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Protein

Activity-dependent neuroprotector homeobox protein

Gene

Adnp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri74 – 9724C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri107 – 12923C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri165 – 18824C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24424C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51022C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53524C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri622 – 64726C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68625C2H2-type 9; atypicalPROSITE-ProRule annotationAdd
BLAST
DNA bindingi754 – 81461HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • beta-tubulin binding Source: RGD
  • chromatin binding Source: Ensembl
  • copper ion binding Source: RGD
  • DNA binding Source: UniProtKB-KW
  • peptide binding Source: RGD

GO - Biological processi

  • activation of protein kinase activity Source: RGD
  • cellular response to extracellular stimulus Source: RGD
  • estrous cycle Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of neuron apoptotic process Source: RGD
  • negative regulation of protein binding Source: RGD
  • negative regulation of synaptic transmission Source: RGD
  • nitric oxide homeostasis Source: RGD
  • positive regulation of axon extension Source: RGD
  • positive regulation of cGMP biosynthetic process Source: RGD
  • positive regulation of neuron projection development Source: RGD
  • positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
  • positive regulation of synapse assembly Source: RGD
  • regulation of protein ADP-ribosylation Source: RGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • response to carbohydrate Source: RGD
  • response to inorganic substance Source: RGD
  • short-term memory Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Activity-dependent neuroprotector homeobox protein
Alternative name(s):
Activity-dependent neuroprotective protein
Gene namesi
Name:Adnp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi71030. Adnp.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • axon Source: RGD
  • cytoplasm Source: RGD
  • dendrite Source: RGD
  • extracellular space Source: RGD
  • neuronal cell body Source: RGD
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11031103Activity-dependent neuroprotector homeobox proteinPRO_0000048809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei98 – 981PhosphoserineBy similarity
Cross-linki144 – 144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki266 – 266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki279 – 279Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki367 – 367Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki408 – 408Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei409 – 4091PhosphoserineBy similarity
Modified residuei413 – 4131PhosphoserineBy similarity
Cross-linki427 – 427Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki600 – 600Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki606 – 606Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki621 – 621Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei709 – 7091PhosphoserineBy similarity
Cross-linki716 – 716Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki731 – 731Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei738 – 7381PhosphoserineBy similarity
Modified residuei805 – 8051PhosphoserineBy similarity
Modified residuei876 – 8761PhosphoserineBy similarity
Modified residuei878 – 8781PhosphoserineBy similarity
Modified residuei886 – 8861PhosphoserineCombined sources
Modified residuei889 – 8891PhosphoserineCombined sources
Modified residuei905 – 9051PhosphoserineCombined sources
Cross-linki929 – 929Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei954 – 9541PhosphoserineCombined sources
Modified residuei956 – 9561PhosphoserineCombined sources
Modified residuei1036 – 10361N6-acetyllysine; alternateBy similarity
Cross-linki1036 – 1036Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1043 – 10431N6-acetyllysineBy similarity
Modified residuei1072 – 10721PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9JKL8.
PRIDEiQ9JKL8.

PTM databases

iPTMnetiQ9JKL8.
PhosphoSiteiQ9JKL8.

Expressioni

Inductioni

By the neuroprotective peptide VIP.

Interactioni

GO - Molecular functioni

  • beta-tubulin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014595.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni354 – 3618Neuroprotective peptide (NAP)By similarity

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri74 – 9724C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri107 – 12923C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri165 – 18824C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24424C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51022C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53524C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri622 – 64726C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68625C2H2-type 9; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIIX. Eukaryota.
ENOG410XYDF. LUCA.
GeneTreeiENSGT00530000063631.
HOGENOMiHOG000232088.
HOVERGENiHBG024319.
InParanoidiQ9JKL8.
OMAiSTGVNMM.
OrthoDBiEOG7GJ6C7.
TreeFamiTF328818.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JKL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQLPVNNLG SLRKARKTVK KILSDIGLEY CKEHIEDFKQ FEPNDFYLKN
60 70 80 90 100
TTWEDVGLWD PSLTKNQDYR TKPFCCSACP FSSKFFSAYK SHFRNVHSED
110 120 130 140 150
FENRILLNCP YCTFNADKKT LETHIKIFHA PNSSAPSSSL STFKDKNKND
160 170 180 190 200
GLKPKQADNV EQAVYYCKKC TYRDPLYEIV RKHIYREHFQ HVAAPYIAKA
210 220 230 240 250
GEKSLNGAVS LGTNAREECN IHCKRCLFMP KSYEALVQHV IEDHERIGYQ
260 270 280 290 300
VTAMIGHTNV VVPRAKPLML IAPKPQEKKS MGLPPRISSL ASGNVRSLPS
310 320 330 340 350
QQMVNRLSIP KPNLNSTGVN MMSNVHLQQN NYGVKSVGQS YGVGQSVRLG
360 370 380 390 400
LGGNAPVSIP QQSQSVKQLL PSGNGRSYGL GAEQRPPAAA RYSLQTANTS
410 420 430 440 450
SLPPGQVKSP SVSQSQASRV LGQSSSKPPP AATGPPPSNH CATQKWKICT
460 470 480 490 500
ICNELFPENV YSVHFEKEHK AEKVPAVANY IMKIHNFTSK CLYCNRYLPT
510 520 530 540 550
DTLLNHMLIH GLSCPYCRST FNDVEKMAAH MRMVHIDEEM GPKTDSTLSF
560 570 580 590 600
DLTLQQGSHT NIHLLVTTYN LRDAPAESVA YHAQNNAPVP PKPQPKVQEK
610 620 630 640 650
ADVPVKSSPQ AAVPYKKDVG KTLCPLCFSI LKGPISDALA HHLRERHQVI
660 670 680 690 700
QTVHPVEKKL TYKCIHCLGV YTSNMTASTI TLHLVHCRGV GKTQNGQDKT
710 720 730 740 750
NAPSRLNQSP GLAPVKRTYE QMEFPLLKKR KLEDENDSPG CFEEKPEEPV
760 770 780 790 800
VLALDPKGHE DDSYEARKSF LTKYFNKQPY PTRREIEKLA ASLWLWKSDI
810 820 830 840 850
ASHFSNKRKK CVRDCEKYKP GVLLGFNMKE LNKVKHEMDF DAEWLFENHD
860 870 880 890 900
EKASRVNASK TVDKKLNLGK EDDSFSDSFE HLEEESNGSG GPFDPVFEVE
910 920 930 940 950
PKIPSDNAEE PVPKVIPEGA LESEKLDQKE EEDGSKYETI HLTEERAKLM
960 970 980 990 1000
HDASDSEVDQ DDVVEWKDGA SPSESGPGSR QVSDFEDNTC EMKPGTWSDE
1010 1020 1030 1040 1050
SSQSEDARSS KPAAKKKATV QDDTEQLKWK NSSYGKVEGF WSKDQSQWEN
1060 1070 1080 1090 1100
ASENAERLPN PQIEWQNSTI DSEDGEQFDS MTDGVADPMH GSLTGVKLSS

QQA
Length:1,103
Mass (Da):123,626
Last modified:October 14, 2015 - v2
Checksum:i91B6D9AD8D62D620
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti499 – 4991P → A in AAF40431 (Ref. 3) Curated
Sequence conflicti866 – 8661L → H in AAF40431 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054626 Genomic DNA. No translation available.
AABR07054627 Genomic DNA. No translation available.
AABR07054628 Genomic DNA. No translation available.
CH474005 Genomic DNA. Translation: EDL96377.1.
AF234680 mRNA. Translation: AAF40431.1.
RefSeqiNP_073172.2. NM_022681.2.
UniGeneiRn.48777.

Genome annotation databases

EnsembliENSRNOT00000014595; ENSRNOP00000014595; ENSRNOG00000010975.
GeneIDi64622.
KEGGirno:64622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054626 Genomic DNA. No translation available.
AABR07054627 Genomic DNA. No translation available.
AABR07054628 Genomic DNA. No translation available.
CH474005 Genomic DNA. Translation: EDL96377.1.
AF234680 mRNA. Translation: AAF40431.1.
RefSeqiNP_073172.2. NM_022681.2.
UniGeneiRn.48777.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014595.

PTM databases

iPTMnetiQ9JKL8.
PhosphoSiteiQ9JKL8.

Proteomic databases

PaxDbiQ9JKL8.
PRIDEiQ9JKL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014595; ENSRNOP00000014595; ENSRNOG00000010975.
GeneIDi64622.
KEGGirno:64622.

Organism-specific databases

CTDi23394.
RGDi71030. Adnp.

Phylogenomic databases

eggNOGiENOG410IIIX. Eukaryota.
ENOG410XYDF. LUCA.
GeneTreeiENSGT00530000063631.
HOGENOMiHOG000232088.
HOVERGENiHBG024319.
InParanoidiQ9JKL8.
OMAiSTGVNMM.
OrthoDBiEOG7GJ6C7.
TreeFamiTF328818.

Miscellaneous databases

NextBioi613559.
PROiQ9JKL8.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequence of a rat protein containing a femtomolar-activity-dependent neuroprotective peptide."
    Dong M., Xu K., Du Y.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 281-1103.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886; SER-889; SER-905; SER-954 AND SER-956, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADNP_RAT
AccessioniPrimary (citable) accession number: Q9JKL8
Secondary accession number(s): G3V7G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 14, 2015
Last modified: April 13, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.