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Protein

Protein-glutamine gamma-glutamyltransferase K

Gene

Tgm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity).By similarity

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei376PROSITE-ProRule annotation1
Active sitei435PROSITE-ProRule annotation1
Active sitei458PROSITE-ProRule annotation1
Metal bindingi498CalciumBy similarity1
Metal bindingi500CalciumBy similarity1
Metal bindingi547CalciumBy similarity1
Metal bindingi552CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: MGI
  • peptide cross-linking Source: InterPro
  • positive regulation of cell cycle Source: UniProtKB
  • positive regulation of keratinocyte proliferation Source: UniProtKB
  • protein metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Keratinization

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi2.3.2.13. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase K (EC:2.3.2.13)
Alternative name(s):
Epidermal TGase
Transglutaminase K
Short name:
TG(K)
Short name:
TGK
Short name:
TGase K
Transglutaminase-1
Short name:
TGase-1
Gene namesi
Name:Tgm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98730. Tgm1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002137021 – 815Protein-glutamine gamma-glutamyltransferase KAdd BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphothreonineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei71PhosphoserineBy similarity1
Modified residuei83PhosphoserineBy similarity1
Modified residuei91PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei803PhosphoserineCombined sources1

Post-translational modificationi

Tyrosine-phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JLF6.
MaxQBiQ9JLF6.
PaxDbiQ9JLF6.
PeptideAtlasiQ9JLF6.
PRIDEiQ9JLF6.

PTM databases

iPTMnetiQ9JLF6.
PhosphoSitePlusiQ9JLF6.

Expressioni

Tissue specificityi

Expressed in large amounts in epithelial tissues (lung, liver and kidney).1 Publication

Gene expression databases

BgeeiENSMUSG00000022218.
CleanExiMM_TGM1.

Interactioni

Protein-protein interaction databases

IntActiQ9JLF6. 3 interactors.
MINTiMINT-4137626.
STRINGi10090.ENSMUSP00000002389.

Structurei

3D structure databases

ProteinModelPortaliQ9JLF6.
SMRiQ9JLF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ9JLF6.
KOiK05619.
PhylomeDBiQ9JLF6.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JLF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPRSDVGR WGRSPWQPPT TPSPEPEPEP EPDRRSRSRR GGGRSFWARC
60 70 80 90 100
CGCCSCGNRG DDDWGPEPSG SRSRGTSSRG RDSRGGRRPE SRGSGVNAAG
110 120 130 140 150
DGTIREGMLV VTGVDLLCSR SDQNRREHHT DEFEYDELIV RRGQPFHMIL
160 170 180 190 200
FLNREYESSD RIALELLIGS NPEVGKGTHV IIPVGKGGSG GWKAQVTKNN
210 220 230 240 250
GHNLNLRVHT SPNAIIGKFQ FTVRTRSEAG EFQLPFDPRN EIYILFNPWC
260 270 280 290 300
PEDIVYVDHE DWRQEYVLNE SGRIYYGTEA QIGERTWNYG QFDHGVLDAC
310 320 330 340 350
LYILDRRGMP YGGRGDPVSV SRVVSAMVNS LDDNGVLIGN WTGDYSRGTN
360 370 380 390 400
PSAWVGSVEI LLSYLRTGYS VPYGQCWVFA GVTTTVLRCL GFATRTVTNF
410 420 430 440 450
NSAHDTDTSL TMDIYFDENM KPLEHLNHDS VWNFHVWNDC WMKRPDLPSG
460 470 480 490 500
FDGWQVVDAT PQETSSGIFC CGPCSVESVK NGLVYMKYDT PFIFAEVNSD
510 520 530 540 550
KVYWQRQDDG SFKIVYVEEK AIGTLIVTKA IHSNNREDIT HIYKHPEGSE
560 570 580 590 600
AERRAVEKAA AHGSKPNVYA TRDSAEDVAM QVEAQDAVMG QDLAVSVVLT
610 620 630 640 650
NRGSSRRTVK LHLYLCVTYY TGVSGPTFKE AKKEVTLAPG ASDSVTMPVA
660 670 680 690 700
YKEYKPHLVD QGAMLLNVSG HVKESGQVLA KQHTFRLRTP DLSLTLLGAA
710 720 730 740 750
VVGQECGVQI VFKNPLPVTL TNVVFRLEGS GLQRPKVLNV GDIGGNETVT
760 770 780 790 800
LRQTFVPVRP GPRQLIASLD SPQLSQVHGV IQVDVAPASG GSGFSDAGGD
810
SRSGENIPMA YRGGA
Length:815
Mass (Da):89,826
Last modified:January 4, 2005 - v2
Checksum:i326DD4E512AEA23E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29E → V in AAF35986 (PubMed:10567386).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186373 mRNA. Translation: AAF35986.1.
BC026422 mRNA. Translation: AAH26422.1.
CCDSiCCDS36932.1.
RefSeqiNP_001155186.1. NM_001161714.1.
NP_001155187.1. NM_001161715.1.
NP_064368.3. NM_019984.3.
XP_006518871.1. XM_006518808.2.
XP_006518872.1. XM_006518809.3.
UniGeneiMm.41964.

Genome annotation databases

GeneIDi21816.
KEGGimmu:21816.
UCSCiuc007uag.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186373 mRNA. Translation: AAF35986.1.
BC026422 mRNA. Translation: AAH26422.1.
CCDSiCCDS36932.1.
RefSeqiNP_001155186.1. NM_001161714.1.
NP_001155187.1. NM_001161715.1.
NP_064368.3. NM_019984.3.
XP_006518871.1. XM_006518808.2.
XP_006518872.1. XM_006518809.3.
UniGeneiMm.41964.

3D structure databases

ProteinModelPortaliQ9JLF6.
SMRiQ9JLF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JLF6. 3 interactors.
MINTiMINT-4137626.
STRINGi10090.ENSMUSP00000002389.

PTM databases

iPTMnetiQ9JLF6.
PhosphoSitePlusiQ9JLF6.

Proteomic databases

EPDiQ9JLF6.
MaxQBiQ9JLF6.
PaxDbiQ9JLF6.
PeptideAtlasiQ9JLF6.
PRIDEiQ9JLF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi21816.
KEGGimmu:21816.
UCSCiuc007uag.2. mouse.

Organism-specific databases

CTDi7051.
MGIiMGI:98730. Tgm1.

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ9JLF6.
KOiK05619.
PhylomeDBiQ9JLF6.
TreeFamiTF324278.

Enzyme and pathway databases

BRENDAi2.3.2.13. 3474.

Miscellaneous databases

PROiQ9JLF6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022218.
CleanExiMM_TGM1.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTGM1_MOUSE
AccessioniPrimary (citable) accession number: Q9JLF6
Secondary accession number(s): Q8R0T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.