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Protein

C-C chemokine receptor type 10

Gene

Ccr10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

  • C-C chemokine receptor activity Source: MGI
  • chemokine receptor activity Source: MGI

GO - Biological processi

  • chemokine-mediated signaling pathway Source: GOC
  • chemotaxis Source: MGI
  • immune response Source: InterPro
  • positive regulation of cytosolic calcium ion concentration Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 10
Short name:
C-C CKR-10
Short name:
CC-CKR-10
Short name:
CCR-10
Alternative name(s):
Chemokine C-C receptor 9
G-protein coupled receptor 2
Gene namesi
Name:Ccr10
Synonyms:Cmkbr9, Gpr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1096320. Ccr10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848ExtracellularSequence analysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini70 – 8011CytoplasmicSequence analysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini102 – 11514ExtracellularSequence analysisAdd
BLAST
Transmembranei116 – 13621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini137 – 15923CytoplasmicSequence analysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini181 – 20828ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini230 – 24718CytoplasmicSequence analysisAdd
BLAST
Transmembranei248 – 26821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini269 – 29123ExtracellularSequence analysisAdd
BLAST
Transmembranei292 – 31221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini313 – 36250CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: MGI
  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362C-C chemokine receptor type 10PRO_0000069294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi113 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9JL21.
PRIDEiQ9JL21.

PTM databases

PhosphoSiteiQ9JL21.

Expressioni

Tissue specificityi

Expressed at high levels in small intestine, colon, lymph nodes, Peyer patches and at lower levels in thymus, lung and spleen.1 Publication

Gene expression databases

BgeeiQ9JL21.
CleanExiMM_CCR10.
GenevisibleiQ9JL21. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062588.

Structurei

3D structure databases

ProteinModelPortaliQ9JL21.
SMRiQ9JL21. Positions 25-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW0E. Eukaryota.
ENOG4110ZGY. LUCA.
GeneTreeiENSGT00840000129952.
HOGENOMiHOG000234122.
HOVERGENiHBG096538.
InParanoidiQ9JL21.
KOiK04185.
OMAiQVSWGPY.
OrthoDBiEOG7SXW4F.
TreeFamiTF330966.

Family and domain databases

InterProiIPR005382. Chemokine_CCR10.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01557. CHEMOKINER10.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JL21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTKPTEQVS WGLYSGYDEE AYSVGPLPEL CYKADVQAFS RAFQPSVSLM
60 70 80 90 100
VAVLGLAGNG LVLATHLAAR RTTRSPTSVH LLQLALADLL LALTLPFAAA
110 120 130 140 150
GALQGWNLGS TTCRAISGLY SASFHAGFLF LACISADRYV AIARALPAGQ
160 170 180 190 200
RPSTPSRAHL VSVFVWLLSL FLALPALLFS RDGPREGQRR CRLIFPESLT
210 220 230 240 250
QTVKGASAVA QVVLGFALPL GVMAACYALL GRTLLAARGP ERRRALRVVV
260 270 280 290 300
ALVVAFVVLQ LPYSLALLLD TADLLAARER SCSSSKRKDL ALLVTGGLTL
310 320 330 340 350
VRCSLNPVLY AFLGLRFRRD LRRLLQGGGC SPKPNPRGRC PRRLRLSSCS
360
APTETHSLSW DN
Length:362
Mass (Da):38,900
Last modified:July 27, 2011 - v2
Checksum:i13C4292859C376CE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351S → N in AAF63710 (PubMed:10725696).Curated
Sequence conflicti135 – 1351S → N in AAF63711 (PubMed:10725696).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215982 mRNA. Translation: AAF63710.1.
AF215983 mRNA. Translation: AAF63711.1.
AF208238 mRNA. Translation: AAF72872.1.
AK090044 mRNA. Translation: BAC41062.1.
AL590969 Genomic DNA. Translation: CAM19572.1.
CH466677 Genomic DNA. Translation: EDL03895.1.
BC117043 mRNA. Translation: AAI17044.1.
BC120542 mRNA. Translation: AAI20543.1.
CCDSiCCDS25454.1.
RefSeqiNP_031747.2. NM_007721.4.
XP_011247012.1. XM_011248710.1.
UniGeneiMm.8021.

Genome annotation databases

EnsembliENSMUST00000062759; ENSMUSP00000062588; ENSMUSG00000044052.
GeneIDi12777.
KEGGimmu:12777.
UCSCiuc007lns.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215982 mRNA. Translation: AAF63710.1.
AF215983 mRNA. Translation: AAF63711.1.
AF208238 mRNA. Translation: AAF72872.1.
AK090044 mRNA. Translation: BAC41062.1.
AL590969 Genomic DNA. Translation: CAM19572.1.
CH466677 Genomic DNA. Translation: EDL03895.1.
BC117043 mRNA. Translation: AAI17044.1.
BC120542 mRNA. Translation: AAI20543.1.
CCDSiCCDS25454.1.
RefSeqiNP_031747.2. NM_007721.4.
XP_011247012.1. XM_011248710.1.
UniGeneiMm.8021.

3D structure databases

ProteinModelPortaliQ9JL21.
SMRiQ9JL21. Positions 25-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062588.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9JL21.

Proteomic databases

PaxDbiQ9JL21.
PRIDEiQ9JL21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062759; ENSMUSP00000062588; ENSMUSG00000044052.
GeneIDi12777.
KEGGimmu:12777.
UCSCiuc007lns.1. mouse.

Organism-specific databases

CTDi2826.
MGIiMGI:1096320. Ccr10.

Phylogenomic databases

eggNOGiENOG410IW0E. Eukaryota.
ENOG4110ZGY. LUCA.
GeneTreeiENSGT00840000129952.
HOGENOMiHOG000234122.
HOVERGENiHBG096538.
InParanoidiQ9JL21.
KOiK04185.
OMAiQVSWGPY.
OrthoDBiEOG7SXW4F.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ9JL21.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JL21.
CleanExiMM_CCR10.
GenevisibleiQ9JL21. MM.

Family and domain databases

InterProiIPR005382. Chemokine_CCR10.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01557. CHEMOKINER10.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine."
    Jarmin D.I., Rits M., Bota D., Gerard N.P., Graham G.J., Clark-Lewis I., Gerard C.
    J. Immunol. 164:3460-3464(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: BALB/cJ.
    Tissue: Peyer patch.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, LIGAND-BINDING.
    Tissue: Thymocyte.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymocyte.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiCCR10_MOUSE
AccessioniPrimary (citable) accession number: Q9JL21
Secondary accession number(s): Q542A4, Q9JIP1, Q9JL20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.