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Q9JKU0

- T2R16_RAT

UniProt

Q9JKU0 - T2R16_RAT

Protein

Taste receptor type 2 member 16

Gene

Tas2r16

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

    GO - Molecular functioni

    1. bitter taste receptor activity Source: Ensembl
    2. taste receptor activity Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 16
    Short name:
    T2R16
    Alternative name(s):
    T2R18
    T2R3
    Gene namesi
    Name:Tas2r16
    Synonyms:Tas2r18, Tas2r3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi620735. Tas2r16.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. external side of plasma membrane Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. trans-Golgi network Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Taste receptor type 2 member 16PRO_0000082268Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9JKU0.
    PRIDEiQ9JKU0.

    PTM databases

    PhosphoSiteiQ9JKU0.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells.1 Publication

    Gene expression databases

    GenevestigatoriQ9JKU0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000031530.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55ExtracellularSequence Analysis
    Topological domaini27 – 4418CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini66 – 8217ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini104 – 12522CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini147 – 18337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini205 – 23329CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini255 – 2584ExtracellularSequence Analysis
    Topological domaini280 – 29920CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei45 – 6521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39234.
    GeneTreeiENSGT00560000076937.
    HOGENOMiHOG000234595.
    HOVERGENiHBG098568.
    InParanoidiQ9JKU0.
    KOiK08474.
    OMAiGALVISC.
    OrthoDBiEOG7JDQZC.
    PhylomeDBiQ9JKU0.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JKU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPTQVTIFS IIMYVLESLV IIVQSCTTVA VLFREWMHFQ RLSPVEIILI    50
    SLGISHFCLQ WTSMLYNFGT YSRPVLLFWK VSVVWEFMNV LTFWLTSLLA 100
    VLYCVKVSSF SHPVFLWLRL KILKLVLWLL LGALIASCLS IIPSVVKYHI 150
    QMELLTLDHL PKNSSLILRL QMFEWYFSNP FKMIGFGVPF LVFLISIILL 200
    TVSLVQHWGQ MKHYSSSSSS LRAQCTVLKS LATFFIFFTS YFLTIVVSFI 250
    GTVFDKKSWF WVCEAVIYGL VCIHFTSLMM SNPTLKKALR LQFWSPESS 299
    Length:299
    Mass (Da):34,642
    Last modified:October 1, 2000 - v1
    Checksum:iECDC2EBB29943B6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227141 mRNA. Translation: AAF43914.1.
    RefSeqiNP_076484.1. NM_023994.1.
    UniGeneiRn.48783.

    Genome annotation databases

    EnsembliENSRNOT00000034936; ENSRNOP00000031530; ENSRNOG00000021799.
    GeneIDi78980.
    KEGGirno:78980.
    UCSCiRGD:620735. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227141 mRNA. Translation: AAF43914.1 .
    RefSeqi NP_076484.1. NM_023994.1.
    UniGenei Rn.48783.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000031530.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9JKU0.

    Proteomic databases

    PaxDbi Q9JKU0.
    PRIDEi Q9JKU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000034936 ; ENSRNOP00000031530 ; ENSRNOG00000021799 .
    GeneIDi 78980.
    KEGGi rno:78980.
    UCSCi RGD:620735. rat.

    Organism-specific databases

    CTDi 387347.
    RGDi 620735. Tas2r16.

    Phylogenomic databases

    eggNOGi NOG39234.
    GeneTreei ENSGT00560000076937.
    HOGENOMi HOG000234595.
    HOVERGENi HBG098568.
    InParanoidi Q9JKU0.
    KOi K08474.
    OMAi GALVISC.
    OrthoDBi EOG7JDQZC.
    PhylomeDBi Q9JKU0.
    TreeFami TF335891.

    Miscellaneous databases

    NextBioi 614462.
    PROi Q9JKU0.

    Gene expression databases

    Genevestigatori Q9JKU0.

    Family and domain databases

    InterProi IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TOPOLOGY.
    2. Cited for: CHARACTERIZATION.
    3. "Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells."
      Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.
      Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. Cited for: REVIEW.
    5. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    6. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiT2R16_RAT
    AccessioniPrimary (citable) accession number: Q9JKU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Several bitter taste receptors are expressed in a single taste receptor cell.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3