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Protein

Glucocorticoid modulatory element-binding protein 1

Gene

Gmeb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi103ZincBy similarity1
Binding sitei129DNABy similarity1
Binding sitei133DNABy similarity1
Binding sitei136DNABy similarity1
Binding sitei147DNABy similarity1
Metal bindingi160ZincBy similarity1
Metal bindingi164ZincBy similarity1
Metal bindingi168ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glucocorticoid modulatory element-binding protein 1
Short name:
GMEB-1
Gene namesi
Name:Gmeb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2135604 Gmeb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000740902 – 562Glucocorticoid modulatory element-binding protein 1Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9JL60
MaxQBiQ9JL60
PaxDbiQ9JL60
PeptideAtlasiQ9JL60
PRIDEiQ9JL60

PTM databases

PhosphoSitePlusiQ9JL60

Expressioni

Tissue specificityi

Ubiquitous. Low levels were detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Gene expression databases

BgeeiENSMUSG00000028901
GenevisibleiQ9JL60 MM

Interactioni

Subunit structurei

Homodimer, and heterodimer of GMEB1 and GMEB2. Interacts with TRIM63 (By similarity). Interacts with the glucocorticoid receptor (NR3C1) and NCOA2/TIF2. May interact with HSP27 and CREB-binding protein (CBP).By similarity

Protein-protein interaction databases

BioGridi208184, 6 interactors
STRINGi10090.ENSMUSP00000030733

Structurei

3D structure databases

ProteinModelPortaliQ9JL60
SMRiQ9JL60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 156SANDPROSITE-ProRule annotationAdd BLAST85

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili311 – 355Sequence analysisAdd BLAST45

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4333 Eukaryota
ENOG410ZMTP LUCA
GeneTreeiENSGT00410000025596
HOVERGENiHBG051742
InParanoidiQ9JL60
OMAiCPITCGD
OrthoDBiEOG091G07Q9
PhylomeDBiQ9JL60
TreeFamiTF317090

Family and domain databases

Gene3Di3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR024830 GMEB1/2
IPR010919 SAND-like_dom_sf
IPR000770 SAND_dom
PANTHERiPTHR10417 PTHR10417, 1 hit
PfamiView protein in Pfam
PF01342 SAND, 1 hit
SMARTiView protein in SMART
SM00258 SAND, 1 hit
SUPFAMiSSF63763 SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS50864 SAND, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JL60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANAEVSVPV GDVVVVPTEG NEGENPEDTK TQVILQLQPV QQGIYEAGSE
60 70 80 90 100
NSAAVVAVET HSIHKIEEGI DASSIEGNED MEIAYPITCG ESKAVLLWKK
110 120 130 140 150
FVCPGINVKC VKFNDQLISP KHFVHLAGKS TLKDWKRAIR LGGIMLRKMM
160 170 180 190 200
DSGQIDFYQH DKVCSNTCRS TKFDLLISSA RAPVPGQQTS VVQTPTSADG
210 220 230 240 250
NITQIAISEE SMEEAGLEWN SALTAAVTMA TEEGIKKESE EISEDTLMFW
260 270 280 290 300
KGIADVGLME EVVCNIQKEM EELLRGVQQR LIQAPFQVTD AAVLNNVANT
310 320 330 340 350
FGLMDAVKRV LDNRRKQVEQ GEEQFLYTLA DLERQLEEQK KQAQDPRLKS
360 370 380 390 400
QTVQNVVLMP VSTPKPPKRP RLQRPASTTV LSPSPVQQPQ FTVISPITIT
410 420 430 440 450
PVGQSFSMGN IPVATLSQGS SPVTVHTLPS GPQLFRYATV VSSAKSNSPD
460 470 480 490 500
TVTIHPSSSL ALLSSTSMQD GSSLGNMATM VSPMELVAME SGLTSAIQAV
510 520 530 540 550
ESTSEDGQTI IEIDPAPDSE ADDTEGKAVI LETGLRTEEK VVAEMEEHQH
560
QVHNVEIVVL ED
Length:562
Mass (Da):61,058
Last modified:July 27, 2011 - v2
Checksum:i733C8A0D50DD477E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263V → I in AAF72874 (PubMed:10692587).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210433 mRNA Translation: AAF72874.1
BX537301 Genomic DNA Translation: CAM14478.1
CH466552 Genomic DNA Translation: EDL30116.1
BC046983 mRNA Translation: AAH46983.1
CCDSiCCDS18720.1
RefSeqiNP_001116464.1, NM_001122992.1
NP_064669.2, NM_020273.2
XP_006539141.1, XM_006539078.3
XP_006539142.1, XM_006539079.3
XP_006539143.1, XM_006539080.3
XP_017175821.1, XM_017320332.1
UniGeneiMm.103489

Genome annotation databases

EnsembliENSMUST00000030733; ENSMUSP00000030733; ENSMUSG00000028901
ENSMUST00000105964; ENSMUSP00000101584; ENSMUSG00000028901
ENSMUST00000105965; ENSMUSP00000101585; ENSMUSG00000028901
ENSMUST00000168553; ENSMUSP00000131331; ENSMUSG00000028901
GeneIDi56809
KEGGimmu:56809
UCSCiuc008vat.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGMEB1_MOUSE
AccessioniPrimary (citable) accession number: Q9JL60
Secondary accession number(s): Q80Y88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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