Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ninjurin-2

Gene

Ninj2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ninjurin-2
Alternative name(s):
Nerve injury-induced protein 2
Gene namesi
Name:Ninj2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1352751. Ninj2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7070ExtracellularSequence analysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Topological domaini92 – 10716CytoplasmicSequence analysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST
Topological domaini129 – 14315ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Ninjurin-2PRO_0000159647Add
BLAST

Proteomic databases

PaxDbiQ9JL89.

Expressioni

Developmental stagei

In the dorsal root ganglia, already detected at embryonic day 14, increasing until postnatal day 2 where the adult level is reached.

Inductioni

By nerve injury; in Schwann cells.

Gene expression databases

BgeeiQ9JL89.
CleanExiMM_NINJ2.
ExpressionAtlasiQ9JL89. baseline and differential.
GenevisibleiQ9JL89. MM.

Family & Domainsi

Sequence similaritiesi

Belongs to the ninjurin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0D7. Eukaryota.
ENOG4111YA5. LUCA.
GeneTreeiENSGT00390000012754.
HOGENOMiHOG000037625.
HOVERGENiHBG052622.
InParanoidiQ9JL89.
OMAiLSHPKKA.
OrthoDBiEOG7QK0F5.
PhylomeDBiQ9JL89.
TreeFamiTF323538.

Family and domain databases

InterProiIPR007007. Ninjurin.
[Graphical view]
PANTHERiPTHR12316. PTHR12316. 1 hit.
PfamiPF04923. Ninjurin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JL89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESDRETIHL QHRHSMRGGN QRIDLNFYAT KKSVAESMLD VALFMSNAMR
60 70 80 90 100
LKSVLQQGPF AEYYTTLVTL IIVSLLLQVV ISLLLVFIAI LNLNEVENQR
110 120 130 140
HLNKLNNAAT ILVFITVVIN IFITAFGAHH AASMAARTSS NPI
Length:143
Mass (Da):15,994
Last modified:October 1, 2000 - v1
Checksum:iA822707AF10132BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205634 mRNA. Translation: AAF42829.1.
CCDSiCCDS39612.1.
RefSeqiNP_057927.1. NM_016718.2.
UniGeneiMm.103668.

Genome annotation databases

EnsembliENSMUST00000112711; ENSMUSP00000108331; ENSMUSG00000041377.
GeneIDi29862.
KEGGimmu:29862.
UCSCiuc009dmx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205634 mRNA. Translation: AAF42829.1.
CCDSiCCDS39612.1.
RefSeqiNP_057927.1. NM_016718.2.
UniGeneiMm.103668.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9JL89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112711; ENSMUSP00000108331; ENSMUSG00000041377.
GeneIDi29862.
KEGGimmu:29862.
UCSCiuc009dmx.1. mouse.

Organism-specific databases

CTDi4815.
MGIiMGI:1352751. Ninj2.

Phylogenomic databases

eggNOGiENOG410J0D7. Eukaryota.
ENOG4111YA5. LUCA.
GeneTreeiENSGT00390000012754.
HOGENOMiHOG000037625.
HOVERGENiHBG052622.
InParanoidiQ9JL89.
OMAiLSHPKKA.
OrthoDBiEOG7QK0F5.
PhylomeDBiQ9JL89.
TreeFamiTF323538.

Miscellaneous databases

ChiTaRSiNinj2. mouse.
NextBioi307070.
PROiQ9JL89.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JL89.
CleanExiMM_NINJ2.
ExpressionAtlasiQ9JL89. baseline and differential.
GenevisibleiQ9JL89. MM.

Family and domain databases

InterProiIPR007007. Ninjurin.
[Graphical view]
PANTHERiPTHR12316. PTHR12316. 1 hit.
PfamiPF04923. Ninjurin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature sensory and enteric neurons and promotes neurite outgrowth."
    Araki T., Milbrandt J.
    J. Neurosci. 20:187-195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNINJ2_MOUSE
AccessioniPrimary (citable) accession number: Q9JL89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: December 9, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.