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Q9JKN5 (OLIG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oligodendrocyte transcription factor 1

Short name=Oligo1
Alternative name(s):
Oligodendrocyte-specific bHLH transcription factor 1
Gene names
Name:Olig1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube. Ref.5

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed specifically in brain. Ref.1

Developmental stage

Expressed in the ventral spinal cord as early as 9.5 dpc. Expression declines to undetectable levels by 10.5 dpc and reappears in a narrow zone within the ventral neuroepithelium of the spinal cord. In the 14.5 dpc spinal cord, expressed in the oligodendrocyte progenitors of the ventral ventricular zone, but not dorsal root ganglia Schwann cells. Also expressed scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. By 15.5 dpc, dispersed throughout the gray matter, with little or no residual expression in the ventricular zone. In the postnatal brain, present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Expressed in the olfactory epithelium from 11.5dpc onward. Ref.3

Induction

By SHH. Ref.4

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence caution

The sequence BAB18906.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Oligodendrocyte transcription factor 1
PRO_0000127412

Regions

Domain94 – 15360bHLH
Compositional bias44 – 529Poly-Ser
Compositional bias90 – 945Poly-Gln

Sequences

Sequence LengthMass (Da)Tools
Q9JKN5 [UniParc].

Last modified August 30, 2002. Version 2.
Checksum: 5EA8A74D9DF0D310

FASTA26027,141
        10         20         30         40         50         60 
MYYAISQARV NAAPATMLRP QRPGDVQLGA SLYELVGYRQ PPISSSSSSS SSTASLLPKP 

        70         80         90        100        110        120 
AREKAEAPLA EPRGPAPESG GARADAKEEQ QQQQLRRKIN SRERKRMQDL NLAMDALREV 

       130        140        150        160        170        180 
ILPYSAAHCQ GAPGRKLSKI ATLLLARNYI LLLGSSLQEL RRALGDGAGP AAPRLLLAGL 

       190        200        210        220        230        240 
PLLAAAPGSV LLAPGAVGPP ETLRPTKYLS LALDEPPCGQ FSLPAGGAGS PGLCSCAVCK 

       250        260 
FPHLVPAGLG LAAVQAQFSK 

« Hide

References

« Hide 'large scale' references
[1]"Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3."
Takebayashi H., Yoshida S., Sugimori M., Kosako H., Kominami R., Nakafuku M., Nabeshima Y.
Mech. Dev. 99:143-148(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: Swiss Webster.
Tissue: Embryo.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[3]"Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors."
Zhou Q., Wang S., Anderson D.J.
Neuron 25:331-343(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-260, DEVELOPMENTAL STAGE.
[4]"Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system."
Lu Q.R., Yuk D.-I., Alberta J.A., Zhu Z., Pawlitzky I., Chan J.A., McMahon A.P., Stiles C.D., Rowitch D.H.
Neuron 25:317-329(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY SHH.
[5]"Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection."
Lu Q.R., Sun T., Zhu Z., Ma N., Garcia M., Stiles C.D., Rowitch D.H.
Cell 109:75-86(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB038696 mRNA. Translation: BAB18906.1. Different initiation.
BC046316 mRNA. Translation: AAH46316.1.
AF232928 Genomic DNA. Translation: AAF61721.1.
CCDSCCDS28324.1.
RefSeqNP_058664.2. NM_016968.4.
UniGeneMm.39300.

3D structure databases

ProteinModelPortalQ9JKN5.
SMRQ9JKN5. Positions 96-158.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid206153. 5 interactions.
IntActQ9JKN5. 5 interactions.
MINTMINT-7295439.
STRING10090.ENSMUSP00000061408.

PTM databases

PhosphoSiteQ9JKN5.

Proteomic databases

PRIDEQ9JKN5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000056882; ENSMUSP00000061408; ENSMUSG00000046160.
GeneID50914.
KEGGmmu:50914.
UCSCuc007zxf.1. mouse.

Organism-specific databases

CTD116448.
MGIMGI:1355334. Olig1.

Phylogenomic databases

eggNOGNOG256163.
GeneTreeENSGT00530000063239.
HOGENOMHOG000015810.
HOVERGENHBG053369.
InParanoidQ9JKN5.
KOK09085.
OMAGSPGLCT.
OrthoDBEOG7HF1KN.
PhylomeDBQ9JKN5.
TreeFamTF322733.

Gene expression databases

BgeeQ9JKN5.
CleanExMM_OLIG1.
GenevestigatorQ9JKN5.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio307907.
PROQ9JKN5.
SOURCESearch...

Entry information

Entry nameOLIG1_MOUSE
AccessionPrimary (citable) accession number: Q9JKN5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot