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Protein

Interleukin-20

Gene

Il20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3.

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-20 receptor binding Source: UniProtKB
  • interleukin-22 receptor binding Source: MGI

GO - Biological processi

  • hemopoiesis Source: UniProtKB
  • positive regulation of osteoclast differentiation Source: MGI
  • STAT protein import into nucleus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-20
Short name:
IL-20
Alternative name(s):
Cytokine Zcyto10
Gene namesi
Name:Il20
Synonyms:Zcyto10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1890473. Il20.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 176152Interleukin-20PRO_0000015382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 126Sequence analysis
Disulfide bondi80 ↔ 132Sequence analysis
Disulfide bondi81 ↔ 134Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9JKV9.
PRIDEiQ9JKV9.

Expressioni

Gene expression databases

BgeeiQ9JKV9.
CleanExiMM_IL20.
ExpressionAtlasiQ9JKV9. baseline.
GenevisibleiQ9JKV9. MM.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-20 receptor binding Source: UniProtKB
  • interleukin-22 receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027673.

Structurei

3D structure databases

ProteinModelPortaliQ9JKV9.
SMRiQ9JKV9. Positions 24-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW76. Eukaryota.
ENOG410YMTB. LUCA.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG108002.
InParanoidiQ9JKV9.
KOiK05444.
OMAiHHTLRKI.
OrthoDBiEOG7060SK.
PhylomeDBiQ9JKV9.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
IPR020442. IL-20.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01935. INTRLEUKIN20.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGFGLAFGL FSAVGFLLWT PLTGLKTLHL GSCVITANLQ AIQKEFSEIR
60 70 80 90 100
DSVQAEDTNI DIRILRTTES LKDIKSLDRC CFLRHLVRFY LDRVFKVYQT
110 120 130 140 150
PDHHTLRKIS SLANSFLIIK KDLSVCHSHM ACHCGEEAME KYNQILSHFI
160 170
ELELQAAVVK ALGELGILLR WMEEML
Length:176
Mass (Da):20,098
Last modified:October 1, 2000 - v1
Checksum:i08577AF656574771
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224267 mRNA. Translation: AAF36680.1.
CCDSiCCDS15263.1.
RefSeqiNP_001298020.1. NM_001311091.1.
NP_067355.1. NM_021380.2.
UniGeneiMm.103794.

Genome annotation databases

EnsembliENSMUST00000027673; ENSMUSP00000027673; ENSMUSG00000026416.
GeneIDi58181.
KEGGimmu:58181.
UCSCiuc007cmr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224267 mRNA. Translation: AAF36680.1.
CCDSiCCDS15263.1.
RefSeqiNP_001298020.1. NM_001311091.1.
NP_067355.1. NM_021380.2.
UniGeneiMm.103794.

3D structure databases

ProteinModelPortaliQ9JKV9.
SMRiQ9JKV9. Positions 24-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027673.

Proteomic databases

PaxDbiQ9JKV9.
PRIDEiQ9JKV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027673; ENSMUSP00000027673; ENSMUSG00000026416.
GeneIDi58181.
KEGGimmu:58181.
UCSCiuc007cmr.1. mouse.

Organism-specific databases

CTDi50604.
MGIiMGI:1890473. Il20.

Phylogenomic databases

eggNOGiENOG410IW76. Eukaryota.
ENOG410YMTB. LUCA.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG108002.
InParanoidiQ9JKV9.
KOiK05444.
OMAiHHTLRKI.
OrthoDBiEOG7060SK.
PhylomeDBiQ9JKV9.
TreeFamiTF333253.

Miscellaneous databases

NextBioi314135.
PROiQ9JKV9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKV9.
CleanExiMM_IL20.
ExpressionAtlasiQ9JKV9. baseline.
GenevisibleiQ9JKV9. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
IPR020442. IL-20.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01935. INTRLEUKIN20.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiIL20_MOUSE
AccessioniPrimary (citable) accession number: Q9JKV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.