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Protein

RNA-binding protein Nova-1

Gene

Nova1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion. It binds specifically to the sequence UCAUY. Most likely acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer.3 Publications

GO - Molecular functioni

  • mRNA binding Source: MGI
  • poly(A) RNA binding Source: MGI

GO - Biological processi

  • mRNA splicing, via spliceosome Source: MGI
  • regulation of RNA metabolic process Source: MGI
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Nova-1
Alternative name(s):
Neuro-oncological ventral antigen 1
Ventral neuron-specific protein 1
Gene namesi
Name:Nova1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:104297. Nova1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Nova1 leads to neuronal death in spinal and brainstem neurons.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501171 – 507RNA-binding protein Nova-1Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei154Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JKN6.
PaxDbiQ9JKN6.
PeptideAtlasiQ9JKN6.
PRIDEiQ9JKN6.

PTM databases

iPTMnetiQ9JKN6.
PhosphoSitePlusiQ9JKN6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021047.
CleanExiMM_NOVA1.
GenevisibleiQ9JKN6. MM.

Interactioni

Subunit structurei

Interacts with PTBP2; the interaction is direct.1 Publication

Protein-protein interaction databases

BioGridi576757. 2 interactors.
IntActiQ9JKN6. 1 interactor.
MINTiMINT-4103983.
STRINGi10090.ENSMUSP00000021438.

Structurei

3D structure databases

ProteinModelPortaliQ9JKN6.
SMRiQ9JKN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 116KH 1PROSITE-ProRule annotationAdd BLAST68
Domaini171 – 237KH 2PROSITE-ProRule annotationAdd BLAST67
Domaini421 – 488KH 3PROSITE-ProRule annotationAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi27 – 43Bipartite nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi273 – 409Ala-richAdd BLAST137

Sequence similaritiesi

Contains 3 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2191. Eukaryota.
ENOG410XRZD. LUCA.
GeneTreeiENSGT00760000119144.
HOGENOMiHOG000007833.
HOVERGENiHBG082048.
InParanoidiQ9JKN6.
KOiK14944.
OMAiISKKGMF.
OrthoDBiEOG091G185U.
PhylomeDBiQ9JKN6.
TreeFamiTF316981.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR033086. NOVA1.
[Graphical view]
PANTHERiPTHR10288:SF150. PTHR10288:SF150. 3 hits.
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAAAPIQQN GTHTGVPIDL DPPDSRKRPL EAPPEAGSTK RTNTGEDGQY
60 70 80 90 100
FLKVLIPSYA AGSIIGKGGQ TIVQLQKETG ATIKLSKSKD FYPGTTERVC
110 120 130 140 150
LIQGTIEALN AVHGFIAEKI REMPQNVAKT EPVSILQPQT TVNPDRIKQT
160 170 180 190 200
LPSSPTTTKS SPSDPMTTSR ANQVKIIVPN STAGLIIGKG GATVKAIMEQ
210 220 230 240 250
SGAWVQLSQK PDGINLQERV VTVSGEPEQN RKAVELIIQK IQEDPQSGSC
260 270 280 290 300
LNISYANVTG PVANSNPTGS PYANTAEVLP TAAAAAGLLG HANLAGVAAF
310 320 330 340 350
PAVLSGFTGN DLVAITSALN TLASYGYNLN TLGLGLSQAA ATGALAAAAA
360 370 380 390 400
SANPAAAAAN LLATYASEAS ASGSTAGGTA GTFALGSLAA ATAATNGYFG
410 420 430 440 450
AASPLAASAI LGTEKSTDGS KDVVEIAVPE NLVGAILGKG GKTLVEYQEL
460 470 480 490 500
TGARIQISKK GEFVPGTRNR KVTITGTPAA TQAAQYLITQ RITYEQGVRA

ANPQKVG
Length:507
Mass (Da):51,756
Last modified:January 9, 2007 - v2
Checksum:iEB68F2D777BF8135
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108802 Genomic DNA. No translation available.
AC156636 Genomic DNA. No translation available.
AF232828 mRNA. Translation: AAF35907.1.
AK047565 mRNA. Translation: BAC33088.1.
CCDSiCCDS49058.1.
RefSeqiNP_067336.1. NM_021361.1.
UniGeneiMm.247195.

Genome annotation databases

EnsembliENSMUST00000021438; ENSMUSP00000021438; ENSMUSG00000021047.
GeneIDi664883.
KEGGimmu:664883.
UCSCiuc007nmd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108802 Genomic DNA. No translation available.
AC156636 Genomic DNA. No translation available.
AF232828 mRNA. Translation: AAF35907.1.
AK047565 mRNA. Translation: BAC33088.1.
CCDSiCCDS49058.1.
RefSeqiNP_067336.1. NM_021361.1.
UniGeneiMm.247195.

3D structure databases

ProteinModelPortaliQ9JKN6.
SMRiQ9JKN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi576757. 2 interactors.
IntActiQ9JKN6. 1 interactor.
MINTiMINT-4103983.
STRINGi10090.ENSMUSP00000021438.

PTM databases

iPTMnetiQ9JKN6.
PhosphoSitePlusiQ9JKN6.

Proteomic databases

MaxQBiQ9JKN6.
PaxDbiQ9JKN6.
PeptideAtlasiQ9JKN6.
PRIDEiQ9JKN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021438; ENSMUSP00000021438; ENSMUSG00000021047.
GeneIDi664883.
KEGGimmu:664883.
UCSCiuc007nmd.2. mouse.

Organism-specific databases

CTDi4857.
MGIiMGI:104297. Nova1.

Phylogenomic databases

eggNOGiKOG2191. Eukaryota.
ENOG410XRZD. LUCA.
GeneTreeiENSGT00760000119144.
HOGENOMiHOG000007833.
HOVERGENiHBG082048.
InParanoidiQ9JKN6.
KOiK14944.
OMAiISKKGMF.
OrthoDBiEOG091G185U.
PhylomeDBiQ9JKN6.
TreeFamiTF316981.

Miscellaneous databases

PROiQ9JKN6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021047.
CleanExiMM_NOVA1.
GenevisibleiQ9JKN6. MM.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR033086. NOVA1.
[Graphical view]
PANTHERiPTHR10288:SF150. PTHR10288:SF150. 3 hits.
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOVA1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKN6
Secondary accession number(s): Q8C8B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.