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Protein

Ras-related protein Rab-37

Gene

Rab37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438GTPBy similarity
Nucleotide bindingi85 – 895GTPBy similarity
Nucleotide bindingi143 – 1464GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-37
Gene namesi
Name:Rab37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1929945. Rab37.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum-Golgi intermediate compartment Source: MGI
  • secretory granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 220219Ras-related protein Rab-37PRO_0000121250Add
BLAST
Propeptidei221 – 2233Removed in mature formSequence analysisPRO_0000370829

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Lipidationi219 – 2191S-geranylgeranyl cysteineBy similarity
Modified residuei220 – 2201Cysteine methyl esterSequence analysis
Lipidationi220 – 2201S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ9JKM7.
MaxQBiQ9JKM7.
PaxDbiQ9JKM7.
PRIDEiQ9JKM7.

PTM databases

PhosphoSiteiQ9JKM7.

Expressioni

Tissue specificityi

Specifically expressed in the bone marrow mast cells.

Gene expression databases

CleanExiMM_RAB37.

Interactioni

Subunit structurei

Interacts with RIMS1.1 Publication

Protein-protein interaction databases

BioGridi208399. 2 interactions.
IntActiQ9JKM7. 5 interactions.
STRINGi10090.ENSMUSP00000021076.

Structurei

3D structure databases

ProteinModelPortaliQ9JKM7.
SMRiQ9JKM7. Positions 26-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 679Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0083. Eukaryota.
ENOG410Z9H6. LUCA.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9JKM7.
KOiK07914.
PhylomeDBiQ9JKM7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JKM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGTPGAATA GDGEAPERSP PFSPNYDLTG KVMLLGDSGV GKTCFLIQFK
60 70 80 90 100
DGAFLSGTFI ATVGIDSRNK VVTVDGARVK LQIWDTAGQE RFRSVTHAYY
110 120 130 140 150
RDAQALLLLY DITNQSSFDN IRAWLTEIHE YAQRDVVIML LGNKADVSSE
160 170 180 190 200
RVIRSEDGET LAREYGVPFM ETSAKTGMNV ELAFLAIAKE LKYRAGRQPD
210 220
EPSFQIRDYV ESQKKRSSCC SFV
Length:223
Mass (Da):24,656
Last modified:April 26, 2004 - v2
Checksum:i8C500ED4CE854C24
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671S → F in AAF67162 (PubMed:10722846).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233582 mRNA. Translation: AAF67162.1.
AK050483 mRNA. Translation: BAC34282.1.
CCDSiCCDS25620.1.
RefSeqiNP_067386.3. NM_021411.4.
UniGeneiMm.143789.

Genome annotation databases

GeneIDi58222.
KEGGimmu:58222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233582 mRNA. Translation: AAF67162.1.
AK050483 mRNA. Translation: BAC34282.1.
CCDSiCCDS25620.1.
RefSeqiNP_067386.3. NM_021411.4.
UniGeneiMm.143789.

3D structure databases

ProteinModelPortaliQ9JKM7.
SMRiQ9JKM7. Positions 26-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208399. 2 interactions.
IntActiQ9JKM7. 5 interactions.
STRINGi10090.ENSMUSP00000021076.

PTM databases

PhosphoSiteiQ9JKM7.

Proteomic databases

EPDiQ9JKM7.
MaxQBiQ9JKM7.
PaxDbiQ9JKM7.
PRIDEiQ9JKM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58222.
KEGGimmu:58222.

Organism-specific databases

CTDi326624.
MGIiMGI:1929945. Rab37.

Phylogenomic databases

eggNOGiKOG0083. Eukaryota.
ENOG410Z9H6. LUCA.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9JKM7.
KOiK07914.
PhylomeDBiQ9JKM7.

Miscellaneous databases

PROiQ9JKM7.
SOURCEiSearch...

Gene expression databases

CleanExiMM_RAB37.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB37_MOUSE
AccessioniPrimary (citable) accession number: Q9JKM7
Secondary accession number(s): Q8C7E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: April 26, 2004
Last modified: July 6, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.