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Protein

Proteoglycan 3

Gene

Prg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiI63.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteoglycan 3
Alternative name(s):
Eosinophil major basic protein 2
Gene namesi
Name:Prg3Imported
Synonyms:Mbp2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1858200. Prg3.

Subcellular locationi


    Note: Localized to the eosinophil secondary granule.1 Publication

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 222205Proteoglycan 3Sequence analysisPRO_0000248860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi126 ↔ 220PROSITE-ProRule annotation
Disulfide bondi197 ↔ 212PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9JL95.
PaxDbiQ9JL95.
PRIDEiQ9JL95.

PTM databases

PhosphoSiteiQ9JL95.

Expressioni

Tissue specificityi

Expressed in bone marrow, spleen, and thymus. Not detected in heart, liver or lung.1 Publication

Gene expression databases

BgeeiQ9JL95.
CleanExiMM_PRG3.
GenevisibleiQ9JL95. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028466.

Structurei

3D structure databases

ProteinModelPortaliQ9JL95.
SMRiQ9JL95. Positions 108-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 221117C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IS3H. Eukaryota.
ENOG410YXBP. LUCA.
GeneTreeiENSGT00440000039859.
HOGENOMiHOG000261603.
HOVERGENiHBG005583.
InParanoidiQ9JL95.
OMAiFCWTDGS.
OrthoDBiEOG779P0F.
PhylomeDBiQ9JL95.
TreeFamiTF336281.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR002352. Eosinophil_major_basic.
[Graphical view]
PANTHERiPTHR10068. PTHR10068. 1 hit.
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
PRINTSiPR00770. EMAJORBASICP.
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9JL95-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQPLILSFL LLGMVSAFHL ETAHLENPKR EESLKQEADG SREQGRELAL
60 70 80 90 100
TQETKQTEGE EVEGSQHQDI FEDEEAMESD PDALNKDSAC PKEEDTTHFQ
110 120 130 140 150
GTPGCKSCNY VLVRTPETFD KAQRVCRRCY RGNLASVHSY SFNYQIQNLA
160 170 180 190 200
RKINQSIVWI GGILRGWFWK KFCWMDGSCW DFGYWAPGQP GSGGGHCVTL
210 220
CTKGGHWRRA SCKSHLPFIC SF
Length:222
Mass (Da):25,204
Last modified:October 1, 2000 - v1
Checksum:i1A28C69888FC52FF
GO
Isoform 2 (identifier: Q9JL95-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-123: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:120
Mass (Da):13,766
Checksum:iA78115A8911B5515
GO

Sequence cautioni

The sequence AAI04390.2 differs from that shown. Reason: Frameshift at position 22. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 123102Missing in isoform 2. 1 PublicationVSP_034564Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202533 mRNA. Translation: AAF26366.1.
AK158110 mRNA. Translation: BAE34360.1.
AL935159 Genomic DNA. Translation: CAM18191.1.
BC104388 mRNA. Translation: AAI04389.1.
BC104389 mRNA. Translation: AAI04390.2. Frameshift.
CCDSiCCDS16199.1. [Q9JL95-1]
RefSeqiNP_058610.1. NM_016914.2. [Q9JL95-1]
XP_006499964.1. XM_006499901.1. [Q9JL95-1]
UniGeneiMm.19943.

Genome annotation databases

EnsembliENSMUST00000028466; ENSMUSP00000028466; ENSMUSG00000027072. [Q9JL95-1]
GeneIDi53856.
KEGGimmu:53856.
UCSCiuc008kjq.1. mouse. [Q9JL95-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Eosinophil major basic protein homolog

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202533 mRNA. Translation: AAF26366.1.
AK158110 mRNA. Translation: BAE34360.1.
AL935159 Genomic DNA. Translation: CAM18191.1.
BC104388 mRNA. Translation: AAI04389.1.
BC104389 mRNA. Translation: AAI04390.2. Frameshift.
CCDSiCCDS16199.1. [Q9JL95-1]
RefSeqiNP_058610.1. NM_016914.2. [Q9JL95-1]
XP_006499964.1. XM_006499901.1. [Q9JL95-1]
UniGeneiMm.19943.

3D structure databases

ProteinModelPortaliQ9JL95.
SMRiQ9JL95. Positions 108-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028466.

Protein family/group databases

MEROPSiI63.001.

PTM databases

PhosphoSiteiQ9JL95.

Proteomic databases

MaxQBiQ9JL95.
PaxDbiQ9JL95.
PRIDEiQ9JL95.

Protocols and materials databases

DNASUi53856.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028466; ENSMUSP00000028466; ENSMUSG00000027072. [Q9JL95-1]
GeneIDi53856.
KEGGimmu:53856.
UCSCiuc008kjq.1. mouse. [Q9JL95-1]

Organism-specific databases

CTDi10394.
MGIiMGI:1858200. Prg3.

Phylogenomic databases

eggNOGiENOG410IS3H. Eukaryota.
ENOG410YXBP. LUCA.
GeneTreeiENSGT00440000039859.
HOGENOMiHOG000261603.
HOVERGENiHBG005583.
InParanoidiQ9JL95.
OMAiFCWTDGS.
OrthoDBiEOG779P0F.
PhylomeDBiQ9JL95.
TreeFamiTF336281.

Miscellaneous databases

PROiQ9JL95.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JL95.
CleanExiMM_PRG3.
GenevisibleiQ9JL95. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR002352. Eosinophil_major_basic.
[Graphical view]
PANTHERiPTHR10068. PTHR10068. 1 hit.
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
PRINTSiPR00770. EMAJORBASICP.
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new murine eosinophil major basic protein (mMBP) gene: cloning and characterization of mMBP-2."
    Macias M.P., Welch K.C., Denzler K.L., Larson K.A., Lee N.A., Lee J.J.
    J. Leukoc. Biol. 67:567-576(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6JImported.
    Tissue: Inner earImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiPRG3_MOUSE
AccessioniPrimary (citable) accession number: Q9JL95
Secondary accession number(s): A2AW01, Q3SXA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.