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Protein

Uroplakin-3a

Gene

Upk3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).By similarity

GO - Biological processi

  • cell morphogenesis Source: MGI
  • epithelial cell differentiation Source: MGI
  • kidney development Source: MGI
  • potassium ion homeostasis Source: MGI
  • sodium ion homeostasis Source: MGI
  • urea transport Source: MGI
  • urinary bladder development Source: MGI
  • water transport Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-3a
Short name:
UP3a
Alternative name(s):
Uroplakin III
Short name:
UPIII
Gene namesi
Name:Upk3a
Synonyms:Upk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:98914. Upk3a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 207189LumenalSequence analysisAdd
BLAST
Transmembranei208 – 23528HelicalSequence analysisAdd
BLAST
Topological domaini236 – 28752CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 287269Uroplakin-3aPRO_0000022638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JKX8.
PRIDEiQ9JKX8.

PTM databases

iPTMnetiQ9JKX8.
PhosphoSiteiQ9JKX8.

Expressioni

Gene expression databases

BgeeiQ9JKX8.
CleanExiMM_UPK3A.
GenevisibleiQ9JKX8. MM.

Interactioni

Subunit structurei

Heterodimer with uroplakin-1B (UPK1B).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Snx31Q6P8Y74EBI-7947322,EBI-10636102

Protein-protein interaction databases

IntActiQ9JKX8. 3 interactions.
STRINGi10090.ENSMUSP00000023070.

Structurei

3D structure databases

ProteinModelPortaliQ9JKX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uroplakin-3 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE9T. Eukaryota.
ENOG41123W4. LUCA.
GeneTreeiENSGT00510000048620.
HOGENOMiHOG000143412.
HOVERGENiHBG058769.
InParanoidiQ9JKX8.
KOiK19520.
OMAiETTHDSQ.
OrthoDBiEOG7J9VQC.
PhylomeDBiQ9JKX8.
TreeFamiTF336628.

Family and domain databases

InterProiIPR024831. Uroplakin-3.
IPR024825. Uroplakin-3a.
[Graphical view]
PANTHERiPTHR15446. PTHR15446. 1 hit.
PTHR15446:SF17. PTHR15446:SF17. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLWALLAL GCLRCGWTVN LQPQLASVTF ATNNPTLTTV ALEKPLCMFD
60 70 80 90 100
SSEPLSGSYE VYLYAMVDSA MSRNVSVQDS AGVPLSTTFR QTQGGRSGPY
110 120 130 140 150
KAAAFDLTPC GDLPSLDAVG DVTQASEILN AYLVRVGNNG TCFWDPNFQG
160 170 180 190 200
LCNPPLTAAT EYRFKYVLVN MSTGLVQDQT LWSDPIWTNR PIPYSAIDTW
210 220 230 240 250
PGRRSGGMIV ITSILGSLPF FLLVGFAGAI ILSFVDMGSS DGEMTHDSQI
260 270 280
TQEAVPKTLG TSEPSYSSVN RGPPLDRAEV FSSKLQD
Length:287
Mass (Da):30,990
Last modified:May 26, 2009 - v3
Checksum:i44CF39DA6CA30E88
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 32LL → PP in AAF34681 (Ref. 1) Curated
Sequence conflicti187 – 1871W → R in AAF34681 (Ref. 1) Curated
Sequence conflicti195 – 1951S → L in AAF34681 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222750 mRNA. Translation: AAF34681.2.
DQ387454 mRNA. Translation: ABD52002.1.
CH466550 Genomic DNA. Translation: EDL04442.1.
BC125336 mRNA. Translation: AAI25337.1.
BC125338 mRNA. Translation: AAI25339.1.
CCDSiCCDS27716.1.
RefSeqiNP_075967.2. NM_023478.2.
UniGeneiMm.46214.

Genome annotation databases

EnsembliENSMUST00000023070; ENSMUSP00000023070; ENSMUSG00000022435.
GeneIDi22270.
KEGGimmu:22270.
UCSCiuc007xcs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222750 mRNA. Translation: AAF34681.2.
DQ387454 mRNA. Translation: ABD52002.1.
CH466550 Genomic DNA. Translation: EDL04442.1.
BC125336 mRNA. Translation: AAI25337.1.
BC125338 mRNA. Translation: AAI25339.1.
CCDSiCCDS27716.1.
RefSeqiNP_075967.2. NM_023478.2.
UniGeneiMm.46214.

3D structure databases

ProteinModelPortaliQ9JKX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JKX8. 3 interactions.
STRINGi10090.ENSMUSP00000023070.

PTM databases

iPTMnetiQ9JKX8.
PhosphoSiteiQ9JKX8.

Proteomic databases

PaxDbiQ9JKX8.
PRIDEiQ9JKX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023070; ENSMUSP00000023070; ENSMUSG00000022435.
GeneIDi22270.
KEGGimmu:22270.
UCSCiuc007xcs.2. mouse.

Organism-specific databases

CTDi7380.
MGIiMGI:98914. Upk3a.

Phylogenomic databases

eggNOGiENOG410IE9T. Eukaryota.
ENOG41123W4. LUCA.
GeneTreeiENSGT00510000048620.
HOGENOMiHOG000143412.
HOVERGENiHBG058769.
InParanoidiQ9JKX8.
KOiK19520.
OMAiETTHDSQ.
OrthoDBiEOG7J9VQC.
PhylomeDBiQ9JKX8.
TreeFamiTF336628.

Miscellaneous databases

NextBioi302375.
PROiQ9JKX8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKX8.
CleanExiMM_UPK3A.
GenevisibleiQ9JKX8. MM.

Family and domain databases

InterProiIPR024831. Uroplakin-3.
IPR024825. Uroplakin-3a.
[Graphical view]
PANTHERiPTHR15446. PTHR15446. 1 hit.
PTHR15446:SF17. PTHR15446:SF17. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse uroplakin III cDNA."
    Kwon D.-N., Hwang K.-C., Chu H.-J.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Urinary bladder.
  2. "Origin of the tetraspanin uroplakins and their co-evolution with associated proteins: implications for uroplakin structure and function."
    Garcia-Espana A., Chung P.-J., Zhao X., Lee A., Pellicer A., Yu J., Sun T.-T., Desalle R.
    Mol. Phylogenet. Evol. 41:355-367(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Urinary bladder.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiUPK3A_MOUSE
AccessioniPrimary (citable) accession number: Q9JKX8
Secondary accession number(s): Q27QV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 26, 2009
Last modified: January 20, 2016
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.