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Protein

Sodium/myo-inositol cotransporter

Gene

Slc5a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.1 Publication
Functions as a retroviral receptor for M813 murine leukemia virus (MuLV) entry.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei24Implicated in sodium couplingBy similarity1
Sitei285Implicated in sodium couplingBy similarity1

GO - Molecular functioni

GO - Biological processi

  • inositol metabolic process Source: MGI
  • myo-inositol transport Source: MGI
  • peripheral nervous system development Source: MGI
  • regulation of respiratory gaseous exchange Source: MGI
  • sodium ion transport Source: UniProtKB-KW

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-429593 Inositol transporters

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/myo-inositol cotransporter
Short name:
Na(+)/myo-inositol cotransporter
Alternative name(s):
Sodium/myo-inositol transporter 1
Short name:
SMIT1
Solute carrier family 5 member 3
Gene namesi
Name:Slc5a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1858226 Slc5a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 29HelicalSequence analysisAdd BLAST20
Topological domaini30 – 38CytoplasmicSequence analysis9
Transmembranei39 – 57HelicalSequence analysisAdd BLAST19
Topological domaini58 – 86ExtracellularSequence analysisAdd BLAST29
Transmembranei87 – 110HelicalSequence analysisAdd BLAST24
Topological domaini111 – 123CytoplasmicSequence analysisAdd BLAST13
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 157ExtracellularSequence analysisAdd BLAST13
Transmembranei158 – 183HelicalSequence analysisAdd BLAST26
Topological domaini184 – 186CytoplasmicSequence analysis3
Transmembranei187 – 205HelicalSequence analysisAdd BLAST19
Topological domaini206 – 303ExtracellularSequence analysisAdd BLAST98
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 353CytoplasmicSequence analysisAdd BLAST29
Transmembranei354 – 376HelicalSequence analysisAdd BLAST23
Topological domaini377 – 406ExtracellularSequence analysisAdd BLAST30
Transmembranei407 – 430HelicalSequence analysisAdd BLAST24
Topological domaini431 – 443CytoplasmicSequence analysisAdd BLAST13
Transmembranei444 – 462HelicalSequence analysisAdd BLAST19
Topological domaini463 – 510ExtracellularSequence analysisAdd BLAST48
Transmembranei511 – 532HelicalSequence analysisAdd BLAST22
Topological domaini533 – 695CytoplasmicSequence analysisAdd BLAST163
Transmembranei696 – 716HelicalSequence analysisAdd BLAST21
Topological domaini717 – 718ExtracellularSequence analysis2

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053821 – 718Sodium/myo-inositol cotransporterAdd BLAST718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei594PhosphoserineBy similarity1
Modified residuei632PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9JKZ2
PaxDbiQ9JKZ2
PeptideAtlasiQ9JKZ2
PRIDEiQ9JKZ2

PTM databases

iPTMnetiQ9JKZ2
PhosphoSitePlusiQ9JKZ2
SwissPalmiQ9JKZ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000089774
ExpressionAtlasiQ9JKZ2 baseline and differential
GenevisibleiQ9JKZ2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109608

Structurei

3D structure databases

ProteinModelPortaliQ9JKZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49 Eukaryota
COG4146 LUCA
GeneTreeiENSGT00760000118955
HOGENOMiHOG000025422
HOVERGENiHBG052859
InParanoidiQ9JKZ2
KOiK14383
OMAiWKRCNEQ
OrthoDBiEOG091G077U
TreeFamiTF352855

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JKZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVLEAADI AVVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVA
60 70 80 90 100
IGASLFVSNI GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI
110 120 130 140 150
YIRSGVYTMP EYLSKRFGGH RIQVYFAALS LLLYIFTKLS VDLYSGALFI
160 170 180 190 200
QESLGWNLYV SVILLIGMTA LLTVTGGLVA VIYTDTLQAL LMIIGALTLM
210 220 230 240 250
VISMVKIGGF EEVKRRYMLA SPDVASILLK YNLSNTNACM VHPKANALKM
260 270 280 290 300
LRDPTDEDVP WPGFILGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL
310 320 330 340 350
MAGFLKLLPM FIIVVPGMIS RIVFADEIAC INPEHCMQVC GSRAGCSNIA
360 370 380 390 400
YPRLVMTLVP VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRK
410 420 430 440 450
SASSRELMIV GRIFVAFMVV ISIAWVPIIV EMQGGQMYLY IQEVADYLTP
460 470 480 490 500
PVAALFLLAI FWKRCNEQGA FYGGMAGFVL GAVRLILAFT YRAPECDQPD
510 520 530 540 550
NRPGFIKDIH YMYVATALFW ITGLITVIVS LLTPPPTKDQ IRTTTFWSKK
560 570 580 590 600
TLVTKESCSQ KDEPYKMQEK SILQCSENSE VISHTIPNGK SEDSIKGLQP
610 620 630 640 650
EDVNLLVTCR EEGNPVASMG HSEAETPVDA YSNGQAALMG EREREKETEN
660 670 680 690 700
RSRYWKFIDW FCGFKSKSLS KRSLRDLMDE EAVCLQMLEE TPQVKVILNI
710
GLFAVCSLGI FMFVYFSL
Length:718
Mass (Da):79,583
Last modified:July 27, 2011 - v2
Checksum:iD0371D6ECF08503B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti653R → Q in AAF43668 (PubMed:10773690).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220915 Genomic DNA Translation: AAF43668.1
CH466602 Genomic DNA Translation: EDL03793.1
BC140982 mRNA Translation: AAI40983.1
BC140983 mRNA Translation: AAI40984.1
CCDSiCCDS37403.1
RefSeqiNP_059087.2, NM_017391.3
UniGeneiMm.217354
Mm.451146

Genome annotation databases

EnsembliENSMUST00000113975; ENSMUSP00000109608; ENSMUSG00000089774
GeneIDi53881
KEGGimmu:53881
UCSCiuc007zyt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSC5A3_MOUSE
AccessioniPrimary (citable) accession number: Q9JKZ2
Secondary accession number(s): B2RU60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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