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Q9JL27

- FUT2_MOUSE

UniProt

Q9JL27 - FUT2_MOUSE

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Protein
Galactoside 2-alpha-L-fucosyltransferase 2
Gene
Fut2, Sec2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway.

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Pathwayi

GO - Molecular functioni

  1. fucosyltransferase activity Source: MGI
  2. galactoside 2-alpha-L-fucosyltransferase activity Source: MGI

GO - Biological processi

  1. fucosylation Source: GOC
  2. protein glycosylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.69. 3474.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT11. Glycosyltransferase Family 11.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside 2-alpha-L-fucosyltransferase 2 (EC:2.4.1.69)
Alternative name(s):
Alpha(1,2)FT 2
Fucosyltransferase 2
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
Secretory blood group protein 2
Gene namesi
Name:Fut2
Synonyms:Sec2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:109374. Fut2.

Subcellular locationi

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein By similarity
Note: Membrane-bound form in trans cisternae of Golgi By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55Cytoplasmic Reviewed prediction
Transmembranei6 – 2621Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini27 – 347321Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi cisterna membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Galactoside 2-alpha-L-fucosyltransferase 2
PRO_0000149109Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi258 – 2581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi286 – 2861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi312 – 3121N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JL27.
PRIDEiQ9JL27.

PTM databases

PhosphoSiteiQ9JL27.

Expressioni

Gene expression databases

ArrayExpressiQ9JL27.
BgeeiQ9JL27.
CleanExiMM_FUT2.
GenevestigatoriQ9JL27.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063719.

Structurei

3D structure databases

ProteinModelPortaliQ9JL27.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG17447.
GeneTreeiENSGT00390000001450.
HOGENOMiHOG000261621.
HOVERGENiHBG004338.
InParanoidiQ9JL27.
KOiK00718.
OMAiFSFPMAH.
OrthoDBiEOG7C5M8F.
PhylomeDBiQ9JL27.
TreeFamiTF315810.

Family and domain databases

InterProiIPR002516. Glyco_trans_11.
[Graphical view]
PANTHERiPTHR11927. PTHR11927. 1 hit.
PfamiPF01531. Glyco_transf_11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JL27-1 [UniParc]FASTAAdd to Basket

« Hide

MASAQVPFSF PLAHFLIFVF VTSTIIHLQQ RIVKLQTLSE KELQAVQMSS    50
PNAARTDMQQ SAKLQGIFTI NSIGRLGNQM GEYATLFALA RMNGRLAFIP 100
ESMHNALAPI FRISLPVLHS DTARRIPWQN YHLNDWMEER YRHIPGQYVR 150
FTGYPCSWTF YHHLRPEILK EFTLHDHVRE EAQAFLRGLR VNGSQPSTFV 200
GVHVRRGDYV HVMPKVWKGV VADRGYLEKA LDRFRARYSS PVFVVTSNGM 250
AWCRENINTS LGDVVFAGNG IEGSPAKDFA LLTQCNHTIM TIGTFGIWAA 300
YLAGGDTIYL ANYTLPDSPF LKIFKPAAAF LPEWMGIPAD LSPLLKH 347
Length:347
Mass (Da):39,243
Last modified:October 1, 2000 - v1
Checksum:iDD5F441046CC8E79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF214656 Genomic DNA. Translation: AAF45146.1.
AK033520 mRNA. Translation: BAC28338.1.
CCDSiCCDS21258.1.
RefSeqiNP_001258922.1. NM_001271993.1.
NP_061364.2. NM_018876.4.
XP_006540680.1. XM_006540617.1.
UniGeneiMm.290046.
Mm.491300.

Genome annotation databases

EnsembliENSMUST00000069800; ENSMUSP00000063719; ENSMUSG00000055978.
GeneIDi14344.
KEGGimmu:14344.
UCSCiuc009gwn.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Fucosyltransferase 2

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF214656 Genomic DNA. Translation: AAF45146.1 .
AK033520 mRNA. Translation: BAC28338.1 .
CCDSi CCDS21258.1.
RefSeqi NP_001258922.1. NM_001271993.1.
NP_061364.2. NM_018876.4.
XP_006540680.1. XM_006540617.1.
UniGenei Mm.290046.
Mm.491300.

3D structure databases

ProteinModelPortali Q9JL27.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000063719.

Protein family/group databases

CAZyi GT11. Glycosyltransferase Family 11.

PTM databases

PhosphoSitei Q9JL27.

Proteomic databases

MaxQBi Q9JL27.
PRIDEi Q9JL27.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069800 ; ENSMUSP00000063719 ; ENSMUSG00000055978 .
GeneIDi 14344.
KEGGi mmu:14344.
UCSCi uc009gwn.1. mouse.

Organism-specific databases

CTDi 2524.
MGIi MGI:109374. Fut2.

Phylogenomic databases

eggNOGi NOG17447.
GeneTreei ENSGT00390000001450.
HOGENOMi HOG000261621.
HOVERGENi HBG004338.
InParanoidi Q9JL27.
KOi K00718.
OMAi FSFPMAH.
OrthoDBi EOG7C5M8F.
PhylomeDBi Q9JL27.
TreeFami TF315810.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BRENDAi 2.4.1.69. 3474.

Miscellaneous databases

NextBioi 285785.
PROi Q9JL27.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JL27.
Bgeei Q9JL27.
CleanExi MM_FUT2.
Genevestigatori Q9JL27.

Family and domain databases

InterProi IPR002516. Glyco_trans_11.
[Graphical view ]
PANTHERi PTHR11927. PTHR11927. 1 hit.
Pfami PF01531. Glyco_transf_11. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract."
    Domino S.E., Zhang L., Lowe J.B.
    J. Biol. Chem. 276:23748-23756(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Ola.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon.

Entry informationi

Entry nameiFUT2_MOUSE
AccessioniPrimary (citable) accession number: Q9JL27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In mouse, there are three genes (Fut1, Fut2 and Sec1) which encode galactoside 2-L-fucosyltransferase.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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