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Q9JLF1

- GBRT_MOUSE

UniProt

Q9JLF1 - GBRT_MOUSE

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Protein
Gamma-aminobutyric acid receptor subunit theta
Gene
Gabrq
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  1. GABA-A receptor activity Source: MGI
  2. chloride channel activity Source: UniProtKB-KW
  3. extracellular ligand-gated ion channel activity Source: InterPro

GO - Biological processi

  1. chloride transport Source: MGI
  2. gamma-aminobutyric acid signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit theta
Alternative name(s):
GABA(A) receptor subunit theta
Gene namesi
Name:Gabrq
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1888498. Gabrq.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 267246Extracellular Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Transmembranei326 – 34621Helical; Reviewed prediction
Add
BLAST
Transmembranei618 – 63821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. integral component of plasma membrane Source: MGI
  4. postsynaptic membrane Source: UniProtKB-SubCell
  5. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 638617Gamma-aminobutyric acid receptor subunit theta
PRO_0000000496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi183 ↔ 197 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9JLF1.

PTM databases

PhosphoSiteiQ9JLF1.

Expressioni

Gene expression databases

ArrayExpressiQ9JLF1.
BgeeiQ9JLF1.
GenevestigatoriQ9JLF1.

Interactioni

Subunit structurei

Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033711.

Structurei

3D structure databases

ProteinModelPortaliQ9JLF1.
SMRiQ9JLF1. Positions 61-351.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG317370.
GeneTreeiENSGT00630000089685.
HOGENOMiHOG000049189.
HOVERGENiHBG051708.
InParanoidiQ9JLF1.
KOiK05192.
OMAiDSIIPTE.
OrthoDBiEOG712TVZ.
PhylomeDBiQ9JLF1.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008101. GABAAt_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PTHR18945:SF87. PTHR18945:SF87. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01725. GABAARTHETA.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 3 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLF1-1 [UniParc]FASTAAdd to Basket

« Hide

MGIRGMLRAA ALLLLIRTWL AESNGPSPTP KFHFELSSST PEVILDLFNC    50
KNCANEAVVQ KILDRVLSTY DVRLRPNFGG APVPVSVSIY VSSIEQISEI 100
NMDYTITMFL HQTWKDTRLA YYETNLNLTL DYRMHEKLWV PDCYFVNSKD 150
AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT AACSLDLQKF PMDKQSCKLE 200
VESYGYTVED IVLSWEDDNA IHITDGLHIP QYTYLGRTIT SKEVYFYTGS 250
YMRLIVKFQV QREVRSYLVQ VYWPTVLTTI LSWISFWMNY DSSAARVTIG 300
LTSILVLTTI DSHMRDKLPH ISCIKAIDIY ILVCLFFVFL SLLEYVYINY 350
LFFSQVPRRN HRRCRKPRRV VARYRYQEVV VANVQDGLIN VEDRVEDRAG 400
PLPDSPMQAH LASQESLGSL VFTSEQAQLA TSESLSLLSS ASSQTQLATG 450
ESLSDLPSTS EQTVPECTIH FHGFLTNDSI IPIKIHSRSD ACDDEDSEES 500
LSSEESHGHG SSHTGRLKLQ ISQRCVQEAS WDLDKIEILQ DDISITSSWL 550
GLDEQCKGDA DSIWSLTDEE LMACDQEKDS SSESEENCSP SPGCSFNEGF 600
SFQLFKPNRV PKVDRWSRFL FPLSFGLFNV VYWLYHVY 638
Length:638
Mass (Da):72,799
Last modified:October 1, 2000 - v1
Checksum:i4E2C4FA02E9BF8A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF189260 mRNA. Translation: AAF70381.1.
CCDSiCCDS30188.1.
RefSeqiNP_065234.1. NM_020488.2.
XP_006528236.1. XM_006528173.1.
UniGeneiMm.117125.
Mm.487532.

Genome annotation databases

EnsembliENSMUST00000033711; ENSMUSP00000033711; ENSMUSG00000031344.
GeneIDi57249.
KEGGimmu:57249.
UCSCiuc009tkq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF189260 mRNA. Translation: AAF70381.1 .
CCDSi CCDS30188.1.
RefSeqi NP_065234.1. NM_020488.2.
XP_006528236.1. XM_006528173.1.
UniGenei Mm.117125.
Mm.487532.

3D structure databases

ProteinModelPortali Q9JLF1.
SMRi Q9JLF1. Positions 61-351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033711.

Chemistry

BindingDBi Q9JLF1.
ChEMBLi CHEMBL2094133.
GuidetoPHARMACOLOGYi 418.

PTM databases

PhosphoSitei Q9JLF1.

Proteomic databases

PRIDEi Q9JLF1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033711 ; ENSMUSP00000033711 ; ENSMUSG00000031344 .
GeneIDi 57249.
KEGGi mmu:57249.
UCSCi uc009tkq.1. mouse.

Organism-specific databases

CTDi 55879.
MGIi MGI:1888498. Gabrq.

Phylogenomic databases

eggNOGi NOG317370.
GeneTreei ENSGT00630000089685.
HOGENOMi HOG000049189.
HOVERGENi HBG051708.
InParanoidi Q9JLF1.
KOi K05192.
OMAi DSIIPTE.
OrthoDBi EOG712TVZ.
PhylomeDBi Q9JLF1.
TreeFami TF315453.

Miscellaneous databases

NextBioi 313527.
PROi Q9JLF1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JLF1.
Bgeei Q9JLF1.
Genevestigatori Q9JLF1.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR008101. GABAAt_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
PTHR18945:SF87. PTHR18945:SF87. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00253. GABAARECEPTR.
PR01725. GABAARTHETA.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 3 hits.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "GABAA receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus."
    Sinkkonen S.T., Hanna M.C., Kirkness E.F., Korpi E.R.
    J. Neurosci. 20:3588-3595(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGBRT_MOUSE
AccessioniPrimary (citable) accession number: Q9JLF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi