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Q9JKZ2

- SC5A3_MOUSE

UniProt

Q9JKZ2 - SC5A3_MOUSE

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Protein

Sodium/myo-inositol cotransporter

Gene

Slc5a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.1 Publication
Functions as a retroviral receptor for M813 murine leukemia virus (MuLV) entry.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei24 – 241Implicated in sodium couplingBy similarity
Sitei285 – 2851Implicated in sodium couplingBy similarity

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. inositol metabolic process Source: MGI
  2. myo-inositol transport Source: MGI
  3. peripheral nervous system development Source: MGI
  4. regulation of respiratory gaseous exchange Source: MGI
  5. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/myo-inositol cotransporter
Short name:
Na(+)/myo-inositol cotransporter
Alternative name(s):
Sodium/myo-inositol transporter 1
Short name:
SMIT1
Solute carrier family 5 member 3
Gene namesi
Name:Slc5a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1858226. Slc5a3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 718718Sodium/myo-inositol cotransporterPRO_0000105382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JKZ2.
PaxDbiQ9JKZ2.
PRIDEiQ9JKZ2.

PTM databases

PhosphoSiteiQ9JKZ2.

Expressioni

Gene expression databases

BgeeiQ9JKZ2.
ExpressionAtlasiQ9JKZ2. baseline and differential.
GenevestigatoriQ9JKZ2.

Structurei

3D structure databases

ProteinModelPortaliQ9JKZ2.
SMRiQ9JKZ2. Positions 9-476.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99ExtracellularSequence Analysis
Topological domaini30 – 389CytoplasmicSequence Analysis
Topological domaini58 – 8629ExtracellularSequence AnalysisAdd
BLAST
Topological domaini111 – 12313CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini145 – 15713ExtracellularSequence AnalysisAdd
BLAST
Topological domaini184 – 1863CytoplasmicSequence Analysis
Topological domaini206 – 30398ExtracellularSequence AnalysisAdd
BLAST
Topological domaini325 – 35329CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini377 – 40630ExtracellularSequence AnalysisAdd
BLAST
Topological domaini431 – 44313CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini463 – 51048ExtracellularSequence AnalysisAdd
BLAST
Topological domaini533 – 695163CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini717 – 7182ExtracellularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 2920HelicalSequence AnalysisAdd
BLAST
Transmembranei39 – 5719HelicalSequence AnalysisAdd
BLAST
Transmembranei87 – 11024HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei158 – 18326HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20519HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST
Transmembranei354 – 37623HelicalSequence AnalysisAdd
BLAST
Transmembranei407 – 43024HelicalSequence AnalysisAdd
BLAST
Transmembranei444 – 46219HelicalSequence AnalysisAdd
BLAST
Transmembranei511 – 53222HelicalSequence AnalysisAdd
BLAST
Transmembranei696 – 71621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4146.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ9JKZ2.
KOiK14383.
OMAiSRYWKFI.
OrthoDBiEOG77126J.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKZ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRAVLEAADI AVVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVA
60 70 80 90 100
IGASLFVSNI GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI
110 120 130 140 150
YIRSGVYTMP EYLSKRFGGH RIQVYFAALS LLLYIFTKLS VDLYSGALFI
160 170 180 190 200
QESLGWNLYV SVILLIGMTA LLTVTGGLVA VIYTDTLQAL LMIIGALTLM
210 220 230 240 250
VISMVKIGGF EEVKRRYMLA SPDVASILLK YNLSNTNACM VHPKANALKM
260 270 280 290 300
LRDPTDEDVP WPGFILGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL
310 320 330 340 350
MAGFLKLLPM FIIVVPGMIS RIVFADEIAC INPEHCMQVC GSRAGCSNIA
360 370 380 390 400
YPRLVMTLVP VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRK
410 420 430 440 450
SASSRELMIV GRIFVAFMVV ISIAWVPIIV EMQGGQMYLY IQEVADYLTP
460 470 480 490 500
PVAALFLLAI FWKRCNEQGA FYGGMAGFVL GAVRLILAFT YRAPECDQPD
510 520 530 540 550
NRPGFIKDIH YMYVATALFW ITGLITVIVS LLTPPPTKDQ IRTTTFWSKK
560 570 580 590 600
TLVTKESCSQ KDEPYKMQEK SILQCSENSE VISHTIPNGK SEDSIKGLQP
610 620 630 640 650
EDVNLLVTCR EEGNPVASMG HSEAETPVDA YSNGQAALMG EREREKETEN
660 670 680 690 700
RSRYWKFIDW FCGFKSKSLS KRSLRDLMDE EAVCLQMLEE TPQVKVILNI
710
GLFAVCSLGI FMFVYFSL
Length:718
Mass (Da):79,583
Last modified:July 27, 2011 - v2
Checksum:iD0371D6ECF08503B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti653 – 6531R → Q in AAF43668. (PubMed:10773690)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220915 Genomic DNA. Translation: AAF43668.1.
CH466602 Genomic DNA. Translation: EDL03793.1.
BC140982 mRNA. Translation: AAI40983.1.
BC140983 mRNA. Translation: AAI40984.1.
CCDSiCCDS37403.1.
RefSeqiNP_059087.2. NM_017391.3.
UniGeneiMm.217354.
Mm.451146.

Genome annotation databases

EnsembliENSMUST00000113975; ENSMUSP00000109608; ENSMUSG00000089774.
GeneIDi53881.
KEGGimmu:53881.
UCSCiuc007zyt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220915 Genomic DNA. Translation: AAF43668.1 .
CH466602 Genomic DNA. Translation: EDL03793.1 .
BC140982 mRNA. Translation: AAI40983.1 .
BC140983 mRNA. Translation: AAI40984.1 .
CCDSi CCDS37403.1.
RefSeqi NP_059087.2. NM_017391.3.
UniGenei Mm.217354.
Mm.451146.

3D structure databases

ProteinModelPortali Q9JKZ2.
SMRi Q9JKZ2. Positions 9-476.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9JKZ2.

Proteomic databases

MaxQBi Q9JKZ2.
PaxDbi Q9JKZ2.
PRIDEi Q9JKZ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113975 ; ENSMUSP00000109608 ; ENSMUSG00000089774 .
GeneIDi 53881.
KEGGi mmu:53881.
UCSCi uc007zyt.2. mouse.

Organism-specific databases

CTDi 6526.
MGIi MGI:1858226. Slc5a3.

Phylogenomic databases

eggNOGi COG4146.
GeneTreei ENSGT00760000118955.
HOGENOMi HOG000025422.
HOVERGENi HBG052859.
InParanoidi Q9JKZ2.
KOi K14383.
OMAi SRYWKFI.
OrthoDBi EOG77126J.
TreeFami TF352855.

Miscellaneous databases

NextBioi 310757.
PROi Q9JKZ2.
SOURCEi Search...

Gene expression databases

Bgeei Q9JKZ2.
ExpressionAtlasi Q9JKZ2. baseline and differential.
Genevestigatori Q9JKZ2.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine chromosome 16 telomeric region, homologous with human chromosome 21q22, contains the osmoregulatory Na(+)/myo-inositol cotransporter (SLC5A3) gene."
    McVeigh K.E., Mallee J.J., Lucente A., Barnoski B.L., Wu S., Berry G.T.
    Cytogenet. Cell Genet. 88:153-158(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Sodium-dependent myo-inositol transporter 1 is a cellular receptor for Mus cervicolor M813 murine leukemia virus."
    Hein S., Prassolov V., Zhang Y., Ivanov D., Lohler J., Ross S.R., Stocking C.
    J. Virol. 77:5926-5932(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS M813 MURINE LEUKEMIA VIRUS RECEPTOR, TOPOLOGY.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSC5A3_MOUSE
AccessioniPrimary (citable) accession number: Q9JKZ2
Secondary accession number(s): B2RU60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3