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Q9JKU0 (T2R16_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 16

Short name=T2R16
Alternative name(s):
T2R18
T2R3
Gene names
Name:Tas2r16
Synonyms:Tas2r18, Tas2r3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells. Ref.3

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Taste receptor type 2 member 16
PRO_0000082268

Regions

Topological domain1 – 55Extracellular Potential
Transmembrane6 – 2621Helical; Name=1; Potential
Topological domain27 – 4418Cytoplasmic Potential
Transmembrane45 – 6521Helical; Name=2; Potential
Topological domain66 – 8217Extracellular Potential
Transmembrane83 – 10321Helical; Name=3; Potential
Topological domain104 – 12522Cytoplasmic Potential
Transmembrane126 – 14621Helical; Name=4; Potential
Topological domain147 – 18337Extracellular Potential
Transmembrane184 – 20421Helical; Name=5; Potential
Topological domain205 – 23329Cytoplasmic Potential
Transmembrane234 – 25421Helical; Name=6; Potential
Topological domain255 – 2584Extracellular Potential
Transmembrane259 – 27921Helical; Name=7; Potential
Topological domain280 – 29920Cytoplasmic Potential

Amino acid modifications

Glycosylation1631N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9JKU0 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: ECDC2EBB29943B6E

FASTA29934,642
        10         20         30         40         50         60 
MVPTQVTIFS IIMYVLESLV IIVQSCTTVA VLFREWMHFQ RLSPVEIILI SLGISHFCLQ 

        70         80         90        100        110        120 
WTSMLYNFGT YSRPVLLFWK VSVVWEFMNV LTFWLTSLLA VLYCVKVSSF SHPVFLWLRL 

       130        140        150        160        170        180 
KILKLVLWLL LGALIASCLS IIPSVVKYHI QMELLTLDHL PKNSSLILRL QMFEWYFSNP 

       190        200        210        220        230        240 
FKMIGFGVPF LVFLISIILL TVSLVQHWGQ MKHYSSSSSS LRAQCTVLKS LATFFIFFTS 

       250        260        270        280        290 
YFLTIVVSFI GTVFDKKSWF WVCEAVIYGL VCIHFTSLMM SNPTLKKALR LQFWSPESS 

« Hide

References

[1]"A novel family of mammalian taste receptors."
Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S.
Cell 100:693-702(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TOPOLOGY.
[2]"T2Rs function as bitter taste receptors."
Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P.
Cell 100:703-711(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[3]"Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells."
Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.
Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[4]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[5]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[6]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF227141 mRNA. Translation: AAF43914.1.
RefSeqNP_076484.1. NM_023994.1.
UniGeneRn.48783.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000031530.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9JKU0.

Proteomic databases

PaxDbQ9JKU0.
PRIDEQ9JKU0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000034936; ENSRNOP00000031530; ENSRNOG00000021799.
GeneID78980.
KEGGrno:78980.
UCSCRGD:620735. rat.

Organism-specific databases

CTD387347.
RGD620735. Tas2r16.

Phylogenomic databases

eggNOGNOG39234.
GeneTreeENSGT00560000076937.
HOGENOMHOG000234595.
HOVERGENHBG098568.
InParanoidQ9JKU0.
KOK08474.
OMASAITNHI.
OrthoDBEOG7JDQZC.
PhylomeDBQ9JKU0.
TreeFamTF335891.

Gene expression databases

GenevestigatorQ9JKU0.

Family and domain databases

InterProIPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614462.
PROQ9JKU0.

Entry information

Entry nameT2R16_RAT
AccessionPrimary (citable) accession number: Q9JKU0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries