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Protein

Proteasomal ubiquitin receptor ADRM1

Gene

Adrm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity.2 Publications

GO - Molecular functioni

GO - Biological processi

  • adipose tissue development Source: BHF-UCL
  • follicle-stimulating hormone signaling pathway Source: BHF-UCL
  • oogenesis Source: BHF-UCL
  • ovarian follicle development Source: BHF-UCL
  • positive regulation of growth hormone receptor signaling pathway Source: BHF-UCL
  • proteasome assembly Source: MGI
  • regulation of T cell differentiation in thymus Source: BHF-UCL
  • seminiferous tubule development Source: BHF-UCL
  • Sertoli cell development Source: BHF-UCL
  • spermatid development Source: BHF-UCL
  • thymus development Source: BHF-UCL
  • transcription elongation from RNA polymerase II promoter Source: MGI
  • ubiquitin-dependent protein catabolic process Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5689603. UCH proteinases.
R-MMU-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasomal ubiquitin receptor ADRM1
Alternative name(s):
110 kDa cell membrane glycoprotein
Short name:
Gp110
Adhesion-regulating molecule 1
Short name:
ARM-1
Rpn13 homolog
Gene namesi
Name:Adrm1
Synonyms:Gp110
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1929289. Adrm1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000206322 – 407Proteasomal ubiquitin receptor ADRM1Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei140PhosphoserineBy similarity1
Modified residuei211PhosphoserineBy similarity1
Modified residuei217PhosphothreonineBy similarity1
Modified residuei405PhosphoserineBy similarity1

Post-translational modificationi

Not N-glycosylated.
Not O-glycosylated.Curated

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9JKV1.
MaxQBiQ9JKV1.
PaxDbiQ9JKV1.
PeptideAtlasiQ9JKV1.
PRIDEiQ9JKV1.

PTM databases

iPTMnetiQ9JKV1.
PhosphoSitePlusiQ9JKV1.

Expressioni

Tissue specificityi

Present in all tissues examined (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000039041.
CleanExiMM_ADRM1.
GenevisibleiQ9JKV1. MM.

Interactioni

Subunit structurei

Interacts with PSMD1, ubiquitin and UCHL5.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207978. 9 interactors.
DIPiDIP-60625N.
IntActiQ9JKV1. 14 interactors.
STRINGi10090.ENSMUSP00000050076.

Structurei

Secondary structure

1407
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 34Combined sources11
Beta strandi37 – 40Combined sources4
Beta strandi45 – 51Combined sources7
Beta strandi57 – 63Combined sources7
Turni64 – 66Combined sources3
Beta strandi69 – 74Combined sources6
Beta strandi79 – 84Combined sources6
Beta strandi93 – 98Combined sources6
Turni99 – 101Combined sources3
Beta strandi104 – 109Combined sources6
Beta strandi111 – 114Combined sources4
Helixi117 – 129Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R2YX-ray1.70A2-150[»]
2Z59NMR-A22-130[»]
ProteinModelPortaliQ9JKV1.
SMRiQ9JKV1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JKV1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 130PHAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 132Interaction with PSMD11 PublicationAdd BLAST131
Regioni362 – 407Interaction with UCHL5By similarityAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi135 – 202Gly-richAdd BLAST68
Compositional biasi193 – 257Ser-richAdd BLAST65
Compositional biasi203 – 213Poly-SerAdd BLAST11

Domaini

The PH domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of K48-linked diubiquitin allows UCHL5 access to the distal subunit.

Sequence similaritiesi

Belongs to the ADRM1 family.Curated
Contains 1 PH domain.Curated

Phylogenomic databases

eggNOGiKOG3037. Eukaryota.
ENOG410XSJJ. LUCA.
GeneTreeiENSGT00390000013839.
HOGENOMiHOG000005947.
HOVERGENiHBG073518.
InParanoidiQ9JKV1.
OMAiKRVDQCK.
OrthoDBiEOG091G0FEO.
PhylomeDBiQ9JKV1.
TreeFamiTF313410.

Family and domain databases

InterProiIPR006773. 26S_Psome_Ubiquitin-recp_Rpn13.
IPR032368. RPN13_C.
[Graphical view]
PANTHERiPTHR12225. PTHR12225. 2 hits.
PfamiPF04683. Proteasom_Rpn13. 1 hit.
PF16550. RPN13_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSGALFPS LVPGSRGSST KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ
60 70 80 90 100
QTDDSLIHFC WKDRTSGTVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA
110 120 130 140 150
GSKRLFFWMQ EPKTDQDEEH CRKVNECLNN PPMPGSLGAS GSSGHELSAL
160 170 180 190 200
GGEGGLQSLL GNMSHSQLMQ LIGPAGLGGL GGLGALTGPG LASLLGSSGP
210 220 230 240 250
PASSSSSSSR SQSAAVTPSS STSSARATPA PSAPAAASAT SPSPAPSSGN
260 270 280 290 300
GTSTAASPTQ PIQLSDLQSI LATMNVPAGP GGSQQVDLAS VLTPEIMAPI
310 320 330 340 350
LANADVQERL LPYLPSGESL PQTADEIQNT LTSPQFQQAL GMFSAALASG
360 370 380 390 400
QLGPLMCQFG LPAEAVEAAN KGDVEAFAKA MQNNAKSDPK EGDTKDKKDE

EEDMSLD
Length:407
Mass (Da):42,060
Last modified:May 1, 2007 - v2
Checksum:i210AFDF7379C962D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109M → I in BAC35889 (PubMed:16141072).Curated1
Sequence conflicti171L → I in BAE26653 (PubMed:16141072).Curated1
Sequence conflicti226R → S in BAC35889 (PubMed:16141072).Curated1
Sequence conflicti359F → I in AAF33401 (PubMed:10919708).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225959 mRNA. Translation: AAF33401.1.
AK075674 mRNA. Translation: BAC35889.1.
AK145474 mRNA. Translation: BAE26457.1.
AK145792 mRNA. Translation: BAE26653.1.
AK166878 mRNA. Translation: BAE39089.1.
AL663027 Genomic DNA. Translation: CAM16214.1.
BC008974 mRNA. Translation: AAH08974.1.
BC031517 mRNA. Translation: AAH31517.1.
CCDSiCCDS17171.1.
RefSeqiNP_062796.2. NM_019822.3.
UniGeneiMm.316654.
Mm.379082.

Genome annotation databases

EnsembliENSMUST00000061437; ENSMUSP00000050076; ENSMUSG00000039041.
GeneIDi56436.
KEGGimmu:56436.
UCSCiuc008oin.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225959 mRNA. Translation: AAF33401.1.
AK075674 mRNA. Translation: BAC35889.1.
AK145474 mRNA. Translation: BAE26457.1.
AK145792 mRNA. Translation: BAE26653.1.
AK166878 mRNA. Translation: BAE39089.1.
AL663027 Genomic DNA. Translation: CAM16214.1.
BC008974 mRNA. Translation: AAH08974.1.
BC031517 mRNA. Translation: AAH31517.1.
CCDSiCCDS17171.1.
RefSeqiNP_062796.2. NM_019822.3.
UniGeneiMm.316654.
Mm.379082.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R2YX-ray1.70A2-150[»]
2Z59NMR-A22-130[»]
ProteinModelPortaliQ9JKV1.
SMRiQ9JKV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207978. 9 interactors.
DIPiDIP-60625N.
IntActiQ9JKV1. 14 interactors.
STRINGi10090.ENSMUSP00000050076.

PTM databases

iPTMnetiQ9JKV1.
PhosphoSitePlusiQ9JKV1.

Proteomic databases

EPDiQ9JKV1.
MaxQBiQ9JKV1.
PaxDbiQ9JKV1.
PeptideAtlasiQ9JKV1.
PRIDEiQ9JKV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061437; ENSMUSP00000050076; ENSMUSG00000039041.
GeneIDi56436.
KEGGimmu:56436.
UCSCiuc008oin.1. mouse.

Organism-specific databases

CTDi11047.
MGIiMGI:1929289. Adrm1.

Phylogenomic databases

eggNOGiKOG3037. Eukaryota.
ENOG410XSJJ. LUCA.
GeneTreeiENSGT00390000013839.
HOGENOMiHOG000005947.
HOVERGENiHBG073518.
InParanoidiQ9JKV1.
OMAiKRVDQCK.
OrthoDBiEOG091G0FEO.
PhylomeDBiQ9JKV1.
TreeFamiTF313410.

Enzyme and pathway databases

ReactomeiR-MMU-5689603. UCH proteinases.
R-MMU-5689880. Ub-specific processing proteases.

Miscellaneous databases

EvolutionaryTraceiQ9JKV1.
PROiQ9JKV1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039041.
CleanExiMM_ADRM1.
GenevisibleiQ9JKV1. MM.

Family and domain databases

InterProiIPR006773. 26S_Psome_Ubiquitin-recp_Rpn13.
IPR032368. RPN13_C.
[Graphical view]
PANTHERiPTHR12225. PTHR12225. 2 hits.
PfamiPF04683. Proteasom_Rpn13. 1 hit.
PF16550. RPN13_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADRM1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKV1
Secondary accession number(s): Q3UKZ8, Q8BPH8, Q922A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2007
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although initially described as a cell membrane glycoprotein, ADRM1 is intracellular and non-glycosylated, and has probably no direct role in cell adhesion.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.