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Q9JLG4

- PK2L2_MOUSE

UniProt

Q9JLG4 - PK2L2_MOUSE

Protein

Polycystic kidney disease 2-like 2 protein

Gene

Pkd2l2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May function as a subunit of a cation channel and play a role in fertilization.

    GO - Molecular functioni

    1. calcium channel activity Source: RefGenome
    2. calcium ion binding Source: InterPro

    GO - Biological processi

    1. calcium ion transmembrane transport Source: GOC
    2. detection of mechanical stimulus Source: RefGenome

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polycystic kidney disease 2-like 2 protein
    Alternative name(s):
    Polycystin-2L2
    Polycystin-L2
    Gene namesi
    Name:Pkd2l2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1858231. Pkd2l2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 621621Polycystic kidney disease 2-like 2 proteinPRO_0000164362Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9JLG4.

    PTM databases

    PhosphoSiteiQ9JLG4.

    Expressioni

    Tissue specificityi

    Expressed only in testis and heart.

    Gene expression databases

    BgeeiQ9JLG4.
    CleanExiMM_PKD2L2.
    GenevestigatoriQ9JLG4.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4998333.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JLG4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini53 – 277225ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 31416CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini336 – 36025ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini382 – 40625CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini428 – 46841ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini490 – 621132CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei361 – 38121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei469 – 48921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili521 – 55131Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi126 – 13813Polycystin motifAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polycystin family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG325704.
    GeneTreeiENSGT00700000104221.
    HOGENOMiHOG000230858.
    HOVERGENiHBG014945.
    InParanoidiB2RS50.
    KOiK04991.
    OMAiTSWQFYS.
    OrthoDBiEOG7N8ZTW.
    TreeFamiTF316484.

    Family and domain databases

    InterProiIPR013122. PKD1_2_channel.
    IPR003915. PKD_2.
    [Graphical view]
    PfamiPF08016. PKD_channel. 1 hit.
    [Graphical view]
    PRINTSiPR01433. POLYCYSTIN2.

    Sequencei

    Sequence statusi: Complete.

    Q9JLG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEATWWYRG GTSKHDLHYR REAEVNTTLE ELLLYFIFLI NLCILTFGMV    50
    NPHMYYLNKV MSSLFVDTSL PDDERSSFRS IRSITEFWKF MEGPLIDGLY 100
    WDSWYGNKQL YSVKNSSRIY YENVLLGIPR VRQLRVRNNT CKVYPAFQSL 150
    VSDCYSKYTV ENEDFSDFGL KRNPEWTHTP SSRTAPWHWG FVGVYRDGGY 200
    IVTLSKSKSE TKAKFVDLRL NNWISRGTRA VFIDFSLYNA NVNLFCIIRL 250
    LAEFPATGGL LTSWQFYSVK LLRYVSYYDY FIASCEVIFC IFLFVFIIQE 300
    LRKVNEFKSA YFRSVWNWLE MLLLLLCFLA VSFYAYCNMQ SFLLLGQLLK 350
    NTDSYPDFYF LAYWHIYYNN VIAITIFFAW IKIFKFISFN ETMSQLSSTL 400
    SRCMKDIVGF AIMFFIIFSA YAQLGFLVFG SQVDDFSTFQ NSIFAQFRIV 450
    LGDFNFAGIQ QANWILGPIY FITFIFFVFF VLLNMFLAII NDTYSEVKAD 500
    YSIGRRPDFE LGKIIQKSCF NVLEKLRLKK AQAKEEKKMQ TTDLAQRARR 550
    DGFDESEIQE AEQMKRWKER LEKKYYSTEI QDDYQPVTQQ EFRELFLYAV 600
    ELEKELHYVS LKLNQLMRKL H 621
    Length:621
    Mass (Da):73,683
    Last modified:July 27, 2011 - v2
    Checksum:iC542425A2C8A7480
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti107 – 1071N → T in AAF65621. (PubMed:10756092)Curated
    Sequence conflicti551 – 5511D → E in AAF65621. (PubMed:10756092)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182033 mRNA. Translation: AAF65621.1.
    BC138717 mRNA. Translation: AAI38718.1.
    CCDSiCCDS29127.1.
    RefSeqiNP_001156476.1. NM_001163004.1.
    NP_058623.2. NM_016927.3.
    XP_006526157.1. XM_006526094.1.
    UniGeneiMm.445792.

    Genome annotation databases

    EnsembliENSMUST00000014647; ENSMUSP00000014647; ENSMUSG00000014503.
    ENSMUST00000166156; ENSMUSP00000127257; ENSMUSG00000014503.
    GeneIDi53871.
    KEGGimmu:53871.
    UCSCiuc008ekm.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182033 mRNA. Translation: AAF65621.1 .
    BC138717 mRNA. Translation: AAI38718.1 .
    CCDSi CCDS29127.1.
    RefSeqi NP_001156476.1. NM_001163004.1.
    NP_058623.2. NM_016927.3.
    XP_006526157.1. XM_006526094.1.
    UniGenei Mm.445792.

    3D structure databases

    ProteinModelPortali Q9JLG4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4998333.

    PTM databases

    PhosphoSitei Q9JLG4.

    Proteomic databases

    PRIDEi Q9JLG4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000014647 ; ENSMUSP00000014647 ; ENSMUSG00000014503 .
    ENSMUST00000166156 ; ENSMUSP00000127257 ; ENSMUSG00000014503 .
    GeneIDi 53871.
    KEGGi mmu:53871.
    UCSCi uc008ekm.2. mouse.

    Organism-specific databases

    CTDi 27039.
    MGIi MGI:1858231. Pkd2l2.

    Phylogenomic databases

    eggNOGi NOG325704.
    GeneTreei ENSGT00700000104221.
    HOGENOMi HOG000230858.
    HOVERGENi HBG014945.
    InParanoidi B2RS50.
    KOi K04991.
    OMAi TSWQFYS.
    OrthoDBi EOG7N8ZTW.
    TreeFami TF316484.

    Miscellaneous databases

    NextBioi 310725.
    PROi Q9JLG4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JLG4.
    CleanExi MM_PKD2L2.
    Genevestigatori Q9JLG4.

    Family and domain databases

    InterProi IPR013122. PKD1_2_channel.
    IPR003915. PKD_2.
    [Graphical view ]
    Pfami PF08016. PKD_channel. 1 hit.
    [Graphical view ]
    PRINTSi PR01433. POLYCYSTIN2.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization."
      Guo L., Schreiber T.H., Weremowicz S., Morton C.C., Lee C., Zhou J.
      Genomics 64:241-251(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPK2L2_MOUSE
    AccessioniPrimary (citable) accession number: Q9JLG4
    Secondary accession number(s): B2RS50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3