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Q9JKN1

- ZNT7_MOUSE

UniProt

Q9JKN1 - ZNT7_MOUSE

Protein

Zinc transporter 7

Gene

Slc30a7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP By similarity.By similarity

    GO - Molecular functioni

    1. cation transmembrane transporter activity Source: InterPro
    2. zinc ion binding Source: MGI

    GO - Biological processi

    1. sequestering of zinc ion Source: BHF-UCL
    2. zinc ion transport Source: MGI

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_207837. Insulin processing.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter 7
    Short name:
    ZnT-7
    Alternative name(s):
    Solute carrier family 30 member 7
    Znt-like transporter 2
    Gene namesi
    Name:Slc30a7
    Synonyms:Znt7, Zntl2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1913750. Slc30a7.

    Subcellular locationi

    Golgi apparatustrans-Golgi network membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. cytoplasmic membrane-bounded vesicle Source: MGI
    3. Golgi apparatus Source: BHF-UCL
    4. Golgi membrane Source: Reactome
    5. integral component of membrane Source: UniProtKB-KW
    6. perinuclear region of cytoplasm Source: BHF-UCL

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Null mutants are viable, fertile, and display no obvious morphological abnormalities. However, reduced food intake (anorexia) and poor growth were observed.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 378378Zinc transporter 7PRO_0000314300Add
    BLAST

    Proteomic databases

    MaxQBiQ9JKN1.
    PaxDbiQ9JKN1.
    PRIDEiQ9JKN1.

    PTM databases

    PhosphoSiteiQ9JKN1.

    Expressioni

    Tissue specificityi

    Highly expressed in liver, spleen, duodenum and part of the jejunum of small intestine (at protein level). Moderately expressed in kidney, lung, and brain. Barely detectable in heart.2 Publications

    Gene expression databases

    BgeeiQ9JKN1.
    GenevestigatoriQ9JKN1.

    Interactioni

    Subunit structurei

    Homooligomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JKN1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini59 – 679ExtracellularSequence Analysis
    Topological domaini89 – 10214CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 14017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini162 – 23877CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 2645ExtracellularSequence Analysis
    Topological domaini286 – 37893CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni161 – 22060His-rich loopAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1230.
    GeneTreeiENSGT00630000089781.
    HOGENOMiHOG000018690.
    HOVERGENiHBG056637.
    InParanoidiQ9JKN1.
    KOiK14692.
    OMAiCSILIAM.
    OrthoDBiEOG7C2R1S.
    PhylomeDBiQ9JKN1.
    TreeFamiTF315217.

    Family and domain databases

    Gene3Di1.20.1510.10. 2 hits.
    InterProiIPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view]
    PANTHERiPTHR11562. PTHR11562. 1 hit.
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01297. CDF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9JKN1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF    50
    VELLYGIWSN CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY 100
    VRAEVLAGFV NGLFLIFTAF FIFSEGVERA LAPPDVHHER LLLVSILGFV 150
    VNLVGIFVFN HGGHGHSHGS GHGHSHSLFN GALDHSHGHE DHCHSHEAKH 200
    GAAHSHDHDH AHGHGHLHSH DGPSFKATAG PSRQILQGVF LHILADTLGS 250
    IGVIASAIMM QNFGLMIADP ICSILIAILI VVSVIPLLRE SVGILMQRTP 300
    PSLENTLPQC YQRVQQLQGV YNLQEQHFWT LCSDVYVGTL KLVVAPDADA 350
    RWILSQTHNI FTQAGVRQLY VQIDFAAM 378
    Length:378
    Mass (Da):41,790
    Last modified:October 1, 2000 - v1
    Checksum:iB98AC19C9A045006
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti257 – 2571A → G in AAH50193. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF529196 mRNA. Translation: AAO17323.1.
    AF233322 mRNA. Translation: AAF43423.1.
    AK010008 mRNA. Translation: BAB26639.1.
    AK075802 mRNA. Translation: BAC35970.1.
    BC017136 mRNA. Translation: AAH17136.1.
    BC050193 mRNA. Translation: AAH50193.1.
    CCDSiCCDS17783.1.
    RefSeqiNP_075703.1. NM_023214.7.
    UniGeneiMm.34550.

    Genome annotation databases

    EnsembliENSMUST00000067485; ENSMUSP00000065254; ENSMUSG00000054414.
    GeneIDi66500.
    KEGGimmu:66500.
    UCSCiuc008rbt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF529196 mRNA. Translation: AAO17323.1 .
    AF233322 mRNA. Translation: AAF43423.1 .
    AK010008 mRNA. Translation: BAB26639.1 .
    AK075802 mRNA. Translation: BAC35970.1 .
    BC017136 mRNA. Translation: AAH17136.1 .
    BC050193 mRNA. Translation: AAH50193.1 .
    CCDSi CCDS17783.1.
    RefSeqi NP_075703.1. NM_023214.7.
    UniGenei Mm.34550.

    3D structure databases

    ProteinModelPortali Q9JKN1.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JKN1.

    Proteomic databases

    MaxQBi Q9JKN1.
    PaxDbi Q9JKN1.
    PRIDEi Q9JKN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067485 ; ENSMUSP00000065254 ; ENSMUSG00000054414 .
    GeneIDi 66500.
    KEGGi mmu:66500.
    UCSCi uc008rbt.2. mouse.

    Organism-specific databases

    CTDi 148867.
    MGIi MGI:1913750. Slc30a7.

    Phylogenomic databases

    eggNOGi COG1230.
    GeneTreei ENSGT00630000089781.
    HOGENOMi HOG000018690.
    HOVERGENi HBG056637.
    InParanoidi Q9JKN1.
    KOi K14692.
    OMAi CSILIAM.
    OrthoDBi EOG7C2R1S.
    PhylomeDBi Q9JKN1.
    TreeFami TF315217.

    Enzyme and pathway databases

    Reactomei REACT_207837. Insulin processing.

    Miscellaneous databases

    NextBioi 321876.
    PROi Q9JKN1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JKN1.
    Genevestigatori Q9JKN1.

    Family and domain databases

    Gene3Di 1.20.1510.10. 2 hits.
    InterProi IPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view ]
    PANTHERi PTHR11562. PTHR11562. 1 hit.
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01297. CDF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus."
      Kirschke C.P., Huang L.
      J. Biol. Chem. 278:4096-4102(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 299-315, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Kidney.
    2. "Cloning of new mammalian zinc transporter like genes."
      Zhu W., Mager S.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pancreas and Tongue.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Embryo and Salivary gland.
    5. "Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation."
      Huang L., Yu Y.Y., Kirschke C.P., Gertz E.R., Lloyd K.K.
      J. Biol. Chem. 282:37053-37063(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiZNT7_MOUSE
    AccessioniPrimary (citable) accession number: Q9JKN1
    Secondary accession number(s): Q80Y27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3