ID   FANCA_MOUSE             Reviewed;        1439 AA.
AC   Q9JL70; E9QKQ4; Q9ESU9; Q9ESV3; Q9ET44; Q9JL64; Q9JL65; Q9JL66; Q9JL67;
AC   Q9JL68; Q9JL69;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   27-MAR-2024, entry version 131.
DE   RecName: Full=Fanconi anemia group A protein homolog;
DE            Short=Protein FACA;
GN   Name=Fanca;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=10754110; DOI=10.1007/s003350010060;
RA   Van de Vrugt H.J., Cheng N.C., De Vries Y., Rooimans M.A., De Groot J.,
RA   Scheper R.J., Zhi Y., Hoatlin M.E., Joenje H., Arwert F.;
RT   "Cloning and characterization of murine Fanconi anemia group A gene: Fanca
RT   protein is expressed in lymphoid tissues, testis, and ovary.";
RL   Mamm. Genome 11:326-331(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=129/SvEvTacfBr, and C57BL/6J;
RX   PubMed=10936049; DOI=10.1006/geno.2000.6252;
RA   Wong J.C., Alon N., Norga K., Kruyt F.A.E., Youssoufian H., Buchwald M.;
RT   "Cloning and analysis of the mouse Fanconi anemia group A cDNA and an
RT   overlapping penta zinc finger cDNA.";
RL   Genomics 67:273-283(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1130-1439.
RA   Hildebrand G., Digweed M.;
RT   "Partial sequence of the murine Fanca gene.";
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA repair protein that may operate in a postreplication
CC       repair or a cell cycle checkpoint function. May be involved in
CC       interstrand DNA cross-link repair and in the maintenance of normal
CC       chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA,
CC       FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM (By
CC       similarity). In complex with FANCF, FANCG and FANCL, but not with
CC       FANCC, nor FANCE, interacts with HES1; this interaction may be
CC       essential for the stability and nuclear localization of FA core complex
CC       proteins (By similarity). The complex with FANCC and FANCG may also
CC       include EIF2AK2 and HSP70. Interacts with FAAP20; interaction is direct
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=The major form is nuclear. The minor form is cytoplasmic.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in testis and lymphoid tissues
CC       like thymus, lymph nodes, and spleen, and at lower levels in kidney and
CC       ovary. {ECO:0000269|PubMed:10754110}.
CC   -!- PTM: Phosphorylated primarily on serine residues. Phosphorylation is
CC       required for the formation of the nuclear complex (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; AF208116; AAF63963.1; -; mRNA.
DR   EMBL; AF208117; AAF63964.1; -; mRNA.
DR   EMBL; AF208118; AAF63965.1; -; mRNA.
DR   EMBL; AF208120; AAF63966.1; -; mRNA.
DR   EMBL; AF208121; AAF63967.1; -; mRNA.
DR   EMBL; AF208122; AAF63968.1; -; mRNA.
DR   EMBL; AF208123; AAF63969.1; -; mRNA.
DR   EMBL; AF178934; AAG01633.1; -; mRNA.
DR   EMBL; AF230373; AAG02637.1; -; Genomic_DNA.
DR   EMBL; AC155810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF247181; AAG00417.1; -; Genomic_DNA.
DR   CCDS; CCDS22753.1; -.
DR   RefSeq; NP_058621.2; NM_016925.3.
DR   AlphaFoldDB; Q9JL70; -.
DR   SMR; Q9JL70; -.
DR   BioGRID; 199591; 2.
DR   STRING; 10090.ENSMUSP00000045217; -.
DR   iPTMnet; Q9JL70; -.
DR   PhosphoSitePlus; Q9JL70; -.
DR   EPD; Q9JL70; -.
DR   MaxQB; Q9JL70; -.
DR   PaxDb; 10090-ENSMUSP00000045217; -.
DR   ProteomicsDB; 277038; -.
DR   Pumba; Q9JL70; -.
DR   Antibodypedia; 30916; 471 antibodies from 39 providers.
DR   DNASU; 14087; -.
DR   Ensembl; ENSMUST00000035495.15; ENSMUSP00000045217.9; ENSMUSG00000032815.17.
DR   GeneID; 14087; -.
DR   KEGG; mmu:14087; -.
DR   UCSC; uc009nve.2; mouse.
DR   AGR; MGI:1341823; -.
DR   CTD; 2175; -.
DR   MGI; MGI:1341823; Fanca.
DR   VEuPathDB; HostDB:ENSMUSG00000032815; -.
DR   eggNOG; ENOG502QT8N; Eukaryota.
DR   GeneTree; ENSGT00390000007852; -.
DR   HOGENOM; CLU_005268_0_0_1; -.
DR   InParanoid; Q9JL70; -.
DR   OMA; AIPHCPA; -.
DR   OrthoDB; 5400084at2759; -.
DR   PhylomeDB; Q9JL70; -.
DR   TreeFam; TF333412; -.
DR   Reactome; R-MMU-6783310; Fanconi Anemia Pathway.
DR   Reactome; R-MMU-9833482; PKR-mediated signaling.
DR   BioGRID-ORCS; 14087; 26 hits in 115 CRISPR screens.
DR   ChiTaRS; Fanca; mouse.
DR   PRO; PR:Q9JL70; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q9JL70; Protein.
DR   Bgee; ENSMUSG00000032815; Expressed in granulocyte and 164 other cell types or tissues.
DR   ExpressionAtlas; Q9JL70; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISO:MGI.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043240; C:Fanconi anaemia nuclear complex; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0008585; P:female gonad development; IMP:MGI.
DR   GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR   GO; GO:0008584; P:male gonad development; IMP:MGI.
DR   GO; GO:0007140; P:male meiotic nuclear division; IMP:MGI.
DR   GO; GO:0006513; P:protein monoubiquitination; ISO:MGI.
DR   GO; GO:2000348; P:regulation of CD40 signaling pathway; IMP:MGI.
DR   GO; GO:1905936; P:regulation of germ cell proliferation; IMP:MGI.
DR   GO; GO:0050727; P:regulation of inflammatory response; IMP:MGI.
DR   GO; GO:0045589; P:regulation of regulatory T cell differentiation; IMP:MGI.
DR   InterPro; IPR003516; FANCA.
DR   InterPro; IPR031729; Fanconi_A_N.
DR   PANTHER; PTHR12047; FANCONI ANEMIA GROUP A PROTEIN; 1.
DR   PANTHER; PTHR12047:SF2; FANCONI ANEMIA GROUP A PROTEIN; 1.
DR   Pfam; PF03511; Fanconi_A; 1.
DR   Pfam; PF15865; Fanconi_A_N; 1.
DR   PRINTS; PR00826; FANCONIAGENE.
DR   Genevisible; Q9JL70; MM.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA damage; DNA repair; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..1439
FT                   /note="Fanconi anemia group A protein homolog"
FT                   /id="PRO_0000087180"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           19..35
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        2
FT                   /note="P -> L (in Ref. 2; AAG01633)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        15
FT                   /note="P -> S (in Ref. 2; AAG01633)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        43
FT                   /note="L -> V (in Ref. 2; AAG01633)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        80
FT                   /note="R -> F (in Ref. 2; AAG01633)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        107..108
FT                   /note="VP -> SS (in Ref. 1; AAF63969)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        110
FT                   /note="G -> GG (in Ref. 1; AAF63969)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        147
FT                   /note="M -> V (in Ref. 1; AAF63963/AAF63964 and 2;
FT                   AAG01633)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        241
FT                   /note="S -> L (in Ref. 1; AAF63965)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        254
FT                   /note="V -> I (in Ref. 1; AAF63965)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        275
FT                   /note="L -> I (in Ref. 2; AAG01633)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        279..288
FT                   /note="EADPQTTLDC -> GGEPKTNLGW (in Ref. 2; AAG01633)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        292..294
FT                   /note="SGW -> GGR (in Ref. 2; AAG01633)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        310
FT                   /note="N -> D (in Ref. 1; AAF63963/AAF63964 and 2;
FT                   AAG01633)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        323
FT                   /note="I -> T (in Ref. 1; AAF63963/AAF63964 and 2;
FT                   AAG01633)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        424
FT                   /note="V -> G (in Ref. 1; AAF63963/AAF63964/AAF63965)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        490
FT                   /note="F -> L (in Ref. 2; AAG01633)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        599
FT                   /note="L -> F (in Ref. 1; AAF63963/AAF63964)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        833
FT                   /note="M -> V (in Ref. 1; AAF63964)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        862..869
FT                   /note="FQFVVLRL -> VRVSHSSF (in Ref. 1; AAF63964)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1049
FT                   /note="R -> Q (in Ref. 2; AAG01633)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1159
FT                   /note="I -> V (in Ref. 4; AAG00417)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1439 AA;  161213 MW;  4E26EA18BBCE6DA4 CRC64;
     MPGSPARGAA MGGGPRGLRK TWTELLAGRV KKQKYDPERE QKLKDSALKL LRYHQNMHDL
     LLEVEEPQCK RLRLSELIDR DSADASSDRS ASFIRSAFRD QASRLGVPVG VLSAKVFARS
     VQQVCVEPSH PVLLSPEQSK KLSSLLMIAR HLLAQNMFSR LTFCQELWKA QNSLLLEAMW
     RLHTHSVVSL QELLQSHPDS EAMAMWLFRN LRSLCEQIGA SCPSPDTTEA MLSGLVQLLI
     SRGFQGSSDP RRLVEPERLP QVATDVLQRM LAFSLDTLEA DPQTTLDCQA VSGWIPIYSG
     HTCCGVVTEN SLKSFFSHTL TQILTHKPVL KVSDAIQMQK EWSFAKTHHL LTDLHCRVLA
     TLGPEESVGR LQEVLEMQEV NWQHVLSCVS TLVVCFPEAQ QLVKGWVASL MARAFESYHL
     DSMVTAFLIV RQATLEGPYV FPSYADWFKE SFGSSHGYHS CSKKTLVFLF KFLSDLVPWE
     APRYMQVHIF HPPLVPSKYH SLLTDYISLA KTRLADLKVS LENVGLYEDL SSPGDIAERE
     SQAVQDVKKA IMVFEQTGKI PMPVLEASIF RRPYYVSHFL PTLLAPRVLP EVPDPRVALI
     ETLKRADKIP SSIYDAYRKA CASAEKQQPE NATSAQRTEA DCAKEPLGLL TAALEELRAL
     MTDPTQYSVI SAQVAVVSEK LNAVLGHRND GGSLQRAKIQ LSVLPSTLQK QDQAVVDLLL
     TAFCQNLMAA SSFVPPERQS PWAVLFVRTL CGHVLLPAVL TRLRQLLRHQ GQSLSTSHVL
     GLAALAVHLG ECRSMLPEVD PDVLAPSAGS LCVPDFLNSL LTCRTRDSLL FCMNFCTAAV
     SYCLCKFSAL RNCLSPGLIK KFQFVVLRLF PEARAPCAPE HAACVPWRPL YLPSADWQRA
     ALSLWRRDSF QELLKDKEFY LTYRDWVQLE LEIQPEADVL SDMERHDFHQ WAIYERYLPA
     PTALGGCGGD LEEACTVLVS EIMDFHQSSR SYNHSEDSDL VLGGRTGNKD ILSRLQEIAL
     DLELDQGSAV PHGCSTPQSH FLFRVFRRRL QALARPDSMA TSLRRQQELL TCKRLLLCLP
     PSVLVGGPQA GQPISPNCGE FFSLVNSELR NFCCHGSVLT SDITIHFFRG LLRVCLRSQD
     PALVANQTLT ECQTKCPVIL TSALLWWSSL EPVLCGRWMR CYQSPLPREL RRLQEAREFA
     SNFASASASP APSPAWIAAA ALHFAWRGVR KEDVTAHLQR LDCQREELLI ALFFFSLMGL
     LSSYLTQRDT AEHLKAVDIC AEVLTCLERR KVSWLVLFQL TEKDAKLGHL LHLAPDQHTR
     LLPLAFYSLL SCFSEGAAVR EAAFLHVAVD MYLKLLQLFV DGETRLQGHS ESQGSPVQLI
     TKARVFLLQL IPQCPKQCFS NMTELLAGRG DCDPEVSNAL RQRQQADPSF DLYQEPQLF
//