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UniProtKB - Q9JKX4 (AATF_MOUSE)

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Protein

Protein AATF

Gene

Aatf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

  • cell adhesion Source: MGI
  • cellular response to DNA damage stimulus Source: Ensembl
  • embryonic cleavage Source: MGI
  • negative regulation of amyloid precursor protein biosynthetic process Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of reactive oxygen species metabolic process Source: MGI
  • negative regulation of superoxide anion generation Source: MGI
  • positive regulation of apoptotic process Source: Reactome
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of mitotic cell cycle Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • ribosome biogenesis Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-193648. NRAGE signals death through JNK.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AATF
Alternative name(s):
Apoptosis-antagonizing transcription factor
Rb-binding protein Che-1
Traube protein
Gene namesi
Name:Aatf
Synonyms:Che1, Trb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1929608. Aatf.

Subcellular locationi

  • Nucleus › nucleolus 1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: Reactome
  • Golgi apparatus Source: Ensembl
  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000566172 – 526Protein AATFAdd BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1
Modified residuei240PhosphoserineBy similarity1
Modified residuei283PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9JKX4.
PaxDbiQ9JKX4.
PeptideAtlasiQ9JKX4.
PRIDEiQ9JKX4.

PTM databases

iPTMnetiQ9JKX4.
PhosphoSitePlusiQ9JKX4.

Expressioni

Tissue specificityi

Expressed in adrenal gland, brain (Purkinje cells), heart, kidney, liver, lung, muscle, ovary and testis (at the protein level).2 Publications

Developmental stagei

Expressed uniformly throughout the embryo until E10.5. From E11.5, the relative expression level increases in the liver, hind brain, spinal cord, dorsal root ganglia, and the posterior commissure.1 Publication

Gene expression databases

BgeeiENSMUSG00000018697.
CleanExiMM_AATF.
GenevisibleiQ9JKX4. MM.

Interactioni

Subunit structurei

Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

BioGridi207901. 2 interactors.
IntActiQ9JKX4. 1 interactor.
MINTiMINT-4130159.
STRINGi10090.ENSMUSP00000018841.

Structurei

3D structure databases

ProteinModelPortaliQ9JKX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni240 – 282Binds POLR2JBy similarityAdd BLAST43
Regioni283 – 338Binds RB1By similarityAdd BLAST56
Regioni339 – 438Binds RB1 and SP1By similarityAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 171Glu-richAdd BLAST76

Sequence similaritiesi

Belongs to the AATF family.Curated

Phylogenomic databases

eggNOGiKOG2773. Eukaryota.
ENOG410XWGK. LUCA.
GeneTreeiENSGT00390000000288.
HOGENOMiHOG000007555.
HOVERGENiHBG080805.
InParanoidiQ9JKX4.
KOiK14782.
OMAiEVLLKWD.
OrthoDBiEOG091G0F1H.
PhylomeDBiQ9JKX4.
TreeFamiTF324341.

Family and domain databases

InterProiView protein in InterPro
IPR025160. AATF.
IPR012617. AATF_C.
PfamiView protein in Pfam
PF13339. AATF-Che1. 1 hit.
PF08164. TRAUB. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JKX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPQPLALQ LEQLLNPRPR EADPEADPEE ATRARVIDRF DEGEEEKDDL 
        60         70         80         90        100
AVSSIRKLAP VSLLDTDKRY SGKTTSRKAW KEDHWEQALP SSSDNEASDE 
       110        120        130        140        150
GGSEDGDSEG LGLEEISEDV DEDLEDNKIS DEGGSEDGDS EGLGLEEFSE 
       160        170        180        190        200
DVEEDLEGED EEDREEDRNS EDDGVVAAFS SVKVSEEVEK GRAVKNQIAL 
       210        220        230        240        250
WDQLLEGRIK LQKALLTTNQ LPQPDVFPVF KDKGGPEFAS ALKNSHKALK 
       260        270        280        290        300
ALLRSLVDLQ EELLFQYPDT RHIVNGAKPN TESEEISSED DELVGEKKKQ 
       310        320        330        340        350
RKAPPKRKLE MEDYPSFMAK RFADFTIYRN HTLQKWHDKT KLASGKLGKG 
       360        370        380        390        400
FGAFERSILT QIDHIMMDKE RLLRRTQTKR SAYRVLGKPE PVPEPVAETL 
       410        420        430        440        450
PGEPETLPQG PANAHLRDLD EEIFDDDDFY HQLLRELIER KTSSLDPNDQ 
       460        470        480        490        500
VAMGRQWLAI QKLRSKIRKK VDRKASKGRK LRFHVLSKLL SFMAPIDHTA 
       510        520 
MSDDARTELF RSLFGQLNPP DADRGK
Length:526
Mass (Da):59,482
Last modified:October 1, 2000 - v1
Checksum:i8AD2A8396F521DCF
GO
Isoform 2 (identifier: Q9JKX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-84: H → P
     85-199: Missing.

Note: No experimental confirmation available.
Show »
Length:411
Mass (Da):47,085
Checksum:i9BFB0EF9774F70ED
GO
Isoform 3 (identifier: Q9JKX4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     433-458: LLRELIERKTSSLDPNDQVAMGRQWL → VRLFLSFLCYNKPGVCILEPLIVSSG
     459-526: Missing.

Show »
Length:458
Mass (Da):51,506
Checksum:iD390D787E8B3612A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3AA → GR in AAP73747 (PubMed:14636992).Curated2
Sequence conflicti4 – 5Missing in AAP73747 (PubMed:14636992).Curated2
Sequence conflicti45E → K in AAP73747 (PubMed:14636992).Curated1
Sequence conflicti237E → K in AAP73747 (PubMed:14636992).Curated1
Sequence conflicti247K → Q in AAP73747 (PubMed:14636992).Curated1
Sequence conflicti258D → G in AAP73747 (PubMed:14636992).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01489784H → P in isoform 2. 1 Publication1
Alternative sequenceiVSP_01489885 – 199Missing in isoform 2. 1 PublicationAdd BLAST115
Alternative sequenceiVSP_014899433 – 458LLREL…GRQWL → VRLFLSFLCYNKPGVCILEP LIVSSG in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_014900459 – 526Missing in isoform 3. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222801 mRNA. Translation: AAF26745.1.
AK077789 mRNA. Translation: BAC37011.1.
AL603708, AL672252 Genomic DNA. Translation: CAI25418.1.
AL672252, AL603708 Genomic DNA. Translation: CAI26153.1.
BC025080 mRNA. Translation: AAH25080.1.
AF322223 Genomic DNA. Translation: AAK07639.1.
AY306199 mRNA. Translation: AAP73747.1.
CCDSiCCDS25186.1. [Q9JKX4-1]
RefSeqiNP_062790.1. NM_019816.1. [Q9JKX4-1]
UniGeneiMm.257482.

Genome annotation databases

EnsembliENSMUST00000018841; ENSMUSP00000018841; ENSMUSG00000018697. [Q9JKX4-1]
GeneIDi56321.
KEGGimmu:56321.
UCSCiuc007kqm.1. mouse. [Q9JKX4-1]
uc007kqn.1. mouse. [Q9JKX4-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222801 mRNA. Translation: AAF26745.1.
AK077789 mRNA. Translation: BAC37011.1.
AL603708, AL672252 Genomic DNA. Translation: CAI25418.1.
AL672252, AL603708 Genomic DNA. Translation: CAI26153.1.
BC025080 mRNA. Translation: AAH25080.1.
AF322223 Genomic DNA. Translation: AAK07639.1.
AY306199 mRNA. Translation: AAP73747.1.
CCDSiCCDS25186.1. [Q9JKX4-1]
RefSeqiNP_062790.1. NM_019816.1. [Q9JKX4-1]
UniGeneiMm.257482.

3D structure databases

ProteinModelPortaliQ9JKX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207901. 2 interactors.
IntActiQ9JKX4. 1 interactor.
MINTiMINT-4130159.
STRINGi10090.ENSMUSP00000018841.

PTM databases

iPTMnetiQ9JKX4.
PhosphoSitePlusiQ9JKX4.

Proteomic databases

EPDiQ9JKX4.
PaxDbiQ9JKX4.
PeptideAtlasiQ9JKX4.
PRIDEiQ9JKX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018841; ENSMUSP00000018841; ENSMUSG00000018697. [Q9JKX4-1]
GeneIDi56321.
KEGGimmu:56321.
UCSCiuc007kqm.1. mouse. [Q9JKX4-1]
uc007kqn.1. mouse. [Q9JKX4-3]

Organism-specific databases

CTDi26574.
MGIiMGI:1929608. Aatf.

Phylogenomic databases

eggNOGiKOG2773. Eukaryota.
ENOG410XWGK. LUCA.
GeneTreeiENSGT00390000000288.
HOGENOMiHOG000007555.
HOVERGENiHBG080805.
InParanoidiQ9JKX4.
KOiK14782.
OMAiEVLLKWD.
OrthoDBiEOG091G0F1H.
PhylomeDBiQ9JKX4.
TreeFamiTF324341.

Enzyme and pathway databases

ReactomeiR-MMU-193648. NRAGE signals death through JNK.

Miscellaneous databases

PROiPR:Q9JKX4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018697.
CleanExiMM_AATF.
GenevisibleiQ9JKX4. MM.

Family and domain databases

InterProiView protein in InterPro
IPR025160. AATF.
IPR012617. AATF_C.
PfamiView protein in Pfam
PF13339. AATF-Che1. 1 hit.
PF08164. TRAUB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAATF_MOUSE
AccessioniPrimary (citable) accession number: Q9JKX4
Secondary accession number(s): Q7TQN1, Q8C5Q2, Q99P89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.