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Q9JLG4 (PK2L2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Polycystic kidney disease 2-like 2 protein
Alternative name(s):
Polycystin-2L2
Polycystin-L2
Gene names
Name:Pkd2l2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length621 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as a subunit of a cation channel and play a role in fertilization.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed only in testis and heart.

Sequence similarities

Belongs to the polycystin family.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Molecular functionIon channel
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 621621Polycystic kidney disease 2-like 2 protein
PRO_0000164362

Regions

Topological domain1 – 3131Cytoplasmic Potential
Transmembrane32 – 5221Helical; Potential
Topological domain53 – 277225Extracellular Potential
Transmembrane278 – 29821Helical; Potential
Topological domain299 – 31416Cytoplasmic Potential
Transmembrane315 – 33521Helical; Potential
Topological domain336 – 36025Extracellular Potential
Transmembrane361 – 38121Helical; Potential
Topological domain382 – 40625Cytoplasmic Potential
Transmembrane407 – 42721Helical; Potential
Topological domain428 – 46841Extracellular Potential
Transmembrane469 – 48921Helical; Potential
Topological domain490 – 621132Cytoplasmic Potential
Coiled coil521 – 55131 Potential
Motif126 – 13813Polycystin motif

Amino acid modifications

Glycosylation1151N-linked (GlcNAc...) Potential
Glycosylation1381N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1071N → T in AAF65621. Ref.1
Sequence conflict5511D → E in AAF65621. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9JLG4 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: C542425A2C8A7480

FASTA62173,683
        10         20         30         40         50         60 
MSEATWWYRG GTSKHDLHYR REAEVNTTLE ELLLYFIFLI NLCILTFGMV NPHMYYLNKV 

        70         80         90        100        110        120 
MSSLFVDTSL PDDERSSFRS IRSITEFWKF MEGPLIDGLY WDSWYGNKQL YSVKNSSRIY 

       130        140        150        160        170        180 
YENVLLGIPR VRQLRVRNNT CKVYPAFQSL VSDCYSKYTV ENEDFSDFGL KRNPEWTHTP 

       190        200        210        220        230        240 
SSRTAPWHWG FVGVYRDGGY IVTLSKSKSE TKAKFVDLRL NNWISRGTRA VFIDFSLYNA 

       250        260        270        280        290        300 
NVNLFCIIRL LAEFPATGGL LTSWQFYSVK LLRYVSYYDY FIASCEVIFC IFLFVFIIQE 

       310        320        330        340        350        360 
LRKVNEFKSA YFRSVWNWLE MLLLLLCFLA VSFYAYCNMQ SFLLLGQLLK NTDSYPDFYF 

       370        380        390        400        410        420 
LAYWHIYYNN VIAITIFFAW IKIFKFISFN ETMSQLSSTL SRCMKDIVGF AIMFFIIFSA 

       430        440        450        460        470        480 
YAQLGFLVFG SQVDDFSTFQ NSIFAQFRIV LGDFNFAGIQ QANWILGPIY FITFIFFVFF 

       490        500        510        520        530        540 
VLLNMFLAII NDTYSEVKAD YSIGRRPDFE LGKIIQKSCF NVLEKLRLKK AQAKEEKKMQ 

       550        560        570        580        590        600 
TTDLAQRARR DGFDESEIQE AEQMKRWKER LEKKYYSTEI QDDYQPVTQQ EFRELFLYAV 

       610        620 
ELEKELHYVS LKLNQLMRKL H

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization."
Guo L., Schreiber T.H., Weremowicz S., Morton C.C., Lee C., Zhou J.
Genomics 64:241-251(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF182033 mRNA. Translation: AAF65621.1.
BC138717 mRNA. Translation: AAI38718.1.
IPIIPI00124289.
RefSeqNP_001156476.1. NM_001163004.1.
NP_058623.2. NM_016927.3.
UniGeneMm.445792.

3D structure databases

ProteinModelPortalQ9JLG4.
SMRQ9JLG4. Positions 410-493.
ModBaseSearch...

PTM databases

PhosphoSiteQ9JLG4.

Proteomic databases

PRIDEQ9JLG4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000014647; ENSMUSP00000014647; ENSMUSG00000014503.
ENSMUST00000166156; ENSMUSP00000127257; ENSMUSG00000014503.
GeneID53871.
KEGGmmu:53871.

Organism-specific databases

CTD27039.
MGIMGI:1858231. Pkd2l2.

Phylogenomic databases

eggNOGNOG325704.
GeneTreeENSGT00700000104221.
HOGENOMHOG000230858.
HOVERGENHBG014945.
InParanoidB2RS50.
KOK04991.
OMAKFMEGPL.
OrthoDBEOG4C5CJ2.

Gene expression databases

BgeeQ9JLG4.
CleanExMM_PKD2L2.
GenevestigatorQ9JLG4.
GermOnlineENSMUSG00000014503. Mus musculus.

Family and domain databases

InterProIPR013122. PKD1_2_channel.
IPR003915. PKD_2.
[Graphical view]
PfamPF08016. PKD_channel. 1 hit.
[Graphical view]
PRINTSPR01433. POLYCYSTIN2.
ProtoNetSearch...

Other

NextBio310725.
SOURCESearch...

Entry information

Entry namePK2L2_MOUSE
AccessionPrimary (citable) accession number: Q9JLG4
Secondary accession number(s): B2RS50
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 27, 2011
Last modified: May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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