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Q9JKU8

- LMX1A_MOUSE

UniProt

Q9JKU8 - LMX1A_MOUSE

Protein

LIM homeobox transcription factor 1-alpha

Gene

Lmx1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi195 – 25460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. axon guidance Source: MGI
    2. central nervous system development Source: MGI
    3. central nervous system neuron differentiation Source: MGI
    4. cerebellum development Source: MGI
    5. dentate gyrus development Source: MGI
    6. dopaminergic neuron differentiation Source: MGI
    7. hippocampus development Source: MGI
    8. midbrain development Source: MGI
    9. negative regulation of neuron differentiation Source: MGI
    10. neuron differentiation Source: MGI
    11. regulation of cell growth Source: MGI
    12. regulation of gene expression Source: MGI
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LIM homeobox transcription factor 1-alpha
    Alternative name(s):
    LIM/homeobox protein 1.1
    Short name:
    LMX-1.1
    LIM/homeobox protein LMX1A
    Gene namesi
    Name:Lmx1a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1888519. Lmx1a.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Lmx1a are the cause of the spontaneous neurologic mutant mouse, called 'dreher' (dr) and results from a failure of the roof plate to develop.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382LIM homeobox transcription factor 1-alphaPRO_0000075827Add
    BLAST

    Proteomic databases

    PRIDEiQ9JKU8.

    PTM databases

    PhosphoSiteiQ9JKU8.

    Expressioni

    Gene expression databases

    BgeeiQ9JKU8.
    CleanExiMM_LMX1A.
    GenevestigatoriQ9JKU8.

    Interactioni

    Protein-protein interaction databases

    BioGridi225780. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JKU8.
    SMRiQ9JKU8. Positions 34-153, 196-258.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 9260LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini92 – 15463LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi240 – 27435Gln-richAdd
    BLAST
    Compositional biasi257 – 2659Poly-Gln

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG243427.
    GeneTreeiENSGT00750000117665.
    HOGENOMiHOG000231629.
    HOVERGENiHBG052335.
    InParanoidiQ9JKU8.
    KOiK09371.
    OMAiYNSDPFR.
    OrthoDBiEOG7BZVTB.
    PhylomeDBiQ9JKU8.
    TreeFamiTF315442.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JKU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDGLKMEEN FQSAIETSAS FSSLLGRAVS PKSVCEGCQR VISDRFLLRL    50
    NDSFWHEQCV QCASCKEPLE TTCFYRDKKL YCKYHYEKLF AVKCGGCFEA 100
    IAPNEFVMRA QKSVYHLSCF CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK 150
    ERELLSLVSP AASDSGKSDD EESLCKSAHG AGKGASEDGK DHKRPKRPRT 200
    ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ VWFQNQRAKM 250
    KKLARRQQQQ QQDQQNTQRL TSAQTNGSGN AGMEGIMNPY TTLPTPQQLL 300
    AIEQSVYNSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD 350
    CFLATSEAGP LQSRVGNPID HLYSMQNSYF TS 382
    Length:382
    Mass (Da):42,857
    Last modified:October 1, 2000 - v1
    Checksum:i6C856843FEAC6706
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226662 mRNA. Translation: AAF43012.1.
    CCDSiCCDS15460.1.
    RefSeqiNP_387501.1. NM_033652.5.
    XP_006496674.1. XM_006496611.1.
    XP_006496675.1. XM_006496612.1.
    UniGeneiMm.330081.

    Genome annotation databases

    EnsembliENSMUST00000028003; ENSMUSP00000028003; ENSMUSG00000026686.
    ENSMUST00000111377; ENSMUSP00000107008; ENSMUSG00000026686.
    GeneIDi110648.
    KEGGimmu:110648.
    UCSCiuc007dlc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226662 mRNA. Translation: AAF43012.1 .
    CCDSi CCDS15460.1.
    RefSeqi NP_387501.1. NM_033652.5.
    XP_006496674.1. XM_006496611.1.
    XP_006496675.1. XM_006496612.1.
    UniGenei Mm.330081.

    3D structure databases

    ProteinModelPortali Q9JKU8.
    SMRi Q9JKU8. Positions 34-153, 196-258.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 225780. 5 interactions.

    PTM databases

    PhosphoSitei Q9JKU8.

    Proteomic databases

    PRIDEi Q9JKU8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028003 ; ENSMUSP00000028003 ; ENSMUSG00000026686 .
    ENSMUST00000111377 ; ENSMUSP00000107008 ; ENSMUSG00000026686 .
    GeneIDi 110648.
    KEGGi mmu:110648.
    UCSCi uc007dlc.1. mouse.

    Organism-specific databases

    CTDi 4009.
    MGIi MGI:1888519. Lmx1a.

    Phylogenomic databases

    eggNOGi NOG243427.
    GeneTreei ENSGT00750000117665.
    HOGENOMi HOG000231629.
    HOVERGENi HBG052335.
    InParanoidi Q9JKU8.
    KOi K09371.
    OMAi YNSDPFR.
    OrthoDBi EOG7BZVTB.
    PhylomeDBi Q9JKU8.
    TreeFami TF315442.

    Miscellaneous databases

    NextBioi 364391.
    PROi Q9JKU8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JKU8.
    CleanExi MM_LMX1A.
    Genevestigatori Q9JKU8.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS."
      Millonig J.H., Millen K.J., Hatten M.E.
      Nature 403:764-769(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3HeB/Fele-a/a.

    Entry informationi

    Entry nameiLMX1A_MOUSE
    AccessioniPrimary (citable) accession number: Q9JKU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3