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Protein

LIM homeobox transcription factor 1-alpha

Gene

Lmx1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 254HomeoboxAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: MGI
  • central nervous system development Source: MGI
  • central nervous system neuron differentiation Source: MGI
  • cerebellum development Source: MGI
  • dentate gyrus development Source: MGI
  • dopaminergic neuron differentiation Source: MGI
  • hippocampus development Source: MGI
  • locomotory behavior Source: ParkinsonsUK-UCL
  • memory Source: ParkinsonsUK-UCL
  • midbrain development Source: MGI
  • midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
  • negative regulation of neuron differentiation Source: MGI
  • neuron differentiation Source: MGI
  • olfactory behavior Source: ParkinsonsUK-UCL
  • positive regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: ParkinsonsUK-UCL
  • positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
  • regulation of cell growth Source: MGI
  • regulation of gene expression Source: MGI
  • synapse organization Source: ParkinsonsUK-UCL

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM homeobox transcription factor 1-alpha
Alternative name(s):
LIM/homeobox protein 1.1
Short name:
LMX-1.1
LIM/homeobox protein LMX1A
Gene namesi
Name:Lmx1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1888519. Lmx1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Lmx1a are the cause of the spontaneous neurologic mutant mouse, called 'dreher' (dr) and results from a failure of the roof plate to develop.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758271 – 382LIM homeobox transcription factor 1-alphaAdd BLAST382

Proteomic databases

PaxDbiQ9JKU8.
PRIDEiQ9JKU8.

PTM databases

PhosphoSitePlusiQ9JKU8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026686.
CleanExiMM_LMX1A.
ExpressionAtlasiQ9JKU8. baseline and differential.
GenevisibleiQ9JKU8. MM.

Interactioni

Protein-protein interaction databases

BioGridi225780. 5 interactors.
STRINGi10090.ENSMUSP00000028003.

Structurei

3D structure databases

ProteinModelPortaliQ9JKU8.
SMRiQ9JKU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 92LIM zinc-binding 1Add BLAST60
Domaini92 – 154LIM zinc-binding 2Add BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi240 – 274Gln-richAdd BLAST35
Compositional biasi257 – 265Poly-Gln9

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000231629.
HOVERGENiHBG052335.
InParanoidiQ9JKU8.
KOiK09371.
OMAiNDSLWHE.
OrthoDBiEOG091G09Z3.
PhylomeDBiQ9JKU8.
TreeFamiTF315442.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9JKU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDGLKMEEN FQSAIETSAS FSSLLGRAVS PKSVCEGCQR VISDRFLLRL
60 70 80 90 100
NDSFWHEQCV QCASCKEPLE TTCFYRDKKL YCKYHYEKLF AVKCGGCFEA
110 120 130 140 150
IAPNEFVMRA QKSVYHLSCF CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK
160 170 180 190 200
ERELLSLVSP AASDSGKSDD EESLCKSAHG AGKGASEDGK DHKRPKRPRT
210 220 230 240 250
ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ VWFQNQRAKM
260 270 280 290 300
KKLARRQQQQ QQDQQNTQRL TSAQTNGSGN AGMEGIMNPY TTLPTPQQLL
310 320 330 340 350
AIEQSVYNSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD
360 370 380
CFLATSEAGP LQSRVGNPID HLYSMQNSYF TS
Length:382
Mass (Da):42,857
Last modified:October 1, 2000 - v1
Checksum:i6C856843FEAC6706
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226662 mRNA. Translation: AAF43012.1.
CCDSiCCDS15460.1.
RefSeqiNP_387501.1. NM_033652.5.
XP_006496674.1. XM_006496611.2.
XP_017177173.1. XM_017321684.1.
UniGeneiMm.330081.

Genome annotation databases

EnsembliENSMUST00000028003; ENSMUSP00000028003; ENSMUSG00000026686.
ENSMUST00000111377; ENSMUSP00000107008; ENSMUSG00000026686.
GeneIDi110648.
KEGGimmu:110648.
UCSCiuc007dlc.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiLMX1A_MOUSE
AccessioniPrimary (citable) accession number: Q9JKU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot