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Protein

C-type lectin domain family 1 member B

Gene

Clec1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: MGI
  • platelet formation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 1 member B
Alternative name(s):
C-type lectin-like receptor 2
Short name:
CLEC-2
Gene namesi
Name:Clec1b
Synonyms:Clec2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1913287. Clec1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131CytoplasmicSequence analysisAdd
BLAST
Transmembranei32 – 5221Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini53 – 229177ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229C-type lectin domain family 1 member BPRO_0000280044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71Phosphotyrosine1 Publication
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Disulfide bondi102 ↔ 113PROSITE-ProRule annotation
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Disulfide bondi130 ↔ 216PROSITE-ProRule annotation
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Disulfide bondi195 ↔ 208PROSITE-ProRule annotation

Post-translational modificationi

Glycosylated.1 Publication
Phosphorylated on tyrosine residue in response to rhodocytin binding.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9JL99.
PaxDbiQ9JL99.
PRIDEiQ9JL99.

PTM databases

iPTMnetiQ9JL99.
PhosphoSiteiQ9JL99.

Expressioni

Tissue specificityi

Hematopoietic cells, megakaryocytes and platelets.2 Publications

Gene expression databases

BgeeiENSMUSG00000030159.
CleanExiMM_CLEC1B.
ExpressionAtlasiQ9JL99. baseline and differential.
GenevisibleiQ9JL99. MM.

Interactioni

Subunit structurei

Homodimer. Interacts (via cytoplasmic domain) with RACK1; promotes CLEC1B ubiquitination and proteasome-mediated degradation. Interacts (dimer) with SYK (via SH2 domains) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032262.

Structurei

3D structure databases

ProteinModelPortaliQ9JL99.
SMRiQ9JL99. Positions 64-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 217109C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000111777.
HOVERGENiHBG094936.
InParanoidiQ9JL99.
KOiK10070.
OMAiKGHKCSP.
OrthoDBiEOG091G0OAQ.
PhylomeDBiQ9JL99.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JL99-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQDEDGYITL NIKPRKQALS SAEPASSWWR VMALVLLISS MGLVVGLVAL
60 70 80 90 100
GIMSVTQQKY LLAEKENLSA TLQQLAKKFC QELIRQSEIK TKSTFEHKCS
110 120 130 140 150
PCATKWRYHG DSCYGFFRRN LTWEESKQYC TEQNATLVKT ASQSTLDYIA
160 170 180 190 200
ERITSVRWIG LSRQNSKKDW MWEDSSVLRK NGINLSGNTE ENMNCAYLHN
210 220
GKIHPASCKE RHYLICERNA GMTRVDQLL
Length:229
Mass (Da):26,239
Last modified:October 1, 2000 - v1
Checksum:i1EC9377F491CA52B
GO
Isoform 2 (identifier: Q9JL99-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     23-54: Missing.

Show »
Length:197
Mass (Da):22,870
Checksum:iE0CBDEEFE2441A5F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei23 – 5432Missing in isoform 2. 1 PublicationVSP_023516Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201457 mRNA. Translation: AAF36831.1.
EF070191 mRNA. Translation: ABK60036.1.
BC064054 mRNA. Translation: AAH64054.1.
CCDSiCCDS20586.1. [Q9JL99-1]
CCDS57452.1. [Q9JL99-2]
RefSeqiNP_001191168.1. NM_001204239.1. [Q9JL99-2]
NP_064369.1. NM_019985.3. [Q9JL99-1]
UniGeneiMm.30700.

Genome annotation databases

EnsembliENSMUST00000032262; ENSMUSP00000032262; ENSMUSG00000030159. [Q9JL99-1]
ENSMUST00000112081; ENSMUSP00000107712; ENSMUSG00000030159. [Q9JL99-2]
GeneIDi56760.
KEGGimmu:56760.
UCSCiuc009efo.2. mouse. [Q9JL99-1]
uc009efp.2. mouse. [Q9JL99-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201457 mRNA. Translation: AAF36831.1.
EF070191 mRNA. Translation: ABK60036.1.
BC064054 mRNA. Translation: AAH64054.1.
CCDSiCCDS20586.1. [Q9JL99-1]
CCDS57452.1. [Q9JL99-2]
RefSeqiNP_001191168.1. NM_001204239.1. [Q9JL99-2]
NP_064369.1. NM_019985.3. [Q9JL99-1]
UniGeneiMm.30700.

3D structure databases

ProteinModelPortaliQ9JL99.
SMRiQ9JL99. Positions 64-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032262.

PTM databases

iPTMnetiQ9JL99.
PhosphoSiteiQ9JL99.

Proteomic databases

MaxQBiQ9JL99.
PaxDbiQ9JL99.
PRIDEiQ9JL99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032262; ENSMUSP00000032262; ENSMUSG00000030159. [Q9JL99-1]
ENSMUST00000112081; ENSMUSP00000107712; ENSMUSG00000030159. [Q9JL99-2]
GeneIDi56760.
KEGGimmu:56760.
UCSCiuc009efo.2. mouse. [Q9JL99-1]
uc009efp.2. mouse. [Q9JL99-2]

Organism-specific databases

CTDi51266.
MGIiMGI:1913287. Clec1b.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000111777.
HOVERGENiHBG094936.
InParanoidiQ9JL99.
KOiK10070.
OMAiKGHKCSP.
OrthoDBiEOG091G0OAQ.
PhylomeDBiQ9JL99.
TreeFamiTF336674.

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.

Miscellaneous databases

PROiQ9JL99.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030159.
CleanExiMM_CLEC1B.
ExpressionAtlasiQ9JL99. baseline and differential.
GenevisibleiQ9JL99. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC1B_MOUSE
AccessioniPrimary (citable) accession number: Q9JL99
Secondary accession number(s): A0T1G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2 (PubMed:16174766).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.