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Protein

Sodium/myo-inositol cotransporter

Gene

Slc5a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.1 Publication
Functions as a retroviral receptor for M813 murine leukemia virus (MuLV) entry.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei24Implicated in sodium couplingBy similarity1
Sitei285Implicated in sodium couplingBy similarity1

GO - Molecular functioni

GO - Biological processi

  • inositol metabolic process Source: MGI
  • myo-inositol transport Source: MGI
  • peripheral nervous system development Source: MGI
  • regulation of respiratory gaseous exchange Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-429593. Inositol transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/myo-inositol cotransporter
Short name:
Na(+)/myo-inositol cotransporter
Alternative name(s):
Sodium/myo-inositol transporter 1
Short name:
SMIT1
Solute carrier family 5 member 3
Gene namesi
Name:Slc5a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1858226. Slc5a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 29HelicalSequence analysisAdd BLAST20
Topological domaini30 – 38CytoplasmicSequence analysis9
Transmembranei39 – 57HelicalSequence analysisAdd BLAST19
Topological domaini58 – 86ExtracellularSequence analysisAdd BLAST29
Transmembranei87 – 110HelicalSequence analysisAdd BLAST24
Topological domaini111 – 123CytoplasmicSequence analysisAdd BLAST13
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 157ExtracellularSequence analysisAdd BLAST13
Transmembranei158 – 183HelicalSequence analysisAdd BLAST26
Topological domaini184 – 186CytoplasmicSequence analysis3
Transmembranei187 – 205HelicalSequence analysisAdd BLAST19
Topological domaini206 – 303ExtracellularSequence analysisAdd BLAST98
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 353CytoplasmicSequence analysisAdd BLAST29
Transmembranei354 – 376HelicalSequence analysisAdd BLAST23
Topological domaini377 – 406ExtracellularSequence analysisAdd BLAST30
Transmembranei407 – 430HelicalSequence analysisAdd BLAST24
Topological domaini431 – 443CytoplasmicSequence analysisAdd BLAST13
Transmembranei444 – 462HelicalSequence analysisAdd BLAST19
Topological domaini463 – 510ExtracellularSequence analysisAdd BLAST48
Transmembranei511 – 532HelicalSequence analysisAdd BLAST22
Topological domaini533 – 695CytoplasmicSequence analysisAdd BLAST163
Transmembranei696 – 716HelicalSequence analysisAdd BLAST21
Topological domaini717 – 718ExtracellularSequence analysis2

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053821 – 718Sodium/myo-inositol cotransporterAdd BLAST718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Modified residuei594PhosphoserineBy similarity1
Modified residuei632PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9JKZ2.
PaxDbiQ9JKZ2.
PeptideAtlasiQ9JKZ2.
PRIDEiQ9JKZ2.

PTM databases

iPTMnetiQ9JKZ2.
PhosphoSitePlusiQ9JKZ2.
SwissPalmiQ9JKZ2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000089774.
ExpressionAtlasiQ9JKZ2. baseline and differential.
GenevisibleiQ9JKZ2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109608.

Structurei

3D structure databases

ProteinModelPortaliQ9JKZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ9JKZ2.
KOiK14383.
OMAiTKESCSQ.
OrthoDBiEOG091G077U.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVLEAADI AVVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVA
60 70 80 90 100
IGASLFVSNI GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI
110 120 130 140 150
YIRSGVYTMP EYLSKRFGGH RIQVYFAALS LLLYIFTKLS VDLYSGALFI
160 170 180 190 200
QESLGWNLYV SVILLIGMTA LLTVTGGLVA VIYTDTLQAL LMIIGALTLM
210 220 230 240 250
VISMVKIGGF EEVKRRYMLA SPDVASILLK YNLSNTNACM VHPKANALKM
260 270 280 290 300
LRDPTDEDVP WPGFILGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL
310 320 330 340 350
MAGFLKLLPM FIIVVPGMIS RIVFADEIAC INPEHCMQVC GSRAGCSNIA
360 370 380 390 400
YPRLVMTLVP VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRK
410 420 430 440 450
SASSRELMIV GRIFVAFMVV ISIAWVPIIV EMQGGQMYLY IQEVADYLTP
460 470 480 490 500
PVAALFLLAI FWKRCNEQGA FYGGMAGFVL GAVRLILAFT YRAPECDQPD
510 520 530 540 550
NRPGFIKDIH YMYVATALFW ITGLITVIVS LLTPPPTKDQ IRTTTFWSKK
560 570 580 590 600
TLVTKESCSQ KDEPYKMQEK SILQCSENSE VISHTIPNGK SEDSIKGLQP
610 620 630 640 650
EDVNLLVTCR EEGNPVASMG HSEAETPVDA YSNGQAALMG EREREKETEN
660 670 680 690 700
RSRYWKFIDW FCGFKSKSLS KRSLRDLMDE EAVCLQMLEE TPQVKVILNI
710
GLFAVCSLGI FMFVYFSL
Length:718
Mass (Da):79,583
Last modified:July 27, 2011 - v2
Checksum:iD0371D6ECF08503B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti653R → Q in AAF43668 (PubMed:10773690).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220915 Genomic DNA. Translation: AAF43668.1.
CH466602 Genomic DNA. Translation: EDL03793.1.
BC140982 mRNA. Translation: AAI40983.1.
BC140983 mRNA. Translation: AAI40984.1.
CCDSiCCDS37403.1.
RefSeqiNP_059087.2. NM_017391.3.
UniGeneiMm.217354.
Mm.451146.

Genome annotation databases

EnsembliENSMUST00000113975; ENSMUSP00000109608; ENSMUSG00000089774.
GeneIDi53881.
KEGGimmu:53881.
UCSCiuc007zyt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220915 Genomic DNA. Translation: AAF43668.1.
CH466602 Genomic DNA. Translation: EDL03793.1.
BC140982 mRNA. Translation: AAI40983.1.
BC140983 mRNA. Translation: AAI40984.1.
CCDSiCCDS37403.1.
RefSeqiNP_059087.2. NM_017391.3.
UniGeneiMm.217354.
Mm.451146.

3D structure databases

ProteinModelPortaliQ9JKZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109608.

PTM databases

iPTMnetiQ9JKZ2.
PhosphoSitePlusiQ9JKZ2.
SwissPalmiQ9JKZ2.

Proteomic databases

MaxQBiQ9JKZ2.
PaxDbiQ9JKZ2.
PeptideAtlasiQ9JKZ2.
PRIDEiQ9JKZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113975; ENSMUSP00000109608; ENSMUSG00000089774.
GeneIDi53881.
KEGGimmu:53881.
UCSCiuc007zyt.2. mouse.

Organism-specific databases

CTDi6526.
MGIiMGI:1858226. Slc5a3.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ9JKZ2.
KOiK14383.
OMAiTKESCSQ.
OrthoDBiEOG091G077U.
TreeFamiTF352855.

Enzyme and pathway databases

ReactomeiR-MMU-429593. Inositol transporters.

Miscellaneous databases

PROiQ9JKZ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000089774.
ExpressionAtlasiQ9JKZ2. baseline and differential.
GenevisibleiQ9JKZ2. MM.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A3_MOUSE
AccessioniPrimary (citable) accession number: Q9JKZ2
Secondary accession number(s): B2RU60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.