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Protein

Methionine-R-sulfoxide reductase B1

Gene

Msrb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.2 Publications

Catalytic activityi

L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin.2 Publications

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23ZincPROSITE-ProRule annotation1
Metal bindingi26ZincPROSITE-ProRule annotation1
Metal bindingi71ZincPROSITE-ProRule annotation1
Metal bindingi74ZincPROSITE-ProRule annotation1
Active sitei95NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • methionine-R-sulfoxide reductase activity Source: MGI
  • peptide-methionine (R)-S-oxide reductase activity Source: UniProtKB
  • zinc ion binding Source: HGNC

GO - Biological processi

  • actin filament polymerization Source: UniProtKB
  • innate immune response Source: UniProtKB
  • protein repair Source: HGNC
  • response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi1.8.4.12. 3474.
ReactomeiR-MMU-5676934. Protein repair.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine-R-sulfoxide reductase B1 (EC:1.8.4.-)
Short name:
MsrB1
Alternative name(s):
Selenoprotein R
Short name:
SelR
Selenoprotein X
Short name:
SelX
Gene namesi
Name:Msrb1
Synonyms:Sepr, Sepx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1351642. Msrb1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytoskeleton Source: UniProtKB-SubCell
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001403221 – 116Methionine-R-sulfoxide reductase B1Add BLAST116

Proteomic databases

MaxQBiQ9JLC3.
PaxDbiQ9JLC3.
PRIDEiQ9JLC3.

PTM databases

iPTMnetiQ9JLC3.
PhosphoSitePlusiQ9JLC3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000075705.
CleanExiMM_SEPX1.
GenevisibleiQ9JLC3. MM.

Interactioni

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099300.

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 14Combined sources3
Beta strandi19 – 23Combined sources5
Turni24 – 26Combined sources3
Beta strandi41 – 43Combined sources3
Beta strandi56 – 59Combined sources4
Beta strandi61 – 63Combined sources3
Beta strandi67 – 70Combined sources4
Turni72 – 75Combined sources4
Beta strandi79 – 81Combined sources3
Turni87 – 90Combined sources4
Turni98 – 100Combined sources3
Beta strandi101 – 105Combined sources5
Beta strandi107 – 109Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KV1NMR-A1-116[»]
ProteinModelPortaliQ9JLC3.
SMRiQ9JLC3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JLC3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 106MsrBPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0856. Eukaryota.
COG0229. LUCA.
GeneTreeiENSGT00510000047678.
HOGENOMiHOG000243424.
HOVERGENiHBG002192.
InParanoidiQ9JLC3.
KOiK07305.
OMAiLKVSCGR.
OrthoDBiEOG091G043K.
PhylomeDBiQ9JLC3.
TreeFamiTF329147.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JLC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFCSFFGGE VFQNHFEPGV YVCAKCSYEL FSSHSKYAHS SPWPAFTETI
60 70 80 90 100
HPDSVTKCPE KNRPEALKVS CGKCGNGLGH EFLNDGPKRG QSRFUIFSSS
110
LKFVPKGKEA AASQGH
Length:116
Mass (Da):12,788
Last modified:February 26, 2008 - v3
Checksum:i7DE4E5EE86CAA333
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei95Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195142 mRNA. Translation: AAF13697.1.
AK002339 mRNA. Translation: BAC55245.1.
AK002652 mRNA. Translation: BAE43148.1.
AK003112 mRNA. Translation: BAC55248.1.
AK003624 mRNA. Translation: BAC55249.1.
BC090646 mRNA. Translation: AAH90646.1.
CCDSiCCDS28495.1.
RefSeqiNP_038787.1. NM_013759.2.
UniGeneiMm.28212.

Genome annotation databases

EnsembliENSMUST00000101800; ENSMUSP00000099300; ENSMUSG00000075705.
ENSMUST00000115262; ENSMUSP00000110917; ENSMUSG00000075705.
GeneIDi27361.
KEGGimmu:27361.
UCSCiuc008ayh.1. mouse.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195142 mRNA. Translation: AAF13697.1.
AK002339 mRNA. Translation: BAC55245.1.
AK002652 mRNA. Translation: BAE43148.1.
AK003112 mRNA. Translation: BAC55248.1.
AK003624 mRNA. Translation: BAC55249.1.
BC090646 mRNA. Translation: AAH90646.1.
CCDSiCCDS28495.1.
RefSeqiNP_038787.1. NM_013759.2.
UniGeneiMm.28212.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KV1NMR-A1-116[»]
ProteinModelPortaliQ9JLC3.
SMRiQ9JLC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099300.

PTM databases

iPTMnetiQ9JLC3.
PhosphoSitePlusiQ9JLC3.

Proteomic databases

MaxQBiQ9JLC3.
PaxDbiQ9JLC3.
PRIDEiQ9JLC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101800; ENSMUSP00000099300; ENSMUSG00000075705.
ENSMUST00000115262; ENSMUSP00000110917; ENSMUSG00000075705.
GeneIDi27361.
KEGGimmu:27361.
UCSCiuc008ayh.1. mouse.

Organism-specific databases

CTDi51734.
MGIiMGI:1351642. Msrb1.

Phylogenomic databases

eggNOGiKOG0856. Eukaryota.
COG0229. LUCA.
GeneTreeiENSGT00510000047678.
HOGENOMiHOG000243424.
HOVERGENiHBG002192.
InParanoidiQ9JLC3.
KOiK07305.
OMAiLKVSCGR.
OrthoDBiEOG091G043K.
PhylomeDBiQ9JLC3.
TreeFamiTF329147.

Enzyme and pathway databases

BRENDAi1.8.4.12. 3474.
ReactomeiR-MMU-5676934. Protein repair.

Miscellaneous databases

EvolutionaryTraceiQ9JLC3.
PROiQ9JLC3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075705.
CleanExiMM_SEPX1.
GenevisibleiQ9JLC3. MM.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSRB1_MOUSE
AccessioniPrimary (citable) accession number: Q9JLC3
Secondary accession number(s): Q545U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.