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Q9JKZ2

- SC5A3_MOUSE

UniProt

Q9JKZ2 - SC5A3_MOUSE

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Protein

Sodium/myo-inositol cotransporter

Gene
Slc5a3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.1 Publication
Functions as a retroviral receptor for M813 murine leukemia virus (MuLV) entry.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei24 – 241Implicated in sodium coupling By similarity
Sitei285 – 2851Implicated in sodium coupling By similarity

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. inositol metabolic process Source: MGI
  2. myo-inositol transport Source: MGI
  3. peripheral nervous system development Source: MGI
  4. regulation of respiratory gaseous exchange Source: MGI
  5. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/myo-inositol cotransporter
Short name:
Na(+)/myo-inositol cotransporter
Alternative name(s):
Sodium/myo-inositol transporter 1
Short name:
SMIT1
Solute carrier family 5 member 3
Gene namesi
Name:Slc5a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1858226. Slc5a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Extracellular Reviewed prediction
Transmembranei10 – 2920Helical; Reviewed predictionAdd
BLAST
Topological domaini30 – 389Cytoplasmic Reviewed prediction
Transmembranei39 – 5719Helical; Reviewed predictionAdd
BLAST
Topological domaini58 – 8629Extracellular Reviewed predictionAdd
BLAST
Transmembranei87 – 11024Helical; Reviewed predictionAdd
BLAST
Topological domaini111 – 12313Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei124 – 14421Helical; Reviewed predictionAdd
BLAST
Topological domaini145 – 15713Extracellular Reviewed predictionAdd
BLAST
Transmembranei158 – 18326Helical; Reviewed predictionAdd
BLAST
Topological domaini184 – 1863Cytoplasmic Reviewed prediction
Transmembranei187 – 20519Helical; Reviewed predictionAdd
BLAST
Topological domaini206 – 30398Extracellular Reviewed predictionAdd
BLAST
Transmembranei304 – 32421Helical; Reviewed predictionAdd
BLAST
Topological domaini325 – 35329Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei354 – 37623Helical; Reviewed predictionAdd
BLAST
Topological domaini377 – 40630Extracellular Reviewed predictionAdd
BLAST
Transmembranei407 – 43024Helical; Reviewed predictionAdd
BLAST
Topological domaini431 – 44313Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei444 – 46219Helical; Reviewed predictionAdd
BLAST
Topological domaini463 – 51048Extracellular Reviewed predictionAdd
BLAST
Transmembranei511 – 53222Helical; Reviewed predictionAdd
BLAST
Topological domaini533 – 695163Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei696 – 71621Helical; Reviewed predictionAdd
BLAST
Topological domaini717 – 7182Extracellular Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 718718Sodium/myo-inositol cotransporterPRO_0000105382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi232 – 2321N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JKZ2.
PRIDEiQ9JKZ2.

PTM databases

PhosphoSiteiQ9JKZ2.

Expressioni

Gene expression databases

BgeeiQ9JKZ2.
GenevestigatoriQ9JKZ2.

Structurei

3D structure databases

ProteinModelPortaliQ9JKZ2.
SMRiQ9JKZ2. Positions 9-476.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4146.
GeneTreeiENSGT00550000074313.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiB2RU60.
KOiK14383.
OMAiSRYWKFI.
OrthoDBiEOG77126J.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKZ2-1 [UniParc]FASTAAdd to Basket

« Hide

MRAVLEAADI AVVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVA    50
IGASLFVSNI GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI 100
YIRSGVYTMP EYLSKRFGGH RIQVYFAALS LLLYIFTKLS VDLYSGALFI 150
QESLGWNLYV SVILLIGMTA LLTVTGGLVA VIYTDTLQAL LMIIGALTLM 200
VISMVKIGGF EEVKRRYMLA SPDVASILLK YNLSNTNACM VHPKANALKM 250
LRDPTDEDVP WPGFILGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL 300
MAGFLKLLPM FIIVVPGMIS RIVFADEIAC INPEHCMQVC GSRAGCSNIA 350
YPRLVMTLVP VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRK 400
SASSRELMIV GRIFVAFMVV ISIAWVPIIV EMQGGQMYLY IQEVADYLTP 450
PVAALFLLAI FWKRCNEQGA FYGGMAGFVL GAVRLILAFT YRAPECDQPD 500
NRPGFIKDIH YMYVATALFW ITGLITVIVS LLTPPPTKDQ IRTTTFWSKK 550
TLVTKESCSQ KDEPYKMQEK SILQCSENSE VISHTIPNGK SEDSIKGLQP 600
EDVNLLVTCR EEGNPVASMG HSEAETPVDA YSNGQAALMG EREREKETEN 650
RSRYWKFIDW FCGFKSKSLS KRSLRDLMDE EAVCLQMLEE TPQVKVILNI 700
GLFAVCSLGI FMFVYFSL 718
Length:718
Mass (Da):79,583
Last modified:July 27, 2011 - v2
Checksum:iD0371D6ECF08503B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti653 – 6531R → Q in AAF43668. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220915 Genomic DNA. Translation: AAF43668.1.
CH466602 Genomic DNA. Translation: EDL03793.1.
BC140982 mRNA. Translation: AAI40983.1.
BC140983 mRNA. Translation: AAI40984.1.
CCDSiCCDS37403.1.
RefSeqiNP_059087.2. NM_017391.3.
UniGeneiMm.217354.
Mm.451146.

Genome annotation databases

EnsembliENSMUST00000113975; ENSMUSP00000109608; ENSMUSG00000089774.
GeneIDi53881.
KEGGimmu:53881.
UCSCiuc007zyt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220915 Genomic DNA. Translation: AAF43668.1 .
CH466602 Genomic DNA. Translation: EDL03793.1 .
BC140982 mRNA. Translation: AAI40983.1 .
BC140983 mRNA. Translation: AAI40984.1 .
CCDSi CCDS37403.1.
RefSeqi NP_059087.2. NM_017391.3.
UniGenei Mm.217354.
Mm.451146.

3D structure databases

ProteinModelPortali Q9JKZ2.
SMRi Q9JKZ2. Positions 9-476.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9JKZ2.

Proteomic databases

PaxDbi Q9JKZ2.
PRIDEi Q9JKZ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113975 ; ENSMUSP00000109608 ; ENSMUSG00000089774 .
GeneIDi 53881.
KEGGi mmu:53881.
UCSCi uc007zyt.2. mouse.

Organism-specific databases

CTDi 6526.
MGIi MGI:1858226. Slc5a3.

Phylogenomic databases

eggNOGi COG4146.
GeneTreei ENSGT00550000074313.
HOGENOMi HOG000025422.
HOVERGENi HBG052859.
InParanoidi B2RU60.
KOi K14383.
OMAi SRYWKFI.
OrthoDBi EOG77126J.
TreeFami TF352855.

Miscellaneous databases

NextBioi 310757.
PROi Q9JKZ2.
SOURCEi Search...

Gene expression databases

Bgeei Q9JKZ2.
Genevestigatori Q9JKZ2.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine chromosome 16 telomeric region, homologous with human chromosome 21q22, contains the osmoregulatory Na(+)/myo-inositol cotransporter (SLC5A3) gene."
    McVeigh K.E., Mallee J.J., Lucente A., Barnoski B.L., Wu S., Berry G.T.
    Cytogenet. Cell Genet. 88:153-158(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Sodium-dependent myo-inositol transporter 1 is a cellular receptor for Mus cervicolor M813 murine leukemia virus."
    Hein S., Prassolov V., Zhang Y., Ivanov D., Lohler J., Ross S.R., Stocking C.
    J. Virol. 77:5926-5932(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS M813 MURINE LEUKEMIA VIRUS RECEPTOR, TOPOLOGY.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSC5A3_MOUSE
AccessioniPrimary (citable) accession number: Q9JKZ2
Secondary accession number(s): B2RU60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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