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Q9JKV2

- ICK_MOUSE

UniProt

Q9JKV2 - ICK_MOUSE

Protein

Serine/threonine-protein kinase ICK

Gene

Ick

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    May play a role in cardiac development.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPBy similarityPROSITE-ProRule annotation
    Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. magnesium ion binding Source: UniProtKB
    4. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. intracellular signal transduction Source: UniProtKB
    2. multicellular organismal development Source: UniProtKB-KW
    3. protein phosphorylation Source: UniProtKB
    4. signal transduction Source: MGI

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase ICK (EC:2.7.11.22)
    Alternative name(s):
    Intestinal cell kinase
    Short name:
    mICK
    MAK-related kinase
    Short name:
    MRK
    Gene namesi
    Name:Ick
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1934157. Ick.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. intracellular membrane-bounded organelle Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 629629Serine/threonine-protein kinase ICKPRO_0000086008Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei157 – 1571PhosphothreonineBy similarity
    Modified residuei159 – 1591PhosphotyrosineBy similarity

    Post-translational modificationi

    Autophosphorylated on serine and threonine residues. May play a role in enzyme activation By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9JKV2.
    PRIDEiQ9JKV2.

    PTM databases

    PhosphoSiteiQ9JKV2.

    Expressioni

    Tissue specificityi

    Highly expressed in colon and lung, lower levels present in heart, esophagus, stomach, small intestine and ovary. Localizes to the crypt region of large and small intestine.1 Publication

    Gene expression databases

    ArrayExpressiQ9JKV2.
    BgeeiQ9JKV2.
    CleanExiMM_ICK.
    GenevestigatoriQ9JKV2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000112961.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JKV2.
    SMRiQ9JKV2. Positions 1-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 284281Protein kinaseCuratedPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00650000093283.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ9JKV2.
    KOiK08828.
    OMAiCIMAEVY.
    OrthoDBiEOG7NCV37.
    PhylomeDBiQ9JKV2.
    TreeFamiTF328769.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JKV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRYTTIKQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE    50
    VKSLKKLNHA NIVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES 100
    AIRNIMYQIL QGLAFIHKHG FFHRDLKPEN LLCMGPELVK IADFGLAREI 150
    RSRPPYTDYV STRWYRAPEV LLRSTNYSSP IDIWAVGCIM AEVYTLRPLF 200
    PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFLWPQ CIPNNLKTLI 250
    PNASSEAIQL LRDLLQWDPK KRPTASQALR YPYFQIGHPL GIISKDSGKP 300
    QREVQDKTGP PPYIKPAPPA QAPAKAYTLI SSRPSQASQP PQHSVHPYKG 350
    DVSRTEQLSH VQEGKPSPPF FPSLHNKNLQ PKILASLEQK NGEIKPKSRR 400
    RWGLISRSTK GSDDWADLDD LDFSPSLTRI DVKNKKRQSD DTLCRFESVL 450
    DLKPSESVGT GTTVSTQASS QRRDTPTLQS SAKQHYLKHS RYLPGINIRN 500
    GVLPNPGKDF LPSNSWSSSG LSGKSSGTVS VVSKITSVGS GSASSSGLTG 550
    SYIPSFLKKE IGSVMQRVQL APLAAPPPGY SSLKAVRPHP GRPFFHTQPR 600
    STPGLIPRPP AAQPVHGRID WSSKYPSRR 629
    Length:629
    Mass (Da):70,592
    Last modified:June 7, 2004 - v2
    Checksum:i43E863847C5FD9C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti533 – 5331S → R in AAF37277. (PubMed:10699974)Curated
    Sequence conflicti616 – 6161H → L in AAF37277. (PubMed:10699974)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF225918 mRNA. Translation: AAF37277.1.
    BC028863 mRNA. Translation: AAH28863.1.
    CCDSiCCDS40697.1.
    RefSeqiNP_001157252.1. NM_001163780.1.
    NP_064371.2. NM_019987.2.
    XP_006511367.1. XM_006511304.1.
    UniGeneiMm.288719.

    Genome annotation databases

    EnsembliENSMUST00000044551; ENSMUSP00000048234; ENSMUSG00000009828.
    ENSMUST00000118869; ENSMUSP00000112961; ENSMUSG00000009828.
    GeneIDi56542.
    KEGGimmu:56542.
    UCSCiuc009qtt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF225918 mRNA. Translation: AAF37277.1 .
    BC028863 mRNA. Translation: AAH28863.1 .
    CCDSi CCDS40697.1.
    RefSeqi NP_001157252.1. NM_001163780.1.
    NP_064371.2. NM_019987.2.
    XP_006511367.1. XM_006511304.1.
    UniGenei Mm.288719.

    3D structure databases

    ProteinModelPortali Q9JKV2.
    SMRi Q9JKV2. Positions 1-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000112961.

    PTM databases

    PhosphoSitei Q9JKV2.

    Proteomic databases

    PaxDbi Q9JKV2.
    PRIDEi Q9JKV2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044551 ; ENSMUSP00000048234 ; ENSMUSG00000009828 .
    ENSMUST00000118869 ; ENSMUSP00000112961 ; ENSMUSG00000009828 .
    GeneIDi 56542.
    KEGGi mmu:56542.
    UCSCi uc009qtt.2. mouse.

    Organism-specific databases

    CTDi 22858.
    MGIi MGI:1934157. Ick.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00650000093283.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q9JKV2.
    KOi K08828.
    OMAi CIMAEVY.
    OrthoDBi EOG7NCV37.
    PhylomeDBi Q9JKV2.
    TreeFami TF328769.

    Miscellaneous databases

    NextBioi 312910.
    PROi Q9JKV2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JKV2.
    Bgeei Q9JKV2.
    CleanExi MM_ICK.
    Genevestigatori Q9JKV2.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases."
      Togawa K., Yan Y.-X., Inomoto T., Slaugenhaupt S.A., Rustgi A.K.
      J. Cell. Physiol. 183:129-139(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Ileum1 Publication and Jejunum1 Publication.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: ColonImported.

    Entry informationi

    Entry nameiICK_MOUSE
    AccessioniPrimary (citable) accession number: Q9JKV2
    Secondary accession number(s): Q8K138
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3