Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9JKN5

- OLIG1_MOUSE

UniProt

Q9JKN5 - OLIG1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Oligodendrocyte transcription factor 1

Gene

Olig1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. neuron fate commitment Source: MGI
  2. regulation of transcription, DNA-templated Source: MGI
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 1
Short name:
Oligo1
Alternative name(s):
Oligodendrocyte-specific bHLH transcription factor 1
Gene namesi
Name:Olig1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1355334. Olig1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Oligodendrocyte transcription factor 1PRO_0000127412Add
BLAST

Proteomic databases

PRIDEiQ9JKN5.

PTM databases

PhosphoSiteiQ9JKN5.

Expressioni

Tissue specificityi

Expressed specifically in brain.1 Publication

Developmental stagei

Expressed in the ventral spinal cord as early as 9.5 dpc. Expression declines to undetectable levels by 10.5 dpc and reappears in a narrow zone within the ventral neuroepithelium of the spinal cord. In the 14.5 dpc spinal cord, expressed in the oligodendrocyte progenitors of the ventral ventricular zone, but not dorsal root ganglia Schwann cells. Also expressed scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. By 15.5 dpc, dispersed throughout the gray matter, with little or no residual expression in the ventricular zone. In the postnatal brain, present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Expressed in the olfactory epithelium from 11.5dpc onward.1 Publication

Inductioni

By SHH.1 Publication

Gene expression databases

BgeeiQ9JKN5.
CleanExiMM_OLIG1.
ExpressionAtlasiQ9JKN5. baseline and differential.
GenevestigatoriQ9JKN5.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Id2P411365EBI-1213712,EBI-309167
Id4P411395EBI-1213712,EBI-1213725

Protein-protein interaction databases

BioGridi206153. 5 interactions.
IntActiQ9JKN5. 5 interactions.
MINTiMINT-7295439.
STRINGi10090.ENSMUSP00000061408.

Structurei

3D structure databases

ProteinModelPortaliQ9JKN5.
SMRiQ9JKN5. Positions 96-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 15360bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 529Poly-Ser
Compositional biasi90 – 945Poly-Gln

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG256163.
GeneTreeiENSGT00530000063239.
HOGENOMiHOG000015810.
HOVERGENiHBG053369.
InParanoidiQ9JKN5.
KOiK09085.
OMAiGSPGLCT.
OrthoDBiEOG7HF1KN.
PhylomeDBiQ9JKN5.
TreeFamiTF322733.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKN5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYYAISQARV NAAPATMLRP QRPGDVQLGA SLYELVGYRQ PPISSSSSSS
60 70 80 90 100
SSTASLLPKP AREKAEAPLA EPRGPAPESG GARADAKEEQ QQQQLRRKIN
110 120 130 140 150
SRERKRMQDL NLAMDALREV ILPYSAAHCQ GAPGRKLSKI ATLLLARNYI
160 170 180 190 200
LLLGSSLQEL RRALGDGAGP AAPRLLLAGL PLLAAAPGSV LLAPGAVGPP
210 220 230 240 250
ETLRPTKYLS LALDEPPCGQ FSLPAGGAGS PGLCSCAVCK FPHLVPAGLG
260
LAAVQAQFSK
Length:260
Mass (Da):27,141
Last modified:August 30, 2002 - v2
Checksum:i5EA8A74D9DF0D310
GO

Sequence cautioni

The sequence BAB18906.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038696 mRNA. Translation: BAB18906.1. Different initiation.
BC046316 mRNA. Translation: AAH46316.1.
AF232928 Genomic DNA. Translation: AAF61721.1.
CCDSiCCDS28324.1.
RefSeqiNP_058664.2. NM_016968.4.
UniGeneiMm.39300.

Genome annotation databases

EnsembliENSMUST00000056882; ENSMUSP00000061408; ENSMUSG00000046160.
GeneIDi50914.
KEGGimmu:50914.
UCSCiuc007zxf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038696 mRNA. Translation: BAB18906.1 . Different initiation.
BC046316 mRNA. Translation: AAH46316.1 .
AF232928 Genomic DNA. Translation: AAF61721.1 .
CCDSi CCDS28324.1.
RefSeqi NP_058664.2. NM_016968.4.
UniGenei Mm.39300.

3D structure databases

ProteinModelPortali Q9JKN5.
SMRi Q9JKN5. Positions 96-158.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206153. 5 interactions.
IntActi Q9JKN5. 5 interactions.
MINTi MINT-7295439.
STRINGi 10090.ENSMUSP00000061408.

PTM databases

PhosphoSitei Q9JKN5.

Proteomic databases

PRIDEi Q9JKN5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000056882 ; ENSMUSP00000061408 ; ENSMUSG00000046160 .
GeneIDi 50914.
KEGGi mmu:50914.
UCSCi uc007zxf.1. mouse.

Organism-specific databases

CTDi 116448.
MGIi MGI:1355334. Olig1.

Phylogenomic databases

eggNOGi NOG256163.
GeneTreei ENSGT00530000063239.
HOGENOMi HOG000015810.
HOVERGENi HBG053369.
InParanoidi Q9JKN5.
KOi K09085.
OMAi GSPGLCT.
OrthoDBi EOG7HF1KN.
PhylomeDBi Q9JKN5.
TreeFami TF322733.

Miscellaneous databases

NextBioi 307907.
PROi Q9JKN5.
SOURCEi Search...

Gene expression databases

Bgeei Q9JKN5.
CleanExi MM_OLIG1.
ExpressionAtlasi Q9JKN5. baseline and differential.
Genevestigatori Q9JKN5.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3."
    Takebayashi H., Yoshida S., Sugimori M., Kosako H., Kominami R., Nakafuku M., Nabeshima Y.
    Mech. Dev. 99:143-148(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Swiss Webster.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  3. "Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors."
    Zhou Q., Wang S., Anderson D.J.
    Neuron 25:331-343(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-260, DEVELOPMENTAL STAGE.
  4. "Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system."
    Lu Q.R., Yuk D.-I., Alberta J.A., Zhu Z., Pawlitzky I., Chan J.A., McMahon A.P., Stiles C.D., Rowitch D.H.
    Neuron 25:317-329(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY SHH.
  5. "Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection."
    Lu Q.R., Sun T., Zhu Z., Ma N., Garcia M., Stiles C.D., Rowitch D.H.
    Cell 109:75-86(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiOLIG1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3