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Protein
Submitted name:

GABA-A receptor epsilon-like subunit

Gene

Gabre

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
GABA-A receptor epsilon-like subunitImported
Gene namesi
Name:GabreImported
Synonyms:EpsilonImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi68320. Gabre.

Subcellular locationi

  • Cell junctionsynapse SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei826 – 84823HelicalSequence analysisAdd
BLAST
Transmembranei969 – 98517HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, SynapseSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 989972Sequence analysisPRO_5004327616Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ9JLE9.

Expressioni

Gene expression databases

GenevisibleiQ9JLE9. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022431.

Structurei

3D structure databases

ProteinModelPortaliQ9JLE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini556 – 760205Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini769 – 877109Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
HOVERGENiHBG051707.
KOiK05185.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008099. GABAAe_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01723. GABAAREPSLON.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JLE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPKVLLMLL NMFLALQWRV GPHIKLENKP PAQDKVVFGP QPQPVPQPLI
60 70 80 90 100
PPESPAGDDV VFDSQPQPQS ESPGHDDVFS SQPQPLPQPQ PLPEPQPLPE
110 120 130 140 150
PEPQPQPQPQ PQPQPQPLAG RQPLPQPLPW PLPQPQPEPE PQPEPQPEPQ
160 170 180 190 200
PEPQPEPQPE PQPEPQPEPQ PQPQPLAGRQ PLPWPLPLPL PEPQPDPQPD
210 220 230 240 250
PQPEPQPEPQ PEPQPQPQTP GQVQAGRQPR PKPQPDPHPH PQPEPQPEPR
260 270 280 290 300
LHPFHRLRLR PHPYPEPHPG PQPEPEPEPE PEPQPEPQPE PQPEPQPEPE
310 320 330 340 350
PQPEPEPEPE PEPEPEPEPE PEPEPEPEPE PEPEPEPEPE PEPQPEPEPE
360 370 380 390 400
PEPEPEPEPE PEPEPEPQPE PQPEPEPEPE PQPEPQPEPE PEPEPEPEPE
410 420 430 440 450
PEPEPEPQPE PQPEPEPQPE PQPDPEPQPE PGPEPGPEPE PEPQLEPQPE
460 470 480 490 500
PEPEPQPEPE SELDLEPEPE PQPLPEPQPE PEPEPEPEPE PEPEPEPEPE
510 520 530 540 550
PEPEPEPEPE PEPELELEPQ SQLEPQPSGK KLPARETELT ADHTTERPRG
560 570 580 590 600
KLTRASQILN TILSNYDHKL RPSIGEKPTV VTVKVFVNSL GPISILDMEY
610 620 630 640 650
SIDIIFYQTW YDERLRYNDT FETLILHGNV VSQLWIPDTF FRNSKRTQEY
660 670 680 690 700
DITIPNQMAL IHKDGKVLYT VRMTIDARCS LHMLNFPMDS HSCPLSFSSF
710 720 730 740 750
SYDEHEMIYK WENFKLKIDA KNTWKLLEFD FTGVNNKTEI ISTPVGDFMV
760 770 780 790 800
MTFFFNVSRR FGFIVFQNYI PSSVTTMLSW VSFWIKIEAA AARASVGVSS
810 820 830 840 850
VLTMATLGTF SRKNFPRVSY LTALDFYIAI CFVLCFCTLL EFTVLNFLTY
860 870 880 890 900
NNIERQASPK FYQFPTNSRA NARTRARART RARARARARQ QQEVFVCEIV
910 920 930 940 950
TYEENAEEGY QWSPRSRRPQ CPWRRCGRSY VCFRVLRKYF CMVPGCEGNS
960 970 980
WQRGRICIHV YRLDNYSRVL FPITFFFFNV VYWVICLNL
Length:989
Mass (Da):113,291
Last modified:October 1, 2000 - v1
Checksum:iF7771145411000A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189262 mRNA. Translation: AAF70383.1.
RefSeqiNP_075579.1. NM_023091.1.
UniGeneiRn.54455.

Genome annotation databases

GeneIDi65191.
KEGGirno:65191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189262 mRNA. Translation: AAF70383.1.
RefSeqiNP_075579.1. NM_023091.1.
UniGeneiRn.54455.

3D structure databases

ProteinModelPortaliQ9JLE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022431.

Proteomic databases

PaxDbiQ9JLE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi65191.
KEGGirno:65191.

Organism-specific databases

CTDi2564.
RGDi68320. Gabre.

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
HOVERGENiHBG051707.
KOiK05185.

Gene expression databases

GenevisibleiQ9JLE9. RN.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008099. GABAAe_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01723. GABAAREPSLON.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "GABAA receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus."
    Sinkkonen S.T., Hanna M.C., Kirkness E.F., Korpi E.R.
    J. Neurosci. 20:3588-3595(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9JLE9_RAT
AccessioniPrimary (citable) accession number: Q9JLE9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.