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Q9JKN1 (ZNT7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter 7

Short name=ZnT-7
Alternative name(s):
Solute carrier family 30 member 7
Znt-like transporter 2
Gene names
Name:Slc30a7
Synonyms:Znt7, Zntl2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP By similarity. Ref.1 Ref.5

Subunit structure

Homooligomer By similarity.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Highly expressed in liver, spleen, duodenum and part of the jejunum of small intestine (at protein level). Moderately expressed in kidney, lung, and brain. Barely detectable in heart. Ref.1 Ref.5

Disruption phenotype

Null mutants are viable, fertile, and display no obvious morphological abnormalities. However, reduced food intake (anorexia) and poor growth were observed. Ref.5

Sequence similarities

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Zinc transporter 7
PRO_0000314300

Regions

Topological domain1 – 3737Cytoplasmic Potential
Transmembrane38 – 5821Helical; Potential
Topological domain59 – 679Extracellular Potential
Transmembrane68 – 8821Helical; Potential
Topological domain89 – 10214Cytoplasmic Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 14017Extracellular Potential
Transmembrane141 – 16121Helical; Potential
Topological domain162 – 23877Cytoplasmic Potential
Transmembrane239 – 25921Helical; Potential
Topological domain260 – 2645Extracellular Potential
Transmembrane265 – 28521Helical; Potential
Topological domain286 – 37893Cytoplasmic Potential
Region161 – 22060His-rich loop

Experimental info

Sequence conflict2571A → G in AAH50193. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9JKN1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: B98AC19C9A045006

FASTA37841,790
        10         20         30         40         50         60 
MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF VELLYGIWSN 

        70         80         90        100        110        120 
CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY VRAEVLAGFV NGLFLIFTAF 

       130        140        150        160        170        180 
FIFSEGVERA LAPPDVHHER LLLVSILGFV VNLVGIFVFN HGGHGHSHGS GHGHSHSLFN 

       190        200        210        220        230        240 
GALDHSHGHE DHCHSHEAKH GAAHSHDHDH AHGHGHLHSH DGPSFKATAG PSRQILQGVF 

       250        260        270        280        290        300 
LHILADTLGS IGVIASAIMM QNFGLMIADP ICSILIAILI VVSVIPLLRE SVGILMQRTP 

       310        320        330        340        350        360 
PSLENTLPQC YQRVQQLQGV YNLQEQHFWT LCSDVYVGTL KLVVAPDADA RWILSQTHNI 

       370 
FTQAGVRQLY VQIDFAAM 

« Hide

References

« Hide 'large scale' references
[1]"ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus."
Kirschke C.P., Huang L.
J. Biol. Chem. 278:4096-4102(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 299-315, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: Kidney.
[2]"Cloning of new mammalian zinc transporter like genes."
Zhu W., Mager S.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Pancreas and Tongue.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Embryo and Salivary gland.
[5]"Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation."
Huang L., Yu Y.Y., Kirschke C.P., Gertz E.R., Lloyd K.K.
J. Biol. Chem. 282:37053-37063(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF529196 mRNA. Translation: AAO17323.1.
AF233322 mRNA. Translation: AAF43423.1.
AK010008 mRNA. Translation: BAB26639.1.
AK075802 mRNA. Translation: BAC35970.1.
BC017136 mRNA. Translation: AAH17136.1.
BC050193 mRNA. Translation: AAH50193.1.
CCDSCCDS17783.1.
RefSeqNP_075703.1. NM_023214.7.
UniGeneMm.34550.

3D structure databases

ProteinModelPortalQ9JKN1.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9JKN1.

Proteomic databases

MaxQBQ9JKN1.
PaxDbQ9JKN1.
PRIDEQ9JKN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000067485; ENSMUSP00000065254; ENSMUSG00000054414.
GeneID66500.
KEGGmmu:66500.
UCSCuc008rbt.2. mouse.

Organism-specific databases

CTD148867.
MGIMGI:1913750. Slc30a7.

Phylogenomic databases

eggNOGCOG1230.
GeneTreeENSGT00630000089781.
HOGENOMHOG000018690.
HOVERGENHBG056637.
InParanoidQ9JKN1.
KOK14692.
OMACSILIAM.
OrthoDBEOG7C2R1S.
PhylomeDBQ9JKN1.
TreeFamTF315217.

Gene expression databases

BgeeQ9JKN1.
GenevestigatorQ9JKN1.

Family and domain databases

Gene3D1.20.1510.10. 2 hits.
InterProIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERPTHR11562. PTHR11562. 1 hit.
PfamPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsTIGR01297. CDF. 1 hit.
ProtoNetSearch...

Other

NextBio321876.
PROQ9JKN1.
SOURCESearch...

Entry information

Entry nameZNT7_MOUSE
AccessionPrimary (citable) accession number: Q9JKN1
Secondary accession number(s): Q80Y27
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot