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Protein

Proteoglycan 3

Gene

Prg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiI63.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteoglycan 3
Alternative name(s):
Eosinophil major basic protein 2
Gene namesi
Name:Prg3Imported
Synonyms:Mbp2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1858200. Prg3.

Subcellular locationi


    Note: Localized to the eosinophil secondary granule.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000024886018 – 222Proteoglycan 3Sequence analysisAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi126 ↔ 220PROSITE-ProRule annotation
Disulfide bondi197 ↔ 212PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9JL95.
PRIDEiQ9JL95.

PTM databases

PhosphoSitePlusiQ9JL95.

Expressioni

Tissue specificityi

Expressed in bone marrow, spleen, and thymus. Not detected in heart, liver or lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000027072.
CleanExiMM_PRG3.
GenevisibleiQ9JL95. MM.

Structurei

3D structure databases

ProteinModelPortaliQ9JL95.
SMRiQ9JL95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 221C-type lectinPROSITE-ProRule annotationAdd BLAST117

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IS3H. Eukaryota.
ENOG410YXBP. LUCA.
GeneTreeiENSGT00440000039859.
HOGENOMiHOG000261603.
HOVERGENiHBG005583.
InParanoidiQ9JL95.
OMAiFCWTDGS.
OrthoDBiEOG091G0LK4.
PhylomeDBiQ9JL95.
TreeFamiTF336281.

Family and domain databases

CDDicd03598. CLECT_EMBP_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR033816. EMBP_CTLD.
IPR002352. Eosinophil_major_basic.
PANTHERiPTHR10068. PTHR10068. 1 hit.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
PRINTSiPR00770. EMAJORBASICP.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9JL95-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQPLILSFL LLGMVSAFHL ETAHLENPKR EESLKQEADG SREQGRELAL
60 70 80 90 100
TQETKQTEGE EVEGSQHQDI FEDEEAMESD PDALNKDSAC PKEEDTTHFQ
110 120 130 140 150
GTPGCKSCNY VLVRTPETFD KAQRVCRRCY RGNLASVHSY SFNYQIQNLA
160 170 180 190 200
RKINQSIVWI GGILRGWFWK KFCWMDGSCW DFGYWAPGQP GSGGGHCVTL
210 220
CTKGGHWRRA SCKSHLPFIC SF
Length:222
Mass (Da):25,204
Last modified:October 1, 2000 - v1
Checksum:i1A28C69888FC52FF
GO
Isoform 2 (identifier: Q9JL95-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-123: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:120
Mass (Da):13,766
Checksum:iA78115A8911B5515
GO

Sequence cautioni

The sequence AAI04390 differs from that shown. Reason: Frameshift at position 22.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03456422 – 123Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202533 mRNA. Translation: AAF26366.1.
AK158110 mRNA. Translation: BAE34360.1.
AL935159 Genomic DNA. Translation: CAM18191.1.
BC104388 mRNA. Translation: AAI04389.1.
BC104389 mRNA. Translation: AAI04390.2. Frameshift.
CCDSiCCDS16199.1. [Q9JL95-1]
RefSeqiNP_058610.1. NM_016914.2. [Q9JL95-1]
XP_006499964.1. XM_006499901.1. [Q9JL95-1]
UniGeneiMm.19943.

Genome annotation databases

EnsembliENSMUST00000028466; ENSMUSP00000028466; ENSMUSG00000027072. [Q9JL95-1]
GeneIDi53856.
KEGGimmu:53856.
UCSCiuc008kjq.1. mouse. [Q9JL95-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPRG3_MOUSE
AccessioniPrimary (citable) accession number: Q9JL95
Secondary accession number(s): A2AW01, Q3SXA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2000
Last modified: July 5, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot