT CKVYPAFQSL 150
VSDCYSKYTV ENEDFSDFGL KRNPEWTHTP SSRTAPWHWG FVGVYRDGGY 200
IVTLSKSKSE TKAKFVDLRL NNWISRGTRA VFIDFSLYNA NVNLFCIIRL 250
LAEFPATGGL LTSWQFYSVK LLRYVSYYDY FIASCEVIFC IFLFVFIIQE 300
LRKVNEFKSA YFRSVWNWLE MLLLLLCFLA VSFYAYCNMQ SFLLLGQLLK 350
NTDSYPDFYF LAYWHIYYNN VIAITIFFAW IKIFKFISFN ETMSQLSSTL 400
SRCMKDIVGF AIMFFIIFSA YAQLGFLVFG SQVDDFSTFQ NSIFAQFRIV 450
LGDFNFAGIQ QANWILGPIY FITFIFFVFF VLLNMFLAII NDTYSEVKAD 500
YSIGRRPDFE LGKIIQKSCF NVLEKLRLKK AQAKEEKKMQ TTDLAQRARR 550
DGFDESEIQE AEQMKRWKER LEKKYYSTEI QDDYQPVTQQ EFRELFLYAV 600
ELEKELHYVS LKLNQLMRKL H 621
Length:621
Mass (Da):73,683
Last modified:July 27, 2011 - v2
Checksum:iC542425A2C8A7480
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1071N → T in AAF65621. 1 Publication
Sequence conflicti551 – 5511D → E in AAF65621. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF182033 mRNA. Translation: AAF65621.1.
BC138717 mRNA. Translation: AAI38718.1.
CCDSiCCDS29127.1.
RefSeqiNP_001156476.1. NM_001163004.1.
NP_058623.2. NM_016927.3.
XP_006526157.1. XM_006526094.1.
UniGeneiMm.445792.

Genome annotation databases

EnsembliENSMUST00000014647; ENSMUSP00000014647; ENSMUSG00000014503.
ENSMUST00000166156; ENSMUSP00000127257; ENSMUSG00000014503.
GeneIDi53871.
KEGGimmu:53871.
UCSCiuc008ekm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF182033 mRNA. Translation: AAF65621.1 .
BC138717 mRNA. Translation: AAI38718.1 .
CCDSi CCDS29127.1.
RefSeqi NP_001156476.1. NM_001163004.1.
NP_058623.2. NM_016927.3.
XP_006526157.1. XM_006526094.1.
UniGenei Mm.445792.

3D structure databases

ProteinModelPortali Q9JLG4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4998333.

PTM databases

PhosphoSitei Q9JLG4.

Proteomic databases

PRIDEi Q9JLG4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000014647 ; ENSMUSP00000014647 ; ENSMUSG00000014503 .
ENSMUST00000166156 ; ENSMUSP00000127257 ; ENSMUSG00000014503 .
GeneIDi 53871.
KEGGi mmu:53871.
UCSCi uc008ekm.2. mouse.

Organism-specific databases

CTDi 27039.
MGIi MGI:1858231. Pkd2l2.

Phylogenomic databases

eggNOGi NOG325704.
GeneTreei ENSGT00700000104221.
HOGENOMi HOG000230858.
HOVERGENi HBG014945.
InParanoidi B2RS50.
KOi K04991.
OMAi TSWQFYS.
OrthoDBi EOG7N8ZTW.
TreeFami TF316484.

Miscellaneous databases

NextBioi 310725.
PROi Q9JLG4.
SOURCEi Search...

Gene expression databases

Bgeei Q9JLG4.
CleanExi MM_PKD2L2.
Genevestigatori Q9JLG4.

Family and domain databases

InterProi IPR013122. PKD1_2_channel.
IPR003915. PKD_2.
[Graphical view ]
Pfami PF08016. PKD_channel. 1 hit.
[Graphical view ]
PRINTSi PR01433. POLYCYSTIN2.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization."
    Guo L., Schreiber T.H., Weremowicz S., Morton C.C., Lee C., Zhou J.
    Genomics 64:241-251(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPK2L2_MOUSE
AccessioniPrimary (citable) accession number: Q9JLG4
Secondary accession number(s): B2RS50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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