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Protein

SERTA domain-containing protein 1

Gene

Sertad1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.1 Publication

GO - Biological processi

  • negative regulation of cell growth Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SERTA domain-containing protein 1
Alternative name(s):
CDK4-binding protein p34SEI1
Short name:
SEI-1
Transcriptional regulator interacting with the PHD-bromodomain 1
Short name:
TRIP-Br1
Gene namesi
Name:Sertad1
Synonyms:Sei1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913438. Sertad1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236SERTA domain-containing protein 1PRO_0000191612Add
BLAST

Post-translational modificationi

Polyubiquitinated, which promotes proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9JL10.

Expressioni

Tissue specificityi

Detected at in testis, lung and, at lower levels, in muscle, liver, spleen, brain and heart.1 Publication

Developmental stagei

Detected as early as 7 dpc and persist until, at least, 17 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000008384.
CleanExiMM_SERTAD1.
ExpressionAtlasiQ9JL10. baseline and differential.
GenevisibleiQ9JL10. MM.

Interactioni

Subunit structurei

Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Interacts with E2F1 and TFDP1; modulates transactivation activity of TFDP1/E2F complexes. Also interacts with CDK4.1 Publication

Protein-protein interaction databases

BioGridi207738. 12 interactions.
STRINGi10090.ENSMUSP00000008528.

Structurei

3D structure databases

ProteinModelPortaliQ9JL10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 8548SERTAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SERTA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J0C8. Eukaryota.
ENOG41114KT. LUCA.
GeneTreeiENSGT00730000111417.
HOGENOMiHOG000133160.
HOVERGENiHBG062592.
InParanoidiQ9JL10.
OMAiGPATGCL.
OrthoDBiEOG091G0X9V.
PhylomeDBiQ9JL10.
TreeFamiTF101069.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JL10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKGLKRKR EEEETMEALS VDSCWLDPSH PAVAQTPPTV ASSSLFDLSV
60 70 80 90 100
VKLHHSLRQS EPDLRHLVLV VNTLRRIQAS MEPAPVLPPE PIQPPAPSVA
110 120 130 140 150
DSLLASSDAG LSASMASLLE DLNHIEDLNQ APQPQADEGP PGRSIGGISP
160 170 180 190 200
NLGALDLLGP ATGCLLDDGL EGLFEDIDTS MYDSELWLPA SEGLKPGPEN
210 220 230
GPAKEEPPEL DEAELDYLMD VLVGTQALER PPGPGR
Length:236
Mass (Da):25,136
Last modified:October 1, 2000 - v1
Checksum:i989ADF8299DE84C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 102KR → NG in BAB25588 (PubMed:16141072).Curated
Sequence conflicti12 – 121E → K in AAK52829 (PubMed:11331592).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218291 mRNA. Translation: AAF27653.1.
AF366400 mRNA. Translation: AAK52829.1.
AF366401 mRNA. Translation: AAK52830.1.
AK004022 mRNA. Translation: BAB23130.1.
AK008303 mRNA. Translation: BAB25588.1.
BC016077 mRNA. Translation: AAH16077.1.
CCDSiCCDS21022.1.
RefSeqiNP_061290.1. NM_018820.4.
XP_006540280.1. XM_006540217.2.
UniGeneiMm.153684.

Genome annotation databases

EnsembliENSMUST00000008528; ENSMUSP00000008528; ENSMUSG00000008384.
GeneIDi55942.
KEGGimmu:55942.
UCSCiuc009fwh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218291 mRNA. Translation: AAF27653.1.
AF366400 mRNA. Translation: AAK52829.1.
AF366401 mRNA. Translation: AAK52830.1.
AK004022 mRNA. Translation: BAB23130.1.
AK008303 mRNA. Translation: BAB25588.1.
BC016077 mRNA. Translation: AAH16077.1.
CCDSiCCDS21022.1.
RefSeqiNP_061290.1. NM_018820.4.
XP_006540280.1. XM_006540217.2.
UniGeneiMm.153684.

3D structure databases

ProteinModelPortaliQ9JL10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207738. 12 interactions.
STRINGi10090.ENSMUSP00000008528.

Proteomic databases

PaxDbiQ9JL10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008528; ENSMUSP00000008528; ENSMUSG00000008384.
GeneIDi55942.
KEGGimmu:55942.
UCSCiuc009fwh.1. mouse.

Organism-specific databases

CTDi29950.
MGIiMGI:1913438. Sertad1.

Phylogenomic databases

eggNOGiENOG410J0C8. Eukaryota.
ENOG41114KT. LUCA.
GeneTreeiENSGT00730000111417.
HOGENOMiHOG000133160.
HOVERGENiHBG062592.
InParanoidiQ9JL10.
OMAiGPATGCL.
OrthoDBiEOG091G0X9V.
PhylomeDBiQ9JL10.
TreeFamiTF101069.

Miscellaneous databases

PROiQ9JL10.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008384.
CleanExiMM_SERTAD1.
ExpressionAtlasiQ9JL10. baseline and differential.
GenevisibleiQ9JL10. MM.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRTD1_MOUSE
AccessioniPrimary (citable) accession number: Q9JL10
Secondary accession number(s): Q925E6, Q9D888
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.