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Q9JLD2 (NEUS_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuroserpin
Alternative name(s):
Peptidase inhibitor 12
Short name=PI-12
Serine protease inhibitor 17
Serpin I1
Gene names
Name:Serpini1
Synonyms:Pi12, Spi17
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the serpin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 410394Neuroserpin
PRO_0000032523

Sites

Site362 – 3632Reactive bond By similarity

Amino acid modifications

Glycosylation1571N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Potential
Glycosylation4011N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict121L → M in AAF70387. Ref.1
Sequence conflict1771H → Q in AAF70387. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9JLD2 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 99008624B3A366D8

FASTA41046,278
        10         20         30         40         50         60 
MAYLGLLSLV ALQSLVTGAA FPDETIAEWS VNVYNHLRAT GEDENILFSP LSIALAMGVM 

        70         80         90        100        110        120 
ELGAQGSTLK EIRHSMGYES LKSGEEFSFL RDFSSMVSAE EGQYVMKIAN SLFVQNGFHI 

       130        140        150        160        170        180 
NEEFLQMMKM YFNAEVNHVD FSENVAVANY INKWVENYTN SLLKDLVSPG DFDAVTHLAL 

       190        200        210        220        230        240 
INAVYFKGNW KSQFRPENTR TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ 

       250        260        270        280        290        300 
VLEIPYEGDE ISMMLVLSRQ EVPLATLEPL LKPQLIEEWA NSVKKQKVEV YLPRFTVEQE 

       310        320        330        340        350        360 
IDLKDILKAL GVTEIFIKDA NLTAMSDKKE LFLSKAVHKS FIEVNEEGSE AAVASGMIAI 

       370        380        390        400        410 
SRMAVLFPQV IVDHPFLFLI KNRKTGTILF MGRVMHPETM NTSGHDFEEL 

« Hide

References

« Hide 'large scale' references
[1]"Neuroserpin is expressed in the pituitary and adrenal glands and induces the extension of neurite-like processes in AtT-20 cells."
Hill R.M., Parmar P.K., Coates L.C., Mezey E., Pearson J.F., Birch N.P.
Biochem. J. 345:595-601(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF193014 mRNA. Translation: AAF70386.1.
AF193015 mRNA. Translation: AAF70387.1.
BC061536 mRNA. Translation: AAH61536.1.
RefSeqNP_446231.1. NM_053779.1.
XP_006232560.1. XM_006232498.1.
UniGeneRn.52632.

3D structure databases

ProteinModelPortalQ9JLD2.
SMRQ9JLD2. Positions 25-64, 101-361, 367-397.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI04.025.

Proteomic databases

PaxDbQ9JLD2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000013904; ENSRNOP00000013905; ENSRNOG00000010248.
GeneID116459.
KEGGrno:116459.
UCSCRGD:619896. rat.

Organism-specific databases

CTD5274.
RGD619896. Serpini1.

Phylogenomic databases

eggNOGCOG4826.
GeneTreeENSGT00740000115014.
HOGENOMHOG000238519.
HOVERGENHBG005957.
InParanoidQ9JLD2.
OMAMMKKYFN.
OrthoDBEOG7327PB.
PhylomeDBQ9JLD2.
TreeFamTF352620.

Gene expression databases

GenevestigatorQ9JLD2.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio618974.
PROQ9JLD2.

Entry information

Entry nameNEUS_RAT
AccessionPrimary (citable) accession number: Q9JLD2
Secondary accession number(s): Q9JLD1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families