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Q9JLD2

- NEUS_RAT

UniProt

Q9JLD2 - NEUS_RAT

Protein

Neuroserpin

Gene

Serpini1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei362 – 3632Reactive bondBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RGD

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of cell adhesion Source: RGD
    3. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroserpin
    Alternative name(s):
    Peptidase inhibitor 12
    Short name:
    PI-12
    Serine protease inhibitor 17
    Serpin I1
    Gene namesi
    Name:Serpini1
    Synonyms:Pi12, Spi17
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi619896. Serpini1.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 410394NeuroserpinPRO_0000032523Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9JLD2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9JLD2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JLD2.
    SMRiQ9JLD2. Positions 25-64, 101-361, 367-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00740000115014.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiQ9JLD2.
    OMAiMMKKYFN.
    OrthoDBiEOG7327PB.
    PhylomeDBiQ9JLD2.
    TreeFamiTF352620.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JLD2-1 [UniParc]FASTAAdd to Basket

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    MAYLGLLSLV ALQSLVTGAA FPDETIAEWS VNVYNHLRAT GEDENILFSP    50
    LSIALAMGVM ELGAQGSTLK EIRHSMGYES LKSGEEFSFL RDFSSMVSAE 100
    EGQYVMKIAN SLFVQNGFHI NEEFLQMMKM YFNAEVNHVD FSENVAVANY 150
    INKWVENYTN SLLKDLVSPG DFDAVTHLAL INAVYFKGNW KSQFRPENTR 200
    TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE 250
    ISMMLVLSRQ EVPLATLEPL LKPQLIEEWA NSVKKQKVEV YLPRFTVEQE 300
    IDLKDILKAL GVTEIFIKDA NLTAMSDKKE LFLSKAVHKS FIEVNEEGSE 350
    AAVASGMIAI SRMAVLFPQV IVDHPFLFLI KNRKTGTILF MGRVMHPETM 400
    NTSGHDFEEL 410
    Length:410
    Mass (Da):46,278
    Last modified:October 1, 2000 - v1
    Checksum:i99008624B3A366D8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121L → M in AAF70387. (PubMed:10642518)Curated
    Sequence conflicti177 – 1771H → Q in AAF70387. (PubMed:10642518)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193014 mRNA. Translation: AAF70386.1.
    AF193015 mRNA. Translation: AAF70387.1.
    BC061536 mRNA. Translation: AAH61536.1.
    RefSeqiNP_446231.1. NM_053779.1.
    XP_006232560.1. XM_006232498.1.
    UniGeneiRn.52632.

    Genome annotation databases

    EnsembliENSRNOT00000013904; ENSRNOP00000013905; ENSRNOG00000010248.
    GeneIDi116459.
    KEGGirno:116459.
    UCSCiRGD:619896. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193014 mRNA. Translation: AAF70386.1 .
    AF193015 mRNA. Translation: AAF70387.1 .
    BC061536 mRNA. Translation: AAH61536.1 .
    RefSeqi NP_446231.1. NM_053779.1.
    XP_006232560.1. XM_006232498.1.
    UniGenei Rn.52632.

    3D structure databases

    ProteinModelPortali Q9JLD2.
    SMRi Q9JLD2. Positions 25-64, 101-361, 367-397.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.025.

    Proteomic databases

    PaxDbi Q9JLD2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013904 ; ENSRNOP00000013905 ; ENSRNOG00000010248 .
    GeneIDi 116459.
    KEGGi rno:116459.
    UCSCi RGD:619896. rat.

    Organism-specific databases

    CTDi 5274.
    RGDi 619896. Serpini1.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00740000115014.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi Q9JLD2.
    OMAi MMKKYFN.
    OrthoDBi EOG7327PB.
    PhylomeDBi Q9JLD2.
    TreeFami TF352620.

    Miscellaneous databases

    NextBioi 618974.
    PROi Q9JLD2.

    Gene expression databases

    Genevestigatori Q9JLD2.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neuroserpin is expressed in the pituitary and adrenal glands and induces the extension of neurite-like processes in AtT-20 cells."
      Hill R.M., Parmar P.K., Coates L.C., Mezey E., Pearson J.F., Birch N.P.
      Biochem. J. 345:595-601(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.

    Entry informationi

    Entry nameiNEUS_RAT
    AccessioniPrimary (citable) accession number: Q9JLD2
    Secondary accession number(s): Q9JLD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3