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Q9JKX3

- TFR2_MOUSE

UniProt

Q9JKX3 - TFR2_MOUSE

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Protein

Transferrin receptor protein 2

Gene
Tfr2, Trfr2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.

GO - Molecular functioni

  1. peptidase activity Source: InterPro
  2. transferrin receptor activity Source: MGI

GO - Biological processi

  1. cellular iron ion homeostasis Source: MGI
  2. receptor-mediated endocytosis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Protein family/group databases

MEROPSiM28.973.

Names & Taxonomyi

Protein namesi
Recommended name:
Transferrin receptor protein 2
Short name:
TfR2
Gene namesi
Name:Tfr2
Synonyms:Trfr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1354956. Tfr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8181Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei82 – 10221Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini103 – 798696Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: MGI
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 798798Transferrin receptor protein 2PRO_0000174137Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi106 – 106Interchain Reviewed prediction
Disulfide bondi109 – 109Interchain Reviewed prediction
Glycosylationi235 – 2351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi334 – 3341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi535 – 5351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9JKX3.
PaxDbiQ9JKX3.
PRIDEiQ9JKX3.

PTM databases

PhosphoSiteiQ9JKX3.

Expressioni

Tissue specificityi

Predominantly expressed in liver. Also expressed in kidney, spleen, brain, lung, heart and muscle with very low expression in kidney, muscle and heart.

Developmental stagei

First expressed between embryo days 8 and 11. In the liver, expression increases during development from embryo day 13 to adulthood while, in the spleen, levels remain constant throughout development.

Inductioni

Down-regulated during erythrocyte differentiation. Expression unchanged by cellular iron status.

Gene expression databases

BgeeiQ9JKX3.
CleanExiMM_TRFR2.
GenevestigatoriQ9JKX3.

Interactioni

Protein-protein interaction databases

IntActiQ9JKX3. 2 interactions.
MINTiMINT-1857634.

Structurei

3D structure databases

ProteinModelPortaliQ9JKX3.
SMRiQ9JKX3. Positions 130-798.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi23 – 264Endocytosis signal Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74799.
GeneTreeiENSGT00550000074421.
HOGENOMiHOG000124067.
HOVERGENiHBG023177.
InParanoidiQ9JKX3.
OMAiLFISWDG.
OrthoDBiEOG780RKW.
PhylomeDBiQ9JKX3.
TreeFamiTF312981.

Family and domain databases

Gene3Di1.20.930.40. 1 hit.
InterProiIPR007484. Peptidase_M28.
IPR003137. Protease-assoc_domain.
IPR007365. TFR-like_dimer_dom.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF04389. Peptidase_M28. 1 hit.
PF04253. TFR_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF47672. SSF47672. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JKX3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEQRWGLLRR VQQWSPRPSQ TIYRRVEGPQ LEHLEEEDRE EGAELPAQFC    50
PMELKGPEHL GSCPGRSIPI PWAAAGRKAA PYLVLITLLI FTGAFLLGYV 100
AFRGSCQACG DSVLVVDEDV NPEDSGRTTL YWSDLQAMFL RFLGEGRMED 150
TIRLTSLRER VAGSARMATL VQDILDKLSR QKLDHVWTDT HYVGLQFPDP 200
AHANTLHWVD ADGSVQEQLP LEDPEVYCPY SATGNATGKL VYAHYGRSED 250
LQDLKAKGVE LAGSLLLVRV GITSFAQKVA VAQDFGAQGV LIYPDPSDFS 300
QDPHKPGLSS HQAVYGHVHL GTGDPYTPGF PSFNQTQFPP VESSGLPSIP 350
AQPISADIAD QLLRKLTGPV APQEWKGHLS GSPYRLGPGP DLRLVVNNHR 400
VSTPISNIFA CIEGFAEPDH YVVIGAQRDA WGPGAAKSAV GTAILLELVR 450
TFSSMVSNGF RPRRSLLFIS WDGGDFGSVG ATEWLEGYLS VLHLKAVVYV 500
SLDNSVLGDG KFHAKTSPLL VSLIENILKQ VDSPNHSGQT LYEQVALTHP 550
SWDAEVIQPL PMDSSAYSFT AFAGVPAVEF SFMEDDRVYP FLHTKEDTYE 600
NLHKMLRGRL PAVVQAVAQL AGQLLIRLSH DHLLPLDFGR YGDVVLRHIG 650
NLNEFSGDLK ERGLTLQWVY SARGDYIRAA EKLRKEIYSS ERNDERLMRM 700
YNVRIMRVEF YFLSQYVSPA DSPFRHIFLG QGDHTLGALV DHLRMLRADG 750
SGAASSRLTA GLGFQESRFR RQLALLTWTL QGAANALSGD VWNIDNNF 798
Length:798
Mass (Da):88,402
Last modified:February 11, 2002 - v2
Checksum:iFA6161FE3FFF2AA4
GO
Isoform 2 (identifier: Q9JKX3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-237: T → TVRFPGWGAHHVLIG
     238-798: Missing.

Note: Lacks most of the extracellular domain. No experimental confirmation available.

Show »
Length:251
Mass (Da):28,167
Checksum:i2A991D52876D5C18
GO
Isoform 3 (identifier: Q9JKX3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-93: Missing.

Show »
Length:716
Mass (Da):79,255
Checksum:iCFDA8CA8F8723197
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei12 – 9382Missing in isoform 3. VSP_005356Add
BLAST
Alternative sequencei237 – 2371T → TVRFPGWGAHHVLIG in isoform 2. VSP_005357
Alternative sequencei238 – 798561Missing in isoform 2. VSP_005358Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251R → P in AAL05977. 1 Publication
Sequence conflicti42 – 421G → V in AAL05977. 1 Publication
Sequence conflicti42 – 421G → V in AAK28830. 1 Publication
Sequence conflicti103 – 1031R → P in AAL05977. 1 Publication
Sequence conflicti151 – 1511T → N in AAH13654. 1 Publication
Sequence conflicti248 – 2481S → L in AAL05976. 1 Publication
Sequence conflicti287 – 2871A → V in AAL05976. 1 Publication
Sequence conflicti595 – 5951K → E in AAF37272. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF222895 mRNA. Translation: AAF37272.1.
AF207741 mRNA. Translation: AAL05976.1.
AF207742 Genomic DNA. Translation: AAL05977.1.
AK004965 mRNA. Translation: BAB23705.1.
AK004848 mRNA. Translation: BAB23614.1.
BC013654 mRNA. Translation: AAH13654.1.
AF312033 Genomic DNA. Translation: AAK28830.1.
CCDSiCCDS39333.1. [Q9JKX3-1]
RefSeqiNP_001276436.1. NM_001289507.1.
NP_001276438.1. NM_001289509.1. [Q9JKX3-1]
NP_001276440.1. NM_001289511.1. [Q9JKX3-1]
NP_056614.3. NM_015799.4. [Q9JKX3-1]
XP_006504656.1. XM_006504593.1. [Q9JKX3-1]
XP_006504657.1. XM_006504594.1. [Q9JKX3-1]
UniGeneiMm.21757.

Genome annotation databases

EnsembliENSMUST00000031729; ENSMUSP00000031729; ENSMUSG00000029716. [Q9JKX3-1]
GeneIDi50765.
KEGGimmu:50765.
UCSCiuc009acv.1. mouse. [Q9JKX3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF222895 mRNA. Translation: AAF37272.1 .
AF207741 mRNA. Translation: AAL05976.1 .
AF207742 Genomic DNA. Translation: AAL05977.1 .
AK004965 mRNA. Translation: BAB23705.1 .
AK004848 mRNA. Translation: BAB23614.1 .
BC013654 mRNA. Translation: AAH13654.1 .
AF312033 Genomic DNA. Translation: AAK28830.1 .
CCDSi CCDS39333.1. [Q9JKX3-1 ]
RefSeqi NP_001276436.1. NM_001289507.1.
NP_001276438.1. NM_001289509.1. [Q9JKX3-1 ]
NP_001276440.1. NM_001289511.1. [Q9JKX3-1 ]
NP_056614.3. NM_015799.4. [Q9JKX3-1 ]
XP_006504656.1. XM_006504593.1. [Q9JKX3-1 ]
XP_006504657.1. XM_006504594.1. [Q9JKX3-1 ]
UniGenei Mm.21757.

3D structure databases

ProteinModelPortali Q9JKX3.
SMRi Q9JKX3. Positions 130-798.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JKX3. 2 interactions.
MINTi MINT-1857634.

Protein family/group databases

MEROPSi M28.973.

PTM databases

PhosphoSitei Q9JKX3.

Proteomic databases

MaxQBi Q9JKX3.
PaxDbi Q9JKX3.
PRIDEi Q9JKX3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031729 ; ENSMUSP00000031729 ; ENSMUSG00000029716 . [Q9JKX3-1 ]
GeneIDi 50765.
KEGGi mmu:50765.
UCSCi uc009acv.1. mouse. [Q9JKX3-1 ]

Organism-specific databases

CTDi 7036.
MGIi MGI:1354956. Tfr2.

Phylogenomic databases

eggNOGi NOG74799.
GeneTreei ENSGT00550000074421.
HOGENOMi HOG000124067.
HOVERGENi HBG023177.
InParanoidi Q9JKX3.
OMAi LFISWDG.
OrthoDBi EOG780RKW.
PhylomeDBi Q9JKX3.
TreeFami TF312981.

Miscellaneous databases

NextBioi 307667.
PROi Q9JKX3.
SOURCEi Search...

Gene expression databases

Bgeei Q9JKX3.
CleanExi MM_TRFR2.
Genevestigatori Q9JKX3.

Family and domain databases

Gene3Di 1.20.930.40. 1 hit.
InterProi IPR007484. Peptidase_M28.
IPR003137. Protease-assoc_domain.
IPR007365. TFR-like_dimer_dom.
[Graphical view ]
Pfami PF02225. PA. 1 hit.
PF04389. Peptidase_M28. 1 hit.
PF04253. TFR_dimer. 1 hit.
[Graphical view ]
SUPFAMi SSF47672. SSF47672. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis."
    Fleming R.E., Migas M.C., Holden C.C., Waheed A., Britton R.S., Tomatsu S., Bacon B.R., Sly W.S.
    Proc. Natl. Acad. Sci. U.S.A. 97:2214-2219(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Erythroleukemia.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  5. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
    Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F.
    Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-278.
    Strain: 129/Sv.

Entry informationi

Entry nameiTFR2_MOUSE
AccessioniPrimary (citable) accession number: Q9JKX3
Secondary accession number(s): Q920I6, Q99MQ9, Q9CPT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi