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Q9JL15

- LEG8_MOUSE

UniProt

Q9JL15 - LEG8_MOUSE

Protein

Galectin-8

Gene

Lgals8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei58 – 581Critical for binding to sialylated and sulfated oligosaccharidesBy similarity
    Binding sitei68 – 681CarbohydrateBy similarity
    Binding sitei78 – 781CarbohydrateBy similarity
    Binding sitei88 – 881CarbohydrateBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: MGI

    GO - Biological processi

    1. plasma cell differentiation Source: MGI
    2. T cell costimulation Source: MGI

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galectin-8
    Short name:
    Gal-8
    Alternative name(s):
    LGALS-8
    Gene namesi
    Name:Lgals8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1928481. Lgals8.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Galectin-8PRO_0000076944Add
    BLAST

    Proteomic databases

    MaxQBiQ9JL15.
    PaxDbiQ9JL15.
    PRIDEiQ9JL15.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JL15.
    BgeeiQ9JL15.
    CleanExiMM_LGALS8.
    GenevestigatoriQ9JL15.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000066355.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JL15.
    SMRiQ9JL15. Positions 1-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 151134Galectin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini186 – 316131Galectin 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni248 – 2547Beta-galactoside bindingBy similarity

    Domaini

    Contains two homologous but distinct carbohydrate-binding domains.

    Sequence similaritiesi

    Contains 2 galectin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG264430.
    GeneTreeiENSGT00750000117534.
    HOGENOMiHOG000290194.
    HOVERGENiHBG002412.
    KOiK06832.
    OrthoDBiEOG73Z2TM.
    PhylomeDBiQ9JL15.
    TreeFamiTF315551.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view]
    PfamiPF00337. Gal-bind_lectin. 2 hits.
    [Graphical view]
    SMARTiSM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    PROSITEiPS51304. GALECTIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JL15-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSLNNLQNI IYNPIIPYVG TITEQLKPGS LIVIRGHVPK DSERFQVDFQ    50
    LGNSLKPRAD VAFHFNPRFK RSSCIVCNTL TQEKWGWEEI TYDMPFRKEK 100
    SFEIVFMVLK NKFQVAVNGR HVLLYAHRIS PEQIDTVGIY GKVNIHSIGF 150
    RFSSDLQSME TSALGLTQIN RENIQKPGKL QLSLPFEARL NASMGPGRTV 200
    VIKGEVNTNA RSFNVDLVAG KTRDIALHLN PRLNVKAFVR NSFLQDAWGE 250
    EERNITCFPF SSGMYFEMII YCDVREFKVA INGVHSLEYK HRFKDLSSID 300
    TLSVDGDIRL LDVRSW 316
    Length:316
    Mass (Da):36,162
    Last modified:October 1, 2000 - v1
    Checksum:i11A20309AEF52C69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218069 mRNA. Translation: AAF27645.1.
    AK029526 mRNA. Translation: BAC26495.1.
    BC040243 mRNA. Translation: AAH40243.1.
    CCDSiCCDS36592.1.
    RefSeqiNP_001185972.1. NM_001199043.1.
    NP_061374.1. NM_018886.5.
    XP_006516777.1. XM_006516714.1.
    XP_006516778.1. XM_006516715.1.
    UniGeneiMm.474138.
    Mm.486765.

    Genome annotation databases

    EnsembliENSMUST00000099820; ENSMUSP00000097408; ENSMUSG00000057554.
    ENSMUST00000099821; ENSMUSP00000097409; ENSMUSG00000057554.
    ENSMUST00000124888; ENSMUSP00000115094; ENSMUSG00000057554.
    GeneIDi56048.
    KEGGimmu:56048.
    UCSCiuc007plm.2. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Galectin-8

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218069 mRNA. Translation: AAF27645.1 .
    AK029526 mRNA. Translation: BAC26495.1 .
    BC040243 mRNA. Translation: AAH40243.1 .
    CCDSi CCDS36592.1.
    RefSeqi NP_001185972.1. NM_001199043.1.
    NP_061374.1. NM_018886.5.
    XP_006516777.1. XM_006516714.1.
    XP_006516778.1. XM_006516715.1.
    UniGenei Mm.474138.
    Mm.486765.

    3D structure databases

    ProteinModelPortali Q9JL15.
    SMRi Q9JL15. Positions 1-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000066355.

    Proteomic databases

    MaxQBi Q9JL15.
    PaxDbi Q9JL15.
    PRIDEi Q9JL15.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000099820 ; ENSMUSP00000097408 ; ENSMUSG00000057554 .
    ENSMUST00000099821 ; ENSMUSP00000097409 ; ENSMUSG00000057554 .
    ENSMUST00000124888 ; ENSMUSP00000115094 ; ENSMUSG00000057554 .
    GeneIDi 56048.
    KEGGi mmu:56048.
    UCSCi uc007plm.2. mouse.

    Organism-specific databases

    CTDi 3964.
    MGIi MGI:1928481. Lgals8.

    Phylogenomic databases

    eggNOGi NOG264430.
    GeneTreei ENSGT00750000117534.
    HOGENOMi HOG000290194.
    HOVERGENi HBG002412.
    KOi K06832.
    OrthoDBi EOG73Z2TM.
    PhylomeDBi Q9JL15.
    TreeFami TF315551.

    Miscellaneous databases

    ChiTaRSi LGALS8. mouse.
    NextBioi 311828.
    PROi Q9JL15.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JL15.
    Bgeei Q9JL15.
    CleanExi MM_LGALS8.
    Genevestigatori Q9JL15.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view ]
    Pfami PF00337. Gal-bind_lectin. 2 hits.
    [Graphical view ]
    SMARTi SM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    PROSITEi PS51304. GALECTIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human Lgals-8 gene: genomic sequence and expression of the prostate carcinoma tumour antigen (PCTA-1) and the Po66 carbohydrate binding protein."
      Maier C., Haeussler J., Roesch K., Moschgath E., Haeusler J., Vogel W.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiLEG8_MOUSE
    AccessioniPrimary (citable) accession number: Q9JL15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3