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Q9JKZ2

- SC5A3_MOUSE

UniProt

Q9JKZ2 - SC5A3_MOUSE

Protein

Sodium/myo-inositol cotransporter

Gene

Slc5a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.1 Publication
    Functions as a retroviral receptor for M813 murine leukemia virus (MuLV) entry.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei24 – 241Implicated in sodium couplingBy similarity
    Sitei285 – 2851Implicated in sodium couplingBy similarity

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. inositol metabolic process Source: MGI
    2. myo-inositol transport Source: MGI
    3. peripheral nervous system development Source: MGI
    4. regulation of respiratory gaseous exchange Source: MGI
    5. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/myo-inositol cotransporter
    Short name:
    Na(+)/myo-inositol cotransporter
    Alternative name(s):
    Sodium/myo-inositol transporter 1
    Short name:
    SMIT1
    Solute carrier family 5 member 3
    Gene namesi
    Name:Slc5a3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1858226. Slc5a3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 718718Sodium/myo-inositol cotransporterPRO_0000105382Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9JKZ2.
    PRIDEiQ9JKZ2.

    PTM databases

    PhosphoSiteiQ9JKZ2.

    Expressioni

    Gene expression databases

    BgeeiQ9JKZ2.
    GenevestigatoriQ9JKZ2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JKZ2.
    SMRiQ9JKZ2. Positions 9-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99ExtracellularSequence Analysis
    Topological domaini30 – 389CytoplasmicSequence Analysis
    Topological domaini58 – 8629ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini111 – 12313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini145 – 15713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 1863CytoplasmicSequence Analysis
    Topological domaini206 – 30398ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini325 – 35329CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini377 – 40630ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini431 – 44313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini463 – 51048ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini533 – 695163CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini717 – 7182ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 2920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei39 – 5719HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 11024HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 18326HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20519HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei354 – 37623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei407 – 43024HelicalSequence AnalysisAdd
    BLAST
    Transmembranei444 – 46219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei511 – 53222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei696 – 71621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4146.
    GeneTreeiENSGT00550000074313.
    HOGENOMiHOG000025422.
    HOVERGENiHBG052859.
    InParanoidiB2RU60.
    KOiK14383.
    OMAiSRYWKFI.
    OrthoDBiEOG77126J.
    TreeFamiTF352855.

    Family and domain databases

    InterProiIPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view]
    PANTHERiPTHR11819. PTHR11819. 1 hit.
    PfamiPF00474. SSF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00813. sss. 1 hit.
    PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JKZ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAVLEAADI AVVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVA    50
    IGASLFVSNI GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI 100
    YIRSGVYTMP EYLSKRFGGH RIQVYFAALS LLLYIFTKLS VDLYSGALFI 150
    QESLGWNLYV SVILLIGMTA LLTVTGGLVA VIYTDTLQAL LMIIGALTLM 200
    VISMVKIGGF EEVKRRYMLA SPDVASILLK YNLSNTNACM VHPKANALKM 250
    LRDPTDEDVP WPGFILGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL 300
    MAGFLKLLPM FIIVVPGMIS RIVFADEIAC INPEHCMQVC GSRAGCSNIA 350
    YPRLVMTLVP VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRK 400
    SASSRELMIV GRIFVAFMVV ISIAWVPIIV EMQGGQMYLY IQEVADYLTP 450
    PVAALFLLAI FWKRCNEQGA FYGGMAGFVL GAVRLILAFT YRAPECDQPD 500
    NRPGFIKDIH YMYVATALFW ITGLITVIVS LLTPPPTKDQ IRTTTFWSKK 550
    TLVTKESCSQ KDEPYKMQEK SILQCSENSE VISHTIPNGK SEDSIKGLQP 600
    EDVNLLVTCR EEGNPVASMG HSEAETPVDA YSNGQAALMG EREREKETEN 650
    RSRYWKFIDW FCGFKSKSLS KRSLRDLMDE EAVCLQMLEE TPQVKVILNI 700
    GLFAVCSLGI FMFVYFSL 718
    Length:718
    Mass (Da):79,583
    Last modified:July 27, 2011 - v2
    Checksum:iD0371D6ECF08503B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti653 – 6531R → Q in AAF43668. (PubMed:10773690)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220915 Genomic DNA. Translation: AAF43668.1.
    CH466602 Genomic DNA. Translation: EDL03793.1.
    BC140982 mRNA. Translation: AAI40983.1.
    BC140983 mRNA. Translation: AAI40984.1.
    CCDSiCCDS37403.1.
    RefSeqiNP_059087.2. NM_017391.3.
    UniGeneiMm.217354.
    Mm.451146.

    Genome annotation databases

    EnsembliENSMUST00000113975; ENSMUSP00000109608; ENSMUSG00000089774.
    GeneIDi53881.
    KEGGimmu:53881.
    UCSCiuc007zyt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220915 Genomic DNA. Translation: AAF43668.1 .
    CH466602 Genomic DNA. Translation: EDL03793.1 .
    BC140982 mRNA. Translation: AAI40983.1 .
    BC140983 mRNA. Translation: AAI40984.1 .
    CCDSi CCDS37403.1.
    RefSeqi NP_059087.2. NM_017391.3.
    UniGenei Mm.217354.
    Mm.451146.

    3D structure databases

    ProteinModelPortali Q9JKZ2.
    SMRi Q9JKZ2. Positions 9-476.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JKZ2.

    Proteomic databases

    PaxDbi Q9JKZ2.
    PRIDEi Q9JKZ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000113975 ; ENSMUSP00000109608 ; ENSMUSG00000089774 .
    GeneIDi 53881.
    KEGGi mmu:53881.
    UCSCi uc007zyt.2. mouse.

    Organism-specific databases

    CTDi 6526.
    MGIi MGI:1858226. Slc5a3.

    Phylogenomic databases

    eggNOGi COG4146.
    GeneTreei ENSGT00550000074313.
    HOGENOMi HOG000025422.
    HOVERGENi HBG052859.
    InParanoidi B2RU60.
    KOi K14383.
    OMAi SRYWKFI.
    OrthoDBi EOG77126J.
    TreeFami TF352855.

    Miscellaneous databases

    NextBioi 310757.
    PROi Q9JKZ2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JKZ2.
    Genevestigatori Q9JKZ2.

    Family and domain databases

    InterProi IPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view ]
    PANTHERi PTHR11819. PTHR11819. 1 hit.
    Pfami PF00474. SSF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00813. sss. 1 hit.
    PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine chromosome 16 telomeric region, homologous with human chromosome 21q22, contains the osmoregulatory Na(+)/myo-inositol cotransporter (SLC5A3) gene."
      McVeigh K.E., Mallee J.J., Lucente A., Barnoski B.L., Wu S., Berry G.T.
      Cytogenet. Cell Genet. 88:153-158(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Sodium-dependent myo-inositol transporter 1 is a cellular receptor for Mus cervicolor M813 murine leukemia virus."
      Hein S., Prassolov V., Zhang Y., Ivanov D., Lohler J., Ross S.R., Stocking C.
      J. Virol. 77:5926-5932(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS M813 MURINE LEUKEMIA VIRUS RECEPTOR, TOPOLOGY.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSC5A3_MOUSE
    AccessioniPrimary (citable) accession number: Q9JKZ2
    Secondary accession number(s): B2RU60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3