Q9JL10 (SRTD1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SERTA domain-containing protein 1

Alternative name(s):
CDK4-binding protein p34SEI1
Short name=SEI-1
Transcriptional regulator interacting with the PHD-bromodomain 1
Short name=TRIP-Br1

Gene names

Name:	Sertad1
Synonyms:	Sei1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a). Ref.2
Subunit structure	Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Binds to DP1. Also interacts with CDK4. Ref.2
Sequence similarities	Contains 1 SERTA domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of cell growth Inferred from sequence alignment PubMed 16098148. Source: MGI positive regulation of transcription, DNA-dependent Inferred from direct assay PubMed 16098148. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from sequence alignment PubMed 16098148. Source: MGI nucleus Inferred from sequence alignment PubMed 16098148. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	SERTA domain-containing protein 1		PRO_0000191612
Regions
	Domain	38 – 85	48	SERTA
Experimental info
	Sequence conflict	9 – 10	2	KR → NG in BAB25588. Ref.3
	Sequence conflict	12	1	E → K in AAK52829. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9JL10 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 989ADF8299DE84C5	FASTA	236	25,136
	10 20 30 40 50 60 MLSKGLKRKR EEEETMEALS VDSCWLDPSH PAVAQTPPTV ASSSLFDLSV VKLHHSLRQS 70 80 90 100 110 120 EPDLRHLVLV VNTLRRIQAS MEPAPVLPPE PIQPPAPSVA DSLLASSDAG LSASMASLLE 130 140 150 160 170 180 DLNHIEDLNQ APQPQADEGP PGRSIGGISP NLGALDLLGP ATGCLLDDGL EGLFEDIDTS 190 200 210 220 230 MYDSELWLPA SEGLKPGPEN GPAKEEPPEL DEAELDYLMD VLVGTQALER PPGPGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of mouse SEI-1 cDNA." Ohtani N., Hara E. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1." Hsu S.-I., Yang C.M., Sim K.G., Hentschel D.M., O'Leary E., Bonventre J.V. EMBO J. 20:2273-2285(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo and Small intestine.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF218291 mRNA. Translation: AAF27653.1. AF366400 mRNA. Translation: AAK52829.1. AF366401 mRNA. Translation: AAK52830.1. AK004022 mRNA. Translation: BAB23130.1. AK008303 mRNA. Translation: BAB25588.1. BC016077 mRNA. Translation: AAH16077.1.
IPI	IPI00121572.
RefSeq	NP_061290.1. NM_018820.4.
UniGene	Mm.153684.
3D structure databases
ProteinModelPortal	Q9JL10.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000008528; ENSMUSP00000008528; ENSMUSG00000008384.
GeneID	55942.
KEGG	mmu:55942.
UCSC	uc009fwh.1. mouse.
Organism-specific databases
CTD	29950.
MGI	MGI:1913438. Sertad1.
Phylogenomic databases
eggNOG	NOG41149.
GeneTree	ENSGT00530000064099.
HOGENOM	HOG000133160.
HOVERGEN	HBG062592.
InParanoid	Q9JL10.
OMA	PATGCLL.
OrthoDB	EOG46T32R.
Gene expression databases
ArrayExpress	Q9JL10.
Bgee	Q9JL10.
CleanEx	MM_SERTAD1.
Genevestigator	Q9JL10.
GermOnline	ENSMUSG00000008384. Mus musculus.
Family and domain databases
InterPro	IPR009263. SERTA. [Graphical view]
Pfam	PF06031. SERTA. 1 hit. [Graphical view]
PROSITE	PS51053. SERTA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	311622.
SOURCE	Search...

Entry information

Entry name

SRTD1_MOUSE

Accession

Primary (citable) accession number: Q9JL10
Secondary accession number(s): Q925E6, Q9D888

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program