Q9JLE9 (Q9JLE9_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
GABA-A receptor epsilon-like subunit EMBL AAF70383.1

Gene names

Name:	Gabre RGD 68320
Synonyms:	Epsilon EMBL AAF70383.1

Organism

Rattus norvegicus (Rat) EMBL AAF70383.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	989 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification] RuleBase RU000687

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane SAAS SAAS006028 Membrane Postsynaptic cell membrane SAAS SAAS006202 Synapse
Domain	Transmembrane Transmembrane helix SAAS SAAS006028
Molecular function	Ion channel SAAS SAAS006028 RuleBase RU000687 Receptor EMBL AAF70383.1
Gene Ontology (GO)
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	GABA-A receptor activity Inferred from electronic annotation. Source: InterPro extracellular ligand-gated ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9JLE9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F7771145411000A9	FASTA	989	113,291
	10 20 30 40 50 60 MLPKVLLMLL NMFLALQWRV GPHIKLENKP PAQDKVVFGP QPQPVPQPLI PPESPAGDDV 70 80 90 100 110 120 VFDSQPQPQS ESPGHDDVFS SQPQPLPQPQ PLPEPQPLPE PEPQPQPQPQ PQPQPQPLAG 130 140 150 160 170 180 RQPLPQPLPW PLPQPQPEPE PQPEPQPEPQ PEPQPEPQPE PQPEPQPEPQ PQPQPLAGRQ 190 200 210 220 230 240 PLPWPLPLPL PEPQPDPQPD PQPEPQPEPQ PEPQPQPQTP GQVQAGRQPR PKPQPDPHPH 250 260 270 280 290 300 PQPEPQPEPR LHPFHRLRLR PHPYPEPHPG PQPEPEPEPE PEPQPEPQPE PQPEPQPEPE 310 320 330 340 350 360 PQPEPEPEPE PEPEPEPEPE PEPEPEPEPE PEPEPEPEPE PEPQPEPEPE PEPEPEPEPE 370 380 390 400 410 420 PEPEPEPQPE PQPEPEPEPE PQPEPQPEPE PEPEPEPEPE PEPEPEPQPE PQPEPEPQPE 430 440 450 460 470 480 PQPDPEPQPE PGPEPGPEPE PEPQLEPQPE PEPEPQPEPE SELDLEPEPE PQPLPEPQPE 490 500 510 520 530 540 PEPEPEPEPE PEPEPEPEPE PEPEPEPEPE PEPELELEPQ SQLEPQPSGK KLPARETELT 550 560 570 580 590 600 ADHTTERPRG KLTRASQILN TILSNYDHKL RPSIGEKPTV VTVKVFVNSL GPISILDMEY 610 620 630 640 650 660 SIDIIFYQTW YDERLRYNDT FETLILHGNV VSQLWIPDTF FRNSKRTQEY DITIPNQMAL 670 680 690 700 710 720 IHKDGKVLYT VRMTIDARCS LHMLNFPMDS HSCPLSFSSF SYDEHEMIYK WENFKLKIDA 730 740 750 760 770 780 KNTWKLLEFD FTGVNNKTEI ISTPVGDFMV MTFFFNVSRR FGFIVFQNYI PSSVTTMLSW 790 800 810 820 830 840 VSFWIKIEAA AARASVGVSS VLTMATLGTF SRKNFPRVSY LTALDFYIAI CFVLCFCTLL 850 860 870 880 890 900 EFTVLNFLTY NNIERQASPK FYQFPTNSRA NARTRARART RARARARARQ QQEVFVCEIV 910 920 930 940 950 960 TYEENAEEGY QWSPRSRRPQ CPWRRCGRSY VCFRVLRKYF CMVPGCEGNS WQRGRICIHV 970 980 YRLDNYSRVL FPITFFFFNV VYWVICLNL

References

[1]	"GABAA receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus." Sinkkonen S.T., Hanna M.C., Kirkness E.F., Korpi E.R. J. Neurosci. 20:3588-3595(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF189262 mRNA. Translation: AAF70383.1.
IPI	IPI00212045.
RefSeq	NP_075579.1. NM_023091.1.
UniGene	Rn.54455.
3D structure databases
ProteinModelPortal	Q9JLE9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	65191.
KEGG	rno:65191.
Organism-specific databases
CTD	2564.
RGD	68320. Gabre.
Phylogenomic databases
HOVERGEN	HBG051707.
InParanoid	Q9JLE9.
KO	K05185.
Gene expression databases
Genevestigator	Q9JLE9.
Family and domain databases
Gene3D	2.70.170.10. 1 hit.
InterPro	IPR006028. GABAA_rcpt. IPR008099. GABAAe_rcpt. IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. [Graphical view]
PANTHER	PTHR18945. PTHR18945. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR00253. GABAARECEPTR. PR01723. GABAAREPSLON. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	614112.

Entry information

Entry name

Q9JLE9_RAT

Accession

Primary (citable) accession number: Q9JLE9

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)