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Protein

Sacsin

Gene

Sacs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Sacsin
Alternative name(s):
DnaJ homolog subfamily C member 29
Short name:
DNAJC29
Gene namesi
Name:Sacs
Synonyms:Kiaa0730
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1354724. Sacs.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Predominantly cytoplasmic, a small portion is present in the nucleus and also shows a partial mitochondrial overlap with the mitochondrial marker Hsp60.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975641 – 4582SacsinAdd BLAST4582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei945N6-acetyllysineBy similarity1
Modified residuei1781PhosphoserineBy similarity1
Modified residuei2513PhosphoserineCombined sources1
Modified residuei2518PhosphothreonineCombined sources1
Modified residuei3437PhosphoserineBy similarity1
Modified residuei4263PhosphothreonineCombined sources1
Modified residuei4266PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9JLC8.
PeptideAtlasiQ9JLC8.
PRIDEiQ9JLC8.

PTM databases

iPTMnetiQ9JLC8.
PhosphoSitePlusiQ9JLC8.

Expressioni

Tissue specificityi

Brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000048279.
CleanExiMM_SACS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206063. 1 interactor.
STRINGi10090.ENSMUSP00000086816.

Structurei

3D structure databases

ProteinModelPortaliQ9JLC8.
SMRiQ9JLC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 84Ubiquitin-likeAdd BLAST78
Domaini4309 – 4396JPROSITE-ProRule annotationAdd BLAST88
Domaini4454 – 4570HEPNPROSITE-ProRule annotationAdd BLAST117

Domaini

The ubiquitin-like domain mediates interaction with the proteasome.By similarity
The J domain is functional and is able to stimulate E.coli dnaK ATPase activity.By similarity

Sequence similaritiesi

Contains 1 HEPN domain.PROSITE-ProRule annotation
Contains 1 J domain.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.Curated

Phylogenomic databases

eggNOGiENOG410IDYY. Eukaryota.
ENOG410XV7A. LUCA.
HOGENOMiHOG000154245.
HOVERGENiHBG093399.
InParanoidiQ9JLC8.
KOiK17592.
PhylomeDBiQ9JLC8.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
3.30.565.10. 3 hits.
InterProiIPR001623. DnaJ_domain.
IPR003594. HATPase_C.
IPR007842. HEPN_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF05168. HEPN. 1 hit.
[Graphical view]
SMARTiSM00748. HEPN. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF55874. SSF55874. 3 hits.
PROSITEiPS50076. DNAJ_2. 1 hit.
PS50910. HEPN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JLC8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METKFQRWVR VTVLRGCVGC RTVAVPATAT GRDLKERIFA ETSFPVAEQR
60 70 80 90 100
LWRGDREVPD WIKIGDLTSK TCHLFVNLQS KGLKGGGRFG QTTPPLVDFL
110 120 130 140 150
KDILRRYPEG GQILKELIQN AEDAGATEVK FLYDETQYGT ETLWSKDMAQ
160 170 180 190 200
YQGSALYVYN NAVFTPEDWH GIQEIARSRK KDDPLKVGRF GIGFNSVYHI
210 220 230 240 250
TDVPCIFSGD QIGMLDPHQT LFGPHESGQC WNLKDDIKEI NELPDQFAPF
260 270 280 290 300
IGVFGSTKET FTNGSFPGTF FRFPLRLQPS QLSSNLYTKQ KVLELFDSFR
310 320 330 340 350
ADADTVLLFL KSVQAVSLHV READGTEKLV FRVTASENKA LKHERPNSIK
360 370 380 390 400
ILGTAISNYC KKIPSNSVTC VTYHINIVLE DESTKDAQKT SWLVCNSVGG
410 420 430 440 450
RGISSKLDSL ADELKFVPII GLAMPLSGKD EENGAISDFS GKAFCFLPLP
460 470 480 490 500
PGEESRTGLP VHISGFFGLT DNRRSIKWRE LDQWRDPAAL WNEYLIVNVV
510 520 530 540 550
PKTYATLILD SIKRLETEKS SDFPLSVDTI YKLWPEASKV KAHWHPVLGP
560 570 580 590 600
LFSELFQHAV IYSIGGEWVK LEQVHFSELD GSLESTRSVL NYLQSSGKQI
610 620 630 640 650
AKVPGNLAAA VQLSAASATS SASPVRKVTP AWVRQVLRKC AHLGSAEEKL
660 670 680 690 700
HLLEFVLSDQ AYSELLGLEL LPLQSGAFVP FSSSVSDQDV VYITSEEFPR
710 720 730 740 750
SLFPGLEARL ILENLKPHLL AALKEAAQTR GRPCTQLQLL NPERFARLIK
760 770 780 790 800
EVMNTFWPGR ELVVQWYPFS EDKRHPSLSW LKMVWKNLYI HFSEDLTLFD
810 820 830 840 850
EMPLIPRTLL NEDQTCVELI RLRIPSVVIL DDETEAQLPE FLADIVQKLG
860 870 880 890 900
GIVLKRLDTS IQHPLVKKYI HSPLPSAILQ IMEKIPLQKL CNQIASLLPT
910 920 930 940 950
HKDALRKFLA SLTDTSEKEK RIIQELTIFK RINHSSDQGI SSYTKLKGCK
960 970 980 990 1000
VLDHTAKLPT DLRLSVSVID SSDEATIRLA NMLKIEKLKT TSCLKFVLKD
1010 1020 1030 1040 1050
IGNAFYTQEE VTQLMLWILE NLSSLKNENS NVLDWLMPLK FIHMSQGHVV
1060 1070 1080 1090 1100
AAGDLFDPDI EVLRDLFYNE EEACFPPTIF TSPDILHSLR QIGLKNESSL
1110 1120 1130 1140 1150
KEKDVVQVAR KIEALQVSSC QNQDVLMKKA KTLLLVLNKN QTLLQSSEGK
1160 1170 1180 1190 1200
MALKKIKWVP ACKERPPNYP GSLVWKGDLC NLCAPPDMCD AAHAVLVGSS
1210 1220 1230 1240 1250
LPLVESVHVN LEQALSIFTK PTINAVLKHF KTVVDWYTSK TFSDEDYYQF
1260 1270 1280 1290 1300
QHILLEIYGF MHDHLSEGKD SFKALKFPWV WTGKNFCPLA QAVIKPTHDL
1310 1320 1330 1340 1350
DLQPYLYNVP KTMAKFHQLF KACGSIEELT SDHISMVIQK VYLKSDQELS
1360 1370 1380 1390 1400
EEESKQNLHL MLNIMRWLYS NQIPASPNTP VPIYHSRNPS KLVMKPIHEC
1410 1420 1430 1440 1450
CYCDIKVDDL NDLLEDSVEP IILVHEDIPM KTAEWLKVPC LSTRLINPEN
1460 1470 1480 1490 1500
MGFEQSGQRE PLTVRIKNIL EEYPSVSDIF KELLQNADDA NATECSFMID
1510 1520 1530 1540 1550
MRRNMDIREN LLDPGMAACH GPALWSFNNS EFSDSDFLNI TRLGESLKRG
1560 1570 1580 1590 1600
EVDKVGKFGL GFNSVYHITD IPIIMSREFM IMFDPNINHI SKHIKDRSNP
1610 1620 1630 1640 1650
GIKINWSKQQ KRLRKFPNQF KPFIDVFGCQ LPLAVEAPYS YNGTLFRLSF
1660 1670 1680 1690 1700
RTQQEAKVSE VSSTCYNTAD IYSLVDEFSL CGHRLIIFTQ SVNSMYLKYL
1710 1720 1730 1740 1750
KIEETNPSLA QDTIIIKKKV CPSKALNAPV LSVLKEAAKL MKTCSSSNKK
1760 1770 1780 1790 1800
LPTDVPKSSC ILQITVEEFH HVFRRIADLQ SPLFRGPDDD PATLFEMAKS
1810 1820 1830 1840 1850
GQSKKPSDEL PQKTVDCTTW LICTCMDTGE ALKFSLNESG RRLGLVPCGA
1860 1870 1880 1890 1900
VGVLLHETQE QKWTVKPHIG EVFCYLPLRI KTGLPIHING CFAVTSNRKE
1910 1920 1930 1940 1950
IWKTDTKGRW NTTFMRHVIV KAYLQALSVL RDLAIGGELT DYTYYAVWPD
1960 1970 1980 1990 2000
PDLVHDDFSV ICKGFYEDIA HGKGKELTRV FSDGSMWVSM KNVRFLDDSI
2010 2020 2030 2040 2050
LQRKDVGSAA FKIFLKYLKK TGSKNLCAVE LPSSVKAGFE EAGCKQILLE
2060 2070 2080 2090 2100
NTFSEKQFFS EVFFPNIQEI EAELRDPLMN FVLNEKLDEF SGILRVTPCV
2110 2120 2130 2140 2150
PCSLEGHPLV LPSRLIHPEG RVAKLFDTKD GRFPYGSTQD YLNPIILIKL
2160 2170 2180 2190 2200
VQLGMAKDDI LWDDMLERAE SVAEINKSDH AAACLRSSIL LSLIDEKLKI
2210 2220 2230 2240 2250
KDPRAKDFAA KYQTIPFLPF LTKPAGFSLE WKGNSFKPET MFAATDIYTA
2260 2270 2280 2290 2300
EYQDIVCLLQ PILNENSHSF RGCGSVSLAV KEFLGLLKKP TVDLVINQLK
2310 2320 2330 2340 2350
QVAKSVDDGI TLYQENITNA CYKYLHEAVL QNEMAKATII EKLKPFCFIL
2360 2370 2380 2390 2400
VENVYVESEK VSFHLNFEAA PYLYQLPNKY KNNFRELFES VGVRQSFTVE
2410 2420 2430 2440 2450
DFALVLESID QERGKKQITE ENFQLCRRII SEGIWSLIRE KRQEFCEKNY
2460 2470 2480 2490 2500
GKILLPDTNL LLLPAKSLCY NDCPWIKVKD STVKYCHADI PREVAVKLGA
2510 2520 2530 2540 2550
IPKRHKALER YASNICFTAL GTEFGQKEKL TSRIKSILNA YPSEKEMLKE
2560 2570 2580 2590 2600
LLQNADDAKA TEICFVFDPR QHPVDRIFDD KWAPLQGPAL CVYNNQPFTE
2610 2620 2630 2640 2650
DDVRGIQNLG KGTKEGNPCK TGHYGIGFNS VYHITDCPSF ISGNDILGIF
2660 2670 2680 2690 2700
DPHARYAPGA TSVSPGRMFR DLDADFRTQF SDVLDLYLGN HFKLDNCTMF
2710 2720 2730 2740 2750
RFPLRNAEMA QVSEISSVPS SDRMVQNLLD KLRSDGAELL MFLNHMEKIS
2760 2770 2780 2790 2800
ICEIDKATGG LNVLYSVKGK ITDGDRLKRK QFHASVIDSV TKKRQLKDIP
2810 2820 2830 2840 2850
VQQITYTMDT EDSEGNLTTW LICNRSGFSS MEKVSKSVIS AHKNQDITLF
2860 2870 2880 2890 2900
PRGGVAACIT HNYKKPHRAF CFLPLSLETG LPFHVNGHFA LDSARRNLWR
2910 2920 2930 2940 2950
DDNGVGVRSD WNNSLMTALI APAYVELLIQ LKKRYFPGSD PTLSVLQNTP
2960 2970 2980 2990 3000
IHVVKDTLKK FLSFFPVNRL DLQPDLYCLV KALYSCIHED MKRLLPVVRA
3010 3020 3030 3040 3050
PNIDGSDLHS AVIITWINMS TSNKTRPFFD NLLQDELQHL KNADYNITTR
3060 3070 3080 3090 3100
KTVAENVYRL KHLLLEIGFN LVYNCDETAN LYHCLVDADI PVSYVTPADV
3110 3120 3130 3140 3150
RSFLMTFSSP DTNCHIGKLP CRLQQTNLKL FHSLKLLVDY CFKDAEESEF
3160 3170 3180 3190 3200
EVEGLPLLIT LDSVLQIFDG KRPKFLTTYH ELIPSRKDLF MNTLYLKYSS
3210 3220 3230 3240 3250
VLLNCKVAKV FDISSFADLL SSVLPREYKT KNCAKWKDNF ASESWLKNAW
3260 3270 3280 3290 3300
HFISESVSVT DDQEEPKPAF DVIVDILKDW ALLPGTKFTV STSQLVVPEG
3310 3320 3330 3340 3350
DVLIPLSLMH IAVFPNAQSD KVFHALMKAG CIQLALNKIC SKDSALVPLL
3360 3370 3380 3390 3400
SCHTANIDSP ASILKAVHYM VQTSTFRTEK LMENDFEALL MYFNCNLSHL
3410 3420 3430 3440 3450
MSQDDIKILK SLPCYKSISG RYMSIAKFGT CYVLTKSIPS AEVEKWTQSS
3460 3470 3480 3490 3500
SSAFLEEKVH LKELYEVLGC VPVDDLEVYL KHLLPKIENL SYDAKLEHLI
3510 3520 3530 3540 3550
YLKNRLASIE EPSEIKEQLF EKLESLLIIH DANNRLKQAK HFYDRTVRVF
3560 3570 3580 3590 3600
EVMLPEKLFI PKEFFKKLEQ VIKPKNQAAF MTSWVEFLRN IGLKYALSQQ
3610 3620 3630 3640 3650
QLLQFAKEIS VRANTENWSK ETLQSTVDIL LHHIFQERMD LLSGNFLKEL
3660 3670 3680 3690 3700
SLIPFLCPER APAEYIRFHP QYQEVNGTLP LIKFNGAQVN PKFKQCDVLQ
3710 3720 3730 3740 3750
LLWTSCPILP EKATPLSIKE QEGSDLAPQE QLEQVLNMLN VNLDPPLDKV
3760 3770 3780 3790 3800
INNCRNICNI TTLDEEMVKT RAKVLRSIYE FLSAEKREFR FQLRGVAFVM
3810 3820 3830 3840 3850
VEDGWKLLKP EEVVINLEYE ADFKPYLYKL PLELGTFHQL FKHLGTEDII
3860 3870 3880 3890 3900
STKQYVEVLS RIFKSSEGKQ LDPNEMRTVK RVVSGLFKSL QNDSVKVRSD
3910 3920 3930 3940 3950
LENARDLALY LPSQDGKLVK SSILVFDDAP HYKSRIQGNI GVQMLVDLSQ
3960 3970 3980 3990 4000
CYLGKDHGFH TKLIMLFPQK LRPRLLSSIL EEQLDEETPK VCQFGALCSL
4010 4020 4030 4040 4050
QGRLQLLLSS EQFITGLIRI MKHENDNAFL ANEEKAIRLC KALREGLKVS
4060 4070 4080 4090 4100
CFEKLQTTLR VKGFNPIPHS RSETFAFLKR FGNAVILLYI QHSDSKDINF
4110 4120 4130 4140 4150
LLALAMTLKS ATDNLISDTS YLIAMLGCND IYRISEKLDS LGVKYDSSEP
4160 4170 4180 4190 4200
SKLELPMPGT PIPAEIHYTL LMDPMNVFYP GEYVGYLVDA EGGDIYGSYQ
4210 4220 4230 4240 4250
PTYTYAIIVQ EVEREDADNT SFLGKIYQID IGYSEYKIVS SLDLYKFSRP
4260 4270 4280 4290 4300
DESSQNRDSA PTTPTSPTEF LTPGLRSIPP LFSGKESHKS PSTKHHSPRK
4310 4320 4330 4340 4350
LKVNALPEIL KEVTSVVEQA WKLPESERKK IIRRLYLKWH PDKNPENHDI
4360 4370 4380 4390 4400
ANEVFKHLQN EINRLEKQAF LDQNADRASR RTFSTSASRF QSDKYSFQRF
4410 4420 4430 4440 4450
YTSWNQEATS HKSERQQQSK EKCPPSAGQT YSQRFFVPPT FKSVGNPVEA
4460 4470 4480 4490 4500
RRWLRQARAN FSAARNDLHK NANEWVCFKC YLSTKLALIA ADYAVRGKSD
4510 4520 4530 4540 4550
KDVKPTALAQ KIEEYSQQLE GLTNDVHTLE AYGVDSLKTR YPDLLPFPQI
4560 4570 4580
PNDRFTSEVA MRVMECTACI IIKLENFIQQ KV
Length:4,582
Mass (Da):520,685
Last modified:January 9, 2007 - v2
Checksum:i2409B6DA64905B48
GO
Isoform 2 (identifier: Q9JLC8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-752: Missing.

Note: No experimental confirmation available.
Show »
Length:3,830
Mass (Da):436,755
Checksum:iB3F9DA5A3B0C3EF1
GO
Isoform 3 (identifier: Q9JLC8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: METKFQ → MGD

Note: No experimental confirmation available.
Show »
Length:4,579
Mass (Da):520,223
Checksum:i3FA662CF0D954276
GO

Sequence cautioni

The sequence BAC32757 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 6KFQ → EET in BAE36019 (PubMed:16141072).Curated3
Sequence conflicti58V → I in BAC35006 (PubMed:16141072).Curated1
Sequence conflicti58V → I in BAE36019 (PubMed:16141072).Curated1
Sequence conflicti224P → H in BAC32757 (PubMed:16141072).Curated1
Sequence conflicti731 – 744GRPCT…LNPER → AQQLLWGYSGRITD in BAC32757 (PubMed:16141072).CuratedAdd BLAST14
Sequence conflicti732 – 768RPCTQ…VQWYP → YVKHDLLTTLERISLAYSGN KNSDSPSRRSPSAVTCK in BAE36019 (PubMed:16141072).CuratedAdd BLAST37

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0223261 – 752Missing in isoform 2. 1 PublicationAdd BLAST752
Alternative sequenceiVSP_0223271 – 6METKFQ → MGD in isoform 3. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193557 Genomic DNA. Translation: AAF31263.1.
AC124555 Genomic DNA. No translation available.
AC138718 Genomic DNA. No translation available.
AK173011 mRNA. Translation: BAD32289.1.
AK038655 mRNA. Translation: BAC30083.1.
AK046501 mRNA. Translation: BAC32757.1. Different initiation.
AK052467 mRNA. Translation: BAC35006.1.
AK160797 mRNA. Translation: BAE36019.1.
RefSeqiNP_766397.2. NM_172809.3.
UniGeneiMm.440703.
Mm.446687.

Genome annotation databases

GeneIDi50720.
KEGGimmu:50720.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193557 Genomic DNA. Translation: AAF31263.1.
AC124555 Genomic DNA. No translation available.
AC138718 Genomic DNA. No translation available.
AK173011 mRNA. Translation: BAD32289.1.
AK038655 mRNA. Translation: BAC30083.1.
AK046501 mRNA. Translation: BAC32757.1. Different initiation.
AK052467 mRNA. Translation: BAC35006.1.
AK160797 mRNA. Translation: BAE36019.1.
RefSeqiNP_766397.2. NM_172809.3.
UniGeneiMm.440703.
Mm.446687.

3D structure databases

ProteinModelPortaliQ9JLC8.
SMRiQ9JLC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206063. 1 interactor.
STRINGi10090.ENSMUSP00000086816.

PTM databases

iPTMnetiQ9JLC8.
PhosphoSitePlusiQ9JLC8.

Proteomic databases

PaxDbiQ9JLC8.
PeptideAtlasiQ9JLC8.
PRIDEiQ9JLC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi50720.
KEGGimmu:50720.

Organism-specific databases

CTDi26278.
MGIiMGI:1354724. Sacs.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IDYY. Eukaryota.
ENOG410XV7A. LUCA.
HOGENOMiHOG000154245.
HOVERGENiHBG093399.
InParanoidiQ9JLC8.
KOiK17592.
PhylomeDBiQ9JLC8.

Miscellaneous databases

ChiTaRSiSacs. mouse.
PROiQ9JLC8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048279.
CleanExiMM_SACS.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
3.30.565.10. 3 hits.
InterProiIPR001623. DnaJ_domain.
IPR003594. HATPase_C.
IPR007842. HEPN_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF05168. HEPN. 1 hit.
[Graphical view]
SMARTiSM00748. HEPN. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF55874. SSF55874. 3 hits.
PROSITEiPS50076. DNAJ_2. 1 hit.
PS50910. HEPN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSACS_MOUSE
AccessioniPrimary (citable) accession number: Q9JLC8
Secondary accession number(s): Q3TUF2
, Q6A007, Q8BQT3, Q8C764, Q8CAJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.