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Protein

Oligodendrocyte transcription factor 1

Gene

Olig1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  • neuron fate commitment Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 1
Short name:
Oligo1
Alternative name(s):
Oligodendrocyte-specific bHLH transcription factor 1
Gene namesi
Name:Olig1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1355334. Olig1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: UniProtKB-SubCell
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Oligodendrocyte transcription factor 1PRO_0000127412Add
BLAST

Proteomic databases

PRIDEiQ9JKN5.

PTM databases

PhosphoSiteiQ9JKN5.

Expressioni

Tissue specificityi

Expressed specifically in brain.1 Publication

Developmental stagei

Expressed in the ventral spinal cord as early as 9.5 dpc. Expression declines to undetectable levels by 10.5 dpc and reappears in a narrow zone within the ventral neuroepithelium of the spinal cord. In the 14.5 dpc spinal cord, expressed in the oligodendrocyte progenitors of the ventral ventricular zone, but not dorsal root ganglia Schwann cells. Also expressed scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. By 15.5 dpc, dispersed throughout the gray matter, with little or no residual expression in the ventricular zone. In the postnatal brain, present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Expressed in the olfactory epithelium from 11.5dpc onward.1 Publication

Inductioni

By SHH.1 Publication

Gene expression databases

BgeeiQ9JKN5.
CleanExiMM_OLIG1.
ExpressionAtlasiQ9JKN5. baseline and differential.
GenevisibleiQ9JKN5. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Id2P411365EBI-1213712,EBI-309167
Id4P411395EBI-1213712,EBI-1213725

Protein-protein interaction databases

BioGridi206153. 5 interactions.
IntActiQ9JKN5. 5 interactions.
MINTiMINT-7295439.
STRINGi10090.ENSMUSP00000061408.

Structurei

3D structure databases

ProteinModelPortaliQ9JKN5.
SMRiQ9JKN5. Positions 96-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 15360bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 529Poly-Ser
Compositional biasi90 – 945Poly-Gln

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG256163.
GeneTreeiENSGT00530000063239.
HOGENOMiHOG000015810.
HOVERGENiHBG053369.
InParanoidiQ9JKN5.
KOiK09085.
OMAiGTMLRPQ.
OrthoDBiEOG7HF1KN.
PhylomeDBiQ9JKN5.
TreeFamiTF322733.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYAISQARV NAAPATMLRP QRPGDVQLGA SLYELVGYRQ PPISSSSSSS
60 70 80 90 100
SSTASLLPKP AREKAEAPLA EPRGPAPESG GARADAKEEQ QQQQLRRKIN
110 120 130 140 150
SRERKRMQDL NLAMDALREV ILPYSAAHCQ GAPGRKLSKI ATLLLARNYI
160 170 180 190 200
LLLGSSLQEL RRALGDGAGP AAPRLLLAGL PLLAAAPGSV LLAPGAVGPP
210 220 230 240 250
ETLRPTKYLS LALDEPPCGQ FSLPAGGAGS PGLCSCAVCK FPHLVPAGLG
260
LAAVQAQFSK
Length:260
Mass (Da):27,141
Last modified:August 30, 2002 - v2
Checksum:i5EA8A74D9DF0D310
GO

Sequence cautioni

The sequence BAB18906.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038696 mRNA. Translation: BAB18906.1. Different initiation.
BC046316 mRNA. Translation: AAH46316.1.
AF232928 Genomic DNA. Translation: AAF61721.1.
CCDSiCCDS28324.1.
RefSeqiNP_058664.2. NM_016968.4.
UniGeneiMm.39300.

Genome annotation databases

EnsembliENSMUST00000056882; ENSMUSP00000061408; ENSMUSG00000046160.
GeneIDi50914.
KEGGimmu:50914.
UCSCiuc007zxf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038696 mRNA. Translation: BAB18906.1. Different initiation.
BC046316 mRNA. Translation: AAH46316.1.
AF232928 Genomic DNA. Translation: AAF61721.1.
CCDSiCCDS28324.1.
RefSeqiNP_058664.2. NM_016968.4.
UniGeneiMm.39300.

3D structure databases

ProteinModelPortaliQ9JKN5.
SMRiQ9JKN5. Positions 96-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206153. 5 interactions.
IntActiQ9JKN5. 5 interactions.
MINTiMINT-7295439.
STRINGi10090.ENSMUSP00000061408.

PTM databases

PhosphoSiteiQ9JKN5.

Proteomic databases

PRIDEiQ9JKN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056882; ENSMUSP00000061408; ENSMUSG00000046160.
GeneIDi50914.
KEGGimmu:50914.
UCSCiuc007zxf.1. mouse.

Organism-specific databases

CTDi116448.
MGIiMGI:1355334. Olig1.

Phylogenomic databases

eggNOGiNOG256163.
GeneTreeiENSGT00530000063239.
HOGENOMiHOG000015810.
HOVERGENiHBG053369.
InParanoidiQ9JKN5.
KOiK09085.
OMAiGTMLRPQ.
OrthoDBiEOG7HF1KN.
PhylomeDBiQ9JKN5.
TreeFamiTF322733.

Miscellaneous databases

NextBioi307907.
PROiQ9JKN5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKN5.
CleanExiMM_OLIG1.
ExpressionAtlasiQ9JKN5. baseline and differential.
GenevisibleiQ9JKN5. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3."
    Takebayashi H., Yoshida S., Sugimori M., Kosako H., Kominami R., Nakafuku M., Nabeshima Y.
    Mech. Dev. 99:143-148(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Swiss Webster.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  3. "Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors."
    Zhou Q., Wang S., Anderson D.J.
    Neuron 25:331-343(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-260, DEVELOPMENTAL STAGE.
  4. "Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system."
    Lu Q.R., Yuk D.-I., Alberta J.A., Zhu Z., Pawlitzky I., Chan J.A., McMahon A.P., Stiles C.D., Rowitch D.H.
    Neuron 25:317-329(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY SHH.
  5. "Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection."
    Lu Q.R., Sun T., Zhu Z., Ma N., Garcia M., Stiles C.D., Rowitch D.H.
    Cell 109:75-86(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiOLIG1_MOUSE
AccessioniPrimary (citable) accession number: Q9JKN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: June 24, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.