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Protein

Exostosin-like 1

Gene

Extl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable glycosyltransferase.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

Names & Taxonomyi

Protein namesi
Recommended name:
Exostosin-like 1 (EC:2.4.1.224)
Alternative name(s):
Exostosin-L
Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Multiple exostosis-like protein
Gene namesi
Name:Extl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1888742. Extl1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini30 – 669LumenalSequence analysisAdd BLAST640

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001496541 – 669Exostosin-like 1Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi263N-linked (GlcNAc...)Sequence analysis1
Glycosylationi480N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi577 ↔ 627By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JKV7.
PRIDEiQ9JKV7.

PTM databases

PhosphoSitePlusiQ9JKV7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028838.
CleanExiMM_EXTL1.
GenevisibleiQ9JKV7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030643.

Structurei

3D structure databases

ProteinModelPortaliQ9JKV7.
SMRiQ9JKV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 47 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1021. Eukaryota.
ENOG410XTFH. LUCA.
GeneTreeiENSGT00550000074496.
HOGENOMiHOG000266990.
HOVERGENiHBG003459.
InParanoidiQ9JKV7.
KOiK02368.
OMAiNATFCLI.
OrthoDBiEOG091G0BDR.
TreeFamiTF314231.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR004263. Exostosin.
IPR027675. Exostosin-like_1.
IPR015338. EXT_C.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11062:SF8. PTHR11062:SF8. 2 hits.
PfamiPF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JKV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWRRKSFWL ALSAFWLLLV LLGVFPLRLA VLPGPLPGRS QGWPRWLDAA
60 70 80 90 100
FLQSFSQSET NPEDVAQLPR VSRGSSCTWG ACFDTSKCRG KVLKIFVHSP
110 120 130 140 150
AGPTSEAQRR ILDSLEGSRY SALSPADACL LLFLPSQDRR GACGPLPPNW
160 170 180 190 200
NGGRNHLVLS LYPAPCTRLG QAMVAEASPS SDIFRPGFDL ALPYLPEAHP
210 220 230 240 250
LRGGAPGKLQ QHSPQPGATL LAVAEEKGRW RITSTHASAC LWDRHCEQDP
260 270 280 290 300
GPQQTYPGET LPNATFCLIP GHRSATSCFL QALQAGCIPV LLSPRWELPF
310 320 330 340 350
SEVIDWTKAA IIADERLPLQ VLAALREMLP SRVLALRQQT QFLWTAYFSS
360 370 380 390 400
VEKVIHTTLE IIQDRIWGAS GHPSLMWNSP PGALLALPTF STSLQDFPFY
410 420 430 440 450
HLQLGSGPGS SFSAVIWVGA SGESLLKLIQ EVAGSRHCAQ ILILWNSEKL
460 470 480 490 500
PPDRWPETAV PLTVIKGHRK VSNRFFPYSN ISTNVILSLD AQSTLSTSEV
510 520 530 540 550
DFAFVVWQSF PERMVGFLSG SHFWDEAQGG WGYRTGMTNE FSMVLTTAAF
560 570 580 590 600
YHRYYHTLFT HSLPKALRTI ADETPTCVDV LMNFLVATVT KLPPIKVPYG
610 620 630 640 650
RQHPEAVPMD SGDPRPVPEP QPLDQDCINR LAAGFGHMPL VSSQVRLDPV
660
LFKDPVSVQR KKYRSLEKP
Length:669
Mass (Da):74,079
Last modified:July 27, 2011 - v2
Checksum:i79629222B6CA3821
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32L → S in AAF61913 (PubMed:10878610).Curated1
Sequence conflicti190L → I in AAF61913 (PubMed:10878610).Curated1
Sequence conflicti361I → V in AAF61913 (PubMed:10878610).Curated1
Sequence conflicti450L → P in AAF61913 (PubMed:10878610).Curated1
Sequence conflicti540E → D in AAF61913 (PubMed:10878610).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224461 mRNA. Translation: AAF61913.1.
AL669982 Genomic DNA. No translation available.
CCDSiCCDS18770.1.
RefSeqiNP_062524.2. NM_019578.2.
UniGeneiMm.30978.

Genome annotation databases

EnsembliENSMUST00000030643; ENSMUSP00000030643; ENSMUSG00000028838.
GeneIDi56219.
KEGGimmu:56219.
UCSCiuc012dmu.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

EXTL1 (putative HS transferase) [GAG Enzyme]

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224461 mRNA. Translation: AAF61913.1.
AL669982 Genomic DNA. No translation available.
CCDSiCCDS18770.1.
RefSeqiNP_062524.2. NM_019578.2.
UniGeneiMm.30978.

3D structure databases

ProteinModelPortaliQ9JKV7.
SMRiQ9JKV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030643.

Protein family/group databases

CAZyiGT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

PTM databases

PhosphoSitePlusiQ9JKV7.

Proteomic databases

PaxDbiQ9JKV7.
PRIDEiQ9JKV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030643; ENSMUSP00000030643; ENSMUSG00000028838.
GeneIDi56219.
KEGGimmu:56219.
UCSCiuc012dmu.1. mouse.

Organism-specific databases

CTDi2134.
MGIiMGI:1888742. Extl1.

Phylogenomic databases

eggNOGiKOG1021. Eukaryota.
ENOG410XTFH. LUCA.
GeneTreeiENSGT00550000074496.
HOGENOMiHOG000266990.
HOVERGENiHBG003459.
InParanoidiQ9JKV7.
KOiK02368.
OMAiNATFCLI.
OrthoDBiEOG091G0BDR.
TreeFamiTF314231.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

PROiQ9JKV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028838.
CleanExiMM_EXTL1.
GenevisibleiQ9JKV7. MM.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR004263. Exostosin.
IPR027675. Exostosin-like_1.
IPR015338. EXT_C.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11062:SF8. PTHR11062:SF8. 2 hits.
PfamiPF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEXTL1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKV7
Secondary accession number(s): E9QKA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.