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Q9JLF1 (GBRT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-aminobutyric acid receptor subunit theta
Alternative name(s):
GABA(A) receptor subunit theta
Gene names
Name:Gabrq
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure

Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1.

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 638617Gamma-aminobutyric acid receptor subunit theta
PRO_0000000496

Regions

Topological domain22 – 267246Extracellular Potential
Transmembrane268 – 28821Helical; Potential
Transmembrane326 – 34621Helical; Potential
Transmembrane618 – 63821Helical; Potential

Amino acid modifications

Glycosylation1271N-linked (GlcNAc...) Potential
Disulfide bond183 ↔ 197 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JLF1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 4E2C4FA02E9BF8A3

FASTA63872,799
        10         20         30         40         50         60 
MGIRGMLRAA ALLLLIRTWL AESNGPSPTP KFHFELSSST PEVILDLFNC KNCANEAVVQ 

        70         80         90        100        110        120 
KILDRVLSTY DVRLRPNFGG APVPVSVSIY VSSIEQISEI NMDYTITMFL HQTWKDTRLA 

       130        140        150        160        170        180 
YYETNLNLTL DYRMHEKLWV PDCYFVNSKD AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT 

       190        200        210        220        230        240 
AACSLDLQKF PMDKQSCKLE VESYGYTVED IVLSWEDDNA IHITDGLHIP QYTYLGRTIT 

       250        260        270        280        290        300 
SKEVYFYTGS YMRLIVKFQV QREVRSYLVQ VYWPTVLTTI LSWISFWMNY DSSAARVTIG 

       310        320        330        340        350        360 
LTSILVLTTI DSHMRDKLPH ISCIKAIDIY ILVCLFFVFL SLLEYVYINY LFFSQVPRRN 

       370        380        390        400        410        420 
HRRCRKPRRV VARYRYQEVV VANVQDGLIN VEDRVEDRAG PLPDSPMQAH LASQESLGSL 

       430        440        450        460        470        480 
VFTSEQAQLA TSESLSLLSS ASSQTQLATG ESLSDLPSTS EQTVPECTIH FHGFLTNDSI 

       490        500        510        520        530        540 
IPIKIHSRSD ACDDEDSEES LSSEESHGHG SSHTGRLKLQ ISQRCVQEAS WDLDKIEILQ 

       550        560        570        580        590        600 
DDISITSSWL GLDEQCKGDA DSIWSLTDEE LMACDQEKDS SSESEENCSP SPGCSFNEGF 

       610        620        630 
SFQLFKPNRV PKVDRWSRFL FPLSFGLFNV VYWLYHVY 

« Hide

References

[1]"GABAA receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus."
Sinkkonen S.T., Hanna M.C., Kirkness E.F., Korpi E.R.
J. Neurosci. 20:3588-3595(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF189260 mRNA. Translation: AAF70381.1.
RefSeqNP_065234.1. NM_020488.1.
XP_006528236.1. XM_006528173.1.
UniGeneMm.117125.
Mm.487532.

3D structure databases

ProteinModelPortalQ9JLF1.
SMRQ9JLF1. Positions 61-351, 610-637.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000033711.

Chemistry

BindingDBQ9JLF1.
ChEMBLCHEMBL2094133.

PTM databases

PhosphoSiteQ9JLF1.

Proteomic databases

PRIDEQ9JLF1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033711; ENSMUSP00000033711; ENSMUSG00000031344.
GeneID57249.
KEGGmmu:57249.
UCSCuc009tkq.1. mouse.

Organism-specific databases

CTD55879.
MGIMGI:1888498. Gabrq.

Phylogenomic databases

eggNOGNOG317370.
GeneTreeENSGT00630000089685.
HOGENOMHOG000049189.
HOVERGENHBG051708.
InParanoidQ9JLF1.
KOK05192.
OMADSIIPTE.
OrthoDBEOG712TVZ.
PhylomeDBQ9JLF1.
TreeFamTF315453.

Gene expression databases

ArrayExpressQ9JLF1.
BgeeQ9JLF1.
GenevestigatorQ9JLF1.

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006028. GABAA_rcpt.
IPR008101. GABAAt_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PTHR18945:SF87. PTHR18945:SF87. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR00253. GABAARECEPTR.
PR01725. GABAARTHETA.
PR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 3 hits.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio313527.
PROQ9JLF1.
SOURCESearch...

Entry information

Entry nameGBRT_MOUSE
AccessionPrimary (citable) accession number: Q9JLF1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot