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Q9JL70

- FANCA_MOUSE

UniProt

Q9JL70 - FANCA_MOUSE

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Protein
Fanconi anemia group A protein homolog
Gene
Fanca
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability By similarity.

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
  2. female gonad development Source: MGI
  3. male gonad development Source: MGI
  4. male meiosis Source: MGI
  5. regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group A protein homolog
Short name:
Protein FACA
Gene namesi
Name:Fanca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1341823. Fanca.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: The major form is nuclear. The minor form is cytoplasmic.

GO - Cellular componenti

  1. Fanconi anaemia nuclear complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14391439Fanconi anemia group A protein homolog
PRO_0000087180Add
BLAST

Post-translational modificationi

Phosphorylated primarily on serine residues. Phosphorylation is required for the formation of the nuclear complex By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9JL70.

PTM databases

PhosphoSiteiQ9JL70.

Expressioni

Tissue specificityi

Mainly expressed in testis and lymphoid tissues like thymus, lymph nodes, and spleen, and at lower levels in kidney and ovary.1 Publication

Gene expression databases

ArrayExpressiQ9JL70.
BgeeiQ9JL70.
CleanExiMM_FANCA.
GenevestigatoriQ9JL70.

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM By similarity. In complex with FANCF, FANCG and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins By similarity. The complex with FANCC and FANCG may also include EIF2AK2 and HSP70. Interacts with FAAP20; interaction is direct By similarity.

Protein-protein interaction databases

BioGridi199591. 1 interaction.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi19 – 3517Nuclear localization signal Reviewed prediction
Add
BLAST

Phylogenomic databases

eggNOGiNOG70694.
GeneTreeiENSGT00390000007852.
HOVERGENiHBG051547.
InParanoidiQ9JL70.
KOiK10888.
OMAiSYSLCKF.
OrthoDBiEOG7X0VG6.
TreeFamiTF333412.

Family and domain databases

InterProiIPR003516. Fanconia.
[Graphical view]
PfamiPF03511. Fanconi_A. 1 hit.
[Graphical view]
PRINTSiPR00826. FANCONIAGENE.

Sequencei

Sequence statusi: Complete.

Q9JL70-1 [UniParc]FASTAAdd to Basket

« Hide

MPGSPARGAA MGGGPRGLRK TWTELLAGRV KKQKYDPERE QKLKDSALKL     50
LRYHQNMHDL LLEVEEPQCK RLRLSELIDR DSADASSDRS ASFIRSAFRD 100
QASRLGVPVG VLSAKVFARS VQQVCVEPSH PVLLSPEQSK KLSSLLMIAR 150
HLLAQNMFSR LTFCQELWKA QNSLLLEAMW RLHTHSVVSL QELLQSHPDS 200
EAMAMWLFRN LRSLCEQIGA SCPSPDTTEA MLSGLVQLLI SRGFQGSSDP 250
RRLVEPERLP QVATDVLQRM LAFSLDTLEA DPQTTLDCQA VSGWIPIYSG 300
HTCCGVVTEN SLKSFFSHTL TQILTHKPVL KVSDAIQMQK EWSFAKTHHL 350
LTDLHCRVLA TLGPEESVGR LQEVLEMQEV NWQHVLSCVS TLVVCFPEAQ 400
QLVKGWVASL MARAFESYHL DSMVTAFLIV RQATLEGPYV FPSYADWFKE 450
SFGSSHGYHS CSKKTLVFLF KFLSDLVPWE APRYMQVHIF HPPLVPSKYH 500
SLLTDYISLA KTRLADLKVS LENVGLYEDL SSPGDIAERE SQAVQDVKKA 550
IMVFEQTGKI PMPVLEASIF RRPYYVSHFL PTLLAPRVLP EVPDPRVALI 600
ETLKRADKIP SSIYDAYRKA CASAEKQQPE NATSAQRTEA DCAKEPLGLL 650
TAALEELRAL MTDPTQYSVI SAQVAVVSEK LNAVLGHRND GGSLQRAKIQ 700
LSVLPSTLQK QDQAVVDLLL TAFCQNLMAA SSFVPPERQS PWAVLFVRTL 750
CGHVLLPAVL TRLRQLLRHQ GQSLSTSHVL GLAALAVHLG ECRSMLPEVD 800
PDVLAPSAGS LCVPDFLNSL LTCRTRDSLL FCMNFCTAAV SYCLCKFSAL 850
RNCLSPGLIK KFQFVVLRLF PEARAPCAPE HAACVPWRPL YLPSADWQRA 900
ALSLWRRDSF QELLKDKEFY LTYRDWVQLE LEIQPEADVL SDMERHDFHQ 950
WAIYERYLPA PTALGGCGGD LEEACTVLVS EIMDFHQSSR SYNHSEDSDL 1000
VLGGRTGNKD ILSRLQEIAL DLELDQGSAV PHGCSTPQSH FLFRVFRRRL 1050
QALARPDSMA TSLRRQQELL TCKRLLLCLP PSVLVGGPQA GQPISPNCGE 1100
FFSLVNSELR NFCCHGSVLT SDITIHFFRG LLRVCLRSQD PALVANQTLT 1150
ECQTKCPVIL TSALLWWSSL EPVLCGRWMR CYQSPLPREL RRLQEAREFA 1200
SNFASASASP APSPAWIAAA ALHFAWRGVR KEDVTAHLQR LDCQREELLI 1250
ALFFFSLMGL LSSYLTQRDT AEHLKAVDIC AEVLTCLERR KVSWLVLFQL 1300
TEKDAKLGHL LHLAPDQHTR LLPLAFYSLL SCFSEGAAVR EAAFLHVAVD 1350
MYLKLLQLFV DGETRLQGHS ESQGSPVQLI TKARVFLLQL IPQCPKQCFS 1400
NMTELLAGRG DCDPEVSNAL RQRQQADPSF DLYQEPQLF 1439
Length:1,439
Mass (Da):161,213
Last modified:July 27, 2011 - v2
Checksum:i4E26EA18BBCE6DA4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21P → L in AAG01633. 1 Publication
Sequence conflicti15 – 151P → S in AAG01633. 1 Publication
Sequence conflicti43 – 431L → V in AAG01633. 1 Publication
Sequence conflicti80 – 801R → F in AAG01633. 1 Publication
Sequence conflicti107 – 1082VP → SS in AAF63969. 1 Publication
Sequence conflicti110 – 1101G → GG in AAF63969. 1 Publication
Sequence conflicti147 – 1471M → V in AAF63963. 1 Publication
Sequence conflicti147 – 1471M → V in AAF63964. 1 Publication
Sequence conflicti147 – 1471M → V in AAG01633. 1 Publication
Sequence conflicti241 – 2411S → L in AAF63965. 1 Publication
Sequence conflicti254 – 2541V → I in AAF63965. 1 Publication
Sequence conflicti275 – 2751L → I in AAG01633. 1 Publication
Sequence conflicti279 – 28810EADPQTTLDC → GGEPKTNLGW in AAG01633. 1 Publication
Sequence conflicti292 – 2943SGW → GGR in AAG01633. 1 Publication
Sequence conflicti310 – 3101N → D in AAF63963. 1 Publication
Sequence conflicti310 – 3101N → D in AAF63964. 1 Publication
Sequence conflicti310 – 3101N → D in AAG01633. 1 Publication
Sequence conflicti323 – 3231I → T in AAF63963. 1 Publication
Sequence conflicti323 – 3231I → T in AAF63964. 1 Publication
Sequence conflicti323 – 3231I → T in AAG01633. 1 Publication
Sequence conflicti424 – 4241V → G in AAF63963. 1 Publication
Sequence conflicti424 – 4241V → G in AAF63964. 1 Publication
Sequence conflicti424 – 4241V → G in AAF63965. 1 Publication
Sequence conflicti490 – 4901F → L in AAG01633. 1 Publication
Sequence conflicti599 – 5991L → F in AAF63963. 1 Publication
Sequence conflicti599 – 5991L → F in AAF63964. 1 Publication
Sequence conflicti833 – 8331M → V in AAF63964. 1 Publication
Sequence conflicti862 – 8698FQFVVLRL → VRVSHSSF in AAF63964. 1 Publication
Sequence conflicti1049 – 10491R → Q in AAG01633. 1 Publication
Sequence conflicti1159 – 11591I → V in AAG00417. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF208116 mRNA. Translation: AAF63963.1.
AF208117 mRNA. Translation: AAF63964.1.
AF208118 mRNA. Translation: AAF63965.1.
AF208120 mRNA. Translation: AAF63966.1.
AF208121 mRNA. Translation: AAF63967.1.
AF208122 mRNA. Translation: AAF63968.1.
AF208123 mRNA. Translation: AAF63969.1.
AF178934 mRNA. Translation: AAG01633.1.
AF230373 Genomic DNA. Translation: AAG02637.1.
AC155810 Genomic DNA. No translation available.
AF247181 Genomic DNA. Translation: AAG00417.1.
CCDSiCCDS22753.1.
RefSeqiNP_058621.2. NM_016925.3.
UniGeneiMm.444516.
Mm.6536.

Genome annotation databases

EnsembliENSMUST00000035495; ENSMUSP00000045217; ENSMUSG00000032815.
GeneIDi14087.
KEGGimmu:14087.
UCSCiuc009nve.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF208116 mRNA. Translation: AAF63963.1 .
AF208117 mRNA. Translation: AAF63964.1 .
AF208118 mRNA. Translation: AAF63965.1 .
AF208120 mRNA. Translation: AAF63966.1 .
AF208121 mRNA. Translation: AAF63967.1 .
AF208122 mRNA. Translation: AAF63968.1 .
AF208123 mRNA. Translation: AAF63969.1 .
AF178934 mRNA. Translation: AAG01633.1 .
AF230373 Genomic DNA. Translation: AAG02637.1 .
AC155810 Genomic DNA. No translation available.
AF247181 Genomic DNA. Translation: AAG00417.1 .
CCDSi CCDS22753.1.
RefSeqi NP_058621.2. NM_016925.3.
UniGenei Mm.444516.
Mm.6536.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199591. 1 interaction.

PTM databases

PhosphoSitei Q9JL70.

Proteomic databases

PRIDEi Q9JL70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035495 ; ENSMUSP00000045217 ; ENSMUSG00000032815 .
GeneIDi 14087.
KEGGi mmu:14087.
UCSCi uc009nve.2. mouse.

Organism-specific databases

CTDi 2175.
MGIi MGI:1341823. Fanca.

Phylogenomic databases

eggNOGi NOG70694.
GeneTreei ENSGT00390000007852.
HOVERGENi HBG051547.
InParanoidi Q9JL70.
KOi K10888.
OMAi SYSLCKF.
OrthoDBi EOG7X0VG6.
TreeFami TF333412.

Miscellaneous databases

ChiTaRSi FANCA. mouse.
NextBioi 285116.
PROi Q9JL70.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JL70.
Bgeei Q9JL70.
CleanExi MM_FANCA.
Genevestigatori Q9JL70.

Family and domain databases

InterProi IPR003516. Fanconia.
[Graphical view ]
Pfami PF03511. Fanconi_A. 1 hit.
[Graphical view ]
PRINTSi PR00826. FANCONIAGENE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of murine Fanconi anemia group A gene: Fanca protein is expressed in lymphoid tissues, testis, and ovary."
    Van de Vrugt H.J., Cheng N.C., De Vries Y., Rooimans M.A., De Groot J., Scheper R.J., Zhi Y., Hoatlin M.E., Joenje H., Arwert F.
    Mamm. Genome 11:326-331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA."
    Wong J.C., Alon N., Norga K., Kruyt F.A.E., Youssoufian H., Buchwald M.
    Genomics 67:273-283(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/SvEvTacfBr and C57BL/6J.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Partial sequence of the murine Fanca gene."
    Hildebrand G., Digweed M.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1130-1439.

Entry informationi

Entry nameiFANCA_MOUSE
AccessioniPrimary (citable) accession number: Q9JL70
Secondary accession number(s): E9QKQ4
, Q9ESU9, Q9ESV3, Q9ET44, Q9JL64, Q9JL65, Q9JL66, Q9JL67, Q9JL68, Q9JL69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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