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Q9JL15

- LEG8_MOUSE

UniProt

Q9JL15 - LEG8_MOUSE

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Protein

Galectin-8

Gene

Lgals8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei58 – 581Critical for binding to sialylated and sulfated oligosaccharidesBy similarity
Binding sitei68 – 681CarbohydrateBy similarity
Binding sitei78 – 781CarbohydrateBy similarity
Binding sitei88 – 881CarbohydrateBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: MGI

GO - Biological processi

  1. plasma cell differentiation Source: MGI
  2. T cell costimulation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-8
Short name:
Gal-8
Alternative name(s):
LGALS-8
Gene namesi
Name:Lgals8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1928481. Lgals8.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Galectin-8PRO_0000076944Add
BLAST

Proteomic databases

MaxQBiQ9JL15.
PaxDbiQ9JL15.
PRIDEiQ9JL15.

Expressioni

Gene expression databases

BgeeiQ9JL15.
CleanExiMM_LGALS8.
ExpressionAtlasiQ9JL15. baseline and differential.
GenevestigatoriQ9JL15.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066355.

Structurei

3D structure databases

ProteinModelPortaliQ9JL15.
SMRiQ9JL15. Positions 1-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 151134Galectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini186 – 316131Galectin 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni248 – 2547Beta-galactoside bindingBy similarity

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG264430.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiQ9JL15.
KOiK06832.
OrthoDBiEOG73Z2TM.
PhylomeDBiQ9JL15.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JL15 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSLNNLQNI IYNPIIPYVG TITEQLKPGS LIVIRGHVPK DSERFQVDFQ
60 70 80 90 100
LGNSLKPRAD VAFHFNPRFK RSSCIVCNTL TQEKWGWEEI TYDMPFRKEK
110 120 130 140 150
SFEIVFMVLK NKFQVAVNGR HVLLYAHRIS PEQIDTVGIY GKVNIHSIGF
160 170 180 190 200
RFSSDLQSME TSALGLTQIN RENIQKPGKL QLSLPFEARL NASMGPGRTV
210 220 230 240 250
VIKGEVNTNA RSFNVDLVAG KTRDIALHLN PRLNVKAFVR NSFLQDAWGE
260 270 280 290 300
EERNITCFPF SSGMYFEMII YCDVREFKVA INGVHSLEYK HRFKDLSSID
310
TLSVDGDIRL LDVRSW
Length:316
Mass (Da):36,162
Last modified:October 1, 2000 - v1
Checksum:i11A20309AEF52C69
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF218069 mRNA. Translation: AAF27645.1.
AK029526 mRNA. Translation: BAC26495.1.
BC040243 mRNA. Translation: AAH40243.1.
CCDSiCCDS36592.1.
RefSeqiNP_001185972.1. NM_001199043.1.
NP_061374.1. NM_018886.5.
XP_006516777.1. XM_006516714.1.
XP_006516778.1. XM_006516715.1.
UniGeneiMm.474138.
Mm.486765.

Genome annotation databases

EnsembliENSMUST00000099820; ENSMUSP00000097408; ENSMUSG00000057554.
ENSMUST00000099821; ENSMUSP00000097409; ENSMUSG00000057554.
ENSMUST00000124888; ENSMUSP00000115094; ENSMUSG00000057554.
GeneIDi56048.
KEGGimmu:56048.
UCSCiuc007plm.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-8

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF218069 mRNA. Translation: AAF27645.1 .
AK029526 mRNA. Translation: BAC26495.1 .
BC040243 mRNA. Translation: AAH40243.1 .
CCDSi CCDS36592.1.
RefSeqi NP_001185972.1. NM_001199043.1.
NP_061374.1. NM_018886.5.
XP_006516777.1. XM_006516714.1.
XP_006516778.1. XM_006516715.1.
UniGenei Mm.474138.
Mm.486765.

3D structure databases

ProteinModelPortali Q9JL15.
SMRi Q9JL15. Positions 1-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000066355.

Proteomic databases

MaxQBi Q9JL15.
PaxDbi Q9JL15.
PRIDEi Q9JL15.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000099820 ; ENSMUSP00000097408 ; ENSMUSG00000057554 .
ENSMUST00000099821 ; ENSMUSP00000097409 ; ENSMUSG00000057554 .
ENSMUST00000124888 ; ENSMUSP00000115094 ; ENSMUSG00000057554 .
GeneIDi 56048.
KEGGi mmu:56048.
UCSCi uc007plm.2. mouse.

Organism-specific databases

CTDi 3964.
MGIi MGI:1928481. Lgals8.

Phylogenomic databases

eggNOGi NOG264430.
GeneTreei ENSGT00760000119105.
HOGENOMi HOG000290194.
HOVERGENi HBG002412.
InParanoidi Q9JL15.
KOi K06832.
OrthoDBi EOG73Z2TM.
PhylomeDBi Q9JL15.
TreeFami TF315551.

Miscellaneous databases

ChiTaRSi LGALS8. mouse.
NextBioi 311828.
PROi Q9JL15.
SOURCEi Search...

Gene expression databases

Bgeei Q9JL15.
CleanExi MM_LGALS8.
ExpressionAtlasi Q9JL15. baseline and differential.
Genevestigatori Q9JL15.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view ]
Pfami PF00337. Gal-bind_lectin. 2 hits.
[Graphical view ]
SMARTi SM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
PROSITEi PS51304. GALECTIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human Lgals-8 gene: genomic sequence and expression of the prostate carcinoma tumour antigen (PCTA-1) and the Po66 carbohydrate binding protein."
    Maier C., Haeussler J., Roesch K., Moschgath E., Haeusler J., Vogel W.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiLEG8_MOUSE
AccessioniPrimary (citable) accession number: Q9JL15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3