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Q9JKV7

- EXTL1_MOUSE

UniProt

Q9JKV7 - EXTL1_MOUSE

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Protein

Exostosin-like 1

Gene

Extl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probable glycosyltransferase.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan.

Pathwayi

GO - Molecular functioni

  1. glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

Names & Taxonomyi

Protein namesi
Recommended name:
Exostosin-like 1 (EC:2.4.1.224)
Alternative name(s):
Exostosin-L
Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Multiple exostosis-like protein
Gene namesi
Name:Extl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1888742. Extl1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intrinsic component of endoplasmic reticulum membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Exostosin-like 1PRO_0000149654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi577 ↔ 627By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JKV7.
PRIDEiQ9JKV7.

PTM databases

PhosphoSiteiQ9JKV7.

Expressioni

Gene expression databases

BgeeiQ9JKV7.
CleanExiMM_EXTL1.
ExpressionAtlasiQ9JKV7. baseline and differential.
GenevestigatoriQ9JKV7.

Structurei

3D structure databases

ProteinModelPortaliQ9JKV7.
SMRiQ9JKV7. Positions 411-593.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence Analysis
Topological domaini30 – 669640LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 47 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272619.
GeneTreeiENSGT00550000074496.
HOGENOMiHOG000266990.
HOVERGENiHBG003459.
InParanoidiQ9JKV7.
KOiK02368.
OMAiNATFCLI.
OrthoDBiEOG7RBZ7Z.
TreeFamiTF314231.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR004263. Exostosin.
IPR027675. Exostosin-like_1.
IPR015338. HexNAc_Trfase_a.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11062. PTHR11062. 1 hit.
PTHR11062:SF8. PTHR11062:SF8. 1 hit.
PfamiPF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JKV7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLWRRKSFWL ALSAFWLLLV LLGVFPLRLA VLPGPLPGRS QGWPRWLDAA
60 70 80 90 100
FLQSFSQSET NPEDVAQLPR VSRGSSCTWG ACFDTSKCRG KVLKIFVHSP
110 120 130 140 150
AGPTSEAQRR ILDSLEGSRY SALSPADACL LLFLPSQDRR GACGPLPPNW
160 170 180 190 200
NGGRNHLVLS LYPAPCTRLG QAMVAEASPS SDIFRPGFDL ALPYLPEAHP
210 220 230 240 250
LRGGAPGKLQ QHSPQPGATL LAVAEEKGRW RITSTHASAC LWDRHCEQDP
260 270 280 290 300
GPQQTYPGET LPNATFCLIP GHRSATSCFL QALQAGCIPV LLSPRWELPF
310 320 330 340 350
SEVIDWTKAA IIADERLPLQ VLAALREMLP SRVLALRQQT QFLWTAYFSS
360 370 380 390 400
VEKVIHTTLE IIQDRIWGAS GHPSLMWNSP PGALLALPTF STSLQDFPFY
410 420 430 440 450
HLQLGSGPGS SFSAVIWVGA SGESLLKLIQ EVAGSRHCAQ ILILWNSEKL
460 470 480 490 500
PPDRWPETAV PLTVIKGHRK VSNRFFPYSN ISTNVILSLD AQSTLSTSEV
510 520 530 540 550
DFAFVVWQSF PERMVGFLSG SHFWDEAQGG WGYRTGMTNE FSMVLTTAAF
560 570 580 590 600
YHRYYHTLFT HSLPKALRTI ADETPTCVDV LMNFLVATVT KLPPIKVPYG
610 620 630 640 650
RQHPEAVPMD SGDPRPVPEP QPLDQDCINR LAAGFGHMPL VSSQVRLDPV
660
LFKDPVSVQR KKYRSLEKP
Length:669
Mass (Da):74,079
Last modified:July 27, 2011 - v2
Checksum:i79629222B6CA3821
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321L → S in AAF61913. (PubMed:10878610)Curated
Sequence conflicti190 – 1901L → I in AAF61913. (PubMed:10878610)Curated
Sequence conflicti361 – 3611I → V in AAF61913. (PubMed:10878610)Curated
Sequence conflicti450 – 4501L → P in AAF61913. (PubMed:10878610)Curated
Sequence conflicti540 – 5401E → D in AAF61913. (PubMed:10878610)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF224461 mRNA. Translation: AAF61913.1.
AL669982 Genomic DNA. No translation available.
CCDSiCCDS18770.1.
RefSeqiNP_062524.2. NM_019578.2.
UniGeneiMm.30978.

Genome annotation databases

EnsembliENSMUST00000030643; ENSMUSP00000030643; ENSMUSG00000028838.
GeneIDi56219.
KEGGimmu:56219.
UCSCiuc012dmu.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

EXTL1 (putative HS transferase) [GAG Enzyme]

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF224461 mRNA. Translation: AAF61913.1 .
AL669982 Genomic DNA. No translation available.
CCDSi CCDS18770.1.
RefSeqi NP_062524.2. NM_019578.2.
UniGenei Mm.30978.

3D structure databases

ProteinModelPortali Q9JKV7.
SMRi Q9JKV7. Positions 411-593.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

PTM databases

PhosphoSitei Q9JKV7.

Proteomic databases

PaxDbi Q9JKV7.
PRIDEi Q9JKV7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030643 ; ENSMUSP00000030643 ; ENSMUSG00000028838 .
GeneIDi 56219.
KEGGi mmu:56219.
UCSCi uc012dmu.1. mouse.

Organism-specific databases

CTDi 2134.
MGIi MGI:1888742. Extl1.

Phylogenomic databases

eggNOGi NOG272619.
GeneTreei ENSGT00550000074496.
HOGENOMi HOG000266990.
HOVERGENi HBG003459.
InParanoidi Q9JKV7.
KOi K02368.
OMAi NATFCLI.
OrthoDBi EOG7RBZ7Z.
TreeFami TF314231.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 312088.
PROi Q9JKV7.
SOURCEi Search...

Gene expression databases

Bgeei Q9JKV7.
CleanExi MM_EXTL1.
ExpressionAtlasi Q9JKV7. baseline and differential.
Genevestigatori Q9JKV7.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR004263. Exostosin.
IPR027675. Exostosin-like_1.
IPR015338. HexNAc_Trfase_a.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR11062. PTHR11062. 1 hit.
PTHR11062:SF8. PTHR11062:SF8. 1 hit.
Pfami PF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis."
    Stickens D., Brown D., Evans G.A.
    Dev. Dyn. 218:452-464(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiEXTL1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKV7
Secondary accession number(s): E9QKA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3