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Q9JKU8 (LMX1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LIM homeobox transcription factor 1-alpha
Alternative name(s):
LIM/homeobox protein 1.1
Short name=LMX-1.1
LIM/homeobox protein LMX1A
Gene names
Name:Lmx1a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.

Subcellular location

Nucleus By similarity.

Involvement in disease

Defects in Lmx1a are the cause of the spontaneous neurologic mutant mouse, called 'dreher' (dr) and results from a failure of the roof plate to develop.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Contains 2 LIM zinc-binding domains.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
LIM domain
Repeat
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Inferred from mutant phenotype PubMed 15183721. Source: MGI

central nervous system development

Inferred from mutant phenotype PubMed 15148302. Source: MGI

central nervous system neuron differentiation

Inferred from mutant phenotype PubMed 17670789. Source: MGI

cerebellum development

Inferred from mutant phenotype PubMed 1638738. Source: MGI

dentate gyrus development

Inferred from mutant phenotype PubMed 1638738. Source: MGI

dopaminergic neuron differentiation

Inferred from mutant phenotype PubMed 21752929. Source: MGI

hippocampus development

Inferred from mutant phenotype PubMed 1638738. Source: MGI

midbrain development

Inferred from mutant phenotype PubMed 21752929. Source: MGI

negative regulation of neuron differentiation

Inferred from mutant phenotype PubMed 15148302. Source: MGI

neuron differentiation

Inferred from mutant phenotype PubMed 15183721. Source: MGI

regulation of cell growth

Inferred from mutant phenotype PubMed 17670789. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 17670789. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382LIM homeobox transcription factor 1-alpha
PRO_0000075827

Regions

Domain33 – 9260LIM zinc-binding 1
Domain92 – 15463LIM zinc-binding 2
DNA binding195 – 25460Homeobox
Compositional bias240 – 27435Gln-rich
Compositional bias257 – 2659Poly-Gln

Sequences

Sequence LengthMass (Da)Tools
Q9JKU8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 6C856843FEAC6706

FASTA38242,857
        10         20         30         40         50         60 
MLDGLKMEEN FQSAIETSAS FSSLLGRAVS PKSVCEGCQR VISDRFLLRL NDSFWHEQCV 

        70         80         90        100        110        120 
QCASCKEPLE TTCFYRDKKL YCKYHYEKLF AVKCGGCFEA IAPNEFVMRA QKSVYHLSCF 

       130        140        150        160        170        180 
CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK ERELLSLVSP AASDSGKSDD EESLCKSAHG 

       190        200        210        220        230        240 
AGKGASEDGK DHKRPKRPRT ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ 

       250        260        270        280        290        300 
VWFQNQRAKM KKLARRQQQQ QQDQQNTQRL TSAQTNGSGN AGMEGIMNPY TTLPTPQQLL 

       310        320        330        340        350        360 
AIEQSVYNSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD CFLATSEAGP 

       370        380 
LQSRVGNPID HLYSMQNSYF TS 

« Hide

References

[1]"The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS."
Millonig J.H., Millen K.J., Hatten M.E.
Nature 403:764-769(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C3HeB/Fele-a/a.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF226662 mRNA. Translation: AAF43012.1.
CCDSCCDS15460.1.
RefSeqNP_387501.1. NM_033652.5.
XP_006496674.1. XM_006496611.1.
XP_006496675.1. XM_006496612.1.
UniGeneMm.330081.

3D structure databases

ProteinModelPortalQ9JKU8.
SMRQ9JKU8. Positions 34-153, 196-258.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid225780. 5 interactions.

PTM databases

PhosphoSiteQ9JKU8.

Proteomic databases

PRIDEQ9JKU8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028003; ENSMUSP00000028003; ENSMUSG00000026686.
ENSMUST00000111377; ENSMUSP00000107008; ENSMUSG00000026686.
GeneID110648.
KEGGmmu:110648.
UCSCuc007dlc.1. mouse.

Organism-specific databases

CTD4009.
MGIMGI:1888519. Lmx1a.

Phylogenomic databases

eggNOGNOG243427.
GeneTreeENSGT00750000117665.
HOGENOMHOG000231629.
HOVERGENHBG052335.
InParanoidQ9JKU8.
KOK09371.
OMAYNSDPFR.
OrthoDBEOG7BZVTB.
PhylomeDBQ9JKU8.
TreeFamTF315442.

Gene expression databases

BgeeQ9JKU8.
CleanExMM_LMX1A.
GenevestigatorQ9JKU8.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio364391.
PROQ9JKU8.
SOURCESearch...

Entry information

Entry nameLMX1A_MOUSE
AccessionPrimary (citable) accession number: Q9JKU8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot