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Protein

High mobility group nucleosome-binding domain-containing protein 5

Gene

Hmgn5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.2 Publications

GO - Molecular functioni

  • chromatin binding Source: MGI
  • nucleosomal DNA binding Source: InterPro

GO - Biological processi

  • chromatin organization Source: MGI
  • glutathione metabolic process Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 5
Alternative name(s):
Nucleosome-binding protein 1
Nucleosome-binding protein 45
Short name:
NBP-45
Protein GARP45
Gene namesi
Name:Hmgn5
Synonyms:Garp45, Nsbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1355295 Hmgn5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi18S → E: May abolish association with nucleosomes; when associated with E-22. 1 Publication1
Mutagenesisi22S → E: May abolish association with nucleosomes; when associated with E-18. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067181 – 406High mobility group nucleosome-binding domain-containing protein 5Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphothreonineBy similarity1
Cross-linki64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9JL35
MaxQBiQ9JL35
PaxDbiQ9JL35
PeptideAtlasiQ9JL35
PRIDEiQ9JL35

PTM databases

iPTMnetiQ9JL35
PhosphoSitePlusiQ9JL35

Expressioni

Tissue specificityi

Expressed in liver, spleen, lung, heart, kidney, muscle and brain (at protein level). Widely expressed with highest levels in submaxillary gland, thymus, kidney and liver and lowest levels in brain, lung, pancreas and eye.2 Publications

Developmental stagei

At E7.5, expression is detected in the ectoplacental cone but not in embryonic tissues. By E9.5 and E12.5, strongly expressed in the giant trophoblast, spongiotrophoblast and decidual cells of the placenta (at protein level). At E9.5 and E11.5, weakly expressed in the developing embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000031245
CleanExiMM_NSBP1
GenevisibleiQ9JL35 MM

Interactioni

Protein-protein interaction databases

IntActiQ9JL35, 1 interactor
MINTiQ9JL35
STRINGi10090.ENSMUSP00000033597

Family & Domainsi

Domaini

Specifically targeted by its C-terminus to nucleosomes in euchromatin.1 Publication

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410JCH1 Eukaryota
ENOG410XQBG LUCA
GeneTreeiENSGT00730000111570
HOGENOMiHOG000070450
HOVERGENiHBG052673
InParanoidiQ9JL35
KOiK17045
OMAiDKSHEAN
OrthoDBiEOG091G12C3
PhylomeDBiQ9JL35
TreeFamiTF105374

Family and domain databases

InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JL35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKAAGDV SQEPKRRSAR LSAMPVPFTP ELKPKRASTS RKTKTTNVVE
60 70 80 90 100
ENKDASTIPI PETKPEDVKD ECNMENAENG EAKIMEAPIP KMEAEEVKEQ
110 120 130 140 150
INEDTEEDGG EKKEAVAAEA KDDELKANIQ DVEKDEDGKE HKDTGEEVED
160 170 180 190 200
GKIEEEGLNE KPGTAKSEDA EVSKDEEEKG DNEKGEDGKE EGDEKEEEKD
210 220 230 240 250
DKEGDTGTEK EVKEQNKEAE EDDGKCKEEE NKEVGKEGQP EEDGKEDLHE
260 270 280 290 300
EVGKEDLHEE DGKEGQPEED GKEIHHEEDG KEGQPEEDGK EYLHEEDGEE
310 320 330 340 350
GQPKEDQKEG QPEEDGKEDQ PEEDGKEGQC KEDGKEGHHE EGGKEDLHEE
360 370 380 390 400
DGKEKDGGKE DRKEEGEQEV AVDEGSDENK VEAEEEGAEN KDFKQDGEKE

EPLSIV
Length:406
Mass (Da):45,344
Last modified:September 19, 2002 - v2
Checksum:i59A4305613EC9679
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74M → V in AAF30179 (PubMed:10692437).Curated1
Sequence conflicti390N → H in BAA33783 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213454 mRNA Translation: AAF30179.1
AB018374 mRNA Translation: BAA33783.2
AK013748 mRNA Translation: BAB28982.2
AK131996 mRNA Translation: BAE20926.1
AL954348 Genomic DNA No translation available.
BC021626 mRNA Translation: AAH21626.1
BC083087 mRNA Translation: AAH83087.1
CCDSiCCDS41101.1
RefSeqiNP_057919.2, NM_016710.2
UniGeneiMm.298443

Genome annotation databases

EnsembliENSMUST00000033597; ENSMUSP00000033597; ENSMUSG00000031245
GeneIDi50887
KEGGimmu:50887
UCSCiuc009ucs.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHMGN5_MOUSE
AccessioniPrimary (citable) accession number: Q9JL35
Secondary accession number(s): O88832
, Q3V272, Q8VC71, Q9CUW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: April 25, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health