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Q9JKU0

- T2R16_RAT

UniProt

Q9JKU0 - T2R16_RAT

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Protein

Taste receptor type 2 member 16

Gene

Tas2r16

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

GO - Molecular functioni

  1. bitter taste receptor activity Source: Ensembl
  2. taste receptor activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_236177. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 16
Short name:
T2R16
Alternative name(s):
T2R18
T2R3
Gene namesi
Name:Tas2r16
Synonyms:Tas2r18, Tas2r3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi620735. Tas2r16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55ExtracellularSequence Analysis
Transmembranei6 – 2621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini27 – 4418CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini66 – 8217ExtracellularSequence AnalysisAdd
BLAST
Transmembranei83 – 10321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini104 – 12522CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini147 – 18337ExtracellularSequence AnalysisAdd
BLAST
Transmembranei184 – 20421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini205 – 23329CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini255 – 2584ExtracellularSequence Analysis
Transmembranei259 – 27921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini280 – 29920CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. external side of plasma membrane Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Taste receptor type 2 member 16PRO_0000082268Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JKU0.
PRIDEiQ9JKU0.

PTM databases

PhosphoSiteiQ9JKU0.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells.1 Publication

Gene expression databases

GenevestigatoriQ9JKU0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031530.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39234.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG098568.
InParanoidiQ9JKU0.
KOiK08474.
OMAiGALVISC.
OrthoDBiEOG7JDQZC.
PhylomeDBiQ9JKU0.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKU0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVPTQVTIFS IIMYVLESLV IIVQSCTTVA VLFREWMHFQ RLSPVEIILI
60 70 80 90 100
SLGISHFCLQ WTSMLYNFGT YSRPVLLFWK VSVVWEFMNV LTFWLTSLLA
110 120 130 140 150
VLYCVKVSSF SHPVFLWLRL KILKLVLWLL LGALIASCLS IIPSVVKYHI
160 170 180 190 200
QMELLTLDHL PKNSSLILRL QMFEWYFSNP FKMIGFGVPF LVFLISIILL
210 220 230 240 250
TVSLVQHWGQ MKHYSSSSSS LRAQCTVLKS LATFFIFFTS YFLTIVVSFI
260 270 280 290
GTVFDKKSWF WVCEAVIYGL VCIHFTSLMM SNPTLKKALR LQFWSPESS
Length:299
Mass (Da):34,642
Last modified:October 1, 2000 - v1
Checksum:iECDC2EBB29943B6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227141 mRNA. Translation: AAF43914.1.
RefSeqiNP_076484.1. NM_023994.1.
UniGeneiRn.48783.

Genome annotation databases

EnsembliENSRNOT00000034936; ENSRNOP00000031530; ENSRNOG00000021799.
GeneIDi78980.
KEGGirno:78980.
UCSCiRGD:620735. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227141 mRNA. Translation: AAF43914.1 .
RefSeqi NP_076484.1. NM_023994.1.
UniGenei Rn.48783.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000031530.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9JKU0.

Proteomic databases

PaxDbi Q9JKU0.
PRIDEi Q9JKU0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000034936 ; ENSRNOP00000031530 ; ENSRNOG00000021799 .
GeneIDi 78980.
KEGGi rno:78980.
UCSCi RGD:620735. rat.

Organism-specific databases

CTDi 387347.
RGDi 620735. Tas2r16.

Phylogenomic databases

eggNOGi NOG39234.
GeneTreei ENSGT00760000119096.
HOGENOMi HOG000234595.
HOVERGENi HBG098568.
InParanoidi Q9JKU0.
KOi K08474.
OMAi GALVISC.
OrthoDBi EOG7JDQZC.
PhylomeDBi Q9JKU0.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_233455. G alpha (i) signalling events.
REACT_236177. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

NextBioi 614462.
PROi Q9JKU0.

Gene expression databases

Genevestigatori Q9JKU0.

Family and domain databases

InterProi IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TOPOLOGY.
  2. Cited for: CHARACTERIZATION.
  3. "Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells."
    Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.
    Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. Cited for: REVIEW.
  5. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  6. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R16_RAT
AccessioniPrimary (citable) accession number: Q9JKU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3