Reviewed, UniProtKB/Swiss-Prot Q9JKS5 (HABP4_MOUSE)

Names and origin

Protein names

Recommended name:
    Intracellular hyaluronan-binding protein 4
      Short name=IHABP4

Gene names

Name:

Habp4

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription By similarity. UniProtKB Q5JVS0
Subunit structure	Interacts with the C-terminus of CHD3. Interacts via its C-terminal region with GNB2L1. Interacts with TP53/p53 By similarity. Ref.1 UniProtKB Q5JVS0
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Transported into the nuclear compartment in activated leukocytes By similarity.
Tissue specificity	Expressed in adult heart, brain, liver, kidney, testis, and in various embryonic tissues, but not in adult spleen, lung or skeletal muscle. Ref.1
Post-translational modification	Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-352 and Thr-373 By similarity. UniProtKB Q5JVS0
Miscellaneous	Able to bind hyaluronan. However, its intracellular localization suggests that this interaction may not be relevant in vivo.
Sequence caution	The sequence BAB30437.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Domain	Coiled coil
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from Experiment. Source: Reactome extracellular region Inferred from Experiment. Source: Reactome nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 411	411	Intracellular hyaluronan-binding protein 4		PRO_0000257973
Regions
	Coiled coil	42 – 62	21	Potential
	Coiled coil	279 – 301	23	Potential
Amino acid modifications
	Modified residue	97	1	Phosphoserine By similarity
	Modified residue	108	1	Phosphoserine By similarity
	Modified residue	352	1	Phosphothreonine; by PKC By similarity UniProtKB Q5JVS0
	Modified residue	373	1	Phosphothreonine; by PKC By similarity UniProtKB Q5JVS0
Experimental info
	Sequence conflict	64	1	A → AA in BAB30437. Ref.2
	Sequence conflict	187	1	P → L in BAE25769. Ref.2
	Sequence conflict	194	1	R → K in AAF36966. Ref.1
	Sequence conflict	266	1	T → A in BAB30437. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9JKS5-1 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 234C0E38C98990F4	FASTA	411	45,924
	10 20 30 40 50 60 MKGALGSPVA AAGAAMQETF GCVVANRFHQ LLDDESDPFD ILREAEHRRQ QQLQRKRRDE 70 80 90 100 110 120 AAAASGAGHR GGRSPAVASG HRPGAGGRRE SQKERKSLAA SGAQQPDSPG GPQPPGQKRT 130 140 150 160 170 180 PRRGEQQGWN DNRGTDVVLE RAERRSYREY RPYETERQAD LPVEKFTDEK PVDRFDRDRP 190 200 210 220 230 240 LRGRGGPRGG LRSRGRGGPG NRAFDSFDQR GKRDFERYSS NDKTNRMEDS MGGCGIRPWG 250 260 270 280 290 300 SGKDTSDTEP PAPMEETSMM EECQGTLDEE SAAKVPELEV EEENQVQEMT LDEWKNLQEQ 310 320 330 340 350 360 TRPKPEFNIR KPESTVPSKA VVIHKSRYRD DMVKEDYEDE SHVFRKAAND ITSQLEINFG 370 380 390 400 410 NLPRPGRGAR GSTRGGRGRM RRTENYGPRA EVVTQDVAPN PDDPEDFPAL A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of a novel intracellular hyaluronan-binding protein." Huang L., Grammatikakis N., Yoneda M., Banerjee S.D., Toole B.P. J. Biol. Chem. 275:29829-29839(2000) [PubMed: 10887182] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF227684 mRNA. Translation: AAF36966.1. AK016800 mRNA. Translation: BAB30437.1. Sequence problems. AK144206 mRNA. Translation: BAE25769.1.
IPI	IPI00123374. IPI00798570.
RefSeq	NP_064370.2.
UniGene	Mm.40989
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9JKS5.
Proteomic databases
PRIDE	Q9JKS5.
Genome annotation databases
Ensembl	ENSMUST00000021929; ENSMUSP00000021929; ENSMUSG00000021476; Mus musculus. [Genome view]
GeneID	56541.
KEGG	mmu:56541.
UCSC	uc007qyl.1. mouse.
Organism-specific databases
CTD	56541.
MGI	MGI:1891713. Habp4.
Phylogenomic databases
HOVERGEN	Q9JKS5.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q9JKS5.
Bgee	Q9JKS5.
CleanEx	MM_HABP4.
Genevestigator	Q9JKS5.
GermOnline	ENSMUSG00000021476. Mus musculus.
Family and domain databases
InterPro	IPR006861. HABP4_PAIRBP1_bd. [Graphical view]
Pfam	PF04774. HABP4_PAI-RBP1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	312906.
SOURCE	Search...

Entry information

Entry name

HABP4_MOUSE

Accession

Primary (citable) accession number: Q9JKS5
Secondary accession number(s): Q3UNH8, Q9D450

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	November 24, 2009
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)