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Q9JLF1

- GBRT_MOUSE

UniProt

Q9JLF1 - GBRT_MOUSE

Protein

Gamma-aminobutyric acid receptor subunit theta

Gene

Gabrq

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB-KW
    2. extracellular ligand-gated ion channel activity Source: InterPro
    3. GABA-A receptor activity Source: MGI

    GO - Biological processi

    1. chloride transport Source: MGI
    2. gamma-aminobutyric acid signaling pathway Source: MGI

    Keywords - Molecular functioni

    Chloride channel, Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit theta
    Alternative name(s):
    GABA(A) receptor subunit theta
    Gene namesi
    Name:Gabrq
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1888498. Gabrq.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. integral component of plasma membrane Source: MGI
    4. postsynaptic membrane Source: UniProtKB-SubCell
    5. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 638617Gamma-aminobutyric acid receptor subunit thetaPRO_0000000496Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi183 ↔ 197By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9JLF1.

    PTM databases

    PhosphoSiteiQ9JLF1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JLF1.
    BgeeiQ9JLF1.
    GenevestigatoriQ9JLF1.

    Interactioni

    Subunit structurei

    Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000033711.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JLF1.
    SMRiQ9JLF1. Positions 61-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 267246ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei618 – 63821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG317370.
    GeneTreeiENSGT00630000089685.
    HOGENOMiHOG000049189.
    HOVERGENiHBG051708.
    InParanoidiQ9JLF1.
    KOiK05192.
    OMAiDSIIPTE.
    OrthoDBiEOG712TVZ.
    PhylomeDBiQ9JLF1.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR008101. GABAAt_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PTHR18945:SF87. PTHR18945:SF87. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00253. GABAARECEPTR.
    PR01725. GABAARTHETA.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 3 hits.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JLF1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGIRGMLRAA ALLLLIRTWL AESNGPSPTP KFHFELSSST PEVILDLFNC    50
    KNCANEAVVQ KILDRVLSTY DVRLRPNFGG APVPVSVSIY VSSIEQISEI 100
    NMDYTITMFL HQTWKDTRLA YYETNLNLTL DYRMHEKLWV PDCYFVNSKD 150
    AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT AACSLDLQKF PMDKQSCKLE 200
    VESYGYTVED IVLSWEDDNA IHITDGLHIP QYTYLGRTIT SKEVYFYTGS 250
    YMRLIVKFQV QREVRSYLVQ VYWPTVLTTI LSWISFWMNY DSSAARVTIG 300
    LTSILVLTTI DSHMRDKLPH ISCIKAIDIY ILVCLFFVFL SLLEYVYINY 350
    LFFSQVPRRN HRRCRKPRRV VARYRYQEVV VANVQDGLIN VEDRVEDRAG 400
    PLPDSPMQAH LASQESLGSL VFTSEQAQLA TSESLSLLSS ASSQTQLATG 450
    ESLSDLPSTS EQTVPECTIH FHGFLTNDSI IPIKIHSRSD ACDDEDSEES 500
    LSSEESHGHG SSHTGRLKLQ ISQRCVQEAS WDLDKIEILQ DDISITSSWL 550
    GLDEQCKGDA DSIWSLTDEE LMACDQEKDS SSESEENCSP SPGCSFNEGF 600
    SFQLFKPNRV PKVDRWSRFL FPLSFGLFNV VYWLYHVY 638
    Length:638
    Mass (Da):72,799
    Last modified:October 1, 2000 - v1
    Checksum:i4E2C4FA02E9BF8A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF189260 mRNA. Translation: AAF70381.1.
    CCDSiCCDS30188.1.
    RefSeqiNP_065234.1. NM_020488.2.
    XP_006528236.1. XM_006528173.1.
    UniGeneiMm.117125.
    Mm.487532.

    Genome annotation databases

    EnsembliENSMUST00000033711; ENSMUSP00000033711; ENSMUSG00000031344.
    GeneIDi57249.
    KEGGimmu:57249.
    UCSCiuc009tkq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF189260 mRNA. Translation: AAF70381.1 .
    CCDSi CCDS30188.1.
    RefSeqi NP_065234.1. NM_020488.2.
    XP_006528236.1. XM_006528173.1.
    UniGenei Mm.117125.
    Mm.487532.

    3D structure databases

    ProteinModelPortali Q9JLF1.
    SMRi Q9JLF1. Positions 61-351.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000033711.

    Chemistry

    BindingDBi Q9JLF1.
    ChEMBLi CHEMBL2094133.
    GuidetoPHARMACOLOGYi 418.

    PTM databases

    PhosphoSitei Q9JLF1.

    Proteomic databases

    PRIDEi Q9JLF1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033711 ; ENSMUSP00000033711 ; ENSMUSG00000031344 .
    GeneIDi 57249.
    KEGGi mmu:57249.
    UCSCi uc009tkq.1. mouse.

    Organism-specific databases

    CTDi 55879.
    MGIi MGI:1888498. Gabrq.

    Phylogenomic databases

    eggNOGi NOG317370.
    GeneTreei ENSGT00630000089685.
    HOGENOMi HOG000049189.
    HOVERGENi HBG051708.
    InParanoidi Q9JLF1.
    KOi K05192.
    OMAi DSIIPTE.
    OrthoDBi EOG712TVZ.
    PhylomeDBi Q9JLF1.
    TreeFami TF315453.

    Miscellaneous databases

    NextBioi 313527.
    PROi Q9JLF1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JLF1.
    Bgeei Q9JLF1.
    Genevestigatori Q9JLF1.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR008101. GABAAt_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    PTHR18945:SF87. PTHR18945:SF87. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00253. GABAARECEPTR.
    PR01725. GABAARTHETA.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 3 hits.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GABAA receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus."
      Sinkkonen S.T., Hanna M.C., Kirkness E.F., Korpi E.R.
      J. Neurosci. 20:3588-3595(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGBRT_MOUSE
    AccessioniPrimary (citable) accession number: Q9JLF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3