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Protein

ADP-ribosylation factor-like protein 6-interacting protein 1

Gene

Arl6ip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (PubMed:18684713). Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 6-interacting protein 1
Short name:
ARL-6-interacting protein 1
Short name:
Aip-1
Alternative name(s):
Protein TBX2
Gene namesi
Name:Arl6ip1
Synonyms:Arl6ip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1858943. Arl6ip1.

Subcellular locationi

  • Endomembrane system By similarity; Multi-pass membrane protein Sequence analysis
  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Endoplasmic reticulum 1 Publication

  • Note: Predominantly localized to intracytoplasmic membranes. Preferentially localizes at the ER tubules and the edge of the ER sheets, both of which are characterized by a high membrane curvature.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141CytoplasmicSequence analysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Topological domaini63 – 653LumenalSequence analysis
Transmembranei66 – 8621HelicalSequence analysisAdd
BLAST
Topological domaini87 – 13347CytoplasmicSequence analysisAdd
BLAST
Transmembranei134 – 17542HelicalSequence analysisAdd
BLAST
Topological domaini176 – 20328LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • endoplasmic reticulum Source: UniProtKB
  • integral component of endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: MGI
  • membrane Source: MGI
  • Sec61 translocon complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203ADP-ribosylation factor-like protein 6-interacting protein 1PRO_0000064656Add
BLAST

Proteomic databases

EPDiQ9JKW0.
MaxQBiQ9JKW0.
PaxDbiQ9JKW0.
PRIDEiQ9JKW0.

PTM databases

iPTMnetiQ9JKW0.
PhosphoSiteiQ9JKW0.
SwissPalmiQ9JKW0.

Expressioni

Tissue specificityi

Expressed in the cerebral cortex, cerebellum, hippocampus, olfactory bulbs, medulla oblongate and limbic system (at protein level). Ubiquitous (PubMed:18684713). Expressed in all hematopoietic cell lineages, with highest levels in early myeloid progenitor cells.2 Publications

Gene expression databases

BgeeiQ9JKW0.
ExpressionAtlasiQ9JKW0. baseline and differential.
GenevisibleiQ9JKW0. MM.

Interactioni

Subunit structurei

Homooligomer (By similarity). Heterodimer with ARL6IP5 (PubMed:18684713). Interacts with ARL6 (PubMed:10508919). Interacts with TMEM33. Interacts with ATL1 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi207603. 1 interaction.
IntActiQ9JKW0. 1 interaction.
MINTiMINT-4088147.
STRINGi10090.ENSMUSP00000032888.

Family & Domainsi

Domaini

The transmembrane domains are required for its ability to shape the endoplasmic reticulum membrane into tubules.By similarity

Sequence similaritiesi

Belongs to the ARL6ip family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHBG. Eukaryota.
ENOG410Z6SH. LUCA.
GeneTreeiENSGT00390000005707.
HOGENOMiHOG000034032.
HOVERGENiHBG050558.
InParanoidiQ9JKW0.
OMAiHGIISKY.
OrthoDBiEOG7CZK70.
PhylomeDBiQ9JKW0.
TreeFamiTF105477.

Sequencei

Sequence statusi: Complete.

Q9JKW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGDNRSSN LLAVETASLE EQLQGWGEVM LMADKVLRWE RAWFPPAIMG
60 70 80 90 100
VVSLLFLIIY YLDPSVLSGV SCFVMFLCLA DYLVPILAPR IFGSNKWTTE
110 120 130 140 150
QQQRFHEICS NLVKTRRRAV GWWKRLFSLK EEKPKMYFMT MIISLAAVAW
160 170 180 190 200
VGQQVHNLLL TYLIVTFVLL LPGLNQHGII LKYIGMAKRE INKLLKQKEK

KNE
Length:203
Mass (Da):23,437
Last modified:October 1, 2000 - v1
Checksum:i34D10BE315F7B669
GO

Sequence cautioni

The sequence AAD33046.1 differs from that shown. Reason: Frameshift at position 116. Curated
The sequence AAF27313.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133669 mRNA. Translation: AAD33046.1. Frameshift.
AF172088 mRNA. Translation: AAF27313.1. Different initiation.
AF223953 mRNA. Translation: AAF34706.1.
BC010196 mRNA. Translation: AAH10196.1.
CCDSiCCDS21769.1.
RefSeqiNP_062292.1. NM_019419.2.
UniGeneiMm.29924.

Genome annotation databases

EnsembliENSMUST00000032888; ENSMUSP00000032888; ENSMUSG00000030654.
GeneIDi54208.
KEGGimmu:54208.
UCSCiuc009jjo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133669 mRNA. Translation: AAD33046.1. Frameshift.
AF172088 mRNA. Translation: AAF27313.1. Different initiation.
AF223953 mRNA. Translation: AAF34706.1.
BC010196 mRNA. Translation: AAH10196.1.
CCDSiCCDS21769.1.
RefSeqiNP_062292.1. NM_019419.2.
UniGeneiMm.29924.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207603. 1 interaction.
IntActiQ9JKW0. 1 interaction.
MINTiMINT-4088147.
STRINGi10090.ENSMUSP00000032888.

PTM databases

iPTMnetiQ9JKW0.
PhosphoSiteiQ9JKW0.
SwissPalmiQ9JKW0.

Proteomic databases

EPDiQ9JKW0.
MaxQBiQ9JKW0.
PaxDbiQ9JKW0.
PRIDEiQ9JKW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032888; ENSMUSP00000032888; ENSMUSG00000030654.
GeneIDi54208.
KEGGimmu:54208.
UCSCiuc009jjo.2. mouse.

Organism-specific databases

CTDi23204.
MGIiMGI:1858943. Arl6ip1.

Phylogenomic databases

eggNOGiENOG410IHBG. Eukaryota.
ENOG410Z6SH. LUCA.
GeneTreeiENSGT00390000005707.
HOGENOMiHOG000034032.
HOVERGENiHBG050558.
InParanoidiQ9JKW0.
OMAiHGIISKY.
OrthoDBiEOG7CZK70.
PhylomeDBiQ9JKW0.
TreeFamiTF105477.

Miscellaneous databases

ChiTaRSiArl6ip1. mouse.
PROiQ9JKW0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKW0.
ExpressionAtlasiQ9JKW0. baseline and differential.
GenevisibleiQ9JKW0. MM.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit."
    Ingley E., Williams J.H., Walker C.E., Tsai S., Colley S., Sayer M.S., Tilbrook P.A., Sarna M., Beaumont J.G., Klinken S.P.
    FEBS Lett. 459:69-74(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ARL6.
  2. "A novel gene cloned from mouse thymic stromal cell line."
    Xie L.P., Chen W.F.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Thymus.
  3. "Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP-ribosylation-like factor-6 interacting protein (ARL6)."
    Pettersson M., Bessonova M., Gu H.F., Groop L.C., Jonsson J.I.
    Genomics 68:351-354(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  5. "Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1."
    Akiduki S., Ikemoto M.J.
    J. Biol. Chem. 283:31323-31332(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-59, FUNCTION, INTERACTION WITH ARL6IP5, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiAR6P1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKW0
Secondary accession number(s): Q9JLI9, Q9WUG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.