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Protein

MAGUK p55 subfamily member 6

Gene

Mpp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • guanylate kinase activity Source: MGI
  • PDZ domain binding Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 6
Alternative name(s):
Dlgh4 protein
P55T protein
Protein associated with Lin-7 2
Gene namesi
Name:Mpp6
Synonyms:Dlgh4, Pals2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1927340 Mpp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945851 – 553MAGUK p55 subfamily member 6Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei513PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JLB0
PRIDEiQ9JLB0

PTM databases

iPTMnetiQ9JLB0
PhosphoSitePlusiQ9JLB0
SwissPalmiQ9JLB0

Expressioni

Gene expression databases

BgeeiENSMUSG00000038388
ExpressionAtlasiQ9JLB0 baseline and differential
GenevisibleiQ9JLB0 MM

Interactioni

Subunit structurei

Interacts with CADM1. Interacts with the LIN7 proteins.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Epb41l2O703183EBI-771456,EBI-643339

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208035, 8 interactors
IntActiQ9JLB0, 9 interactors
MINTiQ9JLB0
STRINGi10090.ENSMUSP00000038772

Structurei

3D structure databases

ProteinModelPortaliQ9JLB0
SMRiQ9JLB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 48L27 1PROSITE-ProRule annotationAdd BLAST48
Domaini49 – 107L27 2PROSITE-ProRule annotationAdd BLAST59
Domaini129 – 208PDZPROSITE-ProRule annotationAdd BLAST80
Domaini228 – 297SH3PROSITE-ProRule annotationAdd BLAST70
Domaini351 – 538Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST188

Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000233034
HOVERGENiHBG001858
InParanoidiQ9JLB0
OMAiDTIIPQQ
OrthoDBiEOG091G065I
PhylomeDBiQ9JLB0
TreeFamiTF314263

Family and domain databases

CDDicd12038 SH3_MPP6, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR035603 MPP6_SH3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF02828 L27, 2 hits
PF00595 PDZ, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00569 L27, 2 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS51022 L27, 2 hits
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: Q9JLB0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQVLENLTE LPSSTGAEEI DLIFLKGIME NPIVKSLAKA HERLEDSKLE
60 70 80 90 100
AVSDNNLELV NEILEDITPL ISVDENVAEL VGILKEPHFQ SLLEAHDIVA
110 120 130 140 150
SKCYDSPPSS PEMNIPSLNN QLPVDAIRIL GIHKKAGEPL GVTFRVENND
160 170 180 190 200
LVIARILHGG MIDRQGLLHV GDIIKEVNGH EVGNNPKELQ ELLKNISGSV
210 220 230 240 250
TLKILPSYRD TITPQQSYVN MERHPAHVRQ VFVKCHFDYN PFNDNLIPCK
260 270 280 290 300
EAGLKFSKGE ILQIVNREDP NWWQASHVKE GGSAGLIPSQ FLEEKRKAFV
310 320 330 340 350
RRDWDNSGPF CGTISNKKKK KMMYLTTRNA EFDRHEIQIY EEVAKMPPFQ
360 370 380 390 400
RKTLVLIGAQ GVGRRSLKNR FIVLNPARFG TTVPFTSRKP REDEKDGQAY
410 420 430 440 450
KFVSRSEMEA DIKAGKYLEH GEYEGNLYGT KIDSILEVVQ TGRTCILDVN
460 470 480 490 500
PQALKVLRTS EFMPYVVFIA APELETLRAM HKAVVDAGIT TKLLTDSDLK
510 520 530 540 550
KTVDESARIQ RAYNHYFDLI IVNDNLDKAF EKLQTAIEKL RMEPQWVPIS

WVY
Length:553
Mass (Da):62,631
Last modified:October 1, 2000 - v1
Checksum:i26F3BE2445ABEDC2
GO
Isoform Alpha (identifier: Q9JLB0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-230: Missing.

Show »
Length:539
Mass (Da):60,925
Checksum:i56409E4E57D25971
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti393 – 394DE → EQ in AAD45009 (Ref. 2) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003161217 – 230Missing in isoform Alpha. 2 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199009 mRNA Translation: AAF63790.1
AF199010 mRNA Translation: AAF63791.1
AF161181 mRNA Translation: AAD45009.1
CCDSiCCDS20128.1 [Q9JLB0-2]
CCDS51770.1 [Q9JLB0-1]
RefSeqiNP_001158205.1, NM_001164733.1 [Q9JLB0-1]
NP_001158206.1, NM_001164734.1 [Q9JLB0-1]
NP_064323.2, NM_019939.2 [Q9JLB0-2]
UniGeneiMm.248361
Mm.41288
Mm.463873

Genome annotation databases

EnsembliENSMUST00000036225; ENSMUSP00000038772; ENSMUSG00000038388 [Q9JLB0-1]
ENSMUST00000036236; ENSMUSP00000039314; ENSMUSG00000038388 [Q9JLB0-2]
ENSMUST00000166318; ENSMUSP00000125880; ENSMUSG00000038388 [Q9JLB0-1]
ENSMUST00000204545; ENSMUSP00000144737; ENSMUSG00000038388 [Q9JLB0-2]
GeneIDi56524
KEGGimmu:56524
UCSCiuc009bwv.2 mouse [Q9JLB0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMPP6_MOUSE
AccessioniPrimary (citable) accession number: Q9JLB0
Secondary accession number(s): Q9JLB1, Q9WV37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health