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Protein

Transferrin receptor protein 2

Gene

Tfr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.

Caution

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-917977 Transferrin endocytosis and recycling

Protein family/group databases

MEROPSiM28.973

Names & Taxonomyi

Protein namesi
Recommended name:
Transferrin receptor protein 2
Short name:
TfR2
Gene namesi
Name:Tfr2
Synonyms:Trfr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1354956 Tfr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 81CytoplasmicSequence analysisAdd BLAST81
Transmembranei82 – 102Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini103 – 798ExtracellularSequence analysisAdd BLAST696

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741371 – 798Transferrin receptor protein 2Add BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi106InterchainSequence analysis
Disulfide bondi109InterchainSequence analysis
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi535N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JKX3
PeptideAtlasiQ9JKX3
PRIDEiQ9JKX3

PTM databases

iPTMnetiQ9JKX3
PhosphoSitePlusiQ9JKX3

Expressioni

Tissue specificityi

Predominantly expressed in liver. Also expressed in kidney, spleen, brain, lung, heart and muscle with very low expression in kidney, muscle and heart.

Developmental stagei

First expressed between embryo days 8 and 11. In the liver, expression increases during development from embryo day 13 to adulthood while, in the spleen, levels remain constant throughout development.

Inductioni

Down-regulated during erythrocyte differentiation. Expression unchanged by cellular iron status.

Gene expression databases

BgeeiENSMUSG00000029716
CleanExiMM_TRFR2
ExpressionAtlasiQ9JKX3 baseline and differential
GenevisibleiQ9JKX3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JKX3 2 interactors.
MINTiQ9JKX3
STRINGi10090.ENSMUSP00000031729

Structurei

3D structure databases

ProteinModelPortaliQ9JKX3
SMRiQ9JKX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi23 – 26Endocytosis signalSequence analysis4

Sequence similaritiesi

Belongs to the peptidase M28 family. M28B subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2195 Eukaryota
COG2234 LUCA
GeneTreeiENSGT00550000074421
HOGENOMiHOG000124067
HOVERGENiHBG023177
InParanoidiQ9JKX3
OMAiLFISWDG
OrthoDBiEOG091G02ZM
PhylomeDBiQ9JKX3
TreeFamiTF312981

Family and domain databases

CDDicd02128 PA_TfR, 1 hit
Gene3Di1.20.930.401 hit
InterProiView protein in InterPro
IPR003137 PA_domain
IPR007484 Peptidase_M28
IPR036757 TFR-like_dimer_dom_sf
IPR037324 TfR1/2_PA
PfamiView protein in Pfam
PF02225 PA, 1 hit
PF04389 Peptidase_M28, 1 hit
SUPFAMiSSF47672 SSF47672, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JKX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQRWGLLRR VQQWSPRPSQ TIYRRVEGPQ LEHLEEEDRE EGAELPAQFC
60 70 80 90 100
PMELKGPEHL GSCPGRSIPI PWAAAGRKAA PYLVLITLLI FTGAFLLGYV
110 120 130 140 150
AFRGSCQACG DSVLVVDEDV NPEDSGRTTL YWSDLQAMFL RFLGEGRMED
160 170 180 190 200
TIRLTSLRER VAGSARMATL VQDILDKLSR QKLDHVWTDT HYVGLQFPDP
210 220 230 240 250
AHANTLHWVD ADGSVQEQLP LEDPEVYCPY SATGNATGKL VYAHYGRSED
260 270 280 290 300
LQDLKAKGVE LAGSLLLVRV GITSFAQKVA VAQDFGAQGV LIYPDPSDFS
310 320 330 340 350
QDPHKPGLSS HQAVYGHVHL GTGDPYTPGF PSFNQTQFPP VESSGLPSIP
360 370 380 390 400
AQPISADIAD QLLRKLTGPV APQEWKGHLS GSPYRLGPGP DLRLVVNNHR
410 420 430 440 450
VSTPISNIFA CIEGFAEPDH YVVIGAQRDA WGPGAAKSAV GTAILLELVR
460 470 480 490 500
TFSSMVSNGF RPRRSLLFIS WDGGDFGSVG ATEWLEGYLS VLHLKAVVYV
510 520 530 540 550
SLDNSVLGDG KFHAKTSPLL VSLIENILKQ VDSPNHSGQT LYEQVALTHP
560 570 580 590 600
SWDAEVIQPL PMDSSAYSFT AFAGVPAVEF SFMEDDRVYP FLHTKEDTYE
610 620 630 640 650
NLHKMLRGRL PAVVQAVAQL AGQLLIRLSH DHLLPLDFGR YGDVVLRHIG
660 670 680 690 700
NLNEFSGDLK ERGLTLQWVY SARGDYIRAA EKLRKEIYSS ERNDERLMRM
710 720 730 740 750
YNVRIMRVEF YFLSQYVSPA DSPFRHIFLG QGDHTLGALV DHLRMLRADG
760 770 780 790
SGAASSRLTA GLGFQESRFR RQLALLTWTL QGAANALSGD VWNIDNNF
Length:798
Mass (Da):88,402
Last modified:February 11, 2002 - v2
Checksum:iFA6161FE3FFF2AA4
GO
Isoform 2 (identifier: Q9JKX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-237: T → TVRFPGWGAHHVLIG
     238-798: Missing.

Note: Lacks most of the extracellular domain. No experimental confirmation available.
Show »
Length:251
Mass (Da):28,167
Checksum:i2A991D52876D5C18
GO
Isoform 3 (identifier: Q9JKX3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-93: Missing.

Show »
Length:716
Mass (Da):79,255
Checksum:iCFDA8CA8F8723197
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25R → P in AAL05977 (PubMed:11535534).Curated1
Sequence conflicti42G → V in AAL05977 (PubMed:11535534).Curated1
Sequence conflicti42G → V in AAK28830 (PubMed:11239002).Curated1
Sequence conflicti103R → P in AAL05977 (PubMed:11535534).Curated1
Sequence conflicti151T → N in AAH13654 (PubMed:15489334).Curated1
Sequence conflicti248S → L in AAL05976 (PubMed:11535534).Curated1
Sequence conflicti287A → V in AAL05976 (PubMed:11535534).Curated1
Sequence conflicti595K → E in AAF37272 (PubMed:10681454).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00535612 – 93Missing in isoform 3. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_005357237T → TVRFPGWGAHHVLIG in isoform 2. 1 Publication1
Alternative sequenceiVSP_005358238 – 798Missing in isoform 2. 1 PublicationAdd BLAST561

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222895 mRNA Translation: AAF37272.1
AF207741 mRNA Translation: AAL05976.1
AF207742 Genomic DNA Translation: AAL05977.1
AK004965 mRNA Translation: BAB23705.1
AK004848 mRNA Translation: BAB23614.1
BC013654 mRNA Translation: AAH13654.1
AF312033 Genomic DNA Translation: AAK28830.1
CCDSiCCDS39333.1 [Q9JKX3-1]
RefSeqiNP_001276436.1, NM_001289507.1
NP_001276438.1, NM_001289509.1 [Q9JKX3-1]
NP_001276440.1, NM_001289511.1 [Q9JKX3-1]
NP_056614.3, NM_015799.4 [Q9JKX3-1]
XP_006504656.1, XM_006504593.3 [Q9JKX3-1]
XP_006504657.1, XM_006504594.3 [Q9JKX3-1]
XP_011239249.1, XM_011240947.2
UniGeneiMm.21757

Genome annotation databases

EnsembliENSMUST00000031729; ENSMUSP00000031729; ENSMUSG00000029716 [Q9JKX3-1]
ENSMUST00000196471; ENSMUSP00000142814; ENSMUSG00000029716 [Q9JKX3-1]
ENSMUST00000198783; ENSMUSP00000142502; ENSMUSG00000029716 [Q9JKX3-1]
ENSMUST00000198866; ENSMUSP00000142720; ENSMUSG00000029716 [Q9JKX3-1]
ENSMUST00000199054; ENSMUSP00000142478; ENSMUSG00000029716 [Q9JKX3-1]
GeneIDi50765
KEGGimmu:50765
UCSCiuc009acv.2 mouse [Q9JKX3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTFR2_MOUSE
AccessioniPrimary (citable) accession number: Q9JKX3
Secondary accession number(s): Q920I6, Q99MQ9, Q9CPT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: April 25, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome