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Q9JLF1

- GBRT_MOUSE

UniProt

Q9JLF1 - GBRT_MOUSE

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Protein

Gamma-aminobutyric acid receptor subunit theta

Gene

Gabrq

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. extracellular ligand-gated ion channel activity Source: InterPro
  3. GABA-A receptor activity Source: MGI

GO - Biological processi

  1. chloride transport Source: MGI
  2. gamma-aminobutyric acid signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_198558. Ligand-gated ion channel transport.
REACT_198560. GABA A receptor activation.
REACT_268398. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit theta
Alternative name(s):
GABA(A) receptor subunit theta
Gene namesi
Name:Gabrq
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1888498. Gabrq.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 267246ExtracellularSequence AnalysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence AnalysisAdd
BLAST
Transmembranei618 – 63821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. integral component of plasma membrane Source: MGI
  4. postsynaptic membrane Source: UniProtKB-KW
  5. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 638617Gamma-aminobutyric acid receptor subunit thetaPRO_0000000496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi183 ↔ 197By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9JLF1.

PTM databases

PhosphoSiteiQ9JLF1.

Expressioni

Gene expression databases

BgeeiQ9JLF1.
ExpressionAtlasiQ9JLF1. baseline and differential.
GenevestigatoriQ9JLF1.

Interactioni

Subunit structurei

Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033711.

Structurei

3D structure databases

ProteinModelPortaliQ9JLF1.
SMRiQ9JLF1. Positions 54-358, 606-637.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG317370.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000049189.
HOVERGENiHBG051708.
InParanoidiQ9JLF1.
KOiK05192.
OMAiDSIIPTE.
OrthoDBiEOG712TVZ.
PhylomeDBiQ9JLF1.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008101. GABAAt_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PTHR18945:SF87. PTHR18945:SF87. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01725. GABAARTHETA.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 3 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLF1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGIRGMLRAA ALLLLIRTWL AESNGPSPTP KFHFELSSST PEVILDLFNC
60 70 80 90 100
KNCANEAVVQ KILDRVLSTY DVRLRPNFGG APVPVSVSIY VSSIEQISEI
110 120 130 140 150
NMDYTITMFL HQTWKDTRLA YYETNLNLTL DYRMHEKLWV PDCYFVNSKD
160 170 180 190 200
AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT AACSLDLQKF PMDKQSCKLE
210 220 230 240 250
VESYGYTVED IVLSWEDDNA IHITDGLHIP QYTYLGRTIT SKEVYFYTGS
260 270 280 290 300
YMRLIVKFQV QREVRSYLVQ VYWPTVLTTI LSWISFWMNY DSSAARVTIG
310 320 330 340 350
LTSILVLTTI DSHMRDKLPH ISCIKAIDIY ILVCLFFVFL SLLEYVYINY
360 370 380 390 400
LFFSQVPRRN HRRCRKPRRV VARYRYQEVV VANVQDGLIN VEDRVEDRAG
410 420 430 440 450
PLPDSPMQAH LASQESLGSL VFTSEQAQLA TSESLSLLSS ASSQTQLATG
460 470 480 490 500
ESLSDLPSTS EQTVPECTIH FHGFLTNDSI IPIKIHSRSD ACDDEDSEES
510 520 530 540 550
LSSEESHGHG SSHTGRLKLQ ISQRCVQEAS WDLDKIEILQ DDISITSSWL
560 570 580 590 600
GLDEQCKGDA DSIWSLTDEE LMACDQEKDS SSESEENCSP SPGCSFNEGF
610 620 630
SFQLFKPNRV PKVDRWSRFL FPLSFGLFNV VYWLYHVY
Length:638
Mass (Da):72,799
Last modified:October 1, 2000 - v1
Checksum:i4E2C4FA02E9BF8A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189260 mRNA. Translation: AAF70381.1.
CCDSiCCDS30188.1.
RefSeqiNP_065234.1. NM_020488.2.
XP_006528236.1. XM_006528173.1.
UniGeneiMm.117125.
Mm.487532.

Genome annotation databases

EnsembliENSMUST00000033711; ENSMUSP00000033711; ENSMUSG00000031344.
GeneIDi57249.
KEGGimmu:57249.
UCSCiuc009tkq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189260 mRNA. Translation: AAF70381.1 .
CCDSi CCDS30188.1.
RefSeqi NP_065234.1. NM_020488.2.
XP_006528236.1. XM_006528173.1.
UniGenei Mm.117125.
Mm.487532.

3D structure databases

ProteinModelPortali Q9JLF1.
SMRi Q9JLF1. Positions 54-358, 606-637.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033711.

Chemistry

ChEMBLi CHEMBL2094133.
GuidetoPHARMACOLOGYi 418.

PTM databases

PhosphoSitei Q9JLF1.

Proteomic databases

PRIDEi Q9JLF1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033711 ; ENSMUSP00000033711 ; ENSMUSG00000031344 .
GeneIDi 57249.
KEGGi mmu:57249.
UCSCi uc009tkq.1. mouse.

Organism-specific databases

CTDi 55879.
MGIi MGI:1888498. Gabrq.

Phylogenomic databases

eggNOGi NOG317370.
GeneTreei ENSGT00760000118821.
HOGENOMi HOG000049189.
HOVERGENi HBG051708.
InParanoidi Q9JLF1.
KOi K05192.
OMAi DSIIPTE.
OrthoDBi EOG712TVZ.
PhylomeDBi Q9JLF1.
TreeFami TF315453.

Enzyme and pathway databases

Reactomei REACT_198558. Ligand-gated ion channel transport.
REACT_198560. GABA A receptor activation.
REACT_268398. Orphan transporters.

Miscellaneous databases

NextBioi 313527.
PROi Q9JLF1.
SOURCEi Search...

Gene expression databases

Bgeei Q9JLF1.
ExpressionAtlasi Q9JLF1. baseline and differential.
Genevestigatori Q9JLF1.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR008101. GABAAt_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
PTHR18945:SF87. PTHR18945:SF87. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00253. GABAARECEPTR.
PR01725. GABAARTHETA.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 3 hits.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "GABAA receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus."
    Sinkkonen S.T., Hanna M.C., Kirkness E.F., Korpi E.R.
    J. Neurosci. 20:3588-3595(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGBRT_MOUSE
AccessioniPrimary (citable) accession number: Q9JLF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3