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Q9JLF6

- TGM1_MOUSE

UniProt

Q9JLF6 - TGM1_MOUSE

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Protein

Protein-glutamine gamma-glutamyltransferase K

Gene
Tgm1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum By similarity.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei376 – 3761 By similarity
Active sitei435 – 4351 By similarity
Active sitei458 – 4581 By similarity
Metal bindingi498 – 4981Calcium By similarity
Metal bindingi500 – 5001Calcium By similarity
Metal bindingi547 – 5471Calcium By similarity
Metal bindingi552 – 5521Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. keratinization Source: UniProtKB-KW
  2. organ morphogenesis Source: MGI
  3. peptide cross-linking Source: InterPro
  4. protein metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Keratinization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase K (EC:2.3.2.13)
Alternative name(s):
Epidermal TGase
Transglutaminase K
Short name:
TG(K)
Short name:
TGK
Short name:
TGase K
Transglutaminase-1
Short name:
TGase-1
Gene namesi
Name:Tgm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:98730. Tgm1.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell adherens junction Source: MGI
  2. intrinsic component of membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 815815Protein-glutamine gamma-glutamyltransferase KPRO_0000213702Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Phosphoserine By similarity
Modified residuei83 – 831Phosphoserine By similarity
Modified residuei91 – 911Phosphoserine1 Publication
Modified residuei94 – 941Phosphoserine2 Publications
Modified residuei803 – 8031Phosphoserine1 Publication

Post-translational modificationi

Tyrosine-phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JLF6.
PaxDbiQ9JLF6.
PRIDEiQ9JLF6.

PTM databases

PhosphoSiteiQ9JLF6.

Expressioni

Tissue specificityi

Expressed in large amounts in epithelial tissues (lung, liver and kidney).1 Publication

Gene expression databases

BgeeiQ9JLF6.
CleanExiMM_TGM1.
GenevestigatoriQ9JLF6.

Interactioni

Protein-protein interaction databases

IntActiQ9JLF6. 3 interactions.
MINTiMINT-4137626.

Structurei

3D structure databases

ProteinModelPortaliQ9JLF6.
SMRiQ9JLF6. Positions 85-786.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
GeneTreeiENSGT00740000115156.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ9JLF6.
KOiK05619.
OrthoDBiEOG7WT40M.
PhylomeDBiQ9JLF6.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JLF6-1 [UniParc]FASTAAdd to Basket

« Hide

MEGPRSDVGR WGRSPWQPPT TPSPEPEPEP EPDRRSRSRR GGGRSFWARC    50
CGCCSCGNRG DDDWGPEPSG SRSRGTSSRG RDSRGGRRPE SRGSGVNAAG 100
DGTIREGMLV VTGVDLLCSR SDQNRREHHT DEFEYDELIV RRGQPFHMIL 150
FLNREYESSD RIALELLIGS NPEVGKGTHV IIPVGKGGSG GWKAQVTKNN 200
GHNLNLRVHT SPNAIIGKFQ FTVRTRSEAG EFQLPFDPRN EIYILFNPWC 250
PEDIVYVDHE DWRQEYVLNE SGRIYYGTEA QIGERTWNYG QFDHGVLDAC 300
LYILDRRGMP YGGRGDPVSV SRVVSAMVNS LDDNGVLIGN WTGDYSRGTN 350
PSAWVGSVEI LLSYLRTGYS VPYGQCWVFA GVTTTVLRCL GFATRTVTNF 400
NSAHDTDTSL TMDIYFDENM KPLEHLNHDS VWNFHVWNDC WMKRPDLPSG 450
FDGWQVVDAT PQETSSGIFC CGPCSVESVK NGLVYMKYDT PFIFAEVNSD 500
KVYWQRQDDG SFKIVYVEEK AIGTLIVTKA IHSNNREDIT HIYKHPEGSE 550
AERRAVEKAA AHGSKPNVYA TRDSAEDVAM QVEAQDAVMG QDLAVSVVLT 600
NRGSSRRTVK LHLYLCVTYY TGVSGPTFKE AKKEVTLAPG ASDSVTMPVA 650
YKEYKPHLVD QGAMLLNVSG HVKESGQVLA KQHTFRLRTP DLSLTLLGAA 700
VVGQECGVQI VFKNPLPVTL TNVVFRLEGS GLQRPKVLNV GDIGGNETVT 750
LRQTFVPVRP GPRQLIASLD SPQLSQVHGV IQVDVAPASG GSGFSDAGGD 800
SRSGENIPMA YRGGA 815
Length:815
Mass (Da):89,826
Last modified:January 4, 2005 - v2
Checksum:i326DD4E512AEA23E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291E → V in AAF35986. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF186373 mRNA. Translation: AAF35986.1.
BC026422 mRNA. Translation: AAH26422.1.
CCDSiCCDS36932.1.
RefSeqiNP_001155186.1. NM_001161714.1.
NP_001155187.1. NM_001161715.1.
NP_064368.3. NM_019984.3.
XP_006518871.1. XM_006518808.1.
XP_006518872.1. XM_006518809.1.
UniGeneiMm.41964.

Genome annotation databases

EnsembliENSMUST00000002389; ENSMUSP00000002389; ENSMUSG00000022218.
ENSMUST00000168729; ENSMUSP00000128090; ENSMUSG00000022218.
ENSMUST00000178034; ENSMUSP00000137642; ENSMUSG00000022218.
GeneIDi21816.
KEGGimmu:21816.
UCSCiuc007uag.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF186373 mRNA. Translation: AAF35986.1 .
BC026422 mRNA. Translation: AAH26422.1 .
CCDSi CCDS36932.1.
RefSeqi NP_001155186.1. NM_001161714.1.
NP_001155187.1. NM_001161715.1.
NP_064368.3. NM_019984.3.
XP_006518871.1. XM_006518808.1.
XP_006518872.1. XM_006518809.1.
UniGenei Mm.41964.

3D structure databases

ProteinModelPortali Q9JLF6.
SMRi Q9JLF6. Positions 85-786.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JLF6. 3 interactions.
MINTi MINT-4137626.

PTM databases

PhosphoSitei Q9JLF6.

Proteomic databases

MaxQBi Q9JLF6.
PaxDbi Q9JLF6.
PRIDEi Q9JLF6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002389 ; ENSMUSP00000002389 ; ENSMUSG00000022218 .
ENSMUST00000168729 ; ENSMUSP00000128090 ; ENSMUSG00000022218 .
ENSMUST00000178034 ; ENSMUSP00000137642 ; ENSMUSG00000022218 .
GeneIDi 21816.
KEGGi mmu:21816.
UCSCi uc007uag.2. mouse.

Organism-specific databases

CTDi 7051.
MGIi MGI:98730. Tgm1.

Phylogenomic databases

eggNOGi NOG80379.
GeneTreei ENSGT00740000115156.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi Q9JLF6.
KOi K05619.
OrthoDBi EOG7WT40M.
PhylomeDBi Q9JLF6.
TreeFami TF324278.

Miscellaneous databases

NextBioi 301220.
PROi Q9JLF6.
SOURCEi Search...

Gene expression databases

Bgeei Q9JLF6.
CleanExi MM_TGM1.
Genevestigatori Q9JLF6.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells."
    Hiiragi T., Sasaki H., Nagafuchi A., Sabe H., Shen S.C., Matsuki M., Yamanishi K., Tsukita S.
    J. Biol. Chem. 274:34148-34154(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91; SER-94 AND SER-803, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTGM1_MOUSE
AccessioniPrimary (citable) accession number: Q9JLF6
Secondary accession number(s): Q8R0T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi