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Q9JL70

- FANCA_MOUSE

UniProt

Q9JL70 - FANCA_MOUSE

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Protein

Fanconi anemia group A protein homolog

Gene

Fanca

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).By similarity

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
  2. female gonad development Source: MGI
  3. male gonad development Source: MGI
  4. male meiosis Source: MGI
  5. regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

ReactomeiREACT_232842. Fanconi Anemia pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group A protein homolog
Short name:
Protein FACA
Gene namesi
Name:Fanca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1341823. Fanca.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: The major form is nuclear. The minor form is cytoplasmic.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. Fanconi anaemia nuclear complex Source: UniProtKB
  3. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14391439Fanconi anemia group A protein homologPRO_0000087180Add
BLAST

Post-translational modificationi

Phosphorylated primarily on serine residues. Phosphorylation is required for the formation of the nuclear complex (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JL70.
PRIDEiQ9JL70.

PTM databases

PhosphoSiteiQ9JL70.

Expressioni

Tissue specificityi

Mainly expressed in testis and lymphoid tissues like thymus, lymph nodes, and spleen, and at lower levels in kidney and ovary.1 Publication

Gene expression databases

BgeeiQ9JL70.
CleanExiMM_FANCA.
ExpressionAtlasiQ9JL70. differential.
GenevestigatoriQ9JL70.

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM (By similarity). In complex with FANCF, FANCG and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins (By similarity). The complex with FANCC and FANCG may also include EIF2AK2 and HSP70. Interacts with FAAP20; interaction is direct (By similarity).By similarity

Protein-protein interaction databases

BioGridi199591. 1 interaction.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi19 – 3517Nuclear localization signalSequence AnalysisAdd
BLAST

Phylogenomic databases

eggNOGiNOG70694.
GeneTreeiENSGT00390000007852.
HOVERGENiHBG051547.
InParanoidiQ9JL70.
KOiK10888.
OMAiSYSLCKF.
OrthoDBiEOG7X0VG6.
TreeFamiTF333412.

Family and domain databases

InterProiIPR003516. Fanconia.
[Graphical view]
PfamiPF03511. Fanconi_A. 1 hit.
[Graphical view]
PRINTSiPR00826. FANCONIAGENE.

Sequencei

Sequence statusi: Complete.

Q9JL70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGSPARGAA MGGGPRGLRK TWTELLAGRV KKQKYDPERE QKLKDSALKL
60 70 80 90 100
LRYHQNMHDL LLEVEEPQCK RLRLSELIDR DSADASSDRS ASFIRSAFRD
110 120 130 140 150
QASRLGVPVG VLSAKVFARS VQQVCVEPSH PVLLSPEQSK KLSSLLMIAR
160 170 180 190 200
HLLAQNMFSR LTFCQELWKA QNSLLLEAMW RLHTHSVVSL QELLQSHPDS
210 220 230 240 250
EAMAMWLFRN LRSLCEQIGA SCPSPDTTEA MLSGLVQLLI SRGFQGSSDP
260 270 280 290 300
RRLVEPERLP QVATDVLQRM LAFSLDTLEA DPQTTLDCQA VSGWIPIYSG
310 320 330 340 350
HTCCGVVTEN SLKSFFSHTL TQILTHKPVL KVSDAIQMQK EWSFAKTHHL
360 370 380 390 400
LTDLHCRVLA TLGPEESVGR LQEVLEMQEV NWQHVLSCVS TLVVCFPEAQ
410 420 430 440 450
QLVKGWVASL MARAFESYHL DSMVTAFLIV RQATLEGPYV FPSYADWFKE
460 470 480 490 500
SFGSSHGYHS CSKKTLVFLF KFLSDLVPWE APRYMQVHIF HPPLVPSKYH
510 520 530 540 550
SLLTDYISLA KTRLADLKVS LENVGLYEDL SSPGDIAERE SQAVQDVKKA
560 570 580 590 600
IMVFEQTGKI PMPVLEASIF RRPYYVSHFL PTLLAPRVLP EVPDPRVALI
610 620 630 640 650
ETLKRADKIP SSIYDAYRKA CASAEKQQPE NATSAQRTEA DCAKEPLGLL
660 670 680 690 700
TAALEELRAL MTDPTQYSVI SAQVAVVSEK LNAVLGHRND GGSLQRAKIQ
710 720 730 740 750
LSVLPSTLQK QDQAVVDLLL TAFCQNLMAA SSFVPPERQS PWAVLFVRTL
760 770 780 790 800
CGHVLLPAVL TRLRQLLRHQ GQSLSTSHVL GLAALAVHLG ECRSMLPEVD
810 820 830 840 850
PDVLAPSAGS LCVPDFLNSL LTCRTRDSLL FCMNFCTAAV SYCLCKFSAL
860 870 880 890 900
RNCLSPGLIK KFQFVVLRLF PEARAPCAPE HAACVPWRPL YLPSADWQRA
910 920 930 940 950
ALSLWRRDSF QELLKDKEFY LTYRDWVQLE LEIQPEADVL SDMERHDFHQ
960 970 980 990 1000
WAIYERYLPA PTALGGCGGD LEEACTVLVS EIMDFHQSSR SYNHSEDSDL
1010 1020 1030 1040 1050
VLGGRTGNKD ILSRLQEIAL DLELDQGSAV PHGCSTPQSH FLFRVFRRRL
1060 1070 1080 1090 1100
QALARPDSMA TSLRRQQELL TCKRLLLCLP PSVLVGGPQA GQPISPNCGE
1110 1120 1130 1140 1150
FFSLVNSELR NFCCHGSVLT SDITIHFFRG LLRVCLRSQD PALVANQTLT
1160 1170 1180 1190 1200
ECQTKCPVIL TSALLWWSSL EPVLCGRWMR CYQSPLPREL RRLQEAREFA
1210 1220 1230 1240 1250
SNFASASASP APSPAWIAAA ALHFAWRGVR KEDVTAHLQR LDCQREELLI
1260 1270 1280 1290 1300
ALFFFSLMGL LSSYLTQRDT AEHLKAVDIC AEVLTCLERR KVSWLVLFQL
1310 1320 1330 1340 1350
TEKDAKLGHL LHLAPDQHTR LLPLAFYSLL SCFSEGAAVR EAAFLHVAVD
1360 1370 1380 1390 1400
MYLKLLQLFV DGETRLQGHS ESQGSPVQLI TKARVFLLQL IPQCPKQCFS
1410 1420 1430
NMTELLAGRG DCDPEVSNAL RQRQQADPSF DLYQEPQLF
Length:1,439
Mass (Da):161,213
Last modified:July 27, 2011 - v2
Checksum:i4E26EA18BBCE6DA4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21P → L in AAG01633. (PubMed:10936049)Curated
Sequence conflicti15 – 151P → S in AAG01633. (PubMed:10936049)Curated
Sequence conflicti43 – 431L → V in AAG01633. (PubMed:10936049)Curated
Sequence conflicti80 – 801R → F in AAG01633. (PubMed:10936049)Curated
Sequence conflicti107 – 1082VP → SS in AAF63969. (PubMed:10754110)Curated
Sequence conflicti110 – 1101G → GG in AAF63969. (PubMed:10754110)Curated
Sequence conflicti147 – 1471M → V in AAF63963. (PubMed:10754110)Curated
Sequence conflicti147 – 1471M → V in AAF63964. (PubMed:10754110)Curated
Sequence conflicti147 – 1471M → V in AAG01633. (PubMed:10936049)Curated
Sequence conflicti241 – 2411S → L in AAF63965. (PubMed:10754110)Curated
Sequence conflicti254 – 2541V → I in AAF63965. (PubMed:10754110)Curated
Sequence conflicti275 – 2751L → I in AAG01633. (PubMed:10936049)Curated
Sequence conflicti279 – 28810EADPQTTLDC → GGEPKTNLGW in AAG01633. (PubMed:10936049)Curated
Sequence conflicti292 – 2943SGW → GGR in AAG01633. (PubMed:10936049)Curated
Sequence conflicti310 – 3101N → D in AAF63963. (PubMed:10754110)Curated
Sequence conflicti310 – 3101N → D in AAF63964. (PubMed:10754110)Curated
Sequence conflicti310 – 3101N → D in AAG01633. (PubMed:10936049)Curated
Sequence conflicti323 – 3231I → T in AAF63963. (PubMed:10754110)Curated
Sequence conflicti323 – 3231I → T in AAF63964. (PubMed:10754110)Curated
Sequence conflicti323 – 3231I → T in AAG01633. (PubMed:10936049)Curated
Sequence conflicti424 – 4241V → G in AAF63963. (PubMed:10754110)Curated
Sequence conflicti424 – 4241V → G in AAF63964. (PubMed:10754110)Curated
Sequence conflicti424 – 4241V → G in AAF63965. (PubMed:10754110)Curated
Sequence conflicti490 – 4901F → L in AAG01633. (PubMed:10936049)Curated
Sequence conflicti599 – 5991L → F in AAF63963. (PubMed:10754110)Curated
Sequence conflicti599 – 5991L → F in AAF63964. (PubMed:10754110)Curated
Sequence conflicti833 – 8331M → V in AAF63964. (PubMed:10754110)Curated
Sequence conflicti862 – 8698FQFVVLRL → VRVSHSSF in AAF63964. (PubMed:10754110)Curated
Sequence conflicti1049 – 10491R → Q in AAG01633. (PubMed:10936049)Curated
Sequence conflicti1159 – 11591I → V in AAG00417. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208116 mRNA. Translation: AAF63963.1.
AF208117 mRNA. Translation: AAF63964.1.
AF208118 mRNA. Translation: AAF63965.1.
AF208120 mRNA. Translation: AAF63966.1.
AF208121 mRNA. Translation: AAF63967.1.
AF208122 mRNA. Translation: AAF63968.1.
AF208123 mRNA. Translation: AAF63969.1.
AF178934 mRNA. Translation: AAG01633.1.
AF230373 Genomic DNA. Translation: AAG02637.1.
AC155810 Genomic DNA. No translation available.
AF247181 Genomic DNA. Translation: AAG00417.1.
CCDSiCCDS22753.1.
RefSeqiNP_058621.2. NM_016925.3.
UniGeneiMm.444516.
Mm.6536.

Genome annotation databases

EnsembliENSMUST00000035495; ENSMUSP00000045217; ENSMUSG00000032815.
GeneIDi14087.
KEGGimmu:14087.
UCSCiuc009nve.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208116 mRNA. Translation: AAF63963.1 .
AF208117 mRNA. Translation: AAF63964.1 .
AF208118 mRNA. Translation: AAF63965.1 .
AF208120 mRNA. Translation: AAF63966.1 .
AF208121 mRNA. Translation: AAF63967.1 .
AF208122 mRNA. Translation: AAF63968.1 .
AF208123 mRNA. Translation: AAF63969.1 .
AF178934 mRNA. Translation: AAG01633.1 .
AF230373 Genomic DNA. Translation: AAG02637.1 .
AC155810 Genomic DNA. No translation available.
AF247181 Genomic DNA. Translation: AAG00417.1 .
CCDSi CCDS22753.1.
RefSeqi NP_058621.2. NM_016925.3.
UniGenei Mm.444516.
Mm.6536.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199591. 1 interaction.

PTM databases

PhosphoSitei Q9JL70.

Proteomic databases

MaxQBi Q9JL70.
PRIDEi Q9JL70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035495 ; ENSMUSP00000045217 ; ENSMUSG00000032815 .
GeneIDi 14087.
KEGGi mmu:14087.
UCSCi uc009nve.2. mouse.

Organism-specific databases

CTDi 2175.
MGIi MGI:1341823. Fanca.

Phylogenomic databases

eggNOGi NOG70694.
GeneTreei ENSGT00390000007852.
HOVERGENi HBG051547.
InParanoidi Q9JL70.
KOi K10888.
OMAi SYSLCKF.
OrthoDBi EOG7X0VG6.
TreeFami TF333412.

Enzyme and pathway databases

Reactomei REACT_232842. Fanconi Anemia pathway.

Miscellaneous databases

ChiTaRSi Fanca. mouse.
NextBioi 285116.
PROi Q9JL70.
SOURCEi Search...

Gene expression databases

Bgeei Q9JL70.
CleanExi MM_FANCA.
ExpressionAtlasi Q9JL70. differential.
Genevestigatori Q9JL70.

Family and domain databases

InterProi IPR003516. Fanconia.
[Graphical view ]
Pfami PF03511. Fanconi_A. 1 hit.
[Graphical view ]
PRINTSi PR00826. FANCONIAGENE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of murine Fanconi anemia group A gene: Fanca protein is expressed in lymphoid tissues, testis, and ovary."
    Van de Vrugt H.J., Cheng N.C., De Vries Y., Rooimans M.A., De Groot J., Scheper R.J., Zhi Y., Hoatlin M.E., Joenje H., Arwert F.
    Mamm. Genome 11:326-331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA."
    Wong J.C., Alon N., Norga K., Kruyt F.A.E., Youssoufian H., Buchwald M.
    Genomics 67:273-283(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/SvEvTacfBr and C57BL/6J.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Partial sequence of the murine Fanca gene."
    Hildebrand G., Digweed M.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1130-1439.

Entry informationi

Entry nameiFANCA_MOUSE
AccessioniPrimary (citable) accession number: Q9JL70
Secondary accession number(s): E9QKQ4
, Q9ESU9, Q9ESV3, Q9ET44, Q9JL64, Q9JL65, Q9JL66, Q9JL67, Q9JL68, Q9JL69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3