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Protein

Glucocorticoid modulatory element-binding protein 1

Gene

Gmeb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi103 – 1031ZincBy similarity
Binding sitei129 – 1291DNABy similarity
Binding sitei133 – 1331DNABy similarity
Binding sitei136 – 1361DNABy similarity
Binding sitei147 – 1471DNABy similarity
Metal bindingi160 – 1601ZincBy similarity
Metal bindingi164 – 1641ZincBy similarity
Metal bindingi168 – 1681ZincBy similarity

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glucocorticoid modulatory element-binding protein 1
Short name:
GMEB-1
Gene namesi
Name:Gmeb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2135604. Gmeb1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleoplasm Source: Ensembl
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 562561Glucocorticoid modulatory element-binding protein 1PRO_0000074090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9JL60.
MaxQBiQ9JL60.
PaxDbiQ9JL60.
PRIDEiQ9JL60.

PTM databases

PhosphoSiteiQ9JL60.

Expressioni

Tissue specificityi

Ubiquitous. Low levels were detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Gene expression databases

BgeeiQ9JL60.
GenevisibleiQ9JL60. MM.

Interactioni

Subunit structurei

Homodimer, and heterodimer of GMEB1 and GMEB2. Interacts with TRIM63 (By similarity). Interacts with the glucocorticoid receptor (NR3C1) and NCOA2/TIF2. May interact with HSP27 and CREB-binding protein (CBP).By similarity

Protein-protein interaction databases

BioGridi208184. 5 interactions.
MINTiMINT-122885.
STRINGi10090.ENSMUSP00000030733.

Structurei

3D structure databases

ProteinModelPortaliQ9JL60.
SMRiQ9JL60. Positions 80-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 15685SANDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili311 – 35545Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 SAND domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4333. Eukaryota.
ENOG410ZMTP. LUCA.
GeneTreeiENSGT00410000025596.
HOVERGENiHBG051742.
InParanoidiQ9JL60.
OMAiAAMQDGG.
OrthoDBiEOG7QZG9C.
PhylomeDBiQ9JL60.
TreeFamiTF317090.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
InterProiIPR024830. GMEB1/2.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
[Graphical view]
PANTHERiPTHR10417. PTHR10417. 1 hit.
PfamiPF01342. SAND. 1 hit.
[Graphical view]
SMARTiSM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF63763. SSF63763. 1 hit.
PROSITEiPS50864. SAND. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JL60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANAEVSVPV GDVVVVPTEG NEGENPEDTK TQVILQLQPV QQGIYEAGSE
60 70 80 90 100
NSAAVVAVET HSIHKIEEGI DASSIEGNED MEIAYPITCG ESKAVLLWKK
110 120 130 140 150
FVCPGINVKC VKFNDQLISP KHFVHLAGKS TLKDWKRAIR LGGIMLRKMM
160 170 180 190 200
DSGQIDFYQH DKVCSNTCRS TKFDLLISSA RAPVPGQQTS VVQTPTSADG
210 220 230 240 250
NITQIAISEE SMEEAGLEWN SALTAAVTMA TEEGIKKESE EISEDTLMFW
260 270 280 290 300
KGIADVGLME EVVCNIQKEM EELLRGVQQR LIQAPFQVTD AAVLNNVANT
310 320 330 340 350
FGLMDAVKRV LDNRRKQVEQ GEEQFLYTLA DLERQLEEQK KQAQDPRLKS
360 370 380 390 400
QTVQNVVLMP VSTPKPPKRP RLQRPASTTV LSPSPVQQPQ FTVISPITIT
410 420 430 440 450
PVGQSFSMGN IPVATLSQGS SPVTVHTLPS GPQLFRYATV VSSAKSNSPD
460 470 480 490 500
TVTIHPSSSL ALLSSTSMQD GSSLGNMATM VSPMELVAME SGLTSAIQAV
510 520 530 540 550
ESTSEDGQTI IEIDPAPDSE ADDTEGKAVI LETGLRTEEK VVAEMEEHQH
560
QVHNVEIVVL ED
Length:562
Mass (Da):61,058
Last modified:July 27, 2011 - v2
Checksum:i733C8A0D50DD477E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti263 – 2631V → I in AAF72874 (PubMed:10692587).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210433 mRNA. Translation: AAF72874.1.
BX537301 Genomic DNA. Translation: CAM14478.1.
CH466552 Genomic DNA. Translation: EDL30116.1.
BC046983 mRNA. Translation: AAH46983.1.
CCDSiCCDS18720.1.
RefSeqiNP_001116464.1. NM_001122992.1.
NP_064669.2. NM_020273.2.
XP_006539141.1. XM_006539078.2.
XP_006539142.1. XM_006539079.2.
XP_006539143.1. XM_006539080.2.
XP_011248610.1. XM_011250308.1.
XP_011248611.1. XM_011250309.1.
UniGeneiMm.103489.

Genome annotation databases

EnsembliENSMUST00000030733; ENSMUSP00000030733; ENSMUSG00000028901.
ENSMUST00000105964; ENSMUSP00000101584; ENSMUSG00000028901.
ENSMUST00000105965; ENSMUSP00000101585; ENSMUSG00000028901.
ENSMUST00000168553; ENSMUSP00000131331; ENSMUSG00000028901.
GeneIDi56809.
KEGGimmu:56809.
UCSCiuc008vat.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210433 mRNA. Translation: AAF72874.1.
BX537301 Genomic DNA. Translation: CAM14478.1.
CH466552 Genomic DNA. Translation: EDL30116.1.
BC046983 mRNA. Translation: AAH46983.1.
CCDSiCCDS18720.1.
RefSeqiNP_001116464.1. NM_001122992.1.
NP_064669.2. NM_020273.2.
XP_006539141.1. XM_006539078.2.
XP_006539142.1. XM_006539079.2.
XP_006539143.1. XM_006539080.2.
XP_011248610.1. XM_011250308.1.
XP_011248611.1. XM_011250309.1.
UniGeneiMm.103489.

3D structure databases

ProteinModelPortaliQ9JL60.
SMRiQ9JL60. Positions 80-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208184. 5 interactions.
MINTiMINT-122885.
STRINGi10090.ENSMUSP00000030733.

PTM databases

PhosphoSiteiQ9JL60.

Proteomic databases

EPDiQ9JL60.
MaxQBiQ9JL60.
PaxDbiQ9JL60.
PRIDEiQ9JL60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030733; ENSMUSP00000030733; ENSMUSG00000028901.
ENSMUST00000105964; ENSMUSP00000101584; ENSMUSG00000028901.
ENSMUST00000105965; ENSMUSP00000101585; ENSMUSG00000028901.
ENSMUST00000168553; ENSMUSP00000131331; ENSMUSG00000028901.
GeneIDi56809.
KEGGimmu:56809.
UCSCiuc008vat.2. mouse.

Organism-specific databases

CTDi10691.
MGIiMGI:2135604. Gmeb1.

Phylogenomic databases

eggNOGiKOG4333. Eukaryota.
ENOG410ZMTP. LUCA.
GeneTreeiENSGT00410000025596.
HOVERGENiHBG051742.
InParanoidiQ9JL60.
OMAiAAMQDGG.
OrthoDBiEOG7QZG9C.
PhylomeDBiQ9JL60.
TreeFamiTF317090.

Miscellaneous databases

NextBioi313365.
PROiQ9JL60.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JL60.
GenevisibleiQ9JL60. MM.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
InterProiIPR024830. GMEB1/2.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
[Graphical view]
PANTHERiPTHR10417. PTHR10417. 1 hit.
PfamiPF01342. SAND. 1 hit.
[Graphical view]
SMARTiSM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF63763. SSF63763. 1 hit.
PROSITEiPS50864. SAND. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family."
    Jimenez-Lara A.M., Heine M.J.S., Gronemeyer H.
    FEBS Lett. 468:203-210(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiGMEB1_MOUSE
AccessioniPrimary (citable) accession number: Q9JL60
Secondary accession number(s): Q80Y88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 27, 2011
Last modified: March 16, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.