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Q9JKN5

- OLIG1_MOUSE

UniProt

Q9JKN5 - OLIG1_MOUSE

Protein

Oligodendrocyte transcription factor 1

Gene

Olig1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (30 Aug 2002)
      Previous versions | rss
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    Functioni

    Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. neuron fate commitment Source: MGI
    2. regulation of transcription, DNA-templated Source: MGI
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oligodendrocyte transcription factor 1
    Short name:
    Oligo1
    Alternative name(s):
    Oligodendrocyte-specific bHLH transcription factor 1
    Gene namesi
    Name:Olig1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1355334. Olig1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Oligodendrocyte transcription factor 1PRO_0000127412Add
    BLAST

    Proteomic databases

    PRIDEiQ9JKN5.

    PTM databases

    PhosphoSiteiQ9JKN5.

    Expressioni

    Tissue specificityi

    Expressed specifically in brain.1 Publication

    Developmental stagei

    Expressed in the ventral spinal cord as early as 9.5 dpc. Expression declines to undetectable levels by 10.5 dpc and reappears in a narrow zone within the ventral neuroepithelium of the spinal cord. In the 14.5 dpc spinal cord, expressed in the oligodendrocyte progenitors of the ventral ventricular zone, but not dorsal root ganglia Schwann cells. Also expressed scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. By 15.5 dpc, dispersed throughout the gray matter, with little or no residual expression in the ventricular zone. In the postnatal brain, present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Expressed in the olfactory epithelium from 11.5dpc onward.1 Publication

    Inductioni

    By SHH.1 Publication

    Gene expression databases

    BgeeiQ9JKN5.
    CleanExiMM_OLIG1.
    GenevestigatoriQ9JKN5.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Id2P411365EBI-1213712,EBI-309167
    Id4P411395EBI-1213712,EBI-1213725

    Protein-protein interaction databases

    BioGridi206153. 5 interactions.
    IntActiQ9JKN5. 5 interactions.
    MINTiMINT-7295439.
    STRINGi10090.ENSMUSP00000061408.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JKN5.
    SMRiQ9JKN5. Positions 96-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini94 – 15360bHLHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi44 – 529Poly-Ser
    Compositional biasi90 – 945Poly-Gln

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG256163.
    GeneTreeiENSGT00530000063239.
    HOGENOMiHOG000015810.
    HOVERGENiHBG053369.
    InParanoidiQ9JKN5.
    KOiK09085.
    OMAiGSPGLCT.
    OrthoDBiEOG7HF1KN.
    PhylomeDBiQ9JKN5.
    TreeFamiTF322733.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JKN5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYYAISQARV NAAPATMLRP QRPGDVQLGA SLYELVGYRQ PPISSSSSSS    50
    SSTASLLPKP AREKAEAPLA EPRGPAPESG GARADAKEEQ QQQQLRRKIN 100
    SRERKRMQDL NLAMDALREV ILPYSAAHCQ GAPGRKLSKI ATLLLARNYI 150
    LLLGSSLQEL RRALGDGAGP AAPRLLLAGL PLLAAAPGSV LLAPGAVGPP 200
    ETLRPTKYLS LALDEPPCGQ FSLPAGGAGS PGLCSCAVCK FPHLVPAGLG 250
    LAAVQAQFSK 260
    Length:260
    Mass (Da):27,141
    Last modified:August 30, 2002 - v2
    Checksum:i5EA8A74D9DF0D310
    GO

    Sequence cautioni

    The sequence BAB18906.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038696 mRNA. Translation: BAB18906.1. Different initiation.
    BC046316 mRNA. Translation: AAH46316.1.
    AF232928 Genomic DNA. Translation: AAF61721.1.
    CCDSiCCDS28324.1.
    RefSeqiNP_058664.2. NM_016968.4.
    UniGeneiMm.39300.

    Genome annotation databases

    EnsembliENSMUST00000056882; ENSMUSP00000061408; ENSMUSG00000046160.
    GeneIDi50914.
    KEGGimmu:50914.
    UCSCiuc007zxf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038696 mRNA. Translation: BAB18906.1 . Different initiation.
    BC046316 mRNA. Translation: AAH46316.1 .
    AF232928 Genomic DNA. Translation: AAF61721.1 .
    CCDSi CCDS28324.1.
    RefSeqi NP_058664.2. NM_016968.4.
    UniGenei Mm.39300.

    3D structure databases

    ProteinModelPortali Q9JKN5.
    SMRi Q9JKN5. Positions 96-158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206153. 5 interactions.
    IntActi Q9JKN5. 5 interactions.
    MINTi MINT-7295439.
    STRINGi 10090.ENSMUSP00000061408.

    PTM databases

    PhosphoSitei Q9JKN5.

    Proteomic databases

    PRIDEi Q9JKN5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000056882 ; ENSMUSP00000061408 ; ENSMUSG00000046160 .
    GeneIDi 50914.
    KEGGi mmu:50914.
    UCSCi uc007zxf.1. mouse.

    Organism-specific databases

    CTDi 116448.
    MGIi MGI:1355334. Olig1.

    Phylogenomic databases

    eggNOGi NOG256163.
    GeneTreei ENSGT00530000063239.
    HOGENOMi HOG000015810.
    HOVERGENi HBG053369.
    InParanoidi Q9JKN5.
    KOi K09085.
    OMAi GSPGLCT.
    OrthoDBi EOG7HF1KN.
    PhylomeDBi Q9JKN5.
    TreeFami TF322733.

    Miscellaneous databases

    NextBioi 307907.
    PROi Q9JKN5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JKN5.
    CleanExi MM_OLIG1.
    Genevestigatori Q9JKN5.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3."
      Takebayashi H., Yoshida S., Sugimori M., Kosako H., Kominami R., Nakafuku M., Nabeshima Y.
      Mech. Dev. 99:143-148(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Swiss Webster.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.
    3. "Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors."
      Zhou Q., Wang S., Anderson D.J.
      Neuron 25:331-343(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-260, DEVELOPMENTAL STAGE.
    4. "Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system."
      Lu Q.R., Yuk D.-I., Alberta J.A., Zhu Z., Pawlitzky I., Chan J.A., McMahon A.P., Stiles C.D., Rowitch D.H.
      Neuron 25:317-329(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY SHH.
    5. "Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection."
      Lu Q.R., Sun T., Zhu Z., Ma N., Garcia M., Stiles C.D., Rowitch D.H.
      Cell 109:75-86(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiOLIG1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JKN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: August 30, 2002
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3