Transferrin receptor protein 2 - Mus musculus (Mouse)

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Q9JKX3 (TFR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Transferrin receptor protein 2
Short name=TfR2

Gene names

Name:	Tfr2
Synonyms:	Trfr2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	798 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
Subcellular location	Cell membrane; Single-pass type II membrane protein. Isoform 3: Cytoplasm.
Tissue specificity	Predominantly expressed in liver. Also expressed in kidney, spleen, brain, lung, heart and muscle with very low expression in kidney, muscle and heart.
Developmental stage	First expressed between embryo days 8 and 11. In the liver, expression increases during development from embryo day 13 to adulthood while, in the spleen, levels remain constant throughout development.
Induction	Down-regulated during erythrocyte differentiation. Expression unchanged by cellular iron status.
Sequence similarities	Belongs to the peptidase M28 family. M28B subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Traceable author statement Ref.1. Source: MGI proteolysis Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from sequence alignment Ref.1. Source: MGI plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	peptidase activity Inferred from electronic annotation. Source: InterPro transferrin receptor activity Traceable author statement Ref.1. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9JKX3-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9JKX3-2) The sequence of this isoform differs from the canonical sequence as follows: 237-237: T → TVRFPGWGAHHVLIG 238-798: Missing.
Note: Lacks most of the extracellular domain. No experimental confirmation available.

Isoform 3 (identifier: Q9JKX3-3) The sequence of this isoform differs from the canonical sequence as follows: 12-93: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 798

798

Transferrin receptor protein 2

PRO_0000174137

Regions

Topological domain

1 – 81

Cytoplasmic Potential

Transmembrane

82 – 102

Helical; Signal-anchor for type II membrane protein; Potential

Topological domain

103 – 798

696

Extracellular Potential

Motif

23 – 26

Endocytosis signal Potential

Amino acid modifications

Glycosylation

235

N-linked (GlcNAc...) Potential

Glycosylation

334

N-linked (GlcNAc...) Potential

Glycosylation

535

N-linked (GlcNAc...) Potential

Disulfide bond

106

Interchain Potential

Disulfide bond

109

Interchain Potential

Natural variations

Alternative sequence

12 – 93

Missing in isoform 3.

VSP_005356

Alternative sequence

237

T → TVRFPGWGAHHVLIG in isoform 2.

VSP_005357

Alternative sequence

238 – 798

561

Missing in isoform 2.

VSP_005358

Experimental info

Sequence conflict

R → P in AAL05977. Ref.2

Sequence conflict

G → V in AAL05977. Ref.2

Sequence conflict

G → V in AAK28830. Ref.5

Sequence conflict

103

R → P in AAL05977. Ref.2

Sequence conflict

151

T → N in AAH13654. Ref.4

Sequence conflict

248

S → L in AAL05976. Ref.2

Sequence conflict

287

A → V in AAL05976. Ref.2

Sequence conflict

595

K → E in AAF37272. Ref.1

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified February 11, 2002. Version 2. Checksum: FA6161FE3FFF2AA4 Show »	FASTA	798	88,402
10 20 30 40 50 60 MEQRWGLLRR VQQWSPRPSQ TIYRRVEGPQ LEHLEEEDRE EGAELPAQFC PMELKGPEHL 70 80 90 100 110 120 GSCPGRSIPI PWAAAGRKAA PYLVLITLLI FTGAFLLGYV AFRGSCQACG DSVLVVDEDV 130 140 150 160 170 180 NPEDSGRTTL YWSDLQAMFL RFLGEGRMED TIRLTSLRER VAGSARMATL VQDILDKLSR 190 200 210 220 230 240 QKLDHVWTDT HYVGLQFPDP AHANTLHWVD ADGSVQEQLP LEDPEVYCPY SATGNATGKL 250 260 270 280 290 300 VYAHYGRSED LQDLKAKGVE LAGSLLLVRV GITSFAQKVA VAQDFGAQGV LIYPDPSDFS 310 320 330 340 350 360 QDPHKPGLSS HQAVYGHVHL GTGDPYTPGF PSFNQTQFPP VESSGLPSIP AQPISADIAD 370 380 390 400 410 420 QLLRKLTGPV APQEWKGHLS GSPYRLGPGP DLRLVVNNHR VSTPISNIFA CIEGFAEPDH 430 440 450 460 470 480 YVVIGAQRDA WGPGAAKSAV GTAILLELVR TFSSMVSNGF RPRRSLLFIS WDGGDFGSVG 490 500 510 520 530 540 ATEWLEGYLS VLHLKAVVYV SLDNSVLGDG KFHAKTSPLL VSLIENILKQ VDSPNHSGQT 550 560 570 580 590 600 LYEQVALTHP SWDAEVIQPL PMDSSAYSFT AFAGVPAVEF SFMEDDRVYP FLHTKEDTYE 610 620 630 640 650 660 NLHKMLRGRL PAVVQAVAQL AGQLLIRLSH DHLLPLDFGR YGDVVLRHIG NLNEFSGDLK 670 680 690 700 710 720 ERGLTLQWVY SARGDYIRAA EKLRKEIYSS ERNDERLMRM YNVRIMRVEF YFLSQYVSPA 730 740 750 760 770 780 DSPFRHIFLG QGDHTLGALV DHLRMLRADG SGAASSRLTA GLGFQESRFR RQLALLTWTL 790 QGAANALSGD VWNIDNNF « Hide
Isoform 2 [UniParc]. Checksum: 2A991D52876D5C18 Show »	FASTA	251	28,167
10 20 30 40 50 60 MEQRWGLLRR VQQWSPRPSQ TIYRRVEGPQ LEHLEEEDRE EGAELPAQFC PMELKGPEHL 70 80 90 100 110 120 GSCPGRSIPI PWAAAGRKAA PYLVLITLLI FTGAFLLGYV AFRGSCQACG DSVLVVDEDV 130 140 150 160 170 180 NPEDSGRTTL YWSDLQAMFL RFLGEGRMED TIRLTSLRER VAGSARMATL VQDILDKLSR 190 200 210 220 230 240 QKLDHVWTDT HYVGLQFPDP AHANTLHWVD ADGSVQEQLP LEDPEVYCPY SATGNATVRF 250 PGWGAHHVLI G « Hide
Isoform 3 [UniParc]. Checksum: CFDA8CA8F8723197 Show »	FASTA	716	79,255
10 20 30 40 50 60 MEQRWGLLRR VAFLLGYVAF RGSCQACGDS VLVVDEDVNP EDSGRTTLYW SDLQAMFLRF 70 80 90 100 110 120 LGEGRMEDTI RLTSLRERVA GSARMATLVQ DILDKLSRQK LDHVWTDTHY VGLQFPDPAH 130 140 150 160 170 180 ANTLHWVDAD GSVQEQLPLE DPEVYCPYSA TGNATGKLVY AHYGRSEDLQ DLKAKGVELA 190 200 210 220 230 240 GSLLLVRVGI TSFAQKVAVA QDFGAQGVLI YPDPSDFSQD PHKPGLSSHQ AVYGHVHLGT 250 260 270 280 290 300 GDPYTPGFPS FNQTQFPPVE SSGLPSIPAQ PISADIADQL LRKLTGPVAP QEWKGHLSGS 310 320 330 340 350 360 PYRLGPGPDL RLVVNNHRVS TPISNIFACI EGFAEPDHYV VIGAQRDAWG PGAAKSAVGT 370 380 390 400 410 420 AILLELVRTF SSMVSNGFRP RRSLLFISWD GGDFGSVGAT EWLEGYLSVL HLKAVVYVSL 430 440 450 460 470 480 DNSVLGDGKF HAKTSPLLVS LIENILKQVD SPNHSGQTLY EQVALTHPSW DAEVIQPLPM 490 500 510 520 530 540 DSSAYSFTAF AGVPAVEFSF MEDDRVYPFL HTKEDTYENL HKMLRGRLPA VVQAVAQLAG 550 560 570 580 590 600 QLLIRLSHDH LLPLDFGRYG DVVLRHIGNL NEFSGDLKER GLTLQWVYSA RGDYIRAAEK 610 620 630 640 650 660 LRKEIYSSER NDERLMRMYN VRIMRVEFYF LSQYVSPADS PFRHIFLGQG DHTLGALVDH 670 680 690 700 710 LRMLRADGSG AASSRLTAGL GFQESRFRRQ LALLTWTLQG AANALSGDVW NIDNNF « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis." Fleming R.E., Migas M.C., Holden C.C., Waheed A., Britton R.S., Tomatsu S., Bacon B.R., Sly W.S. Proc. Natl. Acad. Sci. U.S.A. 97:2214-2219(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Embryo.
[2]	"Regulation of expression of murine transferrin receptor 2." Kawabata H., Germain R.S., Ikezoe T., Tong X., Green E.M., Gombart A.F., Koeffler H.P. Blood 98:1949-1954(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Erythroleukemia.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Liver.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[5]	"Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5." Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F. Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-278. Strain: 129/Sv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222895 mRNA. Translation: AAF37272.1. AF207741 mRNA. Translation: AAL05976.1. AF207742 Genomic DNA. Translation: AAL05977.1. AK004965 mRNA. Translation: BAB23705.1. AK004848 mRNA. Translation: BAB23614.1. BC013654 mRNA. Translation: AAH13654.1. AF312033 Genomic DNA. Translation: AAK28830.1.
IPI	IPI00223650. IPI00223651. IPI00309444.
RefSeq	NP_056614.3. NM_015799.3.
UniGene	Mm.21757.
3D structure databases
ProteinModelPortal	Q9JKX3.
SMR	Q9JKX3. Positions 130-798.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1857634.
Protein family/group databases
MEROPS	M28.973.
PTM databases
PhosphoSite	Q9JKX3.
Proteomic databases
PaxDb	Q9JKX3.
PRIDE	Q9JKX3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031729; ENSMUSP00000031729; ENSMUSG00000029716.
GeneID	50765.
KEGG	mmu:50765.
UCSC	uc009acv.1. mouse.
Organism-specific databases
CTD	7036.
MGI	MGI:1354956. Tfr2.
Phylogenomic databases
eggNOG	NOG74799.
GeneTree	ENSGT00550000074421.
HOGENOM	HOG000124067.
HOVERGEN	HBG023177.
InParanoid	Q9JKX3.
OMA	LEGYLSV.
OrthoDB	EOG41RPTM.
Gene expression databases
Bgee	Q9JKX3.
CleanEx	MM_TRFR2.
Genevestigator	Q9JKX3.
GermOnline	ENSMUSG00000029716. Mus musculus.
Family and domain databases
Gene3D	1.20.930.40. 1 hit.
InterPro	IPR007484. Peptidase_M28. IPR003137. Protease-assoc_domain. IPR007365. TFR-like_dimer_dom. [Graphical view]
Pfam	PF02225. PA. 1 hit. PF04389. Peptidase_M28. 1 hit. PF04253. TFR_dimer. 1 hit. [Graphical view]
SUPFAM	SSF47672. Transferrin_rcpt-like_dimerise. 1 hit.
ProtoNet	Search...
Other
NextBio	307667.
SOURCE	Search...

Entry information

Entry name

TFR2_MOUSE

Accession

Primary (citable) accession number: Q9JKX3
Secondary accession number(s): Q920I6, Q99MQ9, Q9CPT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	February 11, 2002
Last modified:	May 29, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents