Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proteoglycan 3

Gene

Prg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiI63.001

Names & Taxonomyi

Protein namesi
Recommended name:
Proteoglycan 3
Alternative name(s):
Eosinophil major basic protein 2
Gene namesi
Name:Prg3Imported
Synonyms:Mbp2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1858200 Prg3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000024886018 – 222Proteoglycan 3Sequence analysisAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi126 ↔ 220PROSITE-ProRule annotation
Disulfide bondi197 ↔ 212PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9JL95
PRIDEiQ9JL95

PTM databases

PhosphoSitePlusiQ9JL95

Expressioni

Tissue specificityi

Expressed in bone marrow, spleen, and thymus. Not detected in heart, liver or lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000027072
CleanExiMM_PRG3
GenevisibleiQ9JL95 MM

Structurei

3D structure databases

ProteinModelPortaliQ9JL95
SMRiQ9JL95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 221C-type lectinPROSITE-ProRule annotationAdd BLAST117

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IS3H Eukaryota
ENOG410YXBP LUCA
GeneTreeiENSGT00440000039859
HOGENOMiHOG000261603
HOVERGENiHBG005583
InParanoidiQ9JL95
OMAiFCWTDGS
OrthoDBiEOG091G0LK4
PhylomeDBiQ9JL95
TreeFamiTF336281

Family and domain databases

CDDicd03598 CLECT_EMBP_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR033816 EMBP_CTLD
IPR002352 Eosinophil_major_basic
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PRINTSiPR00770 EMAJORBASICP
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9JL95-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQPLILSFL LLGMVSAFHL ETAHLENPKR EESLKQEADG SREQGRELAL
60 70 80 90 100
TQETKQTEGE EVEGSQHQDI FEDEEAMESD PDALNKDSAC PKEEDTTHFQ
110 120 130 140 150
GTPGCKSCNY VLVRTPETFD KAQRVCRRCY RGNLASVHSY SFNYQIQNLA
160 170 180 190 200
RKINQSIVWI GGILRGWFWK KFCWMDGSCW DFGYWAPGQP GSGGGHCVTL
210 220
CTKGGHWRRA SCKSHLPFIC SF
Length:222
Mass (Da):25,204
Last modified:October 1, 2000 - v1
Checksum:i1A28C69888FC52FF
GO
Isoform 2 (identifier: Q9JL95-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-123: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:120
Mass (Da):13,766
Checksum:iA78115A8911B5515
GO

Sequence cautioni

The sequence AAI04390 differs from that shown. Reason: Frameshift at position 22.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03456422 – 123Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202533 mRNA Translation: AAF26366.1
AK158110 mRNA Translation: BAE34360.1
AL935159 Genomic DNA No translation available.
BC104388 mRNA Translation: AAI04389.1
BC104389 mRNA Translation: AAI04390.2 Frameshift.
CCDSiCCDS16199.1 [Q9JL95-1]
RefSeqiNP_058610.1, NM_016914.2 [Q9JL95-1]
XP_006499964.1, XM_006499901.1 [Q9JL95-1]
UniGeneiMm.19943

Genome annotation databases

EnsembliENSMUST00000028466; ENSMUSP00000028466; ENSMUSG00000027072 [Q9JL95-1]
GeneIDi53856
KEGGimmu:53856
UCSCiuc008kjq.1 mouse [Q9JL95-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPRG3_MOUSE
AccessioniPrimary (citable) accession number: Q9JL95
Secondary accession number(s): A2AW01, Q3SXA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health