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Protein

RNA-binding protein Nova-1

Gene

Nova1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion. It binds specifically to the sequence UCAUY. Most likely acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer.3 Publications

GO - Molecular functioni

  • mRNA binding Source: MGI

GO - Biological processi

  • mRNA splicing, via spliceosome Source: MGI
  • regulation of RNA metabolic process Source: MGI

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Nova-1
Alternative name(s):
Neuro-oncological ventral antigen 1
Ventral neuron-specific protein 1
Gene namesi
Name:Nova1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:104297 Nova1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Nova1 leads to neuronal death in spinal and brainstem neurons.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501171 – 507RNA-binding protein Nova-1Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei154Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JKN6
PaxDbiQ9JKN6
PeptideAtlasiQ9JKN6
PRIDEiQ9JKN6

PTM databases

iPTMnetiQ9JKN6
PhosphoSitePlusiQ9JKN6

Expressioni

Gene expression databases

BgeeiENSMUSG00000021047
CleanExiMM_NOVA1
ExpressionAtlasiQ9JKN6 baseline and differential
GenevisibleiQ9JKN6 MM

Interactioni

Subunit structurei

Interacts with PTBP2; the interaction is direct.1 Publication

Protein-protein interaction databases

BioGridi576757, 2 interactors
IntActiQ9JKN6, 1 interactor
MINTiQ9JKN6
STRINGi10090.ENSMUSP00000021438

Structurei

3D structure databases

ProteinModelPortaliQ9JKN6
SMRiQ9JKN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 116KH 1PROSITE-ProRule annotationAdd BLAST68
Domaini171 – 237KH 2PROSITE-ProRule annotationAdd BLAST67
Domaini421 – 488KH 3PROSITE-ProRule annotationAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi27 – 43Bipartite nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi273 – 409Ala-richAdd BLAST137

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2191 Eukaryota
ENOG410XRZD LUCA
GeneTreeiENSGT00760000119144
HOGENOMiHOG000007833
HOVERGENiHBG082048
InParanoidiQ9JKN6
KOiK14944
OMAiVVDFIMD
OrthoDBiEOG091G185U
PhylomeDBiQ9JKN6
TreeFamiTF316981

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR033086 NOVA1
PANTHERiPTHR10288:SF223 PTHR10288:SF223, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits

Sequencei

Sequence statusi: Complete.

Q9JKN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAAAPIQQN GTHTGVPIDL DPPDSRKRPL EAPPEAGSTK RTNTGEDGQY
60 70 80 90 100
FLKVLIPSYA AGSIIGKGGQ TIVQLQKETG ATIKLSKSKD FYPGTTERVC
110 120 130 140 150
LIQGTIEALN AVHGFIAEKI REMPQNVAKT EPVSILQPQT TVNPDRIKQT
160 170 180 190 200
LPSSPTTTKS SPSDPMTTSR ANQVKIIVPN STAGLIIGKG GATVKAIMEQ
210 220 230 240 250
SGAWVQLSQK PDGINLQERV VTVSGEPEQN RKAVELIIQK IQEDPQSGSC
260 270 280 290 300
LNISYANVTG PVANSNPTGS PYANTAEVLP TAAAAAGLLG HANLAGVAAF
310 320 330 340 350
PAVLSGFTGN DLVAITSALN TLASYGYNLN TLGLGLSQAA ATGALAAAAA
360 370 380 390 400
SANPAAAAAN LLATYASEAS ASGSTAGGTA GTFALGSLAA ATAATNGYFG
410 420 430 440 450
AASPLAASAI LGTEKSTDGS KDVVEIAVPE NLVGAILGKG GKTLVEYQEL
460 470 480 490 500
TGARIQISKK GEFVPGTRNR KVTITGTPAA TQAAQYLITQ RITYEQGVRA

ANPQKVG
Length:507
Mass (Da):51,756
Last modified:January 9, 2007 - v2
Checksum:iEB68F2D777BF8135
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108802 Genomic DNA No translation available.
AC156636 Genomic DNA No translation available.
AF232828 mRNA Translation: AAF35907.1
AK047565 mRNA Translation: BAC33088.1
CCDSiCCDS49058.1
RefSeqiNP_067336.1, NM_021361.1
UniGeneiMm.247195

Genome annotation databases

EnsembliENSMUST00000021438; ENSMUSP00000021438; ENSMUSG00000021047
GeneIDi664883
KEGGimmu:664883
UCSCiuc007nmd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNOVA1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKN6
Secondary accession number(s): Q8C8B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: January 9, 2007
Last modified: March 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health