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Protein

Palmitoyltransferase ZDHHC2

Gene

Zdhhc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Palmitoyltransferase specific for GAP43 and DLG4/PSD95.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC2 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 2
Short name:
DHHC-2
Gene namesi
Name:Zdhhc2
Synonyms:Srec
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi628681. Zdhhc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128611 – 366Palmitoyltransferase ZDHHC2Add BLAST366

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9JKR5.

PTM databases

iPTMnetiQ9JKR5.
PhosphoSitePlusiQ9JKR5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000022686.
GenevisibleiQ9JKR5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033473.

Structurei

3D structure databases

SMRiQ9JKR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 176DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1315. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00880000137864.
HOGENOMiHOG000234777.
HOVERGENiHBG055108.
InParanoidiQ9JKR5.
OMAiVCLIAYH.
OrthoDBiEOG091G0AXR.
PhylomeDBiQ9JKR5.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JKR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSGPGGVR RRCRRVLYWI PVVFISLLLG WSYYAYAIQL CIVSMENIGE
60 70 80 90 100
QVVCLMAYHL LFAMFVWSYW KTIFTLPMNP SKEFHLSYAE KELLEREPRG
110 120 130 140 150
EAHQEVLRRA AKDLPIYTRT MSGAIRYCDR CRLIKPDRCH HCSVCDKCIL
160 170 180 190 200
KMDHHCPWVN NCVGFSNYKF FLLFLAYSLL YCLFIAATDL QYFIRFWTNG
210 220 230 240 250
LPDTQAKFHI MFLFFAAAMF SVSLSSLFGY HCWLVSKNKS TLEAFRNPVF
260 270 280 290 300
RHGTDKNGFS LGFSKNMRQV FGDEKKYWLL PIFSSQGDGC SFPTCLVNQD
310 320 330 340 350
PEQPSTPAGL NSTAKNPENH QFPAKPLRES QSHLLTDSQT WTENSSNSGR
360
CKAGMSNPAL TMENET
Length:366
Mass (Da):42,086
Last modified:October 1, 2000 - v1
Checksum:i3D689A3045D52D18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228917 mRNA. Translation: AAF43032.1.
AB217870 mRNA. Translation: BAF37828.1.
UniGeneiRn.17310.

Genome annotation databases

EnsembliENSRNOT00000036092; ENSRNOP00000033473; ENSRNOG00000022686.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZDHC2_RAT
AccessioniPrimary (citable) accession number: Q9JKR5
Secondary accession number(s): A0P8F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families