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Protein

Zinc transporter 7

Gene

Slc30a7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).By similarity2 Publications

GO - Molecular functioni

  • zinc ion binding Source: MGI
  • zinc ion transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • regulation of sequestering of zinc ion Source: GO_Central
  • response to zinc ion Source: GO_Central
  • sequestering of zinc ion Source: BHF-UCL
  • zinc II ion transport Source: MGI

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 7
Short name:
ZnT-7
Alternative name(s):
Solute carrier family 30 member 7
Znt-like transporter 2
Gene namesi
Name:Slc30a7
Synonyms:Znt7, Zntl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913750 Slc30a7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 67ExtracellularSequence analysis9
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 102CytoplasmicSequence analysisAdd BLAST14
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 140ExtracellularSequence analysisAdd BLAST17
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 238CytoplasmicSequence analysisAdd BLAST77
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 264ExtracellularSequence analysis5
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 378CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Null mutants are viable, fertile, and display no obvious morphological abnormalities. However, reduced food intake (anorexia) and poor growth were observed.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003143001 – 378Zinc transporter 7Add BLAST378

Proteomic databases

EPDiQ9JKN1
MaxQBiQ9JKN1
PaxDbiQ9JKN1
PeptideAtlasiQ9JKN1
PRIDEiQ9JKN1

PTM databases

iPTMnetiQ9JKN1
PhosphoSitePlusiQ9JKN1

Expressioni

Tissue specificityi

Highly expressed in liver, spleen, duodenum and part of the jejunum of small intestine (at protein level). Moderately expressed in kidney, lung, and brain. Barely detectable in heart.2 Publications

Gene expression databases

BgeeiENSMUSG00000054414
GenevisibleiQ9JKN1 MM

Interactioni

Subunit structurei

Homooligomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065254

Structurei

3D structure databases

ProteinModelPortaliQ9JKN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 220His-rich loopAdd BLAST60

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1484 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00630000089781
HOGENOMiHOG000018690
HOVERGENiHBG056637
InParanoidiQ9JKN1
KOiK14692
OMAiWKRLIFS
OrthoDBiEOG091G030D
PhylomeDBiQ9JKN1
TreeFamiTF315217

Family and domain databases

Gene3Di1.20.1510.10, 2 hits
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF161111 SSF161111, 2 hits
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JKN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF
60 70 80 90 100
VELLYGIWSN CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY
110 120 130 140 150
VRAEVLAGFV NGLFLIFTAF FIFSEGVERA LAPPDVHHER LLLVSILGFV
160 170 180 190 200
VNLVGIFVFN HGGHGHSHGS GHGHSHSLFN GALDHSHGHE DHCHSHEAKH
210 220 230 240 250
GAAHSHDHDH AHGHGHLHSH DGPSFKATAG PSRQILQGVF LHILADTLGS
260 270 280 290 300
IGVIASAIMM QNFGLMIADP ICSILIAILI VVSVIPLLRE SVGILMQRTP
310 320 330 340 350
PSLENTLPQC YQRVQQLQGV YNLQEQHFWT LCSDVYVGTL KLVVAPDADA
360 370
RWILSQTHNI FTQAGVRQLY VQIDFAAM
Length:378
Mass (Da):41,790
Last modified:October 1, 2000 - v1
Checksum:iB98AC19C9A045006
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257A → G in AAH50193 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529196 mRNA Translation: AAO17323.1
AF233322 mRNA Translation: AAF43423.1
AK010008 mRNA Translation: BAB26639.1
AK075802 mRNA Translation: BAC35970.1
BC017136 mRNA Translation: AAH17136.1
BC050193 mRNA Translation: AAH50193.1
CCDSiCCDS17783.1
RefSeqiNP_075703.1, NM_023214.7
UniGeneiMm.34550

Genome annotation databases

EnsembliENSMUST00000067485; ENSMUSP00000065254; ENSMUSG00000054414
GeneIDi66500
KEGGimmu:66500
UCSCiuc008rbt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiZNT7_MOUSE
AccessioniPrimary (citable) accession number: Q9JKN1
Secondary accession number(s): Q80Y27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health