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Protein

Zinc transporter 7

Gene

Slc30a7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).By similarity

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro
  2. zinc ion binding Source: MGI

GO - Biological processi

  1. sequestering of zinc ion Source: BHF-UCL
  2. zinc ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_207837. Insulin processing.
REACT_256636. Zinc efflux and compartmentalization by the SLC30 family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 7
Short name:
ZnT-7
Alternative name(s):
Solute carrier family 30 member 7
Znt-like transporter 2
Gene namesi
Name:Slc30a7
Synonyms:Znt7, Zntl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1913750. Slc30a7.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Topological domaini59 – 679ExtracellularSequence Analysis
Transmembranei68 – 8821HelicalSequence AnalysisAdd
BLAST
Topological domaini89 – 10214CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Topological domaini124 – 14017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Topological domaini162 – 23877CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Topological domaini260 – 2645ExtracellularSequence Analysis
Transmembranei265 – 28521HelicalSequence AnalysisAdd
BLAST
Topological domaini286 – 37893CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. cytoplasmic membrane-bounded vesicle Source: MGI
  3. extracellular vesicular exosome Source: MGI
  4. Golgi apparatus Source: BHF-UCL
  5. Golgi membrane Source: Reactome
  6. integral component of membrane Source: UniProtKB-KW
  7. perinuclear region of cytoplasm Source: BHF-UCL
  8. vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Null mutants are viable, fertile, and display no obvious morphological abnormalities. However, reduced food intake (anorexia) and poor growth were observed.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Zinc transporter 7PRO_0000314300Add
BLAST

Proteomic databases

MaxQBiQ9JKN1.
PaxDbiQ9JKN1.
PRIDEiQ9JKN1.

PTM databases

PhosphoSiteiQ9JKN1.

Expressioni

Tissue specificityi

Highly expressed in liver, spleen, duodenum and part of the jejunum of small intestine (at protein level). Moderately expressed in kidney, lung, and brain. Barely detectable in heart.2 Publications

Gene expression databases

BgeeiQ9JKN1.
GenevestigatoriQ9JKN1.

Interactioni

Subunit structurei

Homooligomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9JKN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 22060His-rich loopAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000018690.
HOVERGENiHBG056637.
InParanoidiQ9JKN1.
KOiK14692.
OMAiEPPDVHH.
OrthoDBiEOG7C2R1S.
PhylomeDBiQ9JKN1.
TreeFamiTF315217.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JKN1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF
60 70 80 90 100
VELLYGIWSN CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY
110 120 130 140 150
VRAEVLAGFV NGLFLIFTAF FIFSEGVERA LAPPDVHHER LLLVSILGFV
160 170 180 190 200
VNLVGIFVFN HGGHGHSHGS GHGHSHSLFN GALDHSHGHE DHCHSHEAKH
210 220 230 240 250
GAAHSHDHDH AHGHGHLHSH DGPSFKATAG PSRQILQGVF LHILADTLGS
260 270 280 290 300
IGVIASAIMM QNFGLMIADP ICSILIAILI VVSVIPLLRE SVGILMQRTP
310 320 330 340 350
PSLENTLPQC YQRVQQLQGV YNLQEQHFWT LCSDVYVGTL KLVVAPDADA
360 370
RWILSQTHNI FTQAGVRQLY VQIDFAAM
Length:378
Mass (Da):41,790
Last modified:October 1, 2000 - v1
Checksum:iB98AC19C9A045006
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2571A → G in AAH50193. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529196 mRNA. Translation: AAO17323.1.
AF233322 mRNA. Translation: AAF43423.1.
AK010008 mRNA. Translation: BAB26639.1.
AK075802 mRNA. Translation: BAC35970.1.
BC017136 mRNA. Translation: AAH17136.1.
BC050193 mRNA. Translation: AAH50193.1.
CCDSiCCDS17783.1.
RefSeqiNP_075703.1. NM_023214.7.
UniGeneiMm.34550.

Genome annotation databases

EnsembliENSMUST00000067485; ENSMUSP00000065254; ENSMUSG00000054414.
GeneIDi66500.
KEGGimmu:66500.
UCSCiuc008rbt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529196 mRNA. Translation: AAO17323.1.
AF233322 mRNA. Translation: AAF43423.1.
AK010008 mRNA. Translation: BAB26639.1.
AK075802 mRNA. Translation: BAC35970.1.
BC017136 mRNA. Translation: AAH17136.1.
BC050193 mRNA. Translation: AAH50193.1.
CCDSiCCDS17783.1.
RefSeqiNP_075703.1. NM_023214.7.
UniGeneiMm.34550.

3D structure databases

ProteinModelPortaliQ9JKN1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9JKN1.

Proteomic databases

MaxQBiQ9JKN1.
PaxDbiQ9JKN1.
PRIDEiQ9JKN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067485; ENSMUSP00000065254; ENSMUSG00000054414.
GeneIDi66500.
KEGGimmu:66500.
UCSCiuc008rbt.2. mouse.

Organism-specific databases

CTDi148867.
MGIiMGI:1913750. Slc30a7.

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000018690.
HOVERGENiHBG056637.
InParanoidiQ9JKN1.
KOiK14692.
OMAiEPPDVHH.
OrthoDBiEOG7C2R1S.
PhylomeDBiQ9JKN1.
TreeFamiTF315217.

Enzyme and pathway databases

ReactomeiREACT_207837. Insulin processing.
REACT_256636. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

NextBioi321876.
PROiQ9JKN1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JKN1.
GenevestigatoriQ9JKN1.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus."
    Kirschke C.P., Huang L.
    J. Biol. Chem. 278:4096-4102(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 299-315, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Kidney.
  2. "Cloning of new mammalian zinc transporter like genes."
    Zhu W., Mager S.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas and Tongue.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Embryo and Salivary gland.
  5. "Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation."
    Huang L., Yu Y.Y., Kirschke C.P., Gertz E.R., Lloyd K.K.
    J. Biol. Chem. 282:37053-37063(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiZNT7_MOUSE
AccessioniPrimary (citable) accession number: Q9JKN1
Secondary accession number(s): Q80Y27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.