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Q9JKV2 (ICK_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase ICK
EC=2.7.11.22
Alternative name(s):
Intestinal cell kinase
Short name=mICK
MAK-related kinase
Short name=MRK
Gene names
Name:Ick
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length629 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in cardiac development By similarity. UniProtKB Q62726

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity. UniProtKB Q9NYX3

Subcellular location

Cytoplasm › cytosol By similarity.

Tissue specificity

Highly expressed in colon and lung, lower levels present in heart, esophagus, stomach, small intestine and ovary. Localizes to the crypt region of large and small intestine. Ref.1

Post-translational modification

Autophosphorylated on serine and threonine residues. May play a role in enzyme activation By similarity. UniProtKB Q9NYX3

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 629629Serine/threonine-protein kinase ICK
PRO_0000086008

Regions

Domain4 – 284281Protein kinase
Nucleotide binding10 – 189ATP By similarity UniProtKB P06493

Sites

Active site1251Proton acceptor By similarity UniProtKB P06493
Binding site331ATP By similarity UniProtKB Q9NYX3

Amino acid modifications

Modified residue1571Phosphothreonine By similarity UniProtKB Q9NYX3
Modified residue1591Phosphotyrosine By similarity UniProtKB Q9NYX3

Experimental info

Sequence conflict5331S → R in AAF37277. Ref.1
Sequence conflict6161H → L in AAF37277. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9JKV2 [UniParc].

Last modified June 7, 2004. Version 2.
Checksum: 43E863847C5FD9C5

FASTA62970,592
        10         20         30         40         50         60 
MNRYTTIKQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA 

        70         80         90        100        110        120 
NIVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES AIRNIMYQIL QGLAFIHKHG 

       130        140        150        160        170        180 
FFHRDLKPEN LLCMGPELVK IADFGLAREI RSRPPYTDYV STRWYRAPEV LLRSTNYSSP 

       190        200        210        220        230        240 
IDIWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFLWPQ 

       250        260        270        280        290        300 
CIPNNLKTLI PNASSEAIQL LRDLLQWDPK KRPTASQALR YPYFQIGHPL GIISKDSGKP 

       310        320        330        340        350        360 
QREVQDKTGP PPYIKPAPPA QAPAKAYTLI SSRPSQASQP PQHSVHPYKG DVSRTEQLSH 

       370        380        390        400        410        420 
VQEGKPSPPF FPSLHNKNLQ PKILASLEQK NGEIKPKSRR RWGLISRSTK GSDDWADLDD 

       430        440        450        460        470        480 
LDFSPSLTRI DVKNKKRQSD DTLCRFESVL DLKPSESVGT GTTVSTQASS QRRDTPTLQS 

       490        500        510        520        530        540 
SAKQHYLKHS RYLPGINIRN GVLPNPGKDF LPSNSWSSSG LSGKSSGTVS VVSKITSVGS 

       550        560        570        580        590        600 
GSASSSGLTG SYIPSFLKKE IGSVMQRVQL APLAAPPPGY SSLKAVRPHP GRPFFHTQPR 

       610        620 
STPGLIPRPP AAQPVHGRID WSSKYPSRR

« Hide

References

« Hide 'large scale' references
[1]"Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases."
Togawa K., Yan Y.-X., Inomoto T., Slaugenhaupt S.A., Rustgi A.K.
J. Cell. Physiol. 183:129-139(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Ileum and Jejunum.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF225918 mRNA. Translation: AAF37277.1.
BC028863 mRNA. Translation: AAH28863.1.
IPIIPI00331376.
RefSeqNP_001157252.1. NM_001163780.1.
NP_064371.2. NM_019987.2.
UniGeneMm.288719.

3D structure databases

ProteinModelPortalQ9JKV2.
SMRQ9JKV2. Positions 1-413.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000112961.

PTM databases

PhosphoSiteQ9JKV2.

Proteomic databases

PaxDbQ9JKV2.
PRIDEQ9JKV2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044551; ENSMUSP00000048234; ENSMUSG00000009828.
ENSMUST00000118869; ENSMUSP00000112961; ENSMUSG00000009828.
GeneID56542.
KEGGmmu:56542.
UCSCuc009qtt.2. mouse.

Organism-specific databases

CTD22858.
MGIMGI:1934157. Ick.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00650000093283.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidQ9JKV2.
KOK08828.
OMACIMAEVY.
OrthoDBEOG46DM2D.

Gene expression databases

ArrayExpressQ9JKV2.
BgeeQ9JKV2.
CleanExMM_ICK.
GenevestigatorQ9JKV2.
GermOnlineENSMUSG00000009828. Mus musculus.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio312910.
SOURCESearch...

Entry information

Entry nameICK_MOUSE
AccessionPrimary (citable) accession number: Q9JKV2
Secondary accession number(s): Q8K138
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: May 29, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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