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Q9JKN1

- ZNT7_MOUSE

UniProt

Q9JKN1 - ZNT7_MOUSE

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Protein

Zinc transporter 7

Gene

Slc30a7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP By similarity.By similarity

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro
  2. zinc ion binding Source: MGI

GO - Biological processi

  1. sequestering of zinc ion Source: BHF-UCL
  2. zinc ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_207837. Insulin processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 7
Short name:
ZnT-7
Alternative name(s):
Solute carrier family 30 member 7
Znt-like transporter 2
Gene namesi
Name:Slc30a7
Synonyms:Znt7, Zntl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1913750. Slc30a7.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. cytoplasmic membrane-bounded vesicle Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. Golgi apparatus Source: BHF-UCL
  5. Golgi membrane Source: Reactome
  6. integral component of membrane Source: UniProtKB-KW
  7. perinuclear region of cytoplasm Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Null mutants are viable, fertile, and display no obvious morphological abnormalities. However, reduced food intake (anorexia) and poor growth were observed.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Zinc transporter 7PRO_0000314300Add
BLAST

Proteomic databases

MaxQBiQ9JKN1.
PaxDbiQ9JKN1.
PRIDEiQ9JKN1.

PTM databases

PhosphoSiteiQ9JKN1.

Expressioni

Tissue specificityi

Highly expressed in liver, spleen, duodenum and part of the jejunum of small intestine (at protein level). Moderately expressed in kidney, lung, and brain. Barely detectable in heart.2 Publications

Gene expression databases

BgeeiQ9JKN1.
GenevestigatoriQ9JKN1.

Interactioni

Subunit structurei

Homooligomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9JKN1.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini59 – 679ExtracellularSequence Analysis
Topological domaini89 – 10214CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini124 – 14017ExtracellularSequence AnalysisAdd
BLAST
Topological domaini162 – 23877CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini260 – 2645ExtracellularSequence Analysis
Topological domaini286 – 37893CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Transmembranei265 – 28521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 22060His-rich loopAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000018690.
HOVERGENiHBG056637.
InParanoidiQ9JKN1.
KOiK14692.
OMAiCSILIAM.
OrthoDBiEOG7C2R1S.
PhylomeDBiQ9JKN1.
TreeFamiTF315217.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JKN1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF
60 70 80 90 100
VELLYGIWSN CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY
110 120 130 140 150
VRAEVLAGFV NGLFLIFTAF FIFSEGVERA LAPPDVHHER LLLVSILGFV
160 170 180 190 200
VNLVGIFVFN HGGHGHSHGS GHGHSHSLFN GALDHSHGHE DHCHSHEAKH
210 220 230 240 250
GAAHSHDHDH AHGHGHLHSH DGPSFKATAG PSRQILQGVF LHILADTLGS
260 270 280 290 300
IGVIASAIMM QNFGLMIADP ICSILIAILI VVSVIPLLRE SVGILMQRTP
310 320 330 340 350
PSLENTLPQC YQRVQQLQGV YNLQEQHFWT LCSDVYVGTL KLVVAPDADA
360 370
RWILSQTHNI FTQAGVRQLY VQIDFAAM
Length:378
Mass (Da):41,790
Last modified:October 1, 2000 - v1
Checksum:iB98AC19C9A045006
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2571A → G in AAH50193. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF529196 mRNA. Translation: AAO17323.1.
AF233322 mRNA. Translation: AAF43423.1.
AK010008 mRNA. Translation: BAB26639.1.
AK075802 mRNA. Translation: BAC35970.1.
BC017136 mRNA. Translation: AAH17136.1.
BC050193 mRNA. Translation: AAH50193.1.
CCDSiCCDS17783.1.
RefSeqiNP_075703.1. NM_023214.7.
UniGeneiMm.34550.

Genome annotation databases

EnsembliENSMUST00000067485; ENSMUSP00000065254; ENSMUSG00000054414.
GeneIDi66500.
KEGGimmu:66500.
UCSCiuc008rbt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF529196 mRNA. Translation: AAO17323.1 .
AF233322 mRNA. Translation: AAF43423.1 .
AK010008 mRNA. Translation: BAB26639.1 .
AK075802 mRNA. Translation: BAC35970.1 .
BC017136 mRNA. Translation: AAH17136.1 .
BC050193 mRNA. Translation: AAH50193.1 .
CCDSi CCDS17783.1.
RefSeqi NP_075703.1. NM_023214.7.
UniGenei Mm.34550.

3D structure databases

ProteinModelPortali Q9JKN1.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9JKN1.

Proteomic databases

MaxQBi Q9JKN1.
PaxDbi Q9JKN1.
PRIDEi Q9JKN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067485 ; ENSMUSP00000065254 ; ENSMUSG00000054414 .
GeneIDi 66500.
KEGGi mmu:66500.
UCSCi uc008rbt.2. mouse.

Organism-specific databases

CTDi 148867.
MGIi MGI:1913750. Slc30a7.

Phylogenomic databases

eggNOGi COG1230.
GeneTreei ENSGT00630000089781.
HOGENOMi HOG000018690.
HOVERGENi HBG056637.
InParanoidi Q9JKN1.
KOi K14692.
OMAi CSILIAM.
OrthoDBi EOG7C2R1S.
PhylomeDBi Q9JKN1.
TreeFami TF315217.

Enzyme and pathway databases

Reactomei REACT_207837. Insulin processing.

Miscellaneous databases

NextBioi 321876.
PROi Q9JKN1.
SOURCEi Search...

Gene expression databases

Bgeei Q9JKN1.
Genevestigatori Q9JKN1.

Family and domain databases

Gene3Di 1.20.1510.10. 2 hits.
InterProi IPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view ]
PANTHERi PTHR11562. PTHR11562. 1 hit.
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01297. CDF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus."
    Kirschke C.P., Huang L.
    J. Biol. Chem. 278:4096-4102(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 299-315, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Kidney.
  2. "Cloning of new mammalian zinc transporter like genes."
    Zhu W., Mager S.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas and Tongue.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Embryo and Salivary gland.
  5. "Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation."
    Huang L., Yu Y.Y., Kirschke C.P., Gertz E.R., Lloyd K.K.
    J. Biol. Chem. 282:37053-37063(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiZNT7_MOUSE
AccessioniPrimary (citable) accession number: Q9JKN1
Secondary accession number(s): Q80Y27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3