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Q9JKV2

- ICK_MOUSE

UniProt

Q9JKV2 - ICK_MOUSE

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Protein

Serine/threonine-protein kinase ICK

Gene
Ick
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in cardiac development By similarity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarityBy similarity
Active sitei125 – 1251Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. magnesium ion binding Source: UniProtKB
  4. protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. intracellular signal transduction Source: UniProtKB
  2. multicellular organismal development Source: UniProtKB-KW
  3. protein phosphorylation Source: UniProtKB
  4. signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ICK (EC:2.7.11.22)
Alternative name(s):
Intestinal cell kinase
Short name:
mICK
MAK-related kinase
Short name:
MRK
Gene namesi
Name:Ick
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1934157. Ick.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
  2. intracellular membrane-bounded organelle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 629629Serine/threonine-protein kinase ICKPRO_0000086008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei157 – 1571Phosphothreonine By similarityBy similarity
Modified residuei159 – 1591Phosphotyrosine By similarityBy similarity

Post-translational modificationi

Autophosphorylated on serine and threonine residues. May play a role in enzyme activation By similarity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JKV2.
PRIDEiQ9JKV2.

PTM databases

PhosphoSiteiQ9JKV2.

Expressioni

Tissue specificityi

Highly expressed in colon and lung, lower levels present in heart, esophagus, stomach, small intestine and ovary. Localizes to the crypt region of large and small intestine.1 Publication

Gene expression databases

ArrayExpressiQ9JKV2.
BgeeiQ9JKV2.
CleanExiMM_ICK.
GenevestigatoriQ9JKV2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112961.

Structurei

3D structure databases

ProteinModelPortaliQ9JKV2.
SMRiQ9JKV2. Positions 1-413.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 284281Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00650000093283.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ9JKV2.
KOiK08828.
OMAiCIMAEVY.
OrthoDBiEOG7NCV37.
PhylomeDBiQ9JKV2.
TreeFamiTF328769.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKV2-1 [UniParc]FASTAAdd to Basket

« Hide

MNRYTTIKQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE    50
VKSLKKLNHA NIVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES 100
AIRNIMYQIL QGLAFIHKHG FFHRDLKPEN LLCMGPELVK IADFGLAREI 150
RSRPPYTDYV STRWYRAPEV LLRSTNYSSP IDIWAVGCIM AEVYTLRPLF 200
PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFLWPQ CIPNNLKTLI 250
PNASSEAIQL LRDLLQWDPK KRPTASQALR YPYFQIGHPL GIISKDSGKP 300
QREVQDKTGP PPYIKPAPPA QAPAKAYTLI SSRPSQASQP PQHSVHPYKG 350
DVSRTEQLSH VQEGKPSPPF FPSLHNKNLQ PKILASLEQK NGEIKPKSRR 400
RWGLISRSTK GSDDWADLDD LDFSPSLTRI DVKNKKRQSD DTLCRFESVL 450
DLKPSESVGT GTTVSTQASS QRRDTPTLQS SAKQHYLKHS RYLPGINIRN 500
GVLPNPGKDF LPSNSWSSSG LSGKSSGTVS VVSKITSVGS GSASSSGLTG 550
SYIPSFLKKE IGSVMQRVQL APLAAPPPGY SSLKAVRPHP GRPFFHTQPR 600
STPGLIPRPP AAQPVHGRID WSSKYPSRR 629
Length:629
Mass (Da):70,592
Last modified:June 7, 2004 - v2
Checksum:i43E863847C5FD9C5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti533 – 5331S → R in AAF37277. 1 Publication
Sequence conflicti616 – 6161H → L in AAF37277. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF225918 mRNA. Translation: AAF37277.1.
BC028863 mRNA. Translation: AAH28863.1.
CCDSiCCDS40697.1.
RefSeqiNP_001157252.1. NM_001163780.1.
NP_064371.2. NM_019987.2.
XP_006511367.1. XM_006511304.1.
UniGeneiMm.288719.

Genome annotation databases

EnsembliENSMUST00000044551; ENSMUSP00000048234; ENSMUSG00000009828.
ENSMUST00000118869; ENSMUSP00000112961; ENSMUSG00000009828.
GeneIDi56542.
KEGGimmu:56542.
UCSCiuc009qtt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF225918 mRNA. Translation: AAF37277.1 .
BC028863 mRNA. Translation: AAH28863.1 .
CCDSi CCDS40697.1.
RefSeqi NP_001157252.1. NM_001163780.1.
NP_064371.2. NM_019987.2.
XP_006511367.1. XM_006511304.1.
UniGenei Mm.288719.

3D structure databases

ProteinModelPortali Q9JKV2.
SMRi Q9JKV2. Positions 1-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000112961.

PTM databases

PhosphoSitei Q9JKV2.

Proteomic databases

PaxDbi Q9JKV2.
PRIDEi Q9JKV2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044551 ; ENSMUSP00000048234 ; ENSMUSG00000009828 .
ENSMUST00000118869 ; ENSMUSP00000112961 ; ENSMUSG00000009828 .
GeneIDi 56542.
KEGGi mmu:56542.
UCSCi uc009qtt.2. mouse.

Organism-specific databases

CTDi 22858.
MGIi MGI:1934157. Ick.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00650000093283.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.
InParanoidi Q9JKV2.
KOi K08828.
OMAi CIMAEVY.
OrthoDBi EOG7NCV37.
PhylomeDBi Q9JKV2.
TreeFami TF328769.

Miscellaneous databases

NextBioi 312910.
PROi Q9JKV2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JKV2.
Bgeei Q9JKV2.
CleanExi MM_ICK.
Genevestigatori Q9JKV2.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases."
    Togawa K., Yan Y.-X., Inomoto T., Slaugenhaupt S.A., Rustgi A.K.
    J. Cell. Physiol. 183:129-139(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Ileum and Jejunum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiICK_MOUSE
AccessioniPrimary (citable) accession number: Q9JKV2
Secondary accession number(s): Q8K138
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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