Reviewed,
UniProtKB/Swiss-Prot Q9JKV7 (EXTL1_MOUSE)
Last modified
April 14, 2009.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Exostosin-like 1 EC=2.4.1.224 Alternative name(s): Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Exostosin-L Multiple exostosis-like protein | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 669 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Probable glycosyltransferase By similarity. |
| Catalytic activity | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan. |
| Pathway | |
| Subcellular location | Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity. |
| Sequence similarities | Belongs to the glycosyltransferase 47 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane |
| Domain | Signal-anchor Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intrinsic to endoplasmic reticulum membraneInferred from electronic annotation. Source: InterPro |
| Molecular function | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 669 | 669 | Exostosin-like 1 | PRO_0000149654 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 8 | 8 | Cytoplasmic Potential | ||||||||
| Transmembrane | 9 – 29 | 21 | Signal-anchor for type II membrane protein Potential | ||||||||
| Topological domain | 30 – 669 | 640 | Lumenal Potential | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 263 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 480 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 577 ↔ 627 | By similarity | |||||||||
Sequences
| ||||||||||||||||||
References
| [1] | "EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis." Stickens D., Brown D., Evans G.A. Dev. Dyn. 218:452-464(2000) [PubMed: 10878610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain. |
| + | Additional computationally mapped references. |
Web resources
| Functional Glycomics Gateway - GTase EXTL1 (putative HS transferase) [GAG Enzyme] |
Cross-references
Sequence databases | |
|---|---|
| AF224461 mRNA. Translation: AAF61913.1. | |
| IPI | IPI00123491. |
| UniGene | Mm.30978 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1OMX based on UniProtKB Q9ES89. |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT47. Glycosyltransferase Family 47. GT64. Glycosyltransferase Family 64. |
Proteomic databases | |
| PRIDE | Q9JKV7. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000028838. Mus musculus. [Contig view] |
Organism-specific databases | |
| MGI | MGI:1888742. Extl1. |
Phylogenomic databases | |
| HOGENOM | Q9JKV7. |
| HOVERGEN | Q9JKV7. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.224. 244. |
Gene expression databases | |
| ArrayExpress | Q9JKV7. |
| Bgee | Q9JKV7. |
| CleanEx | MM_EXTL1. |
| GermOnline | ENSMUSG00000028838. Mus musculus. |
Family and domain databases | |
| InterPro | IPR004263. Exostosin. IPR015338. HexNAc_Trfase_a. [Graphical view] |
| Pfam | PF03016. Exostosin. 1 hit. PF09258. Glyco_transf_64. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | EXTL1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9JKV7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


