UniProtKB - Q9JKX4 (AATF_MOUSE)
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Protein
Protein AATF
Gene
Aatf
Organism
Mus musculus (Mouse)
Status
Functioni
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity).By similarity
GO - Molecular functioni
- DNA binding transcription factor activity Source: Ensembl
- leucine zipper domain binding Source: MGI
- tau protein binding Source: Ensembl
GO - Biological processi
- cell adhesion Source: MGI
- cellular response to DNA damage stimulus Source: Ensembl
- embryonic cleavage Source: MGI
- negative regulation of amyloid precursor protein biosynthetic process Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of reactive oxygen species metabolic process Source: MGI
- negative regulation of superoxide anion generation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of mitotic cell cycle Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- ribosome biogenesis Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Protein AATFAlternative name(s): Apoptosis-antagonizing transcription factor Rb-binding protein Che-1 Traube protein |
Gene namesi | Name:Aatf Synonyms:Che1, Trb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929608. Aatf. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000056617 | 2 – 526 | Protein AATFAdd BLAST | 525 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 62 | PhosphoserineBy similarity | 1 | |
Modified residuei | 170 | PhosphoserineBy similarity | 1 | |
Modified residuei | 240 | PhosphoserineBy similarity | 1 | |
Modified residuei | 283 | PhosphoserineCombined sources | 1 | |
Modified residuei | 287 | PhosphoserineCombined sources | 1 | |
Modified residuei | 288 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9JKX4. |
PaxDbi | Q9JKX4. |
PeptideAtlasi | Q9JKX4. |
PRIDEi | Q9JKX4. |
PTM databases
iPTMneti | Q9JKX4. |
PhosphoSitePlusi | Q9JKX4. |
Expressioni
Tissue specificityi
Expressed in adrenal gland, brain (Purkinje cells), heart, kidney, liver, lung, muscle, ovary and testis (at the protein level).2 Publications
Developmental stagei
Expressed uniformly throughout the embryo until E10.5. From E11.5, the relative expression level increases in the liver, hind brain, spinal cord, dorsal root ganglia, and the posterior commissure.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000018697. |
CleanExi | MM_AATF. |
Genevisiblei | Q9JKX4. MM. |
Interactioni
Subunit structurei
Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT (By similarity).By similarity
GO - Molecular functioni
- leucine zipper domain binding Source: MGI
- tau protein binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 207901. 3 interactors. |
IntActi | Q9JKX4. 1 interactor. |
MINTi | Q9JKX4. |
STRINGi | 10090.ENSMUSP00000018841. |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 240 – 282 | Binds POLR2JBy similarityAdd BLAST | 43 | |
Regioni | 283 – 338 | Binds RB1By similarityAdd BLAST | 56 | |
Regioni | 339 – 438 | Binds RB1 and SP1By similarityAdd BLAST | 100 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 96 – 171 | Glu-richAdd BLAST | 76 |
Sequence similaritiesi
Belongs to the AATF family.Curated
Phylogenomic databases
eggNOGi | KOG2773. Eukaryota. ENOG410XWGK. LUCA. |
GeneTreei | ENSGT00390000000288. |
HOGENOMi | HOG000007555. |
HOVERGENi | HBG080805. |
InParanoidi | Q9JKX4. |
KOi | K14782. |
OMAi | EVLLKWD. |
OrthoDBi | EOG091G0F1H. |
PhylomeDBi | Q9JKX4. |
TreeFami | TF324341. |
Family and domain databases
InterProi | View protein in InterPro IPR025160. AATF. IPR012617. AATF_C. |
Pfami | View protein in Pfam PF13339. AATF-Che1. 1 hit. PF08164. TRAUB. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9JKX4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAAPQPLALQ LEQLLNPRPR EADPEADPEE ATRARVIDRF DEGEEEKDDL
60 70 80 90 100
AVSSIRKLAP VSLLDTDKRY SGKTTSRKAW KEDHWEQALP SSSDNEASDE
110 120 130 140 150
GGSEDGDSEG LGLEEISEDV DEDLEDNKIS DEGGSEDGDS EGLGLEEFSE
160 170 180 190 200
DVEEDLEGED EEDREEDRNS EDDGVVAAFS SVKVSEEVEK GRAVKNQIAL
210 220 230 240 250
WDQLLEGRIK LQKALLTTNQ LPQPDVFPVF KDKGGPEFAS ALKNSHKALK
260 270 280 290 300
ALLRSLVDLQ EELLFQYPDT RHIVNGAKPN TESEEISSED DELVGEKKKQ
310 320 330 340 350
RKAPPKRKLE MEDYPSFMAK RFADFTIYRN HTLQKWHDKT KLASGKLGKG
360 370 380 390 400
FGAFERSILT QIDHIMMDKE RLLRRTQTKR SAYRVLGKPE PVPEPVAETL
410 420 430 440 450
PGEPETLPQG PANAHLRDLD EEIFDDDDFY HQLLRELIER KTSSLDPNDQ
460 470 480 490 500
VAMGRQWLAI QKLRSKIRKK VDRKASKGRK LRFHVLSKLL SFMAPIDHTA
510 520
MSDDARTELF RSLFGQLNPP DADRGK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 – 3 | AA → GR in AAP73747 (PubMed:14636992).Curated | 2 | |
Sequence conflicti | 4 – 5 | Missing in AAP73747 (PubMed:14636992).Curated | 2 | |
Sequence conflicti | 45 | E → K in AAP73747 (PubMed:14636992).Curated | 1 | |
Sequence conflicti | 237 | E → K in AAP73747 (PubMed:14636992).Curated | 1 | |
Sequence conflicti | 247 | K → Q in AAP73747 (PubMed:14636992).Curated | 1 | |
Sequence conflicti | 258 | D → G in AAP73747 (PubMed:14636992).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014897 | 84 | H → P in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_014898 | 85 – 199 | Missing in isoform 2. 1 PublicationAdd BLAST | 115 | |
Alternative sequenceiVSP_014899 | 433 – 458 | LLREL…GRQWL → VRLFLSFLCYNKPGVCILEP LIVSSG in isoform 3. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_014900 | 459 – 526 | Missing in isoform 3. 1 PublicationAdd BLAST | 68 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF222801 mRNA. Translation: AAF26745.1. AK077789 mRNA. Translation: BAC37011.1. AL603708, AL672252 Genomic DNA. Translation: CAI25418.1. AL672252, AL603708 Genomic DNA. Translation: CAI26153.1. BC025080 mRNA. Translation: AAH25080.1. AF322223 Genomic DNA. Translation: AAK07639.1. AY306199 mRNA. Translation: AAP73747.1. |
CCDSi | CCDS25186.1. [Q9JKX4-1] |
RefSeqi | NP_062790.1. NM_019816.1. [Q9JKX4-1] |
UniGenei | Mm.257482. |
Genome annotation databases
Ensembli | ENSMUST00000018841; ENSMUSP00000018841; ENSMUSG00000018697. [Q9JKX4-1] |
GeneIDi | 56321. |
KEGGi | mmu:56321. |
UCSCi | uc007kqm.1. mouse. [Q9JKX4-1] uc007kqn.1. mouse. [Q9JKX4-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | AATF_MOUSE | |
Accessioni | Q9JKX4Primary (citable) accession number: Q9JKX4 Secondary accession number(s): Q7TQN1, Q8C5Q2, Q99P89 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |