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Protein

Hypoxia up-regulated protein 1

Gene

Hyou1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-3000484. Scavenging by Class F Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxia up-regulated protein 1
Short name:
GRP-170
Alternative name(s):
140 kDa Ca(2+)-binding protein
Short name:
CBP-140
Gene namesi
Name:Hyou1
Synonyms:Grp170
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:108030. Hyou1.

Subcellular locationi

  • Endoplasmic reticulum lumen 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32By similarityAdd BLAST32
ChainiPRO_500005782733 – 999Hypoxia up-regulated protein 1Add BLAST967

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1
Glycosylationi515N-linked (GlcNAc...)1 Publication1
Modified residuei567PhosphoserineBy similarity1
Glycosylationi596N-linked (GlcNAc...)Sequence analysis1
Glycosylationi830N-linked (GlcNAc...)Sequence analysis1
Glycosylationi862N-linked (GlcNAc...)Sequence analysis1
Glycosylationi869N-linked (GlcNAc...)Sequence analysis1
Modified residuei883N6-acetyllysineCombined sources1
Glycosylationi922N-linked (GlcNAc...)Sequence analysis1
Glycosylationi931N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9JKR6.
MaxQBiQ9JKR6.
PaxDbiQ9JKR6.
PeptideAtlasiQ9JKR6.
PRIDEiQ9JKR6.

2D gel databases

REPRODUCTION-2DPAGEIPI00123342.
Q3TZD0.
Q64139.
Q9JKR6.

PTM databases

iPTMnetiQ9JKR6.
PhosphoSitePlusiQ9JKR6.
SwissPalmiQ9JKR6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032115.
CleanExiMM_HYOU1.
ExpressionAtlasiQ9JKR6. baseline and differential.
GenevisibleiQ9JKR6. MM.

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Protein-protein interaction databases

BioGridi198427. 8 interactors.
IntActiQ9JKR6. 6 interactors.
MINTiMINT-4130117.
STRINGi10090.ENSMUSP00000068594.

Structurei

3D structure databases

ProteinModelPortaliQ9JKR6.
SMRiQ9JKR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi996 – 999Prevents secretion from ERSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi603 – 606Poly-Glu4

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0104. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00840000129925.
HOGENOMiHOG000007865.
HOVERGENiHBG106402.
InParanoidiQ9JKR6.
KOiK09486.
OMAiRKQRMVE.
OrthoDBiEOG091G025X.
PhylomeDBiQ9JKR6.
TreeFamiTF105048.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100934. SSF100934. 1 hit.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATVRRQRP RRLLCWALVA VLLADLLALS DTLAVMSVDL GSESMKVAIV
60 70 80 90 100
KPGVPMEIVL NKESRRKTPV TVTLKENERF LGDSAAGMAI KNPKATLRYF
110 120 130 140 150
QHLLGKQADN PHVALYRSRF PEHELIVDPQ RQTVRFQISP QLQFSPEEVL
160 170 180 190 200
GMVLNYSRSL AEDFAEQPIK DAVITVPAFF NQAERRAVLQ AARMAGLKVL
210 220 230 240 250
QLINDNTATA LSYGVFRRKD INSTAQNVMF YDMGSGSTVC TIVTYQTVKT
260 270 280 290 300
KEAGMQPQLQ IRGVGFDRTL GGLEMELRLR EHLAKLFNEQ RKGQKAKDVR
310 320 330 340 350
ENPRAMAKLL REANRLKTVL SANADHMAQI EGLMDDVDFK AKVTRVEFEE
360 370 380 390 400
LCADLFDRVP GPVQQALQSA EMSLDQIEQV ILVGGATRVP KVQEVLLKAV
410 420 430 440 450
GKEELGKNIN ADEAAAMGAV YQAAALSKAF KVKPFVVRDA VIYPILVEFT
460 470 480 490 500
REVEEEPGLR SLKHNKRVLF SRMGPYPQRK VITFNRYSHD FNFHINYGDL
510 520 530 540 550
GFLGPEDLRV FGSQNLTTVK LKGVGESFKK YPDYESKGIK AHFNLDESGV
560 570 580 590 600
LSLDRVESVF ETLVEDSPEE ESTLTKLGNT ISSLFGGGTS SDAKENGTDA
610 620 630 640 650
VQEEEESPAE GSKDEPAEQG ELKEEAEPPA EETSQPPPSE PKGDAAREGE
660 670 680 690 700
KPDEKESGDK PEAQKPNEKG QAGPEGAAPA PEEDKKPKPA RKQKMVEEIG
710 720 730 740 750
VELAVLDLPD LPEDELARSV QKLEELTLRD LEKQEREKAA NSLEAFIFET
760 770 780 790 800
QDKLYQPEYQ EVSTEEQREE ISGKLSATST WLEDEGFGAT TVMLKDKLAE
810 820 830 840 850
LRKLCQGLFF RVEERRKWPE RLSALDNLLN HSSIFLKGAR LIPEMDQVFT
860 870 880 890 900
EVEMTTLEKV INDTWAWKNA TLAEQAKLPA TEKPVLLSKD IEAKMMALDR
910 920 930 940 950
EVQYLLNKAK FTKPRPRPKD KNGTRAEPPL NASAGDQEEK VIPPAGQTEE
960 970 980 990
AKPILEPDKE ETGTEPADSE PLELGGPGAG PEQEEQSAGQ KRPSKNDEL
Length:999
Mass (Da):111,181
Last modified:October 1, 2000 - v1
Checksum:i2951482D1EE2EF36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137Q → L in AAH50107 (PubMed:15489334).Curated1
Sequence conflicti227N → D in AAH50107 (PubMed:15489334).Curated1
Sequence conflicti247T → A in BAE34279 (PubMed:16141072).Curated1
Sequence conflicti290Q → R in BAE42657 (PubMed:16141072).Curated1
Sequence conflicti467R → G in AAB35051 (PubMed:7641295).Curated1
Sequence conflicti540K → R in AAH50107 (PubMed:15489334).Curated1
Sequence conflicti615E → K in AAH50107 (PubMed:15489334).Curated1
Sequence conflicti665Missing in AAB35051 (PubMed:7641295).Curated1
Sequence conflicti687P → L in AAB35051 (PubMed:7641295).Curated1
Sequence conflicti710D → N in AAB35051 (PubMed:7641295).Curated1
Sequence conflicti734Q → R in AAH50107 (PubMed:15489334).Curated1
Sequence conflicti744E → K in AAH50107 (PubMed:15489334).Curated1
Sequence conflicti772S → P in AAH50107 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228709 mRNA. Translation: AAF65544.1.
AK171769 mRNA. Translation: BAE42657.1.
AK145857 mRNA. Translation: BAE26702.1.
AK155721 mRNA. Translation: BAE33401.1.
AK157949 mRNA. Translation: BAE34279.1.
BC050107 mRNA. Translation: AAH50107.1.
S78797 mRNA. Translation: AAB35051.1.
CCDSiCCDS23107.1.
RefSeqiNP_067370.3. NM_021395.4.
XP_006510022.1. XM_006509959.2.
XP_006510023.1. XM_006509960.2.
XP_006510024.1. XM_006509961.2.
UniGeneiMm.116721.

Genome annotation databases

EnsembliENSMUST00000066601; ENSMUSP00000068594; ENSMUSG00000032115.
ENSMUST00000160902; ENSMUSP00000125594; ENSMUSG00000032115.
ENSMUST00000161318; ENSMUSP00000123700; ENSMUSG00000032115.
GeneIDi12282.
KEGGimmu:12282.
UCSCiuc009pdf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228709 mRNA. Translation: AAF65544.1.
AK171769 mRNA. Translation: BAE42657.1.
AK145857 mRNA. Translation: BAE26702.1.
AK155721 mRNA. Translation: BAE33401.1.
AK157949 mRNA. Translation: BAE34279.1.
BC050107 mRNA. Translation: AAH50107.1.
S78797 mRNA. Translation: AAB35051.1.
CCDSiCCDS23107.1.
RefSeqiNP_067370.3. NM_021395.4.
XP_006510022.1. XM_006509959.2.
XP_006510023.1. XM_006509960.2.
XP_006510024.1. XM_006509961.2.
UniGeneiMm.116721.

3D structure databases

ProteinModelPortaliQ9JKR6.
SMRiQ9JKR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198427. 8 interactors.
IntActiQ9JKR6. 6 interactors.
MINTiMINT-4130117.
STRINGi10090.ENSMUSP00000068594.

PTM databases

iPTMnetiQ9JKR6.
PhosphoSitePlusiQ9JKR6.
SwissPalmiQ9JKR6.

2D gel databases

REPRODUCTION-2DPAGEIPI00123342.
Q3TZD0.
Q64139.
Q9JKR6.

Proteomic databases

EPDiQ9JKR6.
MaxQBiQ9JKR6.
PaxDbiQ9JKR6.
PeptideAtlasiQ9JKR6.
PRIDEiQ9JKR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066601; ENSMUSP00000068594; ENSMUSG00000032115.
ENSMUST00000160902; ENSMUSP00000125594; ENSMUSG00000032115.
ENSMUST00000161318; ENSMUSP00000123700; ENSMUSG00000032115.
GeneIDi12282.
KEGGimmu:12282.
UCSCiuc009pdf.2. mouse.

Organism-specific databases

CTDi10525.
MGIiMGI:108030. Hyou1.

Phylogenomic databases

eggNOGiKOG0104. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00840000129925.
HOGENOMiHOG000007865.
HOVERGENiHBG106402.
InParanoidiQ9JKR6.
KOiK09486.
OMAiRKQRMVE.
OrthoDBiEOG091G025X.
PhylomeDBiQ9JKR6.
TreeFamiTF105048.

Enzyme and pathway databases

ReactomeiR-MMU-3000484. Scavenging by Class F Receptors.

Miscellaneous databases

PROiQ9JKR6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032115.
CleanExiMM_HYOU1.
ExpressionAtlasiQ9JKR6. baseline and differential.
GenevisibleiQ9JKR6. MM.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100934. SSF100934. 1 hit.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYOU1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKR6
Secondary accession number(s): Q3TAL1
, Q3TZD0, Q3U1U2, Q64139, Q80X75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.