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Protein

MAGUK p55 subfamily member 6

Gene

Mpp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • guanylate kinase activity Source: MGI

GO - Biological processi

  • GDP metabolic process Source: GOC
  • GMP metabolic process Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 6
Alternative name(s):
Dlgh4 protein
P55T protein
Protein associated with Lin-7 2
Gene namesi
Name:Mpp6
Synonyms:Dlgh4, Pals2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1927340. Mpp6.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553MAGUK p55 subfamily member 6PRO_0000094585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei513 – 5131PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JLB0.
MaxQBiQ9JLB0.
PaxDbiQ9JLB0.
PRIDEiQ9JLB0.

PTM databases

iPTMnetiQ9JLB0.
PhosphoSiteiQ9JLB0.
SwissPalmiQ9JLB0.

Expressioni

Gene expression databases

BgeeiQ9JLB0.
ExpressionAtlasiQ9JLB0. baseline and differential.
GenevisibleiQ9JLB0. MM.

Interactioni

Subunit structurei

Interacts with CADM1. Interacts with the LIN7 proteins.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Epb41l2O703183EBI-771456,EBI-643339

Protein-protein interaction databases

BioGridi208035. 7 interactions.
IntActiQ9JLB0. 9 interactions.
MINTiMINT-4102370.
STRINGi10090.ENSMUSP00000038772.

Structurei

3D structure databases

ProteinModelPortaliQ9JLB0.
SMRiQ9JLB0. Positions 125-552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4848L27 1PROSITE-ProRule annotationAdd
BLAST
Domaini49 – 10759L27 2PROSITE-ProRule annotationAdd
BLAST
Domaini129 – 20880PDZPROSITE-ProRule annotationAdd
BLAST
Domaini228 – 29770SH3PROSITE-ProRule annotationAdd
BLAST
Domaini351 – 538188Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 2 L27 domains.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ9JLB0.
OMAiDTIIPQQ.
OrthoDBiEOG79CXZ5.
PhylomeDBiQ9JLB0.
TreeFamiTF314263.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: Q9JLB0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQVLENLTE LPSSTGAEEI DLIFLKGIME NPIVKSLAKA HERLEDSKLE
60 70 80 90 100
AVSDNNLELV NEILEDITPL ISVDENVAEL VGILKEPHFQ SLLEAHDIVA
110 120 130 140 150
SKCYDSPPSS PEMNIPSLNN QLPVDAIRIL GIHKKAGEPL GVTFRVENND
160 170 180 190 200
LVIARILHGG MIDRQGLLHV GDIIKEVNGH EVGNNPKELQ ELLKNISGSV
210 220 230 240 250
TLKILPSYRD TITPQQSYVN MERHPAHVRQ VFVKCHFDYN PFNDNLIPCK
260 270 280 290 300
EAGLKFSKGE ILQIVNREDP NWWQASHVKE GGSAGLIPSQ FLEEKRKAFV
310 320 330 340 350
RRDWDNSGPF CGTISNKKKK KMMYLTTRNA EFDRHEIQIY EEVAKMPPFQ
360 370 380 390 400
RKTLVLIGAQ GVGRRSLKNR FIVLNPARFG TTVPFTSRKP REDEKDGQAY
410 420 430 440 450
KFVSRSEMEA DIKAGKYLEH GEYEGNLYGT KIDSILEVVQ TGRTCILDVN
460 470 480 490 500
PQALKVLRTS EFMPYVVFIA APELETLRAM HKAVVDAGIT TKLLTDSDLK
510 520 530 540 550
KTVDESARIQ RAYNHYFDLI IVNDNLDKAF EKLQTAIEKL RMEPQWVPIS

WVY
Length:553
Mass (Da):62,631
Last modified:October 1, 2000 - v1
Checksum:i26F3BE2445ABEDC2
GO
Isoform Alpha (identifier: Q9JLB0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-230: Missing.

Show »
Length:539
Mass (Da):60,925
Checksum:i56409E4E57D25971
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti393 – 3942DE → EQ in AAD45009 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei217 – 23014Missing in isoform Alpha. 2 PublicationsVSP_003161Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199009 mRNA. Translation: AAF63790.1.
AF199010 mRNA. Translation: AAF63791.1.
AF161181 mRNA. Translation: AAD45009.1.
CCDSiCCDS20128.1. [Q9JLB0-2]
CCDS51770.1. [Q9JLB0-1]
RefSeqiNP_001158205.1. NM_001164733.1. [Q9JLB0-1]
NP_001158206.1. NM_001164734.1. [Q9JLB0-1]
NP_064323.2. NM_019939.2. [Q9JLB0-2]
UniGeneiMm.248361.
Mm.41288.
Mm.463873.

Genome annotation databases

EnsembliENSMUST00000036225; ENSMUSP00000038772; ENSMUSG00000038388. [Q9JLB0-1]
ENSMUST00000036236; ENSMUSP00000039314; ENSMUSG00000038388. [Q9JLB0-2]
ENSMUST00000166318; ENSMUSP00000125880; ENSMUSG00000038388. [Q9JLB0-1]
ENSMUST00000204545; ENSMUSP00000144737; ENSMUSG00000038388. [Q9JLB0-2]
GeneIDi56524.
KEGGimmu:56524.
UCSCiuc009bwv.2. mouse. [Q9JLB0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199009 mRNA. Translation: AAF63790.1.
AF199010 mRNA. Translation: AAF63791.1.
AF161181 mRNA. Translation: AAD45009.1.
CCDSiCCDS20128.1. [Q9JLB0-2]
CCDS51770.1. [Q9JLB0-1]
RefSeqiNP_001158205.1. NM_001164733.1. [Q9JLB0-1]
NP_001158206.1. NM_001164734.1. [Q9JLB0-1]
NP_064323.2. NM_019939.2. [Q9JLB0-2]
UniGeneiMm.248361.
Mm.41288.
Mm.463873.

3D structure databases

ProteinModelPortaliQ9JLB0.
SMRiQ9JLB0. Positions 125-552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208035. 7 interactions.
IntActiQ9JLB0. 9 interactions.
MINTiMINT-4102370.
STRINGi10090.ENSMUSP00000038772.

PTM databases

iPTMnetiQ9JLB0.
PhosphoSiteiQ9JLB0.
SwissPalmiQ9JLB0.

Proteomic databases

EPDiQ9JLB0.
MaxQBiQ9JLB0.
PaxDbiQ9JLB0.
PRIDEiQ9JLB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036225; ENSMUSP00000038772; ENSMUSG00000038388. [Q9JLB0-1]
ENSMUST00000036236; ENSMUSP00000039314; ENSMUSG00000038388. [Q9JLB0-2]
ENSMUST00000166318; ENSMUSP00000125880; ENSMUSG00000038388. [Q9JLB0-1]
ENSMUST00000204545; ENSMUSP00000144737; ENSMUSG00000038388. [Q9JLB0-2]
GeneIDi56524.
KEGGimmu:56524.
UCSCiuc009bwv.2. mouse. [Q9JLB0-1]

Organism-specific databases

CTDi51678.
MGIiMGI:1927340. Mpp6.

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ9JLB0.
OMAiDTIIPQQ.
OrthoDBiEOG79CXZ5.
PhylomeDBiQ9JLB0.
TreeFamiTF314263.

Miscellaneous databases

NextBioi312858.
PROiQ9JLB0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JLB0.
ExpressionAtlasiQ9JLB0. baseline and differential.
GenevisibleiQ9JLB0. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of Pals, proteins associated with mLin-7."
    Kamberov E., Makarova O., Roh M., Liu A., Karnak D., Straight S., Margolis B.
    J. Biol. Chem. 275:11425-11431(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
  2. Lin L., Chishti A.H.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
  3. "Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells."
    Shingai T., Ikeda W., Kakunaga S., Morimoto K., Takekuni K., Itoh S., Satoh K., Takeuchi M., Imai T., Monden M., Takai Y.
    J. Biol. Chem. 278:35421-35427(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CADM1.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen and Testis.

Entry informationi

Entry nameiMPP6_MOUSE
AccessioniPrimary (citable) accession number: Q9JLB0
Secondary accession number(s): Q9JLB1, Q9WV37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: April 13, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.