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Protein

Intracellular hyaluronan-binding protein 4

Gene

Habp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Intracellular hyaluronan-binding protein 4
Short name:
IHABP-4
Short name:
IHABP4
Gene namesi
Name:Habp4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1891713. Habp4.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Transported into the nuclear compartment in activated leukocytes (By similarity). Interacts with SPIN1.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
  • sarcomere Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002579731 – 411Intracellular hyaluronan-binding protein 4Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei70Omega-N-methylarginineBy similarity1
Modified residuei74PhosphoserineBy similarity1
Modified residuei108PhosphoserineBy similarity1
Modified residuei352Phosphothreonine; by PKCBy similarity1
Modified residuei373Phosphothreonine; by PKCBy similarity1

Post-translational modificationi

Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-352 and Thr-373.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9JKS5.
PaxDbiQ9JKS5.
PRIDEiQ9JKS5.

PTM databases

iPTMnetiQ9JKS5.
PhosphoSitePlusiQ9JKS5.

Expressioni

Tissue specificityi

Expressed in adult heart, brain, liver, kidney, testis, and in various embryonic tissues, but not in adult spleen, lung or skeletal muscle.1 Publication

Gene expression databases

CleanExiMM_HABP4.

Interactioni

Subunit structurei

Interacts with the C-terminus of CHD3. Interacts via its C-terminal region with RACK1. Interacts with p53/TP53 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9JKS5. 1 interactor.
MINTiMINT-4130138.
STRINGi10090.ENSMUSP00000021929.

Structurei

3D structure databases

ProteinModelPortaliQ9JKS5.
SMRiQ9JKS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili42 – 62Sequence analysisAdd BLAST21
Coiled coili279 – 301Sequence analysisAdd BLAST23

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2945. Eukaryota.
ENOG410YBHR. LUCA.
HOGENOMiHOG000220826.
HOVERGENiHBG056357.
InParanoidiQ9JKS5.
KOiK19019.
PhylomeDBiQ9JKS5.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR032381. IHABP4_N.
[Graphical view]
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF16174. IHABP4_N. 1 hit.
[Graphical view]
SMARTiSM01233. HABP4_PAI-RBP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGALGSPVA AAGAAMQETF GCVVANRFHQ LLDDESDPFD ILREAEHRRQ
60 70 80 90 100
QQLQRKRRDE AAAASGAGHR GGRSPAVASG HRPGAGGRRE SQKERKSLAA
110 120 130 140 150
SGAQQPDSPG GPQPPGQKRT PRRGEQQGWN DNRGTDVVLE RAERRSYREY
160 170 180 190 200
RPYETERQAD LPVEKFTDEK PVDRFDRDRP LRGRGGPRGG LRSRGRGGPG
210 220 230 240 250
NRAFDSFDQR GKRDFERYSS NDKTNRMEDS MGGCGIRPWG SGKDTSDTEP
260 270 280 290 300
PAPMEETSMM EECQGTLDEE SAAKVPELEV EEENQVQEMT LDEWKNLQEQ
310 320 330 340 350
TRPKPEFNIR KPESTVPSKA VVIHKSRYRD DMVKEDYEDE SHVFRKAAND
360 370 380 390 400
ITSQLEINFG NLPRPGRGAR GSTRGGRGRM RRTENYGPRA EVVTQDVAPN
410
PDDPEDFPAL A
Length:411
Mass (Da):45,924
Last modified:October 31, 2006 - v2
Checksum:i234C0E38C98990F4
GO

Sequence cautioni

The sequence BAB30437 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64A → AA in BAB30437 (PubMed:16141072).Curated1
Sequence conflicti187P → L in BAE25769 (PubMed:16141072).Curated1
Sequence conflicti194R → K in AAF36966 (PubMed:10887182).Curated1
Sequence conflicti266T → A in BAB30437 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227684 mRNA. Translation: AAF36966.1.
AK016800 mRNA. Translation: BAB30437.1. Sequence problems.
AK144206 mRNA. Translation: BAE25769.1.
RefSeqiNP_064370.2. NM_019986.3.
UniGeneiMm.40989.

Genome annotation databases

GeneIDi56541.
KEGGimmu:56541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF227684 mRNA. Translation: AAF36966.1.
AK016800 mRNA. Translation: BAB30437.1. Sequence problems.
AK144206 mRNA. Translation: BAE25769.1.
RefSeqiNP_064370.2. NM_019986.3.
UniGeneiMm.40989.

3D structure databases

ProteinModelPortaliQ9JKS5.
SMRiQ9JKS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JKS5. 1 interactor.
MINTiMINT-4130138.
STRINGi10090.ENSMUSP00000021929.

PTM databases

iPTMnetiQ9JKS5.
PhosphoSitePlusiQ9JKS5.

Proteomic databases

MaxQBiQ9JKS5.
PaxDbiQ9JKS5.
PRIDEiQ9JKS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56541.
KEGGimmu:56541.

Organism-specific databases

CTDi22927.
MGIiMGI:1891713. Habp4.

Phylogenomic databases

eggNOGiKOG2945. Eukaryota.
ENOG410YBHR. LUCA.
HOGENOMiHOG000220826.
HOVERGENiHBG056357.
InParanoidiQ9JKS5.
KOiK19019.
PhylomeDBiQ9JKS5.

Miscellaneous databases

ChiTaRSiHabp4. mouse.
PROiQ9JKS5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HABP4.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR032381. IHABP4_N.
[Graphical view]
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF16174. IHABP4_N. 1 hit.
[Graphical view]
SMARTiSM01233. HABP4_PAI-RBP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHABP4_MOUSE
AccessioniPrimary (citable) accession number: Q9JKS5
Secondary accession number(s): Q3UNH8, Q9D450
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 2, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Able to bind hyaluronan. However, its intracellular localization suggests that this interaction may not be relevant in vivo.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.