ID   LMX1A_MOUSE             Reviewed;         382 AA.
AC   Q9JKU8;
DT   27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 169.
DE   RecName: Full=LIM homeobox transcription factor 1-alpha;
DE   AltName: Full=LIM/homeobox protein 1.1;
DE            Short=LMX-1.1;
DE   AltName: Full=LIM/homeobox protein LMX1A;
GN   Name=Lmx1a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C3HeB/Fele-a/a;
RX   PubMed=10693804; DOI=10.1038/35001573;
RA   Millonig J.H., Millen K.J., Hatten M.E.;
RT   "The mouse Dreher gene Lmx1a controls formation of the roof plate in the
RT   vertebrate CNS.";
RL   Nature 403:764-769(2000).
CC   -!- FUNCTION: Acts as a transcriptional activator by binding to an A/T-rich
CC       sequence, the FLAT element, in the insulin gene promoter. Required for
CC       development of the roof plate and, in turn, for specification of dorsal
CC       cell fates in the CNS and developing vertebrae.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DISEASE: Note=Defects in Lmx1a are the cause of the spontaneous
CC       neurologic mutant mouse, called 'dreher' (dr) and results from a
CC       failure of the roof plate to develop.
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DR   EMBL; AF226662; AAF43012.1; -; mRNA.
DR   CCDS; CCDS15460.1; -.
DR   RefSeq; NP_387501.1; NM_033652.5.
DR   RefSeq; XP_006496674.1; XM_006496611.2.
DR   RefSeq; XP_017177173.1; XM_017321684.1.
DR   AlphaFoldDB; Q9JKU8; -.
DR   SMR; Q9JKU8; -.
DR   BioGRID; 225780; 5.
DR   IntAct; Q9JKU8; 4.
DR   STRING; 10090.ENSMUSP00000028003; -.
DR   PhosphoSitePlus; Q9JKU8; -.
DR   PaxDb; 10090-ENSMUSP00000028003; -.
DR   ProteomicsDB; 292345; -.
DR   Antibodypedia; 20523; 238 antibodies from 28 providers.
DR   DNASU; 110648; -.
DR   Ensembl; ENSMUST00000028003.9; ENSMUSP00000028003.7; ENSMUSG00000026686.15.
DR   Ensembl; ENSMUST00000111377.8; ENSMUSP00000107008.2; ENSMUSG00000026686.15.
DR   GeneID; 110648; -.
DR   KEGG; mmu:110648; -.
DR   UCSC; uc007dlc.1; mouse.
DR   AGR; MGI:1888519; -.
DR   CTD; 4009; -.
DR   MGI; MGI:1888519; Lmx1a.
DR   VEuPathDB; HostDB:ENSMUSG00000026686; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000157774; -.
DR   HOGENOM; CLU_027802_0_0_1; -.
DR   InParanoid; Q9JKU8; -.
DR   OMA; DGIMNPY; -.
DR   OrthoDB; 932158at2759; -.
DR   PhylomeDB; Q9JKU8; -.
DR   TreeFam; TF315442; -.
DR   BioGRID-ORCS; 110648; 4 hits in 78 CRISPR screens.
DR   ChiTaRS; Lmx1a; mouse.
DR   PRO; PR:Q9JKU8; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q9JKU8; Protein.
DR   Bgee; ENSMUSG00000026686; Expressed in roof plate and 54 other cell types or tissues.
DR   ExpressionAtlas; Q9JKU8; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0007411; P:axon guidance; IMP:MGI.
DR   GO; GO:0007417; P:central nervous system development; IMP:MGI.
DR   GO; GO:0021953; P:central nervous system neuron differentiation; IMP:MGI.
DR   GO; GO:0021549; P:cerebellum development; IMP:MGI.
DR   GO; GO:0021542; P:dentate gyrus development; IMP:MGI.
DR   GO; GO:0071542; P:dopaminergic neuron differentiation; IMP:MGI.
DR   GO; GO:0021766; P:hippocampus development; IMP:MGI.
DR   GO; GO:0007626; P:locomotory behavior; IGI:ParkinsonsUK-UCL.
DR   GO; GO:0007613; P:memory; IGI:ParkinsonsUK-UCL.
DR   GO; GO:0030901; P:midbrain development; IMP:MGI.
DR   GO; GO:1904948; P:midbrain dopaminergic neuron differentiation; IDA:ParkinsonsUK-UCL.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; IMP:MGI.
DR   GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR   GO; GO:0042048; P:olfactory behavior; IGI:ParkinsonsUK-UCL.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IC:ParkinsonsUK-UCL.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:ParkinsonsUK-UCL.
DR   GO; GO:0001558; P:regulation of cell growth; IMP:MGI.
DR   GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0050808; P:synapse organization; IGI:ParkinsonsUK-UCL.
DR   CDD; cd00086; homeodomain; 1.
DR   CDD; cd09370; LIM1_Lmx1a; 1.
DR   CDD; cd09378; LIM2_Lmx1a_Lmx1b; 1.
DR   Gene3D; 2.10.110.10; Cysteine Rich Protein; 2.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR042688; Lmx1a_LIM1.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24208:SF88; LIM HOMEOBOX TRANSCRIPTION FACTOR 1-ALPHA; 1.
DR   PANTHER; PTHR24208; LIM/HOMEOBOX PROTEIN LHX; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00132; LIM; 2.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR   Genevisible; Q9JKU8; MM.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Homeobox; LIM domain;
KW   Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..382
FT                   /note="LIM homeobox transcription factor 1-alpha"
FT                   /id="PRO_0000075827"
FT   DOMAIN          33..92
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          92..154
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DNA_BIND        195..254
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          161..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          252..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..195
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..282
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   382 AA;  42857 MW;  6C856843FEAC6706 CRC64;
     MLDGLKMEEN FQSAIETSAS FSSLLGRAVS PKSVCEGCQR VISDRFLLRL NDSFWHEQCV
     QCASCKEPLE TTCFYRDKKL YCKYHYEKLF AVKCGGCFEA IAPNEFVMRA QKSVYHLSCF
     CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK ERELLSLVSP AASDSGKSDD EESLCKSAHG
     AGKGASEDGK DHKRPKRPRT ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ
     VWFQNQRAKM KKLARRQQQQ QQDQQNTQRL TSAQTNGSGN AGMEGIMNPY TTLPTPQQLL
     AIEQSVYNSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD CFLATSEAGP
     LQSRVGNPID HLYSMQNSYF TS
//