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Protein

Gamma-aminobutyric acid receptor subunit theta

Gene

Gabrq

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

GO - Biological processi

  • chloride transport Source: MGI
  • gamma-aminobutyric acid signaling pathway Source: MGI

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-MMU-977441. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit theta
Alternative name(s):
GABA(A) receptor subunit theta
Gene namesi
Name:Gabrq
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1888498. Gabrq.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 267ExtracellularSequence analysisAdd BLAST246
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei618 – 638HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2094133.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000049622 – 638Gamma-aminobutyric acid receptor subunit thetaAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi183 ↔ 197By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JLF1.
PRIDEiQ9JLF1.

PTM databases

PhosphoSitePlusiQ9JLF1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031344.
ExpressionAtlasiQ9JLF1. baseline and differential.
GenevisibleiQ9JLF1. MM.

Interactioni

Subunit structurei

Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033711.

Structurei

3D structure databases

ProteinModelPortaliQ9JLF1.
SMRiQ9JLF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000049189.
HOVERGENiHBG051708.
InParanoidiQ9JLF1.
KOiK05192.
OMAiFFHQTWK.
OrthoDBiEOG091G0805.
PhylomeDBiQ9JLF1.
TreeFamiTF315453.

Family and domain databases

Gene3Di1.20.58.390. 1 hit.
2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006028. GABAA/Glycine_rcpt.
IPR008101. GABAAt_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR036734. Neur_chan_lig-bd_sf.
IPR006201. Neur_channel.
IPR036719. Neuro-gated_channel_TM_sf.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
PRINTSiPR00253. GABAARECEPTR.
PR01725. GABAARTHETA.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 3 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIRGMLRAA ALLLLIRTWL AESNGPSPTP KFHFELSSST PEVILDLFNC
60 70 80 90 100
KNCANEAVVQ KILDRVLSTY DVRLRPNFGG APVPVSVSIY VSSIEQISEI
110 120 130 140 150
NMDYTITMFL HQTWKDTRLA YYETNLNLTL DYRMHEKLWV PDCYFVNSKD
160 170 180 190 200
AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT AACSLDLQKF PMDKQSCKLE
210 220 230 240 250
VESYGYTVED IVLSWEDDNA IHITDGLHIP QYTYLGRTIT SKEVYFYTGS
260 270 280 290 300
YMRLIVKFQV QREVRSYLVQ VYWPTVLTTI LSWISFWMNY DSSAARVTIG
310 320 330 340 350
LTSILVLTTI DSHMRDKLPH ISCIKAIDIY ILVCLFFVFL SLLEYVYINY
360 370 380 390 400
LFFSQVPRRN HRRCRKPRRV VARYRYQEVV VANVQDGLIN VEDRVEDRAG
410 420 430 440 450
PLPDSPMQAH LASQESLGSL VFTSEQAQLA TSESLSLLSS ASSQTQLATG
460 470 480 490 500
ESLSDLPSTS EQTVPECTIH FHGFLTNDSI IPIKIHSRSD ACDDEDSEES
510 520 530 540 550
LSSEESHGHG SSHTGRLKLQ ISQRCVQEAS WDLDKIEILQ DDISITSSWL
560 570 580 590 600
GLDEQCKGDA DSIWSLTDEE LMACDQEKDS SSESEENCSP SPGCSFNEGF
610 620 630
SFQLFKPNRV PKVDRWSRFL FPLSFGLFNV VYWLYHVY
Length:638
Mass (Da):72,799
Last modified:October 1, 2000 - v1
Checksum:i4E2C4FA02E9BF8A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189260 mRNA. Translation: AAF70381.1.
CCDSiCCDS30188.1.
RefSeqiNP_065234.1. NM_020488.2.
XP_006528236.1. XM_006528173.1.
UniGeneiMm.117125.
Mm.487532.

Genome annotation databases

EnsembliENSMUST00000033711; ENSMUSP00000033711; ENSMUSG00000031344.
GeneIDi57249.
KEGGimmu:57249.
UCSCiuc009tkq.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiGBRT_MOUSE
AccessioniPrimary (citable) accession number: Q9JLF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families