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Protein

Neuroserpin

Gene

Serpini1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei362 – 3632Reactive bondBy similarity

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: RGD

GO - Biological processi

  • negative regulation of endopeptidase activity Source: GO_Central
  • regulation of cell adhesion Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.025.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroserpin
Alternative name(s):
Peptidase inhibitor 12
Short name:
PI-12
Serine protease inhibitor 17
Serpin I1
Gene namesi
Name:Serpini1
Synonyms:Pi12, Spi17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi619896. Serpini1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 410394NeuroserpinPRO_0000032523Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JLD2.

Expressioni

Gene expression databases

GenevisibleiQ9JLD2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013905.

Structurei

3D structure databases

ProteinModelPortaliQ9JLD2.
SMRiQ9JLD2. Positions 25-64, 101-361, 367-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ9JLD2.
OMAiPQLIEEW.
OrthoDBiEOG7327PB.
PhylomeDBiQ9JLD2.
TreeFamiTF352620.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JLD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYLGLLSLV ALQSLVTGAA FPDETIAEWS VNVYNHLRAT GEDENILFSP
60 70 80 90 100
LSIALAMGVM ELGAQGSTLK EIRHSMGYES LKSGEEFSFL RDFSSMVSAE
110 120 130 140 150
EGQYVMKIAN SLFVQNGFHI NEEFLQMMKM YFNAEVNHVD FSENVAVANY
160 170 180 190 200
INKWVENYTN SLLKDLVSPG DFDAVTHLAL INAVYFKGNW KSQFRPENTR
210 220 230 240 250
TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE
260 270 280 290 300
ISMMLVLSRQ EVPLATLEPL LKPQLIEEWA NSVKKQKVEV YLPRFTVEQE
310 320 330 340 350
IDLKDILKAL GVTEIFIKDA NLTAMSDKKE LFLSKAVHKS FIEVNEEGSE
360 370 380 390 400
AAVASGMIAI SRMAVLFPQV IVDHPFLFLI KNRKTGTILF MGRVMHPETM
410
NTSGHDFEEL
Length:410
Mass (Da):46,278
Last modified:October 1, 2000 - v1
Checksum:i99008624B3A366D8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121L → M in AAF70387 (PubMed:10642518).Curated
Sequence conflicti177 – 1771H → Q in AAF70387 (PubMed:10642518).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193014 mRNA. Translation: AAF70386.1.
AF193015 mRNA. Translation: AAF70387.1.
BC061536 mRNA. Translation: AAH61536.1.
RefSeqiNP_446231.1. NM_053779.1.
XP_008759298.1. XM_008761076.1.
UniGeneiRn.52632.

Genome annotation databases

EnsembliENSRNOT00000013904; ENSRNOP00000013905; ENSRNOG00000010248.
GeneIDi116459.
KEGGirno:116459.
UCSCiRGD:619896. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193014 mRNA. Translation: AAF70386.1.
AF193015 mRNA. Translation: AAF70387.1.
BC061536 mRNA. Translation: AAH61536.1.
RefSeqiNP_446231.1. NM_053779.1.
XP_008759298.1. XM_008761076.1.
UniGeneiRn.52632.

3D structure databases

ProteinModelPortaliQ9JLD2.
SMRiQ9JLD2. Positions 25-64, 101-361, 367-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013905.

Protein family/group databases

MEROPSiI04.025.

Proteomic databases

PaxDbiQ9JLD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013904; ENSRNOP00000013905; ENSRNOG00000010248.
GeneIDi116459.
KEGGirno:116459.
UCSCiRGD:619896. rat.

Organism-specific databases

CTDi5274.
RGDi619896. Serpini1.

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ9JLD2.
OMAiPQLIEEW.
OrthoDBiEOG7327PB.
PhylomeDBiQ9JLD2.
TreeFamiTF352620.

Miscellaneous databases

NextBioi618974.
PROiQ9JLD2.

Gene expression databases

GenevisibleiQ9JLD2. RN.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neuroserpin is expressed in the pituitary and adrenal glands and induces the extension of neurite-like processes in AtT-20 cells."
    Hill R.M., Parmar P.K., Coates L.C., Mezey E., Pearson J.F., Birch N.P.
    Biochem. J. 345:595-601(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiNEUS_RAT
AccessioniPrimary (citable) accession number: Q9JLD2
Secondary accession number(s): Q9JLD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.