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Q9JKV7 (EXTL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exostosin-like 1

EC=2.4.1.224
Alternative name(s):
Exostosin-L
Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Multiple exostosis-like protein
Gene names
Name:Extl1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length669 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable glycosyltransferase By similarity.

Catalytic activity

UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 47 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 669669Exostosin-like 1
PRO_0000149654

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 2921Helical; Signal-anchor for type II membrane protein; Potential
Topological domain30 – 669640Lumenal Potential

Amino acid modifications

Glycosylation2631N-linked (GlcNAc...) Potential
Glycosylation4801N-linked (GlcNAc...) Potential
Disulfide bond577 ↔ 627 By similarity

Experimental info

Sequence conflict321L → S in AAF61913. Ref.1
Sequence conflict1901L → I in AAF61913. Ref.1
Sequence conflict3611I → V in AAF61913. Ref.1
Sequence conflict4501L → P in AAF61913. Ref.1
Sequence conflict5401E → D in AAF61913. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9JKV7 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 79629222B6CA3821

FASTA66974,079
        10         20         30         40         50         60 
MLWRRKSFWL ALSAFWLLLV LLGVFPLRLA VLPGPLPGRS QGWPRWLDAA FLQSFSQSET 

        70         80         90        100        110        120 
NPEDVAQLPR VSRGSSCTWG ACFDTSKCRG KVLKIFVHSP AGPTSEAQRR ILDSLEGSRY 

       130        140        150        160        170        180 
SALSPADACL LLFLPSQDRR GACGPLPPNW NGGRNHLVLS LYPAPCTRLG QAMVAEASPS 

       190        200        210        220        230        240 
SDIFRPGFDL ALPYLPEAHP LRGGAPGKLQ QHSPQPGATL LAVAEEKGRW RITSTHASAC 

       250        260        270        280        290        300 
LWDRHCEQDP GPQQTYPGET LPNATFCLIP GHRSATSCFL QALQAGCIPV LLSPRWELPF 

       310        320        330        340        350        360 
SEVIDWTKAA IIADERLPLQ VLAALREMLP SRVLALRQQT QFLWTAYFSS VEKVIHTTLE 

       370        380        390        400        410        420 
IIQDRIWGAS GHPSLMWNSP PGALLALPTF STSLQDFPFY HLQLGSGPGS SFSAVIWVGA 

       430        440        450        460        470        480 
SGESLLKLIQ EVAGSRHCAQ ILILWNSEKL PPDRWPETAV PLTVIKGHRK VSNRFFPYSN 

       490        500        510        520        530        540 
ISTNVILSLD AQSTLSTSEV DFAFVVWQSF PERMVGFLSG SHFWDEAQGG WGYRTGMTNE 

       550        560        570        580        590        600 
FSMVLTTAAF YHRYYHTLFT HSLPKALRTI ADETPTCVDV LMNFLVATVT KLPPIKVPYG 

       610        620        630        640        650        660 
RQHPEAVPMD SGDPRPVPEP QPLDQDCINR LAAGFGHMPL VSSQVRLDPV LFKDPVSVQR 


KKYRSLEKP 

« Hide

Web resources

Functional Glycomics Gateway - GTase

EXTL1 (putative HS transferase) [GAG Enzyme]

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF224461 mRNA. Translation: AAF61913.1.
AL669982 Genomic DNA. No translation available.
RefSeqNP_062524.2. NM_019578.2.
UniGeneMm.30978.

3D structure databases

ProteinModelPortalQ9JKV7.
SMRQ9JKV7. Positions 410-660.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

PTM databases

PhosphoSiteQ9JKV7.

Proteomic databases

PaxDbQ9JKV7.
PRIDEQ9JKV7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030643; ENSMUSP00000030643; ENSMUSG00000028838.
GeneID56219.
KEGGmmu:56219.
UCSCuc012dmu.1. mouse.

Organism-specific databases

CTD2134.
MGIMGI:1888742. Extl1.

Phylogenomic databases

eggNOGNOG272619.
GeneTreeENSGT00550000074496.
HOGENOMHOG000266990.
HOVERGENHBG003459.
InParanoidQ9JKV7.
KOK02368.
OMANATFCLI.
OrthoDBEOG7RBZ7Z.
TreeFamTF314231.

Enzyme and pathway databases

UniPathwayUPA00378.

Gene expression databases

ArrayExpressQ9JKV7.
BgeeQ9JKV7.
CleanExMM_EXTL1.
GenevestigatorQ9JKV7.

Family and domain databases

InterProIPR004263. Exostosin.
IPR027675. Exostosin-like_1.
IPR015338. HexNAc_Trfase_a.
[Graphical view]
PANTHERPTHR11062. PTHR11062. 1 hit.
PTHR11062:SF8. PTHR11062:SF8. 1 hit.
PfamPF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio312088.
PROQ9JKV7.
SOURCESearch...

Entry information

Entry nameEXTL1_MOUSE
AccessionPrimary (citable) accession number: Q9JKV7
Secondary accession number(s): E9QKA3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot