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Q9JL27

- FUT2_MOUSE

UniProt

Q9JL27 - FUT2_MOUSE

Protein

Galactoside 2-alpha-L-fucosyltransferase 2

Gene

Fut2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway.

    Catalytic activityi

    GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

    Pathwayi

    GO - Molecular functioni

    1. fucosyltransferase activity Source: MGI
    2. galactoside 2-alpha-L-fucosyltransferase activity Source: MGI

    GO - Biological processi

    1. fucosylation Source: GOC
    2. protein glycosylation Source: MGI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.69. 3474.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT11. Glycosyltransferase Family 11.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 2 (EC:2.4.1.69)
    Alternative name(s):
    Alpha(1,2)FT 2
    Fucosyltransferase 2
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
    Secretory blood group protein 2
    Gene namesi
    Name:Fut2
    Synonyms:Sec2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:109374. Fut2.

    Subcellular locationi

    Golgi apparatusGolgi stack membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Membrane-bound form in trans cisternae of Golgi.By similarity

    GO - Cellular componenti

    1. Golgi cisterna membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Galactoside 2-alpha-L-fucosyltransferase 2PRO_0000149109Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9JL27.
    PRIDEiQ9JL27.

    PTM databases

    PhosphoSiteiQ9JL27.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JL27.
    BgeeiQ9JL27.
    CleanExiMM_FUT2.
    GenevestigatoriQ9JL27.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000063719.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JL27.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55CytoplasmicSequence Analysis
    Topological domaini27 – 347321LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 11 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG17447.
    GeneTreeiENSGT00390000001450.
    HOGENOMiHOG000261621.
    HOVERGENiHBG004338.
    InParanoidiQ9JL27.
    KOiK00718.
    OMAiFSFPMAH.
    OrthoDBiEOG7C5M8F.
    PhylomeDBiQ9JL27.
    TreeFamiTF315810.

    Family and domain databases

    InterProiIPR002516. Glyco_trans_11.
    [Graphical view]
    PANTHERiPTHR11927. PTHR11927. 1 hit.
    PfamiPF01531. Glyco_transf_11. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JL27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASAQVPFSF PLAHFLIFVF VTSTIIHLQQ RIVKLQTLSE KELQAVQMSS    50
    PNAARTDMQQ SAKLQGIFTI NSIGRLGNQM GEYATLFALA RMNGRLAFIP 100
    ESMHNALAPI FRISLPVLHS DTARRIPWQN YHLNDWMEER YRHIPGQYVR 150
    FTGYPCSWTF YHHLRPEILK EFTLHDHVRE EAQAFLRGLR VNGSQPSTFV 200
    GVHVRRGDYV HVMPKVWKGV VADRGYLEKA LDRFRARYSS PVFVVTSNGM 250
    AWCRENINTS LGDVVFAGNG IEGSPAKDFA LLTQCNHTIM TIGTFGIWAA 300
    YLAGGDTIYL ANYTLPDSPF LKIFKPAAAF LPEWMGIPAD LSPLLKH 347
    Length:347
    Mass (Da):39,243
    Last modified:October 1, 2000 - v1
    Checksum:iDD5F441046CC8E79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF214656 Genomic DNA. Translation: AAF45146.1.
    AK033520 mRNA. Translation: BAC28338.1.
    CCDSiCCDS21258.1.
    RefSeqiNP_001258922.1. NM_001271993.1.
    NP_061364.2. NM_018876.4.
    XP_006540680.1. XM_006540617.1.
    UniGeneiMm.290046.
    Mm.491300.

    Genome annotation databases

    EnsembliENSMUST00000069800; ENSMUSP00000063719; ENSMUSG00000055978.
    GeneIDi14344.
    KEGGimmu:14344.
    UCSCiuc009gwn.1. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - GTase

    Fucosyltransferase 2

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF214656 Genomic DNA. Translation: AAF45146.1 .
    AK033520 mRNA. Translation: BAC28338.1 .
    CCDSi CCDS21258.1.
    RefSeqi NP_001258922.1. NM_001271993.1.
    NP_061364.2. NM_018876.4.
    XP_006540680.1. XM_006540617.1.
    UniGenei Mm.290046.
    Mm.491300.

    3D structure databases

    ProteinModelPortali Q9JL27.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000063719.

    Protein family/group databases

    CAZyi GT11. Glycosyltransferase Family 11.

    PTM databases

    PhosphoSitei Q9JL27.

    Proteomic databases

    MaxQBi Q9JL27.
    PRIDEi Q9JL27.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069800 ; ENSMUSP00000063719 ; ENSMUSG00000055978 .
    GeneIDi 14344.
    KEGGi mmu:14344.
    UCSCi uc009gwn.1. mouse.

    Organism-specific databases

    CTDi 2524.
    MGIi MGI:109374. Fut2.

    Phylogenomic databases

    eggNOGi NOG17447.
    GeneTreei ENSGT00390000001450.
    HOGENOMi HOG000261621.
    HOVERGENi HBG004338.
    InParanoidi Q9JL27.
    KOi K00718.
    OMAi FSFPMAH.
    OrthoDBi EOG7C5M8F.
    PhylomeDBi Q9JL27.
    TreeFami TF315810.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BRENDAi 2.4.1.69. 3474.

    Miscellaneous databases

    NextBioi 285785.
    PROi Q9JL27.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JL27.
    Bgeei Q9JL27.
    CleanExi MM_FUT2.
    Genevestigatori Q9JL27.

    Family and domain databases

    InterProi IPR002516. Glyco_trans_11.
    [Graphical view ]
    PANTHERi PTHR11927. PTHR11927. 1 hit.
    Pfami PF01531. Glyco_transf_11. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract."
      Domino S.E., Zhang L., Lowe J.B.
      J. Biol. Chem. 276:23748-23756(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Ola.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Colon.

    Entry informationi

    Entry nameiFUT2_MOUSE
    AccessioniPrimary (citable) accession number: Q9JL27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In mouse, there are three genes (Fut1, Fut2 and Sec1) which encode galactoside 2-L-fucosyltransferase.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3