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Q9JKV7

- EXTL1_MOUSE

UniProt

Q9JKV7 - EXTL1_MOUSE

Protein

Exostosin-like 1

Gene

Extl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Probable glycosyltransferase.By similarity

    Catalytic activityi

    UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan.

    Pathwayi

    GO - Molecular functioni

    1. glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT47. Glycosyltransferase Family 47.
    GT64. Glycosyltransferase Family 64.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exostosin-like 1 (EC:2.4.1.224)
    Alternative name(s):
    Exostosin-L
    Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
    Multiple exostosis-like protein
    Gene namesi
    Name:Extl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1888742. Extl1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intrinsic component of endoplasmic reticulum membrane Source: InterPro

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 669669Exostosin-like 1PRO_0000149654Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi577 ↔ 627By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9JKV7.
    PRIDEiQ9JKV7.

    PTM databases

    PhosphoSiteiQ9JKV7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JKV7.
    BgeeiQ9JKV7.
    CleanExiMM_EXTL1.
    GenevestigatoriQ9JKV7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JKV7.
    SMRiQ9JKV7. Positions 411-593.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini30 – 669640LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 47 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG272619.
    GeneTreeiENSGT00550000074496.
    HOGENOMiHOG000266990.
    HOVERGENiHBG003459.
    InParanoidiQ9JKV7.
    KOiK02368.
    OMAiNATFCLI.
    OrthoDBiEOG7RBZ7Z.
    TreeFamiTF314231.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR004263. Exostosin.
    IPR027675. Exostosin-like_1.
    IPR015338. HexNAc_Trfase_a.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PANTHERiPTHR11062. PTHR11062. 1 hit.
    PTHR11062:SF8. PTHR11062:SF8. 1 hit.
    PfamiPF03016. Exostosin. 1 hit.
    PF09258. Glyco_transf_64. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9JKV7-1 [UniParc]FASTAAdd to Basket

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    MLWRRKSFWL ALSAFWLLLV LLGVFPLRLA VLPGPLPGRS QGWPRWLDAA    50
    FLQSFSQSET NPEDVAQLPR VSRGSSCTWG ACFDTSKCRG KVLKIFVHSP 100
    AGPTSEAQRR ILDSLEGSRY SALSPADACL LLFLPSQDRR GACGPLPPNW 150
    NGGRNHLVLS LYPAPCTRLG QAMVAEASPS SDIFRPGFDL ALPYLPEAHP 200
    LRGGAPGKLQ QHSPQPGATL LAVAEEKGRW RITSTHASAC LWDRHCEQDP 250
    GPQQTYPGET LPNATFCLIP GHRSATSCFL QALQAGCIPV LLSPRWELPF 300
    SEVIDWTKAA IIADERLPLQ VLAALREMLP SRVLALRQQT QFLWTAYFSS 350
    VEKVIHTTLE IIQDRIWGAS GHPSLMWNSP PGALLALPTF STSLQDFPFY 400
    HLQLGSGPGS SFSAVIWVGA SGESLLKLIQ EVAGSRHCAQ ILILWNSEKL 450
    PPDRWPETAV PLTVIKGHRK VSNRFFPYSN ISTNVILSLD AQSTLSTSEV 500
    DFAFVVWQSF PERMVGFLSG SHFWDEAQGG WGYRTGMTNE FSMVLTTAAF 550
    YHRYYHTLFT HSLPKALRTI ADETPTCVDV LMNFLVATVT KLPPIKVPYG 600
    RQHPEAVPMD SGDPRPVPEP QPLDQDCINR LAAGFGHMPL VSSQVRLDPV 650
    LFKDPVSVQR KKYRSLEKP 669
    Length:669
    Mass (Da):74,079
    Last modified:July 27, 2011 - v2
    Checksum:i79629222B6CA3821
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321L → S in AAF61913. (PubMed:10878610)Curated
    Sequence conflicti190 – 1901L → I in AAF61913. (PubMed:10878610)Curated
    Sequence conflicti361 – 3611I → V in AAF61913. (PubMed:10878610)Curated
    Sequence conflicti450 – 4501L → P in AAF61913. (PubMed:10878610)Curated
    Sequence conflicti540 – 5401E → D in AAF61913. (PubMed:10878610)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF224461 mRNA. Translation: AAF61913.1.
    AL669982 Genomic DNA. No translation available.
    CCDSiCCDS18770.1.
    RefSeqiNP_062524.2. NM_019578.2.
    UniGeneiMm.30978.

    Genome annotation databases

    EnsembliENSMUST00000030643; ENSMUSP00000030643; ENSMUSG00000028838.
    GeneIDi56219.
    KEGGimmu:56219.
    UCSCiuc012dmu.1. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - GTase

    EXTL1 (putative HS transferase) [GAG Enzyme]

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF224461 mRNA. Translation: AAF61913.1 .
    AL669982 Genomic DNA. No translation available.
    CCDSi CCDS18770.1.
    RefSeqi NP_062524.2. NM_019578.2.
    UniGenei Mm.30978.

    3D structure databases

    ProteinModelPortali Q9JKV7.
    SMRi Q9JKV7. Positions 411-593.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT47. Glycosyltransferase Family 47.
    GT64. Glycosyltransferase Family 64.

    PTM databases

    PhosphoSitei Q9JKV7.

    Proteomic databases

    PaxDbi Q9JKV7.
    PRIDEi Q9JKV7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030643 ; ENSMUSP00000030643 ; ENSMUSG00000028838 .
    GeneIDi 56219.
    KEGGi mmu:56219.
    UCSCi uc012dmu.1. mouse.

    Organism-specific databases

    CTDi 2134.
    MGIi MGI:1888742. Extl1.

    Phylogenomic databases

    eggNOGi NOG272619.
    GeneTreei ENSGT00550000074496.
    HOGENOMi HOG000266990.
    HOVERGENi HBG003459.
    InParanoidi Q9JKV7.
    KOi K02368.
    OMAi NATFCLI.
    OrthoDBi EOG7RBZ7Z.
    TreeFami TF314231.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    NextBioi 312088.
    PROi Q9JKV7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JKV7.
    Bgeei Q9JKV7.
    CleanExi MM_EXTL1.
    Genevestigatori Q9JKV7.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR004263. Exostosin.
    IPR027675. Exostosin-like_1.
    IPR015338. HexNAc_Trfase_a.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    PANTHERi PTHR11062. PTHR11062. 1 hit.
    PTHR11062:SF8. PTHR11062:SF8. 1 hit.
    Pfami PF03016. Exostosin. 1 hit.
    PF09258. Glyco_transf_64. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis."
      Stickens D., Brown D., Evans G.A.
      Dev. Dyn. 218:452-464(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiEXTL1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JKV7
    Secondary accession number(s): E9QKA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3