SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9JKV7

- EXTL1_MOUSE

UniProt

Q9JKV7 - EXTL1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Exostosin-like 1
Gene
Extl1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable glycosyltransferase By similarity.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan.

Pathwayi

GO - Molecular functioni

  1. glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

Names & Taxonomyi

Protein namesi
Recommended name:
Exostosin-like 1 (EC:2.4.1.224)
Alternative name(s):
Exostosin-L
Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Multiple exostosis-like protein
Gene namesi
Name:Extl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1888742. Extl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88Cytoplasmic Reviewed prediction
Transmembranei9 – 2921Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini30 – 669640Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intrinsic component of endoplasmic reticulum membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Exostosin-like 1
PRO_0000149654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi263 – 2631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi480 – 4801N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi577 ↔ 627 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JKV7.
PRIDEiQ9JKV7.

PTM databases

PhosphoSiteiQ9JKV7.

Expressioni

Gene expression databases

ArrayExpressiQ9JKV7.
BgeeiQ9JKV7.
CleanExiMM_EXTL1.
GenevestigatoriQ9JKV7.

Structurei

3D structure databases

ProteinModelPortaliQ9JKV7.
SMRiQ9JKV7. Positions 411-593.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272619.
GeneTreeiENSGT00550000074496.
HOGENOMiHOG000266990.
HOVERGENiHBG003459.
InParanoidiQ9JKV7.
KOiK02368.
OMAiNATFCLI.
OrthoDBiEOG7RBZ7Z.
TreeFamiTF314231.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR004263. Exostosin.
IPR027675. Exostosin-like_1.
IPR015338. HexNAc_Trfase_a.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11062. PTHR11062. 1 hit.
PTHR11062:SF8. PTHR11062:SF8. 1 hit.
PfamiPF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JKV7-1 [UniParc]FASTAAdd to Basket

« Hide

MLWRRKSFWL ALSAFWLLLV LLGVFPLRLA VLPGPLPGRS QGWPRWLDAA    50
FLQSFSQSET NPEDVAQLPR VSRGSSCTWG ACFDTSKCRG KVLKIFVHSP 100
AGPTSEAQRR ILDSLEGSRY SALSPADACL LLFLPSQDRR GACGPLPPNW 150
NGGRNHLVLS LYPAPCTRLG QAMVAEASPS SDIFRPGFDL ALPYLPEAHP 200
LRGGAPGKLQ QHSPQPGATL LAVAEEKGRW RITSTHASAC LWDRHCEQDP 250
GPQQTYPGET LPNATFCLIP GHRSATSCFL QALQAGCIPV LLSPRWELPF 300
SEVIDWTKAA IIADERLPLQ VLAALREMLP SRVLALRQQT QFLWTAYFSS 350
VEKVIHTTLE IIQDRIWGAS GHPSLMWNSP PGALLALPTF STSLQDFPFY 400
HLQLGSGPGS SFSAVIWVGA SGESLLKLIQ EVAGSRHCAQ ILILWNSEKL 450
PPDRWPETAV PLTVIKGHRK VSNRFFPYSN ISTNVILSLD AQSTLSTSEV 500
DFAFVVWQSF PERMVGFLSG SHFWDEAQGG WGYRTGMTNE FSMVLTTAAF 550
YHRYYHTLFT HSLPKALRTI ADETPTCVDV LMNFLVATVT KLPPIKVPYG 600
RQHPEAVPMD SGDPRPVPEP QPLDQDCINR LAAGFGHMPL VSSQVRLDPV 650
LFKDPVSVQR KKYRSLEKP 669
Length:669
Mass (Da):74,079
Last modified:July 27, 2011 - v2
Checksum:i79629222B6CA3821
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321L → S in AAF61913. 1 Publication
Sequence conflicti190 – 1901L → I in AAF61913. 1 Publication
Sequence conflicti361 – 3611I → V in AAF61913. 1 Publication
Sequence conflicti450 – 4501L → P in AAF61913. 1 Publication
Sequence conflicti540 – 5401E → D in AAF61913. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF224461 mRNA. Translation: AAF61913.1.
AL669982 Genomic DNA. No translation available.
CCDSiCCDS18770.1.
RefSeqiNP_062524.2. NM_019578.2.
UniGeneiMm.30978.

Genome annotation databases

EnsembliENSMUST00000030643; ENSMUSP00000030643; ENSMUSG00000028838.
GeneIDi56219.
KEGGimmu:56219.
UCSCiuc012dmu.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

EXTL1 (putative HS transferase) [GAG Enzyme]

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF224461 mRNA. Translation: AAF61913.1 .
AL669982 Genomic DNA. No translation available.
CCDSi CCDS18770.1.
RefSeqi NP_062524.2. NM_019578.2.
UniGenei Mm.30978.

3D structure databases

ProteinModelPortali Q9JKV7.
SMRi Q9JKV7. Positions 411-593.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

PTM databases

PhosphoSitei Q9JKV7.

Proteomic databases

PaxDbi Q9JKV7.
PRIDEi Q9JKV7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030643 ; ENSMUSP00000030643 ; ENSMUSG00000028838 .
GeneIDi 56219.
KEGGi mmu:56219.
UCSCi uc012dmu.1. mouse.

Organism-specific databases

CTDi 2134.
MGIi MGI:1888742. Extl1.

Phylogenomic databases

eggNOGi NOG272619.
GeneTreei ENSGT00550000074496.
HOGENOMi HOG000266990.
HOVERGENi HBG003459.
InParanoidi Q9JKV7.
KOi K02368.
OMAi NATFCLI.
OrthoDBi EOG7RBZ7Z.
TreeFami TF314231.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 312088.
PROi Q9JKV7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JKV7.
Bgeei Q9JKV7.
CleanExi MM_EXTL1.
Genevestigatori Q9JKV7.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR004263. Exostosin.
IPR027675. Exostosin-like_1.
IPR015338. HexNAc_Trfase_a.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR11062. PTHR11062. 1 hit.
PTHR11062:SF8. PTHR11062:SF8. 1 hit.
Pfami PF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis."
    Stickens D., Brown D., Evans G.A.
    Dev. Dyn. 218:452-464(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiEXTL1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKV7
Secondary accession number(s): E9QKA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi