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Q9JL15 (LEG8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galectin-8

Short name=Gal-8
Alternative name(s):
LGALS-8
Gene names
Name:Lgals8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Domain

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similarities

Contains 2 galectin domains.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRepeat
   LigandLectin
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell costimulation

Inferred from direct assay PubMed 22357632. Source: MGI

plasma cell differentiation

Inferred from direct assay PubMed 21753146. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncarbohydrate binding

Inferred from direct assay PubMed 21753146. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Galectin-8
PRO_0000076944

Regions

Domain18 – 151134Galectin 1
Domain186 – 316131Galectin 2
Region248 – 2547Beta-galactoside binding By similarity

Sites

Binding site681Carbohydrate By similarity
Binding site781Carbohydrate By similarity
Binding site881Carbohydrate By similarity
Site581Critical for binding to sialylated and sulfated oligosaccharides By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JL15 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 11A20309AEF52C69

FASTA31636,162
        10         20         30         40         50         60 
MLSLNNLQNI IYNPIIPYVG TITEQLKPGS LIVIRGHVPK DSERFQVDFQ LGNSLKPRAD 

        70         80         90        100        110        120 
VAFHFNPRFK RSSCIVCNTL TQEKWGWEEI TYDMPFRKEK SFEIVFMVLK NKFQVAVNGR 

       130        140        150        160        170        180 
HVLLYAHRIS PEQIDTVGIY GKVNIHSIGF RFSSDLQSME TSALGLTQIN RENIQKPGKL 

       190        200        210        220        230        240 
QLSLPFEARL NASMGPGRTV VIKGEVNTNA RSFNVDLVAG KTRDIALHLN PRLNVKAFVR 

       250        260        270        280        290        300 
NSFLQDAWGE EERNITCFPF SSGMYFEMII YCDVREFKVA INGVHSLEYK HRFKDLSSID 

       310 
TLSVDGDIRL LDVRSW 

« Hide

References

« Hide 'large scale' references
[1]"The human Lgals-8 gene: genomic sequence and expression of the prostate carcinoma tumour antigen (PCTA-1) and the Po66 carbohydrate binding protein."
Maier C., Haeussler J., Roesch K., Moschgath E., Haeusler J., Vogel W.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF218069 mRNA. Translation: AAF27645.1.
AK029526 mRNA. Translation: BAC26495.1.
BC040243 mRNA. Translation: AAH40243.1.
CCDSCCDS36592.1.
RefSeqNP_001185972.1. NM_001199043.1.
NP_061374.1. NM_018886.5.
XP_006516777.1. XM_006516714.1.
XP_006516778.1. XM_006516715.1.
UniGeneMm.474138.
Mm.486765.

3D structure databases

ProteinModelPortalQ9JL15.
SMRQ9JL15. Positions 1-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000066355.

Proteomic databases

MaxQBQ9JL15.
PaxDbQ9JL15.
PRIDEQ9JL15.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000099820; ENSMUSP00000097408; ENSMUSG00000057554.
ENSMUST00000099821; ENSMUSP00000097409; ENSMUSG00000057554.
ENSMUST00000124888; ENSMUSP00000115094; ENSMUSG00000057554.
GeneID56048.
KEGGmmu:56048.
UCSCuc007plm.2. mouse.

Organism-specific databases

CTD3964.
MGIMGI:1928481. Lgals8.

Phylogenomic databases

eggNOGNOG264430.
GeneTreeENSGT00750000117534.
HOGENOMHOG000290194.
HOVERGENHBG002412.
KOK06832.
OrthoDBEOG73Z2TM.
PhylomeDBQ9JL15.
TreeFamTF315551.

Gene expression databases

ArrayExpressQ9JL15.
BgeeQ9JL15.
CleanExMM_LGALS8.
GenevestigatorQ9JL15.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]
PfamPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
PROSITEPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLGALS8. mouse.
NextBio311828.
PROQ9JL15.
SOURCESearch...

Entry information

Entry nameLEG8_MOUSE
AccessionPrimary (citable) accession number: Q9JL15
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot