Q9JKS6 (PCLO_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein piccolo

Alternative name(s):
Aczonin
Multidomain presynaptic cytomatrix protein

Gene names

Name:

Pclo

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	5085 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking By similarity. UniProtKB Q9QYX7
Subunit structure	Interacts with RABAC1/PRA1, RIMS2 and profilin By similarity. Ref.1
Subcellular location	Cell junction › synapse. Note: Concentrated at presynaptic side of synaptic junctions.
Domain	C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change. Ref.3
Sequence similarities	Contains 2 C2 domains. Ref.3 Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Cellular component	Cell junction Synapse
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Calcium Calcium/phospholipid-binding Metal-binding Zinc
PTM	Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytoskeleton organization Inferred from sequence or structural similarity. Source: UniProtKB synaptic vesicle targeting Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW synapse Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	calcium ion binding Inferred from direct assay Ref.3. Source: UniProtKB calcium-dependent phospholipid binding Inferred from direct assay Ref.3. Source: UniProtKB profilin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Rabac1	Q9Z0S9	3	EBI-2271602,EBI-476965	From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9JKS6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9JKS6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     4876-4880: TKPTN → SKRRK
     4881-5085: Missing.

Isoform 3 (identifier: Q9JKS6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     4687-4695: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 5085

5085

Protein piccolo

PRO_0000058252

Regions

Domain

4442 – 4536

95

PDZ Ref.3

Domain

4653 – 4752

100

C2 1 Ref.3

Domain

4968 – 5059

92

C2 2 Ref.3

Zinc finger

523 – 547

25

C4-type Potential Ref.1

Zinc finger

1010 – 1033

24

C4-type Potential Ref.1

Region

372 – 491

120

12 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X

Compositional bias

2351 – 2362

12

Poly-Pro Ref.3

Amino acid modifications

Modified residue

617

1

Phosphoserine By similarity

Modified residue

756

1

Phosphoserine By similarity

Modified residue

873

1

Phosphothreonine By similarity

Modified residue

1133

1

Phosphothreonine By similarity

Modified residue

1352

1

Phosphoserine By similarity

Modified residue

1353

1

Phosphoserine By similarity

Modified residue

1412

1

Phosphoserine By similarity

Modified residue

1451

1

Phosphoserine By similarity

Modified residue

1456

1

Phosphoserine By similarity

Modified residue

1469

1

Phosphoserine By similarity

Modified residue

1587

1

Phosphoserine By similarity

Modified residue

1597

1

Phosphoserine By similarity

Modified residue

1772

1

Phosphothreonine By similarity

Modified residue

1775

1

Phosphoserine By similarity

Modified residue

1778

1

Phosphoserine By similarity

Modified residue

1784

1

Phosphoserine By similarity

Modified residue

1820

1

Phosphoserine By similarity

Modified residue

1840

1

Phosphotyrosine By similarity

Modified residue

1841

1

Phosphoserine By similarity

Modified residue

3014

1

Phosphothreonine By similarity

Modified residue

3374

1

Phosphoserine By similarity

Modified residue

3392

1

Phosphothreonine By similarity

Modified residue

3529

1

Phosphothreonine By similarity

Modified residue

3561

1

Phosphoserine By similarity

Modified residue

3626

1

Phosphoserine By similarity

Modified residue

3632

1

Phosphoserine By similarity

Modified residue

3779

1

Phosphotyrosine By similarity

Modified residue

3781

1

Phosphoserine By similarity

Modified residue

3912

1

Phosphothreonine By similarity

Modified residue

3913

1

Phosphothreonine By similarity

Modified residue

3954

1

Phosphoserine By similarity

Modified residue

3970

1

Phosphoserine By similarity

Modified residue

4304

1

Phosphoserine By similarity

Modified residue

4308

1

Phosphoserine By similarity

Modified residue

4311

1

Phosphoserine By similarity

Modified residue

4343

1

Phosphoserine By similarity

Glycosylation

2702

1

O-linked (GlcNAc) By similarity

Glycosylation

2976

1

O-linked (GlcNAc) By similarity

Natural variations

Alternative sequence

4687 – 4695

9

Missing in isoform 3.

VSP_018194

Alternative sequence

4876 – 4880

5

TKPTN → SKRRK in isoform 2. Ref.3

VSP_003930

Alternative sequence

4881 – 5085

205

Missing in isoform 2. Ref.3

VSP_003931

Experimental info

Mutagenesis

4668

1

D → A: Complete loss of calcium-binding and calcium-dependent phospholipid binding activity. Ref.3

Mutagenesis

4674

1

D → A: Complete loss of calcium-binding and calcium-dependent phospholipid binding activity. Ref.3

Mutagenesis

4688 – 4689

2

VM → SS: 10-fold increase in affinity for calcium. Ref.3

Mutagenesis

4688

1

V → S: Small increase in affinity for calcium. Ref.3

Mutagenesis

4689

1

M → S: Increased affinity for calcium. Ref.3

Mutagenesis

4690 – 4691

2

VV → SS: 10-fold increase in affinity for calcium. Ref.3

Mutagenesis

4692 – 4693

2

QN → AA: Moderate increase in affinity for calcium. Ref.3

Mutagenesis

4694

1

A → S: No effect on calcium-binding activity. Ref.3

Secondary structure

1

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5085

Helix Strand Turn

Details...

Beta strand

4642 – 4650

9

Beta strand

4653 – 4663

11

Beta strand

4668 – 4671

4

Beta strand

4676 – 4681

6

Helix

4696 – 4699

4

Turn

4700 – 4705

6

Helix

4706 – 4709

4

Beta strand

4712 – 4719

8

Helix

4724 – 4727

4

Beta strand

4731 – 4739

9

Beta strand

4741 – 4743

3

Beta strand

4745 – 4754

10

Helix

4759 – 4761

3

Beta strand

4766 – 4769

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 5A1BB543201A7450	FASTA	5,085	552,716
	10 20 30 40 50 60 MGNEASLEGE GLPEGLAAAA GAGGSGSALH PGIPAGMEAD LSQLSEEERR QIAAVMSRAQ 70 80 90 100 110 120 GLPKGSVPPA AAESPSMHRK QELDSSQAPQ QPGKPPDPGR PTQPGLSKSR TTDTFRSEQK 130 140 150 160 170 180 LPGRSPSTIS LKESKSRTDF KEEYKSSMMP GFFSDVNPLS AVSSVVNKFN PFDLISDSEA 190 200 210 220 230 240 SQEETTKKQK VVQKEQGKSE GMAKPPLQQP SPKPIPKQQG QVKEVIQQDS SPKSVSSQQA 250 260 270 280 290 300 EKVKPQAPGT GKPSQQSPAQ TPAQQASPGK PVAQQPGSAK ATVQQPGPAK SPAQPAGTGK 310 320 330 340 350 360 SPAQPPAKTP GQQAGLEKTS SSQQPGPKSL AQTPGHGKFP LGPVKSPAQQ PGTAKHPAQQ 370 380 390 400 410 420 PGPQTAAKVP GPTKTPAQQS GPGKTPAQQP GPTKPSPQQP IPAKPQPQQP VATKTQPQQS 430 440 450 460 470 480 APAKPQPQQP APAKPQPQQP TPAKPQPQPP TPAKPQPQPP TATKPQPQPP TATKPHHQQP 490 500 510 520 530 540 GLAKPSAQQP TKSISQTVTG RPLQPPPTSA AQTPAQGLSK TICPLCNTTE LLLHIPEKAN 550 560 570 580 590 600 FNTCTECQST VCSLCGFNPN PHLTEIKEWL CLNCQMQRAL GGDLAAAIPS SPQPTPKAAT 610 620 630 640 650 660 APTATASKSP VPSQQASPKK EPPSKQDSPK ALESKKPPEP KKPPEPKKPP EPKKPPPLVK 670 680 690 700 710 720 QPTLHGPTPA TAPQLPVAEA LPEPAPPKEP SGPLPEQAKA PVGDVEPKQP KMTETRADIQ 730 740 750 760 770 780 SSSTTKPDIL SSQVQSQAQV KTASPLKTDS AKPSQSFPPT GEKTTPLDSK AMPRPASDSK 790 800 810 820 830 840 IISQPGPGSE SKDPKHIDPI QKKDEPKKAQ PKGSPKPETK PVPKGSPTPS GTRPTAGQAA 850 860 870 880 890 900 PPSQQPPKPQ EQSRRFSLNL GGITDAPKSQ PTTPQETVTG KLFGFGASIF SQASNLISTA 910 920 930 940 950 960 GQQGPHPQTG PAAPSKQAPT PSQSPAAQGP AKSTGQLPPA PAKATAVKKE AKAAAAENLE 970 980 990 1000 1010 1020 SKPEQAPTAK KTEKDKKPPP AKVGKPPPSE PEKAVPAHKP DKTTKPKPAC PLCRTELNLG 1030 1040 1050 1060 1070 1080 SQEPPNFNTC TECKNQVCNL CGFNPTPHLT EIQEWLCLNC QTQRAISGQL GDMGKMPPAP 1090 1100 1110 1120 1130 1140 SGPKASPMPA PAEPSSQKTP TGTQVKGKKK EAEGKTEAEK PVPEKETASI EKTPPMVTTD 1150 1160 1170 1180 1190 1200 QKLEESEGKK SKVSALPEKK PSEEEKAISA DKKERKPPAE EKPPLEEKKP IPVDKKLPPE 1210 1220 1230 1240 1250 1260 AKPLSSEGEE KHEILKAHVQ IPEEEPTGKV AAKAGEEEQQ PDSRPEALPG ATPLTLPKAG 1270 1280 1290 1300 1310 1320 EKERAVAQPQ AEGSSKDGQG ERSKEKTEKE EDKSDTSSSQ QPKSPQGLSD TGYSSDGISG 1330 1340 1350 1360 1370 1380 SLGEIPSLIP SDEKDLLKGL KKDSFSQESS PSSPSDLAKL ESTVLSILEA QASTLVGEKA 1390 1400 1410 1420 1430 1440 EKKTQPQKIS PEKPQDQQKT QTASETLDIT ISEEEIKESQ EKKVSPKKDS EQGFPSRKEH 1450 1460 1470 1480 1490 1500 KEKPELVDDL SPRRASYDSV EDSSESENSP VVRRKRRTSI GSSSSDEYKQ EDSQGSGEEE 1510 1520 1530 1540 1550 1560 DFIRKQIIEM SADEDASGSE DEEFIRSQLK EISGVGESQK REEAKGKGKG VAGKHRRLTR 1570 1580 1590 1600 1610 1620 KSSTSFDDDA GRRHSWHDED DETFDESPEL KFRETKSQES EELVVAGGGG LRRFKTIELN 1630 1640 1650 1660 1670 1680 STIADKYSSE SSQKKTILYF DEEPELEMES LTDSPEDRSR GEGSSSLHAS SFTPGTSPTS 1690 1700 1710 1720 1730 1740 VSSLDEDSDS SPSHKKGESK QQRKARHRSH GPLLPTIEDS SEEEELREEE ELLKEQEKQR 1750 1760 1770 1780 1790 1800 ELEQQQRKSS SKKSKKDKDE LRAQRRRERP KTPPSNLSPI EDASPTEELR QAAEMEELHR 1810 1820 1830 1840 1850 1860 SSCSEYSPSI ESDPEGFEIS PEKIIEVQKV YKLPAAVSLY SPTDEQSVMQ KEGVQKALKS 1870 1880 1890 1900 1910 1920 AEEMYEEMMQ KPHKYKAFPA ANERDEVFEK EPLYGGMLIE DYIYESLVED TYNGSVDGSL 1930 1940 1950 1960 1970 1980 LTRQEEQNGF MQQRGREQKV RLQEQIYDDP MQKISDLQKE FYELESLHSV VPQEDIVSSS 1990 2000 2010 2020 2030 2040 YIIPESHEIV DLGSMVMSTS EEKKLLDADS AYEELMRRQQ VQVTDGSSPV QTTIGDDMAE 2050 2060 2070 2080 2090 2100 STLDFDRVQD ASLTSSILSG ASLTDSTSSA TLSIPDVKIT QQFSAEELED EYVTDYTREI 2110 2120 2130 2140 2150 2160 QDIIAHESLI LTYSEPSESA TSVPPSDTPS LTSSISSVCT TDSSSPVTTL DSLTTVYTEP 2170 2180 2190 2200 2210 2220 ADVMTKFKDS EEISSTYFPG SIIDYPEDIS VSLDRTIMPE SRTNEDRIVL SFSGMAPSVV 2230 2240 2250 2260 2270 2280 ESVGTKPERP QADTISTDLP ISEKDLIKGK KETGDGIILE VLDAYKDKRE ESEAELTKIS 2290 2300 2310 2320 2330 2340 LPEPGLAQAP SSVTAPQIKE QHVSPHSVSG KISGQEKPTY RLPSGSLPVS THPSKSRPFF 2350 2360 2370 2380 2390 2400 RSSSLDISAQ PPPPPPPPPP SPSTSSPPPT PPLPPATSPK PPTYPKKKLA VAATVTSTTI 2410 2420 2430 2440 2450 2460 VTTHVDALTM VEAAAARRSN GLPATKMCAI APPPVPPKPS QIPTGLVFTH RPEAIKPPIA 2470 2480 2490 2500 2510 2520 PKPAVPQIPV TTQKPTDTCP KPTGLSLTST MSLNLVTSAD YNVPSPTSPL SPHSNKSSPR 2530 2540 2550 2560 2570 2580 YSKSLMDTYV VITLPSEPGT PTDSSAAQAI TSWPLGSPPK DLVSLETVFS VVPPMTSTEI 2590 2600 2610 2620 2630 2640 PSASQPTLYT SGALGTFSVT PAVTASLFQT VPTSLTQFLP AEASKPEVSA VSSAVPSVAP 2650 2660 2670 2680 2690 2700 RSVSIPIPPE PLALDRHQYK ENGKLPLIGD AIDLRTIPKS EVKVTEKCMD LSASAMDVKR 2710 2720 2730 2740 2750 2760 QTTANEVYRR QISAVQPSII NLSAASSLGT PVTMDSKTVA VVTCTDTTIY TTGTESQVGI 2770 2780 2790 2800 2810 2820 EHAVTSPLQL TTSKHTELPY RKPSSQAFPT IRDEAPINLS LGPSAQAVTL AVTKPVTVPP 2830 2840 2850 2860 2870 2880 VGVTNGWTDS TLSQGVADGE VVDLSTSKSH RTVVTMDEST SNVVTKIIED DEKPVDLTAG 2890 2900 2910 2920 2930 2940 RRAVCCDMVY TLPFGRSCTA QQPATTLPED RFGYRDDHYQ YDRSGPYGYR GIGGMKPSMS 2950 2960 2970 2980 2990 3000 DTNLPEAGHF FYKSKNAFDY SGGTGAAVDL TSGRVSTGEV MDYSSKTTGP YPETRQVISG 3010 3020 3030 3040 3050 3060 VGISTPQYST ARLTPPPGPQ YGVGSVLRSS NGVVYSSVAT PIPSTFAITT QPGSIFSTTV 3070 3080 3090 3100 3110 3120 RDLSGIPTTD AMTSLSALHQ SQPMPRSYFI TTGASETDIA VTGIDINASL QTITMETLPA 3130 3140 3150 3160 3170 3180 ETMDSVPTLT TASEVFSEVV GEESTLLIVP DEDKQQQQLD LERELLELEK IKQQRFAEEL 3190 3200 3210 3220 3230 3240 EWERQEIQRF REQEKIMVQK KLEELQSMKQ HLLYQQEEER QAQFMMRQET LAQQQLQLEQ 3250 3260 3270 3280 3290 3300 IQQLQQQLHQ QLEEQKLRQI YQYNYDPSGT SSPQTTTEQA ILEGQYAATE GSQFWATEDA 3310 3320 3330 3340 3350 3360 TTTASTVVAI EIPQSQGWYT VQSDGVTQYI APPGILSTVS EIPLTDVVVK EEKQPKKRSS 3370 3380 3390 3400 3410 3420 GAKVRGQYDE MGESVADDPR NLKKIVDSGV QTDDEETADR SYASRRRRTK KSVDTSVQTD 3430 3440 3450 3460 3470 3480 DEDQDEWDMP SRSRRKARTG KYGDSTAEGD KTKPLSKVSS VAVQTVAEIS VQTEPVGTIR 3490 3500 3510 3520 3530 3540 TPSIRARVDA KVEIIKHISA PEKTYKGGSL GCQTETDSDT QSPPYLGATS PPKDKKRPTP 3550 3560 3570 3580 3590 3600 LEIGYSSSHL RADPTVQLAP SPPKSPKVLY SPISPLSPGN ALEPAFVPYE KPLPDDISPQ 3610 3620 3630 3640 3650 3660 KVLHPDMAKV PPASPKTAKM MQRSMSDPKP LSPTADESSR APFQYSEGFT TKGSQTMTAS 3670 3680 3690 3700 3710 3720 GTQKKVKRTL PNPPPEEVST GTQSTYSTMG TASRRRMCRT NTMARAKILQ DIDRELDLVE 3730 3740 3750 3760 3770 3780 RESAKLRKKQ AELDEEEKEI DAKLRYLEMG INRRKEALLK EREKRERAYL QGVAEDRDYM 3790 3800 3810 3820 3830 3840 SDSEVSSTRP SRVESQHGVE RPRTAPQTEF SQFIPPQTQT EAQLVPPTSP YTQYQYSSPA 3850 3860 3870 3880 3890 3900 LPTQAPTPYT QQSHFQQQTL YHQQVSPYQT QPTFQAVATM SFTPQAQPTP TPQPSYQLPS 3910 3920 3930 3940 3950 3960 QMMVIQQKPR QTTLYLEPKI TSNYEVIRNQ PLMIAPVSTD NTYAVSHLGS KYNSLDLRIG 3970 3980 3990 4000 4010 4020 LEERSSMAGS PISSISADSF YADIDHHTSR NYVLIDDIGD ITKGTAALST VFSLHEKDLS 4030 4040 4050 4060 4070 4080 KTDRLLRTTE TRRSQEVTDF LAPLQTSSRL HSYVKADEDP MEDPYELKLL KHQIKQEFRR 4090 4100 4110 4120 4130 4140 GTESLDHLAG LSHYYHADTS YRHFPKSEKY SISRLTLEKQ AAKQLPAAIL YQKQSKHKKS 4150 4160 4170 4180 4190 4200 LIDPKMSKFS PIQESRDLEP DYPTYMSSGT SSIGGISSRA RLLQDDITFG LRKNITDQQK 4210 4220 4230 4240 4250 4260 FMGSSLGSGL GTLGNTIRSA LQDEADKPYS SGSRSRPSSR PSSVYGLDLS IKRDSSSSSL 4270 4280 4290 4300 4310 4320 RLKAQEAEAL DVSFGHSSSS ARTKPTSLPI SQSRGRIPIV AQSSEEESPL SPVGQPMGMA 4330 4340 4350 4360 4370 4380 RAAAGPLPPI SADTRDQFGS SHSLPEVQQH MREESRTRGY DRDIAFIMDD FQHAMSDSEA 4390 4400 4410 4420 4430 4440 YHLRREETDW FDKPRESRLE NGHGLDRKLP ERLVHSRPLS QHQEQILQMN GKTIHYIFPH 4450 4460 4470 4480 4490 4500 ARVKITRDFK DHTGSGNGLG IRIVGGKEIP GHSGEIGAYI AKILPGESAE HTGPLMEGMQ 4510 4520 4530 4540 4550 4560 VLEWNGVPLT SKTYEEVQSI INQQSGEAEI CVRLDLNMLS DSENPQHLEL HEPPKVDKAK 4570 4580 4590 4600 4610 4620 SPGVDPKQLA AELQKVSLQQ SPLVMSSVVE KGSHAHSGPT SAGSSSVPSP GQPGSPSVSK 4630 4640 4650 4660 4670 4680 KKHSSTKPTD GPKAASHPIT GEIQLQINYD LGNLIIHILQ ARNLVPRDNN GYSDPFVKVY 4690 4700 4710 4720 4730 4740 LLPGRGQVMV VQNASAEYKR RTKYVQKSLN PEWNQTVIYK SISMEQLMKK TLEVTVWDYD 4750 4760 4770 4780 4790 4800 RFSSNDFLGE VLIDLSSTSH LDNTPRWYPL KEQTESIDHG KSHSSQNSQQ SPKPSVIKSR 4810 4820 4830 4840 4850 4860 SHGIFPDPSK DMQVPTIEKS HSSPGSSKSS SEGHLRSHGP SRSQSKTSVA QTHLEDAGVA 4870 4880 4890 4900 4910 4920 IAAAEAAVQQ LRIQPTKPTN HRPAESSVST GSSGSSVGSG YSVDSEGSSC VAGEPNLLPI 4930 4940 4950 4960 4970 4980 PRIGKMGQNG QDPVKQPGMG ATDTEGKTQV MGEIKLALKK EMKTDGEQLI VEILQCRNIT 4990 5000 5010 5020 5030 5040 YKFKSPDHLP DLYVKLYVIN ISTQKKVIKK KTRVCRHDRE PSFNETFRFS LSPAGHSLQI 5050 5060 5070 5080 LLFSNGGKFM KKTLIGEACI WLDKVDLRKR IVNWHKLLVS PTQTH
	Isoform 2 [UniParc]. Checksum: 73951EE4ED83EA68	FASTA	4,880	530,153
	10 20 30 40 50 60 MGNEASLEGE GLPEGLAAAA GAGGSGSALH PGIPAGMEAD LSQLSEEERR QIAAVMSRAQ 70 80 90 100 110 120 GLPKGSVPPA AAESPSMHRK QELDSSQAPQ QPGKPPDPGR PTQPGLSKSR TTDTFRSEQK 130 140 150 160 170 180 LPGRSPSTIS LKESKSRTDF KEEYKSSMMP GFFSDVNPLS AVSSVVNKFN PFDLISDSEA 190 200 210 220 230 240 SQEETTKKQK VVQKEQGKSE GMAKPPLQQP SPKPIPKQQG QVKEVIQQDS SPKSVSSQQA 250 260 270 280 290 300 EKVKPQAPGT GKPSQQSPAQ TPAQQASPGK PVAQQPGSAK ATVQQPGPAK SPAQPAGTGK 310 320 330 340 350 360 SPAQPPAKTP GQQAGLEKTS SSQQPGPKSL AQTPGHGKFP LGPVKSPAQQ PGTAKHPAQQ 370 380 390 400 410 420 PGPQTAAKVP GPTKTPAQQS GPGKTPAQQP GPTKPSPQQP IPAKPQPQQP VATKTQPQQS 430 440 450 460 470 480 APAKPQPQQP APAKPQPQQP TPAKPQPQPP TPAKPQPQPP TATKPQPQPP TATKPHHQQP 490 500 510 520 530 540 GLAKPSAQQP TKSISQTVTG RPLQPPPTSA AQTPAQGLSK TICPLCNTTE LLLHIPEKAN 550 560 570 580 590 600 FNTCTECQST VCSLCGFNPN PHLTEIKEWL CLNCQMQRAL GGDLAAAIPS SPQPTPKAAT 610 620 630 640 650 660 APTATASKSP VPSQQASPKK EPPSKQDSPK ALESKKPPEP KKPPEPKKPP EPKKPPPLVK 670 680 690 700 710 720 QPTLHGPTPA TAPQLPVAEA LPEPAPPKEP SGPLPEQAKA PVGDVEPKQP KMTETRADIQ 730 740 750 760 770 780 SSSTTKPDIL SSQVQSQAQV KTASPLKTDS AKPSQSFPPT GEKTTPLDSK AMPRPASDSK 790 800 810 820 830 840 IISQPGPGSE SKDPKHIDPI QKKDEPKKAQ PKGSPKPETK PVPKGSPTPS GTRPTAGQAA 850 860 870 880 890 900 PPSQQPPKPQ EQSRRFSLNL GGITDAPKSQ PTTPQETVTG KLFGFGASIF SQASNLISTA 910 920 930 940 950 960 GQQGPHPQTG PAAPSKQAPT PSQSPAAQGP AKSTGQLPPA PAKATAVKKE AKAAAAENLE 970 980 990 1000 1010 1020 SKPEQAPTAK KTEKDKKPPP AKVGKPPPSE PEKAVPAHKP DKTTKPKPAC PLCRTELNLG 1030 1040 1050 1060 1070 1080 SQEPPNFNTC TECKNQVCNL CGFNPTPHLT EIQEWLCLNC QTQRAISGQL GDMGKMPPAP 1090 1100 1110 1120 1130 1140 SGPKASPMPA PAEPSSQKTP TGTQVKGKKK EAEGKTEAEK PVPEKETASI EKTPPMVTTD 1150 1160 1170 1180 1190 1200 QKLEESEGKK SKVSALPEKK PSEEEKAISA DKKERKPPAE EKPPLEEKKP IPVDKKLPPE 1210 1220 1230 1240 1250 1260 AKPLSSEGEE KHEILKAHVQ IPEEEPTGKV AAKAGEEEQQ PDSRPEALPG ATPLTLPKAG 1270 1280 1290 1300 1310 1320 EKERAVAQPQ AEGSSKDGQG ERSKEKTEKE EDKSDTSSSQ QPKSPQGLSD TGYSSDGISG 1330 1340 1350 1360 1370 1380 SLGEIPSLIP SDEKDLLKGL KKDSFSQESS PSSPSDLAKL ESTVLSILEA QASTLVGEKA 1390 1400 1410 1420 1430 1440 EKKTQPQKIS PEKPQDQQKT QTASETLDIT ISEEEIKESQ EKKVSPKKDS EQGFPSRKEH 1450 1460 1470 1480 1490 1500 KEKPELVDDL SPRRASYDSV EDSSESENSP VVRRKRRTSI GSSSSDEYKQ EDSQGSGEEE 1510 1520 1530 1540 1550 1560 DFIRKQIIEM SADEDASGSE DEEFIRSQLK EISGVGESQK REEAKGKGKG VAGKHRRLTR 1570 1580 1590 1600 1610 1620 KSSTSFDDDA GRRHSWHDED DETFDESPEL KFRETKSQES EELVVAGGGG LRRFKTIELN 1630 1640 1650 1660 1670 1680 STIADKYSSE SSQKKTILYF DEEPELEMES LTDSPEDRSR GEGSSSLHAS SFTPGTSPTS 1690 1700 1710 1720 1730 1740 VSSLDEDSDS SPSHKKGESK QQRKARHRSH GPLLPTIEDS SEEEELREEE ELLKEQEKQR 1750 1760 1770 1780 1790 1800 ELEQQQRKSS SKKSKKDKDE LRAQRRRERP KTPPSNLSPI EDASPTEELR QAAEMEELHR 1810 1820 1830 1840 1850 1860 SSCSEYSPSI ESDPEGFEIS PEKIIEVQKV YKLPAAVSLY SPTDEQSVMQ KEGVQKALKS 1870 1880 1890 1900 1910 1920 AEEMYEEMMQ KPHKYKAFPA ANERDEVFEK EPLYGGMLIE DYIYESLVED TYNGSVDGSL 1930 1940 1950 1960 1970 1980 LTRQEEQNGF MQQRGREQKV RLQEQIYDDP MQKISDLQKE FYELESLHSV VPQEDIVSSS 1990 2000 2010 2020 2030 2040 YIIPESHEIV DLGSMVMSTS EEKKLLDADS AYEELMRRQQ VQVTDGSSPV QTTIGDDMAE 2050 2060 2070 2080 2090 2100 STLDFDRVQD ASLTSSILSG ASLTDSTSSA TLSIPDVKIT QQFSAEELED EYVTDYTREI 2110 2120 2130 2140 2150 2160 QDIIAHESLI LTYSEPSESA TSVPPSDTPS LTSSISSVCT TDSSSPVTTL DSLTTVYTEP 2170 2180 2190 2200 2210 2220 ADVMTKFKDS EEISSTYFPG SIIDYPEDIS VSLDRTIMPE SRTNEDRIVL SFSGMAPSVV 2230 2240 2250 2260 2270 2280 ESVGTKPERP QADTISTDLP ISEKDLIKGK KETGDGIILE VLDAYKDKRE ESEAELTKIS 2290 2300 2310 2320 2330 2340 LPEPGLAQAP SSVTAPQIKE QHVSPHSVSG KISGQEKPTY RLPSGSLPVS THPSKSRPFF 2350 2360 2370 2380 2390 2400 RSSSLDISAQ PPPPPPPPPP SPSTSSPPPT PPLPPATSPK PPTYPKKKLA VAATVTSTTI 2410 2420 2430 2440 2450 2460 VTTHVDALTM VEAAAARRSN GLPATKMCAI APPPVPPKPS QIPTGLVFTH RPEAIKPPIA 2470 2480 2490 2500 2510 2520 PKPAVPQIPV TTQKPTDTCP KPTGLSLTST MSLNLVTSAD YNVPSPTSPL SPHSNKSSPR 2530 2540 2550 2560 2570 2580 YSKSLMDTYV VITLPSEPGT PTDSSAAQAI TSWPLGSPPK DLVSLETVFS VVPPMTSTEI 2590 2600 2610 2620 2630 2640 PSASQPTLYT SGALGTFSVT PAVTASLFQT VPTSLTQFLP AEASKPEVSA VSSAVPSVAP 2650 2660 2670 2680 2690 2700 RSVSIPIPPE PLALDRHQYK ENGKLPLIGD AIDLRTIPKS EVKVTEKCMD LSASAMDVKR 2710 2720 2730 2740 2750 2760 QTTANEVYRR QISAVQPSII NLSAASSLGT PVTMDSKTVA VVTCTDTTIY TTGTESQVGI 2770 2780 2790 2800 2810 2820 EHAVTSPLQL TTSKHTELPY RKPSSQAFPT IRDEAPINLS LGPSAQAVTL AVTKPVTVPP 2830 2840 2850 2860 2870 2880 VGVTNGWTDS TLSQGVADGE VVDLSTSKSH RTVVTMDEST SNVVTKIIED DEKPVDLTAG 2890 2900 2910 2920 2930 2940 RRAVCCDMVY TLPFGRSCTA QQPATTLPED RFGYRDDHYQ YDRSGPYGYR GIGGMKPSMS 2950 2960 2970 2980 2990 3000 DTNLPEAGHF FYKSKNAFDY SGGTGAAVDL TSGRVSTGEV MDYSSKTTGP YPETRQVISG 3010 3020 3030 3040 3050 3060 VGISTPQYST ARLTPPPGPQ YGVGSVLRSS NGVVYSSVAT PIPSTFAITT QPGSIFSTTV 3070 3080 3090 3100 3110 3120 RDLSGIPTTD AMTSLSALHQ SQPMPRSYFI TTGASETDIA VTGIDINASL QTITMETLPA 3130 3140 3150 3160 3170 3180 ETMDSVPTLT TASEVFSEVV GEESTLLIVP DEDKQQQQLD LERELLELEK IKQQRFAEEL 3190 3200 3210 3220 3230 3240 EWERQEIQRF REQEKIMVQK KLEELQSMKQ HLLYQQEEER QAQFMMRQET LAQQQLQLEQ 3250 3260 3270 3280 3290 3300 IQQLQQQLHQ QLEEQKLRQI YQYNYDPSGT SSPQTTTEQA ILEGQYAATE GSQFWATEDA 3310 3320 3330 3340 3350 3360 TTTASTVVAI EIPQSQGWYT VQSDGVTQYI APPGILSTVS EIPLTDVVVK EEKQPKKRSS 3370 3380 3390 3400 3410 3420 GAKVRGQYDE MGESVADDPR NLKKIVDSGV QTDDEETADR SYASRRRRTK KSVDTSVQTD 3430 3440 3450 3460 3470 3480 DEDQDEWDMP SRSRRKARTG KYGDSTAEGD KTKPLSKVSS VAVQTVAEIS VQTEPVGTIR 3490 3500 3510 3520 3530 3540 TPSIRARVDA KVEIIKHISA PEKTYKGGSL GCQTETDSDT QSPPYLGATS PPKDKKRPTP 3550 3560 3570 3580 3590 3600 LEIGYSSSHL RADPTVQLAP SPPKSPKVLY SPISPLSPGN ALEPAFVPYE KPLPDDISPQ 3610 3620 3630 3640 3650 3660 KVLHPDMAKV PPASPKTAKM MQRSMSDPKP LSPTADESSR APFQYSEGFT TKGSQTMTAS 3670 3680 3690 3700 3710 3720 GTQKKVKRTL PNPPPEEVST GTQSTYSTMG TASRRRMCRT NTMARAKILQ DIDRELDLVE 3730 3740 3750 3760 3770 3780 RESAKLRKKQ AELDEEEKEI DAKLRYLEMG INRRKEALLK EREKRERAYL QGVAEDRDYM 3790 3800 3810 3820 3830 3840 SDSEVSSTRP SRVESQHGVE RPRTAPQTEF SQFIPPQTQT EAQLVPPTSP YTQYQYSSPA 3850 3860 3870 3880 3890 3900 LPTQAPTPYT QQSHFQQQTL YHQQVSPYQT QPTFQAVATM SFTPQAQPTP TPQPSYQLPS 3910 3920 3930 3940 3950 3960 QMMVIQQKPR QTTLYLEPKI TSNYEVIRNQ PLMIAPVSTD NTYAVSHLGS KYNSLDLRIG 3970 3980 3990 4000 4010 4020 LEERSSMAGS PISSISADSF YADIDHHTSR NYVLIDDIGD ITKGTAALST VFSLHEKDLS 4030 4040 4050 4060 4070 4080 KTDRLLRTTE TRRSQEVTDF LAPLQTSSRL HSYVKADEDP MEDPYELKLL KHQIKQEFRR 4090 4100 4110 4120 4130 4140 GTESLDHLAG LSHYYHADTS YRHFPKSEKY SISRLTLEKQ AAKQLPAAIL YQKQSKHKKS 4150 4160 4170 4180 4190 4200 LIDPKMSKFS PIQESRDLEP DYPTYMSSGT SSIGGISSRA RLLQDDITFG LRKNITDQQK 4210 4220 4230 4240 4250 4260 FMGSSLGSGL GTLGNTIRSA LQDEADKPYS SGSRSRPSSR PSSVYGLDLS IKRDSSSSSL 4270 4280 4290 4300 4310 4320 RLKAQEAEAL DVSFGHSSSS ARTKPTSLPI SQSRGRIPIV AQSSEEESPL SPVGQPMGMA 4330 4340 4350 4360 4370 4380 RAAAGPLPPI SADTRDQFGS SHSLPEVQQH MREESRTRGY DRDIAFIMDD FQHAMSDSEA 4390 4400 4410 4420 4430 4440 YHLRREETDW FDKPRESRLE NGHGLDRKLP ERLVHSRPLS QHQEQILQMN GKTIHYIFPH 4450 4460 4470 4480 4490 4500 ARVKITRDFK DHTGSGNGLG IRIVGGKEIP GHSGEIGAYI AKILPGESAE HTGPLMEGMQ 4510 4520 4530 4540 4550 4560 VLEWNGVPLT SKTYEEVQSI INQQSGEAEI CVRLDLNMLS DSENPQHLEL HEPPKVDKAK 4570 4580 4590 4600 4610 4620 SPGVDPKQLA AELQKVSLQQ SPLVMSSVVE KGSHAHSGPT SAGSSSVPSP GQPGSPSVSK 4630 4640 4650 4660 4670 4680 KKHSSTKPTD GPKAASHPIT GEIQLQINYD LGNLIIHILQ ARNLVPRDNN GYSDPFVKVY 4690 4700 4710 4720 4730 4740 LLPGRGQVMV VQNASAEYKR RTKYVQKSLN PEWNQTVIYK SISMEQLMKK TLEVTVWDYD 4750 4760 4770 4780 4790 4800 RFSSNDFLGE VLIDLSSTSH LDNTPRWYPL KEQTESIDHG KSHSSQNSQQ SPKPSVIKSR 4810 4820 4830 4840 4850 4860 SHGIFPDPSK DMQVPTIEKS HSSPGSSKSS SEGHLRSHGP SRSQSKTSVA QTHLEDAGVA 4870 4880 IAAAEAAVQQ LRIQPSKRRK
	Isoform 3 [UniParc]. Checksum: 41D97D62D0F389D9	FASTA	5,076	551,758
	10 20 30 40 50 60 MGNEASLEGE GLPEGLAAAA GAGGSGSALH PGIPAGMEAD LSQLSEEERR QIAAVMSRAQ 70 80 90 100 110 120 GLPKGSVPPA AAESPSMHRK QELDSSQAPQ QPGKPPDPGR PTQPGLSKSR TTDTFRSEQK 130 140 150 160 170 180 LPGRSPSTIS LKESKSRTDF KEEYKSSMMP GFFSDVNPLS AVSSVVNKFN PFDLISDSEA 190 200 210 220 230 240 SQEETTKKQK VVQKEQGKSE GMAKPPLQQP SPKPIPKQQG QVKEVIQQDS SPKSVSSQQA 250 260 270 280 290 300 EKVKPQAPGT GKPSQQSPAQ TPAQQASPGK PVAQQPGSAK ATVQQPGPAK SPAQPAGTGK 310 320 330 340 350 360 SPAQPPAKTP GQQAGLEKTS SSQQPGPKSL AQTPGHGKFP LGPVKSPAQQ PGTAKHPAQQ 370 380 390 400 410 420 PGPQTAAKVP GPTKTPAQQS GPGKTPAQQP GPTKPSPQQP IPAKPQPQQP VATKTQPQQS 430 440 450 460 470 480 APAKPQPQQP APAKPQPQQP TPAKPQPQPP TPAKPQPQPP TATKPQPQPP TATKPHHQQP 490 500 510 520 530 540 GLAKPSAQQP TKSISQTVTG RPLQPPPTSA AQTPAQGLSK TICPLCNTTE LLLHIPEKAN 550 560 570 580 590 600 FNTCTECQST VCSLCGFNPN PHLTEIKEWL CLNCQMQRAL GGDLAAAIPS SPQPTPKAAT 610 620 630 640 650 660 APTATASKSP VPSQQASPKK EPPSKQDSPK ALESKKPPEP KKPPEPKKPP EPKKPPPLVK 670 680 690 700 710 720 QPTLHGPTPA TAPQLPVAEA LPEPAPPKEP SGPLPEQAKA PVGDVEPKQP KMTETRADIQ 730 740 750 760 770 780 SSSTTKPDIL SSQVQSQAQV KTASPLKTDS AKPSQSFPPT GEKTTPLDSK AMPRPASDSK 790 800 810 820 830 840 IISQPGPGSE SKDPKHIDPI QKKDEPKKAQ PKGSPKPETK PVPKGSPTPS GTRPTAGQAA 850 860 870 880 890 900 PPSQQPPKPQ EQSRRFSLNL GGITDAPKSQ PTTPQETVTG KLFGFGASIF SQASNLISTA 910 920 930 940 950 960 GQQGPHPQTG PAAPSKQAPT PSQSPAAQGP AKSTGQLPPA PAKATAVKKE AKAAAAENLE 970 980 990 1000 1010 1020 SKPEQAPTAK KTEKDKKPPP AKVGKPPPSE PEKAVPAHKP DKTTKPKPAC PLCRTELNLG 1030 1040 1050 1060 1070 1080 SQEPPNFNTC TECKNQVCNL CGFNPTPHLT EIQEWLCLNC QTQRAISGQL GDMGKMPPAP 1090 1100 1110 1120 1130 1140 SGPKASPMPA PAEPSSQKTP TGTQVKGKKK EAEGKTEAEK PVPEKETASI EKTPPMVTTD 1150 1160 1170 1180 1190 1200 QKLEESEGKK SKVSALPEKK PSEEEKAISA DKKERKPPAE EKPPLEEKKP IPVDKKLPPE 1210 1220 1230 1240 1250 1260 AKPLSSEGEE KHEILKAHVQ IPEEEPTGKV AAKAGEEEQQ PDSRPEALPG ATPLTLPKAG 1270 1280 1290 1300 1310 1320 EKERAVAQPQ AEGSSKDGQG ERSKEKTEKE EDKSDTSSSQ QPKSPQGLSD TGYSSDGISG 1330 1340 1350 1360 1370 1380 SLGEIPSLIP SDEKDLLKGL KKDSFSQESS PSSPSDLAKL ESTVLSILEA QASTLVGEKA 1390 1400 1410 1420 1430 1440 EKKTQPQKIS PEKPQDQQKT QTASETLDIT ISEEEIKESQ EKKVSPKKDS EQGFPSRKEH 1450 1460 1470 1480 1490 1500 KEKPELVDDL SPRRASYDSV EDSSESENSP VVRRKRRTSI GSSSSDEYKQ EDSQGSGEEE 1510 1520 1530 1540 1550 1560 DFIRKQIIEM SADEDASGSE DEEFIRSQLK EISGVGESQK REEAKGKGKG VAGKHRRLTR 1570 1580 1590 1600 1610 1620 KSSTSFDDDA GRRHSWHDED DETFDESPEL KFRETKSQES EELVVAGGGG LRRFKTIELN 1630 1640 1650 1660 1670 1680 STIADKYSSE SSQKKTILYF DEEPELEMES LTDSPEDRSR GEGSSSLHAS SFTPGTSPTS 1690 1700 1710 1720 1730 1740 VSSLDEDSDS SPSHKKGESK QQRKARHRSH GPLLPTIEDS SEEEELREEE ELLKEQEKQR 1750 1760 1770 1780 1790 1800 ELEQQQRKSS SKKSKKDKDE LRAQRRRERP KTPPSNLSPI EDASPTEELR QAAEMEELHR 1810 1820 1830 1840 1850 1860 SSCSEYSPSI ESDPEGFEIS PEKIIEVQKV YKLPAAVSLY SPTDEQSVMQ KEGVQKALKS 1870 1880 1890 1900 1910 1920 AEEMYEEMMQ KPHKYKAFPA ANERDEVFEK EPLYGGMLIE DYIYESLVED TYNGSVDGSL 1930 1940 1950 1960 1970 1980 LTRQEEQNGF MQQRGREQKV RLQEQIYDDP MQKISDLQKE FYELESLHSV VPQEDIVSSS 1990 2000 2010 2020 2030 2040 YIIPESHEIV DLGSMVMSTS EEKKLLDADS AYEELMRRQQ VQVTDGSSPV QTTIGDDMAE 2050 2060 2070 2080 2090 2100 STLDFDRVQD ASLTSSILSG ASLTDSTSSA TLSIPDVKIT QQFSAEELED EYVTDYTREI 2110 2120 2130 2140 2150 2160 QDIIAHESLI LTYSEPSESA TSVPPSDTPS LTSSISSVCT TDSSSPVTTL DSLTTVYTEP 2170 2180 2190 2200 2210 2220 ADVMTKFKDS EEISSTYFPG SIIDYPEDIS VSLDRTIMPE SRTNEDRIVL SFSGMAPSVV 2230 2240 2250 2260 2270 2280 ESVGTKPERP QADTISTDLP ISEKDLIKGK KETGDGIILE VLDAYKDKRE ESEAELTKIS 2290 2300 2310 2320 2330 2340 LPEPGLAQAP SSVTAPQIKE QHVSPHSVSG KISGQEKPTY RLPSGSLPVS THPSKSRPFF 2350 2360 2370 2380 2390 2400 RSSSLDISAQ PPPPPPPPPP SPSTSSPPPT PPLPPATSPK PPTYPKKKLA VAATVTSTTI 2410 2420 2430 2440 2450 2460 VTTHVDALTM VEAAAARRSN GLPATKMCAI APPPVPPKPS QIPTGLVFTH RPEAIKPPIA 2470 2480 2490 2500 2510 2520 PKPAVPQIPV TTQKPTDTCP KPTGLSLTST MSLNLVTSAD YNVPSPTSPL SPHSNKSSPR 2530 2540 2550 2560 2570 2580 YSKSLMDTYV VITLPSEPGT PTDSSAAQAI TSWPLGSPPK DLVSLETVFS VVPPMTSTEI 2590 2600 2610 2620 2630 2640 PSASQPTLYT SGALGTFSVT PAVTASLFQT VPTSLTQFLP AEASKPEVSA VSSAVPSVAP 2650 2660 2670 2680 2690 2700 RSVSIPIPPE PLALDRHQYK ENGKLPLIGD AIDLRTIPKS EVKVTEKCMD LSASAMDVKR 2710 2720 2730 2740 2750 2760 QTTANEVYRR QISAVQPSII NLSAASSLGT PVTMDSKTVA VVTCTDTTIY TTGTESQVGI 2770 2780 2790 2800 2810 2820 EHAVTSPLQL TTSKHTELPY RKPSSQAFPT IRDEAPINLS LGPSAQAVTL AVTKPVTVPP 2830 2840 2850 2860 2870 2880 VGVTNGWTDS TLSQGVADGE VVDLSTSKSH RTVVTMDEST SNVVTKIIED DEKPVDLTAG 2890 2900 2910 2920 2930 2940 RRAVCCDMVY TLPFGRSCTA QQPATTLPED RFGYRDDHYQ YDRSGPYGYR GIGGMKPSMS 2950 2960 2970 2980 2990 3000 DTNLPEAGHF FYKSKNAFDY SGGTGAAVDL TSGRVSTGEV MDYSSKTTGP YPETRQVISG 3010 3020 3030 3040 3050 3060 VGISTPQYST ARLTPPPGPQ YGVGSVLRSS NGVVYSSVAT PIPSTFAITT QPGSIFSTTV 3070 3080 3090 3100 3110 3120 RDLSGIPTTD AMTSLSALHQ SQPMPRSYFI TTGASETDIA VTGIDINASL QTITMETLPA 3130 3140 3150 3160 3170 3180 ETMDSVPTLT TASEVFSEVV GEESTLLIVP DEDKQQQQLD LERELLELEK IKQQRFAEEL 3190 3200 3210 3220 3230 3240 EWERQEIQRF REQEKIMVQK KLEELQSMKQ HLLYQQEEER QAQFMMRQET LAQQQLQLEQ 3250 3260 3270 3280 3290 3300 IQQLQQQLHQ QLEEQKLRQI YQYNYDPSGT SSPQTTTEQA ILEGQYAATE GSQFWATEDA 3310 3320 3330 3340 3350 3360 TTTASTVVAI EIPQSQGWYT VQSDGVTQYI APPGILSTVS EIPLTDVVVK EEKQPKKRSS 3370 3380 3390 3400 3410 3420 GAKVRGQYDE MGESVADDPR NLKKIVDSGV QTDDEETADR SYASRRRRTK KSVDTSVQTD 3430 3440 3450 3460 3470 3480 DEDQDEWDMP SRSRRKARTG KYGDSTAEGD KTKPLSKVSS VAVQTVAEIS VQTEPVGTIR 3490 3500 3510 3520 3530 3540 TPSIRARVDA KVEIIKHISA PEKTYKGGSL GCQTETDSDT QSPPYLGATS PPKDKKRPTP 3550 3560 3570 3580 3590 3600 LEIGYSSSHL RADPTVQLAP SPPKSPKVLY SPISPLSPGN ALEPAFVPYE KPLPDDISPQ 3610 3620 3630 3640 3650 3660 KVLHPDMAKV PPASPKTAKM MQRSMSDPKP LSPTADESSR APFQYSEGFT TKGSQTMTAS 3670 3680 3690 3700 3710 3720 GTQKKVKRTL PNPPPEEVST GTQSTYSTMG TASRRRMCRT NTMARAKILQ DIDRELDLVE 3730 3740 3750 3760 3770 3780 RESAKLRKKQ AELDEEEKEI DAKLRYLEMG INRRKEALLK EREKRERAYL QGVAEDRDYM 3790 3800 3810 3820 3830 3840 SDSEVSSTRP SRVESQHGVE RPRTAPQTEF SQFIPPQTQT EAQLVPPTSP YTQYQYSSPA 3850 3860 3870 3880 3890 3900 LPTQAPTPYT QQSHFQQQTL YHQQVSPYQT QPTFQAVATM SFTPQAQPTP TPQPSYQLPS 3910 3920 3930 3940 3950 3960 QMMVIQQKPR QTTLYLEPKI TSNYEVIRNQ PLMIAPVSTD NTYAVSHLGS KYNSLDLRIG 3970 3980 3990 4000 4010 4020 LEERSSMAGS PISSISADSF YADIDHHTSR NYVLIDDIGD ITKGTAALST VFSLHEKDLS 4030 4040 4050 4060 4070 4080 KTDRLLRTTE TRRSQEVTDF LAPLQTSSRL HSYVKADEDP MEDPYELKLL KHQIKQEFRR 4090 4100 4110 4120 4130 4140 GTESLDHLAG LSHYYHADTS YRHFPKSEKY SISRLTLEKQ AAKQLPAAIL YQKQSKHKKS 4150 4160 4170 4180 4190 4200 LIDPKMSKFS PIQESRDLEP DYPTYMSSGT SSIGGISSRA RLLQDDITFG LRKNITDQQK 4210 4220 4230 4240 4250 4260 FMGSSLGSGL GTLGNTIRSA LQDEADKPYS SGSRSRPSSR PSSVYGLDLS IKRDSSSSSL 4270 4280 4290 4300 4310 4320 RLKAQEAEAL DVSFGHSSSS ARTKPTSLPI SQSRGRIPIV AQSSEEESPL SPVGQPMGMA 4330 4340 4350 4360 4370 4380 RAAAGPLPPI SADTRDQFGS SHSLPEVQQH MREESRTRGY DRDIAFIMDD FQHAMSDSEA 4390 4400 4410 4420 4430 4440 YHLRREETDW FDKPRESRLE NGHGLDRKLP ERLVHSRPLS QHQEQILQMN GKTIHYIFPH 4450 4460 4470 4480 4490 4500 ARVKITRDFK DHTGSGNGLG IRIVGGKEIP GHSGEIGAYI AKILPGESAE HTGPLMEGMQ 4510 4520 4530 4540 4550 4560 VLEWNGVPLT SKTYEEVQSI INQQSGEAEI CVRLDLNMLS DSENPQHLEL HEPPKVDKAK 4570 4580 4590 4600 4610 4620 SPGVDPKQLA AELQKVSLQQ SPLVMSSVVE KGSHAHSGPT SAGSSSVPSP GQPGSPSVSK 4630 4640 4650 4660 4670 4680 KKHSSTKPTD GPKAASHPIT GEIQLQINYD LGNLIIHILQ ARNLVPRDNN GYSDPFVKVY 4690 4700 4710 4720 4730 4740 LLPGRGAEYK RRTKYVQKSL NPEWNQTVIY KSISMEQLMK KTLEVTVWDY DRFSSNDFLG 4750 4760 4770 4780 4790 4800 EVLIDLSSTS HLDNTPRWYP LKEQTESIDH GKSHSSQNSQ QSPKPSVIKS RSHGIFPDPS 4810 4820 4830 4840 4850 4860 KDMQVPTIEK SHSSPGSSKS SSEGHLRSHG PSRSQSKTSV AQTHLEDAGV AIAAAEAAVQ 4870 4880 4890 4900 4910 4920 QLRIQPTKPT NHRPAESSVS TGSSGSSVGS GYSVDSEGSS CVAGEPNLLP IPRIGKMGQN 4930 4940 4950 4960 4970 4980 GQDPVKQPGM GATDTEGKTQ VMGEIKLALK KEMKTDGEQL IVEILQCRNI TYKFKSPDHL 4990 5000 5010 5020 5030 5040 PDLYVKLYVI NISTQKKVIK KKTRVCRHDR EPSFNETFRF SLSPAGHSLQ ILLFSNGGKF 5050 5060 5070 MKKTLIGEAC IWLDKVDLRK RIVNWHKLLV SPTQTH

References

[1]	"Piccolo, a presynaptic zinc finger protein structurally related to bassoon." Fenster S.D., Chung W.J., Zhai R., Cases-Langhoff C., Voss B., Garner A.M., Kaempf U., Kindler S., Gundelfinger E.D., Garner C.C. Neuron 25:203-214(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH RABAC1.
[2]	Fenster S.D., Cases-Langhoff C., Gundelfinger E.D., Garner C.C. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"An unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release." Gerber S.H., Garcia J., Rizo J., Suedhof T.C. EMBO J. 20:1605-1619(2001) [PubMed] [Europe PMC] [Abstract] Cited for: CALCIUM-BINDING, MUTAGENESIS OF ASP-4668; ASP-4674; VAL-4688; 4688-VAL-MET-4689; MET-4689; 4690-VAL-VAL-4691; 4692-GLN-ASN-4693 AND ALA-4694.
[4]	"A conformational switch in the Piccolo C2A domain regulated by alternative splicing." Garcia J., Gerber S.H., Sugita S., Suedhof T.C., Rizo J. Nat. Struct. Mol. Biol. 11:45-53(2004) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 4635-4776, ALTERNATIVE SPLICING (ISOFORM 3).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF138789 mRNA. Translation: AAF07822.2.
AF227534 mRNA. Translation: AAF63196.1.

IPI

IPI00203018.
IPI00231831.
IPI00758462.

RefSeq

NP_001104267.1. NM_001110797.1.
NP_064483.1. NM_020098.1.

UniGene

Rn.53925.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1RH8	NMR	-	A	4635-4776	[»]

ProteinModelPortal

Q9JKS6.

SMR

Q9JKS6. Positions 4430-4538, 4635-4776.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9JKS6. 4 interactions.

STRING

10116.ENSRNOP00000008637.

PTM databases

PhosphoSite

Q9JKS6.

Proteomic databases

PaxDb

Q9JKS6.

PRIDE

Q9JKS6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

56768.

KEGG

rno:56768.

Organism-specific databases

CTD

27445.

RGD

69406. Pclo.

Phylogenomic databases

eggNOG

COG5038.

HOGENOM

HOG000168263.

HOVERGEN

HBG031058.

InParanoid

Q9JKS6.

KO

K16882.

Gene expression databases

ArrayExpress

Q9JKS6.

Genevestigator

Q9JKS6.

GermOnline

ENSRNOG00000005726. Rattus norvegicus.

Family and domain databases

Gene3D

3.30.40.10. 2 hits.

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR018029. C2_membr_targeting.
IPR001478. PDZ.
IPR011011. Znf_FYVE_PHD.
IPR008899. Znf_piccolo.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Pfam

PF00168. C2. 2 hits.
PF00595. PDZ. 1 hit.
PF05715. zf-piccolo. 2 hits.
[Graphical view]

SMART

SM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 2 hits.
SSF57903. FYVE_PHD_ZnF. 2 hits.
SSF50156. PDZ. 1 hit.

PROSITE

PS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9JKS6.

NextBio

611161.

Entry information

Entry name

PCLO_RAT

Accession

Primary (citable) accession number: Q9JKS6
Secondary accession number(s): Q9JLT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	October 1, 2000
Last modified:	May 29, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program