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Protein

Huntingtin-interacting protein 1-related protein

Gene

Hip1r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.

GO - Molecular functioni

  • actin binding Source: MGI
  • actin filament binding Source: ParkinsonsUK-UCL
  • clathrin adaptor activity Source: ParkinsonsUK-UCL
  • clathrin binding Source: ParkinsonsUK-UCL
  • clathrin light chain binding Source: ParkinsonsUK-UCL
  • identical protein binding Source: MGI
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: MGI
  • phosphatidylinositol-3,4-bisphosphate binding Source: MGI
  • phosphatidylinositol-3,5-bisphosphate binding Source: MGI
  • phosphatidylinositol-4,5-bisphosphate binding Source: MGI
  • phosphatidylinositol binding Source: UniProtKB
  • protein heterodimerization activity Source: ParkinsonsUK-UCL
  • protein homodimerization activity Source: ParkinsonsUK-UCL
  • SH3 domain binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • apoptotic process Source: InterPro
  • clathrin coat assembly Source: ParkinsonsUK-UCL
  • digestive system development Source: ParkinsonsUK-UCL
  • membrane organization Source: ParkinsonsUK-UCL
  • negative regulation of actin filament polymerization Source: ParkinsonsUK-UCL
  • negative regulation of apoptotic process Source: ParkinsonsUK-UCL
  • negative regulation of Arp2/3 complex-mediated actin nucleation Source: ParkinsonsUK-UCL
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of clathrin coat assembly Source: ParkinsonsUK-UCL
  • positive regulation of clathrin-dependent endocytosis Source: ParkinsonsUK-UCL
  • positive regulation of epidermal growth factor receptor signaling pathway Source: MGI
  • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: MGI
  • positive regulation of platelet-derived growth factor receptor-beta signaling pathway Source: MGI
  • positive regulation of protein binding Source: MGI
  • protein stabilization Source: MGI
  • receptor-mediated endocytosis Source: MGI
  • regulation of actin cytoskeleton organization Source: ParkinsonsUK-UCL
  • regulation of clathrin-dependent endocytosis Source: ParkinsonsUK-UCL
  • regulation of endocytosis Source: MGI
  • regulation of gastric acid secretion Source: ParkinsonsUK-UCL

Keywordsi

Molecular functionActin-binding
Biological processEndocytosis

Enzyme and pathway databases

ReactomeiR-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Huntingtin-interacting protein 1-related protein
Short name:
HIP1-related protein
Gene namesi
Name:Hip1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1352504 Hip1r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Disruption phenotypei

Hip1 and Hip1r double knockout mice are dwarfed, afflicted with severe vertebral defects and die in early adulthood.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839851 – 1068Huntingtin-interacting protein 1-related proteinAdd BLAST1068

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9JKY5
MaxQBiQ9JKY5
PaxDbiQ9JKY5
PRIDEiQ9JKY5

PTM databases

iPTMnetiQ9JKY5
PhosphoSitePlusiQ9JKY5

Expressioni

Tissue specificityi

Widely expressed. Expressed at lower levels in skeletal muscle and heart. The level of expression does not change appreciably during development.

Gene expression databases

BgeeiENSMUSG00000000915
CleanExiMM_HIP1R
ExpressionAtlasiQ9JKY5 baseline and differential
GenevisibleiQ9JKY5 MM

Interactioni

Subunit structurei

Interacts with actin. Does not interact with huntingtin (By similarity). Interacts with CLTB and HIP1. Homodimer. Homodimerization promotes actin binding.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin binding Source: MGI
  • actin filament binding Source: ParkinsonsUK-UCL
  • clathrin adaptor activity Source: ParkinsonsUK-UCL
  • clathrin binding Source: ParkinsonsUK-UCL
  • clathrin light chain binding Source: ParkinsonsUK-UCL
  • identical protein binding Source: MGI
  • protein heterodimerization activity Source: ParkinsonsUK-UCL
  • protein homodimerization activity Source: ParkinsonsUK-UCL
  • SH3 domain binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi205896, 2 interactors
IntActiQ9JKY5, 8 interactors
MINTiQ9JKY5
STRINGi10090.ENSMUSP00000000939

Structurei

3D structure databases

ProteinModelPortaliQ9JKY5
SMRiQ9JKY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 151ENTHPROSITE-ProRule annotationAdd BLAST129
Domaini771 – 1012I/LWEQPROSITE-ProRule annotationAdd BLAST242

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni867 – 924Important for actin bindingBy similarityAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili346 – 644Sequence analysisAdd BLAST299

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi311 – 316Poly-Glu6

Domaini

Binds F-actin via the talin-like I/LWEQ domain.

Sequence similaritiesi

Belongs to the SLA2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0980 Eukaryota
ENOG410XRXQ LUCA
GeneTreeiENSGT00550000074542
HOVERGENiHBG005968
InParanoidiQ9JKY5
KOiK20040
OMAiVFRQLNT
OrthoDBiEOG091G07Y5
TreeFamiTF316860

Family and domain databases

Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR011417 ANTH_dom
IPR013809 ENTH
IPR008942 ENTH_VHS
IPR032422 HIP1_clath-bd
IPR030555 HIP1R
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR030224 Sla2_fam
PANTHERiPTHR10407 PTHR10407, 1 hit
PTHR10407:SF10 PTHR10407:SF10, 1 hit
PfamiView protein in Pfam
PF07651 ANTH, 1 hit
PF16515 HIP1_clath_bdg, 1 hit
PF01608 I_LWEQ, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011820 ILWEQ, 1 hit
SMARTiView protein in SMART
SM00273 ENTH, 1 hit
SM00307 ILWEQ, 1 hit
SUPFAMiSSF109885 SSF109885, 1 hit
SSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50942 ENTH, 1 hit
PS50945 I_LWEQ, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JKY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSIKNVPAR VLSRRPGHSL EAEREQFDKT QAISISKAIN SQEAPVKEKH
60 70 80 90 100
ARRIILGTHH EKGAFTFWSY AIGLPLSSSS ILSWKFCHVL HKVLRDGHPN
110 120 130 140 150
VLHDYQRYRS NIREIGDLWG HLRDQYGHLV NIYTKLLLTK ISFHLKHPQF
160 170 180 190 200
PAGLEVTDEV LEKAAGTDVN NIFQLTVEMF DYMDCELKLS ESVFRQLNTA
210 220 230 240 250
IAVSQMSSGQ CRLAPLIQVI QDCSHLYHYT VKLMFKLHSC LPADTLQGHR
260 270 280 290 300
DRFHEQFHSL KNFFRRASDM LYFKRLIQIP RLPEGPPNFL RASALAEHIK
310 320 330 340 350
PVVVIPEEAP EEEEPENLIE ISSAPPAGEP VVVADLFDQT FGPPNGSMKD
360 370 380 390 400
DRDLQIENLK REVETLRAEL EKIKMEAQRY ISQLKGQVNG LEAELEEQRK
410 420 430 440 450
QKQKALVDNE QLRHELAQLK ALQLEGARNQ GLREEAERKA SATEARYSKL
460 470 480 490 500
KEKHSELINT HAELLRKNAD TAKQLTVTQQ SQEEVARVKE QLAFQMEQAK
510 520 530 540 550
RESEMKMEEQ SDQLEKLKRE LAARAGELAR AQEALSRTEQ SGSELSSRLD
560 570 580 590 600
TLNAEKEALS GVVRQREAEL LAAQSLVREK EEALSQEQQR SSQEKGELRG
610 620 630 640 650
QLAEKESQEQ GLRQKLLDEQ LAVLRSAAAE AEAILQDAVS KLDDPLHLRC
660 670 680 690 700
TSSPDYLVSR AQAALDSVSG LEQGHTQYLA SSEDASALVA ALTRFSHLAA
710 720 730 740 750
DTIVNGAATS HLAPTDPADR LMDTCRECGA RALELVGQLQ DQTVLPRAQP
760 770 780 790 800
SLMRAPLQGI LQLGQDLKPK SLDVRQEELG AMVDKEMAAT SAAIEDAVRR
810 820 830 840 850
IEDMMSQARH ESSGVKLEVN ERILNSCTDL MKAIRLLVMT STSLQKEIVE
860 870 880 890 900
SGRGAATQQE FYAKNSRWTE GLISASKAVG WGATQLVESA DKVVLHMGKY
910 920 930 940 950
EELIVCSHEI AASTAQLVAA SKVKANKNSP HLSRLQECSR TVNERAANVV
960 970 980 990 1000
ASTKSGQEQI EDRDTMDFSG LSLIKLKKQE METQVRVLEL EKTLEAERVR
1010 1020 1030 1040 1050
LGELRKQHYV LAGGMGTPSE EEPSRPSPAP RSGATKKPPL AQKPSIAPRT
1060
DNQLDKKDGV YPAQLVNY
Length:1,068
Mass (Da):119,426
Last modified:July 27, 2011 - v2
Checksum:i992FD4D3FA3F8A6C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti746P → R in AAF34662 (PubMed:10613908).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221713 mRNA Translation: AAF34662.1
AK146663 mRNA Translation: BAE27341.1
CCDSiCCDS39276.1
RefSeqiNP_659507.3, NM_145070.3
UniGeneiMm.149954

Genome annotation databases

EnsembliENSMUST00000000939; ENSMUSP00000000939; ENSMUSG00000000915
GeneIDi29816
KEGGimmu:29816
UCSCiuc008zos.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHIP1R_MOUSE
AccessioniPrimary (citable) accession number: Q9JKY5
Secondary accession number(s): Q3UJ14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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