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Protein
Submitted name:

Cytochrome P450 CYP2D22

Gene

Cyp2d22

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211981. Xenobiotics.

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450 CYP2D22Imported
Submitted name:
MCG20388, isoform CRA_bImported
Submitted name:
Protein Cyp2d22Imported
Gene namesi
Name:Cyp2d22Imported
ORF Names:mCG_20388Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1929474. Cyp2d22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2820HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

MINTiMINT-4130200.
STRINGi10090.ENSMUSP00000023083.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOVERGENiHBG015789.
KOiK07414.
OMAiVTEEARC.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPTGAELW PIAIFTVIFL ILVNLMHWRQ RWTAHYPPGP MPWPVLGNLL
60 70 80 90 100
HMDFQNMPAG FQKLRGRYGD LFSLQLASES VVVLNGLTAL REALVKHSED
110 120 130 140 150
TADRPPLHFN DLLGFGPRSQ GIVLARYGPA WRQQRRFSVS TMHHFGLGKK
160 170 180 190 200
SLEQWVTEEA RCLCAAFADH TGHPFSPNTL LDKAVCNVIA SLLYACRFEY
210 220 230 240 250
DDPRFIRLLG LLKETLKEEA GFLPMFLNVF PMLLRIPGLV GKVFPGKRAF
260 270 280 290 300
VTMLDELLAE HKTTWDPTQP PRDLTDAFLA EVEKAKGNPE SSFNDENLRT
310 320 330 340 350
VVGDLFSAGM VTTSTTLSWA LMLMILHPDV QRRVQQEIDE VIGQVQCPEM
360 370 380 390 400
ADQARMPYTN AVIHEVQRFA DILPLGVPHK TSRDIELQGF LIPKGTTLIT
410 420 430 440 450
NLSSALKDET VWEKPLCFHP EHFLDAQGHF VKPEAFMPFS AGRRSCLGEP
460 470 480 490 500
LARMELFLFF TCLLQRFSIS VPDGQPQPSD HGVFRALTTP CPYQLCALPR
Length:500
Mass (Da):56,468
Last modified:October 1, 2000 - v1
Checksum:iFACB35854CBC3F1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104325 Genomic DNA. No translation available.
AC113593 Genomic DNA. No translation available.
AF221525 mRNA. Translation: AAF34652.1.
CH466550 Genomic DNA. Translation: EDL04505.1.
RefSeqiNP_001156944.1. NM_001163472.1.
NP_062797.3. NM_019823.4.
UniGeneiMm.474216.

Genome annotation databases

EnsembliENSMUST00000023083; ENSMUSP00000023083; ENSMUSG00000061740.
GeneIDi56448.
KEGGimmu:56448.
UCSCiuc007wzd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104325 Genomic DNA. No translation available.
AC113593 Genomic DNA. No translation available.
AF221525 mRNA. Translation: AAF34652.1.
CH466550 Genomic DNA. Translation: EDL04505.1.
RefSeqiNP_001156944.1. NM_001163472.1.
NP_062797.3. NM_019823.4.
UniGeneiMm.474216.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4130200.
STRINGi10090.ENSMUSP00000023083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023083; ENSMUSP00000023083; ENSMUSG00000061740.
GeneIDi56448.
KEGGimmu:56448.
UCSCiuc007wzd.2. mouse.

Organism-specific databases

CTDi56448.
MGIiMGI:1929474. Cyp2d22.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOVERGENiHBG015789.
KOiK07414.
OMAiVTEEARC.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiR-MMU-211981. Xenobiotics.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells."
    Blume N., Leonard J., Xu Z.J., Watanabe O., Remotti H., Fishman J.
    Arch. Biochem. Biophys. 381:191-204(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9JKY7_MOUSE
AccessioniPrimary (citable) accession number: Q9JKY7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.