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Protein

Chromatin accessibility complex protein 1

Gene

Chrac1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin accessibility complex protein 1
Short name:
CHRAC-1
Alternative name(s):
DNA polymerase epsilon subunit p15
NF-YC-like protein
YC-like protein 1
Short name:
YCL1
Gene namesi
Name:Chrac1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2135796. Chrac1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 129128Chromatin accessibility complex protein 1PRO_0000089657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei102 – 1021N6-acetyllysineBy similarity
Modified residuei122 – 1221PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9JKP8.
MaxQBiQ9JKP8.
PaxDbiQ9JKP8.
PeptideAtlasiQ9JKP8.
PRIDEiQ9JKP8.

PTM databases

iPTMnetiQ9JKP8.
PhosphoSiteiQ9JKP8.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSMUSG00000068391.
CleanExiMM_CHRAC1.
ExpressionAtlasiQ9JKP8. baseline and differential.
GenevisibleiQ9JKP8. MM.

Interactioni

Subunit structurei

Interacts with POLE3. Together with POLE3, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC (By similarity).By similarity

Protein-protein interaction databases

BioGridi220245. 1 interaction.
IntActiQ9JKP8. 1 interaction.
MINTiMINT-8178504.
STRINGi10090.ENSMUSP00000087197.

Structurei

3D structure databases

ProteinModelPortaliQ9JKP8.
SMRiQ9JKP8. Positions 28-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili104 – 12017Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1657. Eukaryota.
COG5208. LUCA.
GeneTreeiENSGT00510000048543.
HOGENOMiHOG000068045.
HOVERGENiHBG050946.
InParanoidiQ9JKP8.
KOiK11656.
OMAiKIRVHEF.
OrthoDBiEOG091G0Y96.
PhylomeDBiQ9JKP8.
TreeFamiTF350392.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR033048. CHRAC1.
IPR009072. Histone-fold.
[Graphical view]
PANTHERiPTHR10252:SF47. PTHR10252:SF47. 1 hit.
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAAVGKEK CGDQRLVSLP LSRIRVIMKS SPEVSSINQE ALVLTAKATE
60 70 80 90 100
LFVQYLATCS YRHGSGKAKK ALTYSDLAST AEDSETLQFL ADILPKKILA
110 120
SKYLKMLKEK REEEEDNEDD GSDLGEALA
Length:129
Mass (Da):14,127
Last modified:October 1, 2000 - v1
Checksum:iCDF843A5D96D5520
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230805 mRNA. Translation: AAF67145.1.
AK010812 mRNA. Translation: BAB27197.1.
BC016593 mRNA. Translation: AAH16593.1.
BC061043 mRNA. Translation: AAH61043.1.
CCDSiCCDS27516.1.
RefSeqiNP_444298.1. NM_053068.3.
UniGeneiMm.23095.

Genome annotation databases

EnsembliENSMUST00000089765; ENSMUSP00000087197; ENSMUSG00000068391.
GeneIDi93696.
KEGGimmu:93696.
UCSCiuc007wbq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230805 mRNA. Translation: AAF67145.1.
AK010812 mRNA. Translation: BAB27197.1.
BC016593 mRNA. Translation: AAH16593.1.
BC061043 mRNA. Translation: AAH61043.1.
CCDSiCCDS27516.1.
RefSeqiNP_444298.1. NM_053068.3.
UniGeneiMm.23095.

3D structure databases

ProteinModelPortaliQ9JKP8.
SMRiQ9JKP8. Positions 28-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220245. 1 interaction.
IntActiQ9JKP8. 1 interaction.
MINTiMINT-8178504.
STRINGi10090.ENSMUSP00000087197.

PTM databases

iPTMnetiQ9JKP8.
PhosphoSiteiQ9JKP8.

Proteomic databases

EPDiQ9JKP8.
MaxQBiQ9JKP8.
PaxDbiQ9JKP8.
PeptideAtlasiQ9JKP8.
PRIDEiQ9JKP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089765; ENSMUSP00000087197; ENSMUSG00000068391.
GeneIDi93696.
KEGGimmu:93696.
UCSCiuc007wbq.1. mouse.

Organism-specific databases

CTDi54108.
MGIiMGI:2135796. Chrac1.

Phylogenomic databases

eggNOGiKOG1657. Eukaryota.
COG5208. LUCA.
GeneTreeiENSGT00510000048543.
HOGENOMiHOG000068045.
HOVERGENiHBG050946.
InParanoidiQ9JKP8.
KOiK11656.
OMAiKIRVHEF.
OrthoDBiEOG091G0Y96.
PhylomeDBiQ9JKP8.
TreeFamiTF350392.

Miscellaneous databases

PROiQ9JKP8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068391.
CleanExiMM_CHRAC1.
ExpressionAtlasiQ9JKP8. baseline and differential.
GenevisibleiQ9JKP8. MM.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR033048. CHRAC1.
IPR009072. Histone-fold.
[Graphical view]
PANTHERiPTHR10252:SF47. PTHR10252:SF47. 1 hit.
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCHRC1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKP8
Secondary accession number(s): Q91VG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.