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Protein

Chromatin accessibility complex protein 1

Gene

Chrac1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin accessibility complex protein 1
Short name:
CHRAC-1
Alternative name(s):
DNA polymerase epsilon subunit p15
NF-YC-like protein
YC-like protein 1
Short name:
YCL1
Gene namesi
Name:Chrac1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2135796. Chrac1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 129128Chromatin accessibility complex protein 1PRO_0000089657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei102 – 1021N6-acetyllysineBy similarity
Modified residuei122 – 1221PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9JKP8.
MaxQBiQ9JKP8.
PaxDbiQ9JKP8.
PRIDEiQ9JKP8.

PTM databases

iPTMnetiQ9JKP8.
PhosphoSiteiQ9JKP8.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiQ9JKP8.
CleanExiMM_CHRAC1.
ExpressionAtlasiQ9JKP8. baseline and differential.
GenevisibleiQ9JKP8. MM.

Interactioni

Subunit structurei

Interacts with POLE3. Together with POLE3, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC (By similarity).By similarity

Protein-protein interaction databases

BioGridi220245. 1 interaction.
IntActiQ9JKP8. 1 interaction.
MINTiMINT-8178504.
STRINGi10090.ENSMUSP00000087197.

Structurei

3D structure databases

ProteinModelPortaliQ9JKP8.
SMRiQ9JKP8. Positions 28-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili104 – 12017Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1657. Eukaryota.
COG5208. LUCA.
GeneTreeiENSGT00510000048543.
HOGENOMiHOG000068045.
HOVERGENiHBG050946.
InParanoidiQ9JKP8.
KOiK11656.
OMAiKIRVHEF.
OrthoDBiEOG7RJPTD.
PhylomeDBiQ9JKP8.
TreeFamiTF350392.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR033048. CHRAC1.
IPR009072. Histone-fold.
[Graphical view]
PANTHERiPTHR10252:SF47. PTHR10252:SF47. 1 hit.
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAAVGKEK CGDQRLVSLP LSRIRVIMKS SPEVSSINQE ALVLTAKATE
60 70 80 90 100
LFVQYLATCS YRHGSGKAKK ALTYSDLAST AEDSETLQFL ADILPKKILA
110 120
SKYLKMLKEK REEEEDNEDD GSDLGEALA
Length:129
Mass (Da):14,127
Last modified:October 1, 2000 - v1
Checksum:iCDF843A5D96D5520
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230805 mRNA. Translation: AAF67145.1.
AK010812 mRNA. Translation: BAB27197.1.
BC016593 mRNA. Translation: AAH16593.1.
BC061043 mRNA. Translation: AAH61043.1.
CCDSiCCDS27516.1.
RefSeqiNP_444298.1. NM_053068.3.
UniGeneiMm.23095.

Genome annotation databases

EnsembliENSMUST00000089765; ENSMUSP00000087197; ENSMUSG00000068391.
GeneIDi93696.
KEGGimmu:93696.
UCSCiuc007wbq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230805 mRNA. Translation: AAF67145.1.
AK010812 mRNA. Translation: BAB27197.1.
BC016593 mRNA. Translation: AAH16593.1.
BC061043 mRNA. Translation: AAH61043.1.
CCDSiCCDS27516.1.
RefSeqiNP_444298.1. NM_053068.3.
UniGeneiMm.23095.

3D structure databases

ProteinModelPortaliQ9JKP8.
SMRiQ9JKP8. Positions 28-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220245. 1 interaction.
IntActiQ9JKP8. 1 interaction.
MINTiMINT-8178504.
STRINGi10090.ENSMUSP00000087197.

PTM databases

iPTMnetiQ9JKP8.
PhosphoSiteiQ9JKP8.

Proteomic databases

EPDiQ9JKP8.
MaxQBiQ9JKP8.
PaxDbiQ9JKP8.
PRIDEiQ9JKP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089765; ENSMUSP00000087197; ENSMUSG00000068391.
GeneIDi93696.
KEGGimmu:93696.
UCSCiuc007wbq.1. mouse.

Organism-specific databases

CTDi54108.
MGIiMGI:2135796. Chrac1.

Phylogenomic databases

eggNOGiKOG1657. Eukaryota.
COG5208. LUCA.
GeneTreeiENSGT00510000048543.
HOGENOMiHOG000068045.
HOVERGENiHBG050946.
InParanoidiQ9JKP8.
KOiK11656.
OMAiKIRVHEF.
OrthoDBiEOG7RJPTD.
PhylomeDBiQ9JKP8.
TreeFamiTF350392.

Miscellaneous databases

PROiQ9JKP8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKP8.
CleanExiMM_CHRAC1.
ExpressionAtlasiQ9JKP8. baseline and differential.
GenevisibleiQ9JKP8. MM.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR033048. CHRAC1.
IPR009072. Histone-fold.
[Graphical view]
PANTHERiPTHR10252:SF47. PTHR10252:SF47. 1 hit.
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the histone-fold proteins YBL1 and YCL1."
    Bolognese F., Imbriano C., Caretti G., Mantovani R.
    Nucleic Acids Res. 28:3830-3838(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: B-cell lymphoma.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland and Testis.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiCHRC1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKP8
Secondary accession number(s): Q91VG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.