SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9JKU8

- LMX1A_MOUSE

UniProt

Q9JKU8 - LMX1A_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

LIM homeobox transcription factor 1-alpha

Gene
Lmx1a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi195 – 25460HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. axon guidance Source: MGI
  2. central nervous system development Source: MGI
  3. central nervous system neuron differentiation Source: MGI
  4. cerebellum development Source: MGI
  5. dentate gyrus development Source: MGI
  6. dopaminergic neuron differentiation Source: MGI
  7. hippocampus development Source: MGI
  8. midbrain development Source: MGI
  9. negative regulation of neuron differentiation Source: MGI
  10. neuron differentiation Source: MGI
  11. regulation of cell growth Source: MGI
  12. regulation of gene expression Source: MGI
  13. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM homeobox transcription factor 1-alpha
Alternative name(s):
LIM/homeobox protein 1.1
Short name:
LMX-1.1
LIM/homeobox protein LMX1A
Gene namesi
Name:Lmx1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1888519. Lmx1a.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Lmx1a are the cause of the spontaneous neurologic mutant mouse, called 'dreher' (dr) and results from a failure of the roof plate to develop.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382LIM homeobox transcription factor 1-alphaPRO_0000075827Add
BLAST

Proteomic databases

PRIDEiQ9JKU8.

PTM databases

PhosphoSiteiQ9JKU8.

Expressioni

Gene expression databases

BgeeiQ9JKU8.
CleanExiMM_LMX1A.
GenevestigatoriQ9JKU8.

Interactioni

Protein-protein interaction databases

BioGridi225780. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9JKU8.
SMRiQ9JKU8. Positions 34-153, 196-258.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 9260LIM zinc-binding 1Add
BLAST
Domaini92 – 15463LIM zinc-binding 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi240 – 27435Gln-richAdd
BLAST
Compositional biasi257 – 2659Poly-Gln

Sequence similaritiesi

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG243427.
GeneTreeiENSGT00750000117665.
HOGENOMiHOG000231629.
HOVERGENiHBG052335.
InParanoidiQ9JKU8.
KOiK09371.
OMAiYNSDPFR.
OrthoDBiEOG7BZVTB.
PhylomeDBiQ9JKU8.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKU8-1 [UniParc]FASTAAdd to Basket

« Hide

MLDGLKMEEN FQSAIETSAS FSSLLGRAVS PKSVCEGCQR VISDRFLLRL    50
NDSFWHEQCV QCASCKEPLE TTCFYRDKKL YCKYHYEKLF AVKCGGCFEA 100
IAPNEFVMRA QKSVYHLSCF CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK 150
ERELLSLVSP AASDSGKSDD EESLCKSAHG AGKGASEDGK DHKRPKRPRT 200
ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ VWFQNQRAKM 250
KKLARRQQQQ QQDQQNTQRL TSAQTNGSGN AGMEGIMNPY TTLPTPQQLL 300
AIEQSVYNSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD 350
CFLATSEAGP LQSRVGNPID HLYSMQNSYF TS 382
Length:382
Mass (Da):42,857
Last modified:October 1, 2000 - v1
Checksum:i6C856843FEAC6706
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF226662 mRNA. Translation: AAF43012.1.
CCDSiCCDS15460.1.
RefSeqiNP_387501.1. NM_033652.5.
XP_006496674.1. XM_006496611.1.
XP_006496675.1. XM_006496612.1.
UniGeneiMm.330081.

Genome annotation databases

EnsembliENSMUST00000028003; ENSMUSP00000028003; ENSMUSG00000026686.
ENSMUST00000111377; ENSMUSP00000107008; ENSMUSG00000026686.
GeneIDi110648.
KEGGimmu:110648.
UCSCiuc007dlc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF226662 mRNA. Translation: AAF43012.1 .
CCDSi CCDS15460.1.
RefSeqi NP_387501.1. NM_033652.5.
XP_006496674.1. XM_006496611.1.
XP_006496675.1. XM_006496612.1.
UniGenei Mm.330081.

3D structure databases

ProteinModelPortali Q9JKU8.
SMRi Q9JKU8. Positions 34-153, 196-258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 225780. 5 interactions.

PTM databases

PhosphoSitei Q9JKU8.

Proteomic databases

PRIDEi Q9JKU8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028003 ; ENSMUSP00000028003 ; ENSMUSG00000026686 .
ENSMUST00000111377 ; ENSMUSP00000107008 ; ENSMUSG00000026686 .
GeneIDi 110648.
KEGGi mmu:110648.
UCSCi uc007dlc.1. mouse.

Organism-specific databases

CTDi 4009.
MGIi MGI:1888519. Lmx1a.

Phylogenomic databases

eggNOGi NOG243427.
GeneTreei ENSGT00750000117665.
HOGENOMi HOG000231629.
HOVERGENi HBG052335.
InParanoidi Q9JKU8.
KOi K09371.
OMAi YNSDPFR.
OrthoDBi EOG7BZVTB.
PhylomeDBi Q9JKU8.
TreeFami TF315442.

Miscellaneous databases

NextBioi 364391.
PROi Q9JKU8.
SOURCEi Search...

Gene expression databases

Bgeei Q9JKU8.
CleanExi MM_LMX1A.
Genevestigatori Q9JKU8.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS."
    Millonig J.H., Millen K.J., Hatten M.E.
    Nature 403:764-769(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3HeB/Fele-a/a.

Entry informationi

Entry nameiLMX1A_MOUSE
AccessioniPrimary (citable) accession number: Q9JKU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi