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Q9JLF7

- TLR5_MOUSE

UniProt

Q9JLF7 - TLR5_MOUSE

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Protein
Toll-like receptor 5
Gene
Tlr5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  2. defense response to bacterium Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
  4. innate immune response Source: UniProtKB-KW
  5. positive regulation of cytokine production Source: InterPro
  6. regulation of cytokine secretion Source: InterPro
  7. toll-like receptor 5 signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 5
Gene namesi
Name:Tlr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1858171. Tlr5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 641615Extracellular Reviewed prediction
Add
BLAST
Transmembranei642 – 66221Helical; Reviewed prediction
Add
BLAST
Topological domaini663 – 859197Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 859833Toll-like receptor 5
PRO_0000034730Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi46 – 461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi246 – 2461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi343 – 3431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi438 – 4381N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi584 ↔ 611 By similarity
Disulfide bondi586 ↔ 630 By similarity
Glycosylationi596 – 5961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi599 – 5991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi624 – 6241N-linked (GlcNAc...) Reviewed prediction
Modified residuei799 – 7991Phosphotyrosine By similarity

Post-translational modificationi

Phosphorylated at Tyr-799 upon flagellin binding; required for signaling By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9JLF7.

PTM databases

PhosphoSiteiQ9JLF7.

Expressioni

Tissue specificityi

Highly expressed in liver. Detected in lung and at very low levels in most other tissues.

Gene expression databases

CleanExiMM_TLR5.
GenevestigatoriQ9JLF7.

Interactioni

Subunit structurei

Homodimer both in the absence and presence of ligand. Binds MYD88 via their respective TIR domains By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
flagQ560862EBI-6548397,EBI-6548623From a different organism.
fliCE1WGJ52EBI-6548397,EBI-6548383From a different organism.

Protein-protein interaction databases

IntActiQ9JLF7. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9JLF7.
SMRiQ9JLF7. Positions 24-838.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 6925LRR 1
Add
BLAST
Repeati72 – 9423LRR 2
Add
BLAST
Repeati96 – 11823LRR 3
Add
BLAST
Repeati121 – 14424LRR 4
Add
BLAST
Repeati147 – 16721LRR 5
Add
BLAST
Repeati172 – 19322LRR 6
Add
BLAST
Repeati198 – 21215LRR 7
Add
BLAST
Repeati215 – 23016LRR 8
Add
BLAST
Repeati235 – 2362LRR 9
Repeati261 – 28525LRR 11
Add
BLAST
Repeati290 – 30213LRR 12
Add
BLAST
Repeati314 – 33522LRR 13
Add
BLAST
Repeati338 – 35619LRR 14
Add
BLAST
Repeati386 – 40217LRR 16
Add
BLAST
Repeati413 – 43220LRR 17
Add
BLAST
Repeati450 – 47122LRR 18
Add
BLAST
Repeati475 – 49622LRR 19
Add
BLAST
Repeati504 – 52522LRR 20
Add
BLAST
Repeati528 – 54720LRR 21
Add
BLAST
Repeati550 – 56819LRR 22
Add
BLAST
Domaini580 – 63253LRRCT
Add
BLAST
Domaini692 – 838147TIR
Add
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 TIR domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271351.
HOGENOMiHOG000008675.
HOVERGENiHBG023182.
InParanoidiQ9JLF7.
KOiK10168.
PhylomeDBiQ9JLF7.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027176. TLR5.
[Graphical view]
PANTHERiPTHR24365:SF221. PTHR24365:SF221. 1 hit.
PfamiPF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 14 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLF7-1 [UniParc]FASTAAdd to Basket

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MACQLDLLIG VIFMASPVLV ISPCSSDGRI AFFRGCNLTQ IPWILNTTTE    50
RLLLSFNYIS MVVATSFPLL ERLQLLELGT QYANLTIGPG AFRNLPNLRI 100
LDLGQSQIEV LNRDAFQGLP HLLELRLFSC GLSSAVLSDG YFRNLYSLAR 150
LDLSGNQIHS LRLHSSFREL NSLSDVNFAF NQIFTICEDE LEPLQGKTLS 200
FFGLKLTKLF SRVSVGWETC RNPFRGVRLE TLDLSENGWT VDITRNFSNI 250
IQGSQISSLI LKHHIMGPGF GFQNIRDPDQ STFASLARSS VLQLDLSHGF 300
IFSLNPRLFG TLKDLKMLNL AFNKINKIGE NAFYGLDSLQ VLNLSYNLLG 350
ELYNSNFYGL PRVAYVDLQR NHIGIIQDQT FRLLKTLQTL DLRDNALKAI 400
GFIPSIQMVL LGGNKLVHLP HIHFTANFLE LSENRLENLS DLYFLLRVPQ 450
LQFLILNQNR LSSCKAAHTP SENPSLEQLF LTENMLQLAW ETGLCWDVFQ 500
GLSRLQILYL SNNYLNFLPP GIFNDLVALR MLSLSANKLT VLSPGSLPAN 550
LEILDISRNQ LLCPDPALFS SLRVLDITHN EFVCNCELST FISWLNQTNV 600
TLFGSPADVY CMYPNSLLGG SLYNISTEDC DEEEAMRSLK FSLFILCTVT 650
LTLFLVITLV VIKFRGICFL CYKTIQKLVF KDKVWSLEPG AYRYDAYFCF 700
SSKDFEWAQN ALLKHLDAHY SSRNRLRLCF EERDFIPGEN HISNIQAAVW 750
GSRKTVCLVS RHFLKDGWCL EAFRYAQSRS LSDLKSILIV VVVGSLSQYQ 800
LMRHETIRGF LQKQQYLRWP EDLQDVGWFL DKLSGCILKE EKGKKRSSSI 850
QLRTIATIS 859
Length:859
Mass (Da):97,627
Last modified:October 1, 2000 - v1
Checksum:i74CD915EA3F0275F
GO

Polymorphismi

The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). The strain MOLF/Ei is highly susceptible to the infection, has an unique TLR5 haplotype and a lower expression of TRL5.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti226 – 2261G → D in strain: MOLF/Ei.
Natural varianti399 – 3991A → T in strain: MOLF/Ei.
Natural varianti470 – 4701P → T in strain: MOLF/Ei.
Natural varianti482 – 4821T → A in strain: MOLF/Ei.
Natural varianti609 – 6091V → M in strain: MOLF/Ei.
Natural varianti619 – 6191G → A in strain: MOLF/Ei.
Natural varianti835 – 8351G → E in strain: MOLF/Ei.
Natural varianti843 – 8431G → A in strain: MOLF/Ei.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF186107 mRNA. Translation: AAF65625.1.
RefSeqiNP_058624.2. NM_016928.2.
UniGeneiMm.116894.

Genome annotation databases

GeneIDi53791.
KEGGimmu:53791.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF186107 mRNA. Translation: AAF65625.1 .
RefSeqi NP_058624.2. NM_016928.2.
UniGenei Mm.116894.

3D structure databases

ProteinModelPortali Q9JLF7.
SMRi Q9JLF7. Positions 24-838.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JLF7. 3 interactions.

PTM databases

PhosphoSitei Q9JLF7.

Proteomic databases

PRIDEi Q9JLF7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 53791.
KEGGi mmu:53791.

Organism-specific databases

CTDi 7100.
MGIi MGI:1858171. Tlr5.

Phylogenomic databases

eggNOGi NOG271351.
HOGENOMi HOG000008675.
HOVERGENi HBG023182.
InParanoidi Q9JLF7.
KOi K10168.
PhylomeDBi Q9JLF7.

Miscellaneous databases

NextBioi 310633.
PROi Q9JLF7.
SOURCEi Search...

Gene expression databases

CleanExi MM_TLR5.
Genevestigatori Q9JLF7.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027176. TLR5.
[Graphical view ]
PANTHERi PTHR24365:SF221. PTHR24365:SF221. 1 hit.
Pfami PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 14 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of the murine Toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice."
    Sebastiani G., Leveque G., Lariviere L., Laroche L., Skamene E., Gros P., Malo D.
    Genomics 64:230-240(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS.
    Strain: C57BL/6J and MOLF/Ei.
    Tissue: Liver.

Entry informationi

Entry nameiTLR5_MOUSE
AccessioniPrimary (citable) accession number: Q9JLF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi