Exostosin-like 1 - Mus musculus (Mouse)

Contribute

Send feedback

Read comments (?) or add your own

Q9JKV7 (EXTL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 87. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Exostosin-like 1
EC=2.4.1.224

Alternative name(s):
Exostosin-L
Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Multiple exostosis-like protein

Gene names

Name:

Extl1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	669 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable glycosyltransferase By similarity.
Catalytic activity	UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 47 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein glycosylation Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intrinsic to endoplasmic reticulum membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 669

669

Exostosin-like 1

PRO_0000149654

Regions

Topological domain

1 – 8

Cytoplasmic Potential

Transmembrane

9 – 29

Helical; Signal-anchor for type II membrane protein; Potential

Topological domain

30 – 669

640

Lumenal Potential

Amino acid modifications

Glycosylation

263

N-linked (GlcNAc...) Potential

Glycosylation

480

N-linked (GlcNAc...) Potential

Disulfide bond

577 ↔ 627

By similarity

Experimental info

Sequence conflict

L → S in AAF61913. Ref.1

Sequence conflict

190

L → I in AAF61913. Ref.1

Sequence conflict

361

I → V in AAF61913. Ref.1

Sequence conflict

450

L → P in AAF61913. Ref.1

Sequence conflict

540

E → D in AAF61913. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9JKV7 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 79629222B6CA3821
Show »

FASTA

669

74,079

        10         20         30         40         50         60 
MLWRRKSFWL ALSAFWLLLV LLGVFPLRLA VLPGPLPGRS QGWPRWLDAA FLQSFSQSET 

        70         80         90        100        110        120 
NPEDVAQLPR VSRGSSCTWG ACFDTSKCRG KVLKIFVHSP AGPTSEAQRR ILDSLEGSRY 

       130        140        150        160        170        180 
SALSPADACL LLFLPSQDRR GACGPLPPNW NGGRNHLVLS LYPAPCTRLG QAMVAEASPS 

       190        200        210        220        230        240 
SDIFRPGFDL ALPYLPEAHP LRGGAPGKLQ QHSPQPGATL LAVAEEKGRW RITSTHASAC 

       250        260        270        280        290        300 
LWDRHCEQDP GPQQTYPGET LPNATFCLIP GHRSATSCFL QALQAGCIPV LLSPRWELPF 

       310        320        330        340        350        360 
SEVIDWTKAA IIADERLPLQ VLAALREMLP SRVLALRQQT QFLWTAYFSS VEKVIHTTLE 

       370        380        390        400        410        420 
IIQDRIWGAS GHPSLMWNSP PGALLALPTF STSLQDFPFY HLQLGSGPGS SFSAVIWVGA 

       430        440        450        460        470        480 
SGESLLKLIQ EVAGSRHCAQ ILILWNSEKL PPDRWPETAV PLTVIKGHRK VSNRFFPYSN 

       490        500        510        520        530        540 
ISTNVILSLD AQSTLSTSEV DFAFVVWQSF PERMVGFLSG SHFWDEAQGG WGYRTGMTNE 

       550        560        570        580        590        600 
FSMVLTTAAF YHRYYHTLFT HSLPKALRTI ADETPTCVDV LMNFLVATVT KLPPIKVPYG 

       610        620        630        640        650        660 
RQHPEAVPMD SGDPRPVPEP QPLDQDCINR LAAGFGHMPL VSSQVRLDPV LFKDPVSVQR 


KKYRSLEKP

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis." Stickens D., Brown D., Evans G.A. Dev. Dyn. 218:452-464(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - GTase

EXTL1 (putative HS transferase) [GAG Enzyme]

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF224461 mRNA. Translation: AAF61913.1. AL669982 Genomic DNA. No translation available.
IPI	IPI00123491.
RefSeq	NP_062524.2. NM_019578.2.
UniGene	Mm.30978.
3D structure databases
ProteinModelPortal	Q9JKV7.
SMR	Q9JKV7. Positions 411-593.
ModBase	Search...
Protein family/group databases
CAZy	GT47. Glycosyltransferase Family 47. GT64. Glycosyltransferase Family 64.
PTM databases
PhosphoSite	Q9JKV7.
Proteomic databases
PaxDb	Q9JKV7.
PRIDE	Q9JKV7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030643; ENSMUSP00000030643; ENSMUSG00000028838.
GeneID	56219.
KEGG	mmu:56219.
UCSC	uc012dmu.1. mouse.
Organism-specific databases
CTD	2134.
MGI	MGI:1888742. Extl1.
Phylogenomic databases
eggNOG	NOG272619.
GeneTree	ENSGT00550000074496.
HOGENOM	HOG000266990.
HOVERGEN	HBG003459.
InParanoid	Q9JKV7.
KO	K02368.
OMA	RYYHTLF.
OrthoDB	EOG47M1XC.
Enzyme and pathway databases
UniPathway	UPA00378.
Gene expression databases
ArrayExpress	Q9JKV7.
Bgee	Q9JKV7.
CleanEx	MM_EXTL1.
Genevestigator	Q9JKV7.
GermOnline	ENSMUSG00000028838. Mus musculus.
Family and domain databases
InterPro	IPR004263. Exostosin. IPR015338. HexNAc_Trfase_a. [Graphical view]
Pfam	PF03016. Exostosin. 1 hit. PF09258. Glyco_transf_64. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	312088.
SOURCE	Search...

Entry information

Entry name

EXTL1_MOUSE

Accession

Primary (citable) accession number: Q9JKV7
Secondary accession number(s): E9QKA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents