ID   Q9JL41_MOUSE            Unreviewed;       185 AA.
AC   Q9JL41;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 87.
DE   SubName: Full=ATP-binding cassette protein {ECO:0000313|EMBL:AAF31429.1};
DE   Flags: Fragment;
GN   Name=Abcc1 {ECO:0000313|MGI:MGI:102676};
GN   Synonyms=Abcc1b {ECO:0000313|EMBL:AAF31429.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAF31429.1};
RN   [1] {ECO:0000313|EMBL:AAF31429.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6xDBA {ECO:0000313|EMBL:AAF31429.1};
RX   PubMed=10708515; DOI=10.1006/geno.1999.6102;
RA   Schriml L.M., Dean M.;
RT   "Identification of 18 mouse ABC genes and characterization of the ABC
RT   superfamily in Mus musculus.";
RL   Genomics 64:24-31(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + vincristine(in) = ADP + H(+) + phosphate +
CC         vincristine(out); Xref=Rhea:RHEA:60160, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:143658, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00036384};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60161;
CC         Evidence={ECO:0000256|ARBA:ARBA00036384};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+)
CC         + phosphate; Xref=Rhea:RHEA:33147, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:64677, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00036199};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33148;
CC         Evidence={ECO:0000256|ARBA:ARBA00036199};
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DR   EMBL; AF213389; AAF31429.1; -; mRNA.
DR   AlphaFoldDB; Q9JL41; -.
DR   PeptideAtlas; Q9JL41; -.
DR   AGR; MGI:102676; -.
DR   MGI; MGI:102676; Abcc1.
DR   ChiTaRS; Abcc1; mouse.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR   PANTHER; PTHR24223:SF241; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000313|EMBL:AAF31429.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          1..133
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|Pfam:PF00005"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAF31429.1"
SQ   SEQUENCE   185 AA;  20245 MW;  D3D182BB9E2F6329 CRC64;
     IVGRTGAGKS SLTLGLFRIN ESAEGEIIID GVNIAKIGLH NLRFKITIIP QDPVLFSGSL
     RMNLDPFSQY SDEEVWMALE LAHLKGFVSA LPDKLNHECA EGGENLSVGQ RHCVCLARAL
     LRKTKILVLD EATEAVDLET VTLSVHHPTQ FEDSTVLTIA QRLTHNGLTR GMSGQRRSSG
     VWCTL
//