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Protein

Chromatin accessibility complex protein 1

Gene

Chrac1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin accessibility complex protein 1
Short name:
CHRAC-1
Alternative name(s):
DNA polymerase epsilon subunit p15
NF-YC-like protein
YC-like protein 1
Short name:
YCL1
Gene namesi
Name:Chrac1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2135796 Chrac1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000896572 – 129Chromatin accessibility complex protein 1Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei102N6-acetyllysineBy similarity1
Modified residuei122PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9JKP8
MaxQBiQ9JKP8
PaxDbiQ9JKP8
PeptideAtlasiQ9JKP8
PRIDEiQ9JKP8

PTM databases

iPTMnetiQ9JKP8
PhosphoSitePlusiQ9JKP8

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSMUSG00000068391
CleanExiMM_CHRAC1
ExpressionAtlasiQ9JKP8 baseline and differential
GenevisibleiQ9JKP8 MM

Interactioni

Subunit structurei

Interacts with POLE3. Together with POLE3, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi220245, 1 interactor
IntActiQ9JKP8, 1 interactor
MINTiQ9JKP8
STRINGi10090.ENSMUSP00000087197

Structurei

3D structure databases

ProteinModelPortaliQ9JKP8
SMRiQ9JKP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili104 – 120Sequence analysisAdd BLAST17

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1657 Eukaryota
COG5208 LUCA
GeneTreeiENSGT00510000048543
HOGENOMiHOG000068045
HOVERGENiHBG050946
InParanoidiQ9JKP8
KOiK11656
OMAiKIRVHEF
OrthoDBiEOG091G0Y96
PhylomeDBiQ9JKP8
TreeFamiTF350392

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAAVGKEK CGDQRLVSLP LSRIRVIMKS SPEVSSINQE ALVLTAKATE
60 70 80 90 100
LFVQYLATCS YRHGSGKAKK ALTYSDLAST AEDSETLQFL ADILPKKILA
110 120
SKYLKMLKEK REEEEDNEDD GSDLGEALA
Length:129
Mass (Da):14,127
Last modified:October 1, 2000 - v1
Checksum:iCDF843A5D96D5520
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230805 mRNA Translation: AAF67145.1
AK010812 mRNA Translation: BAB27197.1
BC016593 mRNA Translation: AAH16593.1
BC061043 mRNA Translation: AAH61043.1
CCDSiCCDS27516.1
RefSeqiNP_444298.1, NM_053068.3
UniGeneiMm.23095

Genome annotation databases

EnsembliENSMUST00000089765; ENSMUSP00000087197; ENSMUSG00000068391
GeneIDi93696
KEGGimmu:93696
UCSCiuc007wbq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCHRC1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKP8
Secondary accession number(s): Q91VG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health