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Protein

Lysophosphatidic acid receptor 2

Gene

Lpar2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity).By similarity

GO - Molecular functioni

  • lysophosphatidic acid receptor activity Source: InterPro
  • PDZ domain binding Source: MGI

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of Rho protein signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 2
Short name:
LPA receptor 2
Short name:
LPA-2
Alternative name(s):
Lysophosphatidic acid receptor Edg-4
Gene namesi
Name:Lpar2
Synonyms:Edg4, Lpa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1858422. Lpar2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence analysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini52 – 6615CytoplasmicSequence analysisAdd
BLAST
Transmembranei67 – 8721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini88 – 10417ExtracellularSequence analysisAdd
BLAST
Transmembranei105 – 12420Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 14420CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini166 – 18520ExtracellularSequence analysisAdd
BLAST
Transmembranei186 – 20621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini207 – 23933CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27010ExtracellularSequence analysis
Transmembranei271 – 29121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 34857CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi273.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Lysophosphatidic acid receptor 2PRO_0000069426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence analysis
Lipidationi308 – 3081S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ9JL06.

PTM databases

PhosphoSiteiQ9JL06.

Expressioni

Tissue specificityi

Most abundantly expressed in testes, kidney, and embryonic brain. Other organs also express the transcript, including heart, lung, spleen, thymus, stomach, and adult brain. Several have little or no expression, including liver, small intestine, and skeletal muscle.

Interactioni

Subunit structurei

Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and ADRBK1 (By similarity).By similarity

GO - Molecular functioni

  • PDZ domain binding Source: MGI

Protein-protein interaction databases

IntActiQ9JL06. 2 interactions.
MINTiMINT-1897279.

Structurei

3D structure databases

ProteinModelPortaliQ9JL06.
SMRiQ9JL06. Positions 3-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi345 – 3484PDZ-binding

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9JL06.
PhylomeDBiQ9JL06.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR004066. LPA_rcpt_EDG4.
[Graphical view]
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01528. EDG4RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JL06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQCYYNETI GFFYNNSGKE LSLHWRPKDV VVVALGLTVS VLVLLTNLLV
60 70 80 90 100
IAAIASNRRF HQPIYYLLGN LAAADLFAGM AYLFLMFHTG PPHCQALHQR
110 120 130 140 150
LVPATGPAGH QPHGVSGHTA GIAVERHRSV MAVQLHSRLP RGRVVTLIVG
160 170 180 190 200
VWAAALGLGL LPAHFWHCLC DLDSCSRMVP LFSRSYLAAW ALSSLLVFLL
210 220 230 240 250
MVAVYTRIFF YVRRRVERMA EHVSCHPRYR ETTLSLVKTV VIILGAFVVC
260 270 280 290 300
WTPGQVVLLL DGLDCKTCNV LAVEKYFLLL AEANSLVNAV VYSCRDAEMR
310 320 330 340
RTFRRLLCCM CLRWSSHKSA RYSASAQTGA STRIMLPENG RPLMDSTL
Length:348
Mass (Da):38,777
Last modified:October 1, 2000 - v1
Checksum:iE3594382D616052C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218844 Genomic DNA. Translation: AAF65684.1.
UniGeneiMm.23253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218844 Genomic DNA. Translation: AAF65684.1.
UniGeneiMm.23253.

3D structure databases

ProteinModelPortaliQ9JL06.
SMRiQ9JL06. Positions 3-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JL06. 2 interactions.
MINTiMINT-1897279.

Chemistry

GuidetoPHARMACOLOGYi273.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9JL06.

Proteomic databases

PRIDEiQ9JL06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1858422. Lpar2.

Phylogenomic databases

HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9JL06.
PhylomeDBiQ9JL06.

Miscellaneous databases

PROiQ9JL06.
SOURCEiSearch...

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR004066. LPA_rcpt_EDG4.
[Graphical view]
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01528. EDG4RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA."
    Contos J.J.A., Chun J.
    Genomics 64:155-169(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "Lysophosphatidic acid receptors."
    Contos J.J.A., Ishii I., Chun J.
    Mol. Pharmacol. 58:1188-1196(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiLPAR2_MOUSE
AccessioniPrimary (citable) accession number: Q9JL06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.