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Protein

Activity-dependent neuroprotector homeobox protein

Gene

Adnp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri74 – 97C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri107 – 129C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 188C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri221 – 244C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri447 – 469C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 510C2H2-type 6PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri512 – 535C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri622 – 647C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri662 – 686C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST25
DNA bindingi754 – 814HomeoboxPROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

  • beta-tubulin binding Source: RGD
  • chromatin binding Source: Ensembl
  • copper ion binding Source: RGD
  • DNA binding Source: UniProtKB-KW
  • peptide binding Source: RGD

GO - Biological processi

  • activation of protein kinase activity Source: RGD
  • cellular response to extracellular stimulus Source: RGD
  • estrous cycle Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of neuron apoptotic process Source: RGD
  • negative regulation of protein binding Source: RGD
  • negative regulation of synaptic transmission Source: RGD
  • nitric oxide homeostasis Source: RGD
  • positive regulation of axon extension Source: RGD
  • positive regulation of cGMP biosynthetic process Source: RGD
  • positive regulation of neuron projection development Source: RGD
  • positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
  • positive regulation of synapse assembly Source: RGD
  • regulation of protein ADP-ribosylation Source: RGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • response to carbohydrate Source: RGD
  • response to inorganic substance Source: RGD
  • short-term memory Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Activity-dependent neuroprotector homeobox protein
Alternative name(s):
Activity-dependent neuroprotective protein
Gene namesi
Name:Adnp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi71030. Adnp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488091 – 1103Activity-dependent neuroprotector homeobox proteinAdd BLAST1103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei98PhosphoserineBy similarity1
Cross-linki144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki231Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki274Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki279Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki311Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki335Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei348Asymmetric dimethylarginineBy similarity1
Cross-linki367Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki408Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei409PhosphoserineBy similarity1
Modified residuei413PhosphoserineBy similarity1
Cross-linki427Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki600Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki606Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei608PhosphoserineBy similarity1
Cross-linki616Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki621Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki632Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki658Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki699Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei709PhosphoserineBy similarity1
Cross-linki716Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki728Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki731Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei738PhosphoserineBy similarity1
Cross-linki745Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei805PhosphoserineBy similarity1
Cross-linki807Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki829Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki835Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei876PhosphoserineBy similarity1
Modified residuei878PhosphoserineBy similarity1
Modified residuei886PhosphoserineCombined sources1
Modified residuei889PhosphoserineCombined sources1
Modified residuei905PhosphoserineCombined sources1
Cross-linki914Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki929Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki936Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei954PhosphoserineCombined sources1
Modified residuei956PhosphoserineCombined sources1
Cross-linki1017Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1036N6-acetyllysine; alternateBy similarity1
Cross-linki1036Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1043N6-acetyllysine; alternateBy similarity1
Cross-linki1043Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1072PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9JKL8.
PeptideAtlasiQ9JKL8.
PRIDEiQ9JKL8.

PTM databases

iPTMnetiQ9JKL8.
PhosphoSitePlusiQ9JKL8.

Expressioni

Inductioni

By the neuroprotective peptide VIP.

Gene expression databases

BgeeiENSRNOG00000010975.

Interactioni

GO - Molecular functioni

  • beta-tubulin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014595.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni354 – 361Neuroprotective peptide (NAP)By similarity8

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri74 – 97C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri107 – 129C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 188C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri221 – 244C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri447 – 469C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 510C2H2-type 6PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri512 – 535C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri622 – 647C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri662 – 686C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIIX. Eukaryota.
ENOG410XYDF. LUCA.
GeneTreeiENSGT00530000063631.
HOGENOMiHOG000232088.
HOVERGENiHBG024319.
InParanoidiQ9JKL8.
OMAiCRSTFND.
OrthoDBiEOG091G00XX.
TreeFamiTF328818.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JKL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQLPVNNLG SLRKARKTVK KILSDIGLEY CKEHIEDFKQ FEPNDFYLKN
60 70 80 90 100
TTWEDVGLWD PSLTKNQDYR TKPFCCSACP FSSKFFSAYK SHFRNVHSED
110 120 130 140 150
FENRILLNCP YCTFNADKKT LETHIKIFHA PNSSAPSSSL STFKDKNKND
160 170 180 190 200
GLKPKQADNV EQAVYYCKKC TYRDPLYEIV RKHIYREHFQ HVAAPYIAKA
210 220 230 240 250
GEKSLNGAVS LGTNAREECN IHCKRCLFMP KSYEALVQHV IEDHERIGYQ
260 270 280 290 300
VTAMIGHTNV VVPRAKPLML IAPKPQEKKS MGLPPRISSL ASGNVRSLPS
310 320 330 340 350
QQMVNRLSIP KPNLNSTGVN MMSNVHLQQN NYGVKSVGQS YGVGQSVRLG
360 370 380 390 400
LGGNAPVSIP QQSQSVKQLL PSGNGRSYGL GAEQRPPAAA RYSLQTANTS
410 420 430 440 450
SLPPGQVKSP SVSQSQASRV LGQSSSKPPP AATGPPPSNH CATQKWKICT
460 470 480 490 500
ICNELFPENV YSVHFEKEHK AEKVPAVANY IMKIHNFTSK CLYCNRYLPT
510 520 530 540 550
DTLLNHMLIH GLSCPYCRST FNDVEKMAAH MRMVHIDEEM GPKTDSTLSF
560 570 580 590 600
DLTLQQGSHT NIHLLVTTYN LRDAPAESVA YHAQNNAPVP PKPQPKVQEK
610 620 630 640 650
ADVPVKSSPQ AAVPYKKDVG KTLCPLCFSI LKGPISDALA HHLRERHQVI
660 670 680 690 700
QTVHPVEKKL TYKCIHCLGV YTSNMTASTI TLHLVHCRGV GKTQNGQDKT
710 720 730 740 750
NAPSRLNQSP GLAPVKRTYE QMEFPLLKKR KLEDENDSPG CFEEKPEEPV
760 770 780 790 800
VLALDPKGHE DDSYEARKSF LTKYFNKQPY PTRREIEKLA ASLWLWKSDI
810 820 830 840 850
ASHFSNKRKK CVRDCEKYKP GVLLGFNMKE LNKVKHEMDF DAEWLFENHD
860 870 880 890 900
EKASRVNASK TVDKKLNLGK EDDSFSDSFE HLEEESNGSG GPFDPVFEVE
910 920 930 940 950
PKIPSDNAEE PVPKVIPEGA LESEKLDQKE EEDGSKYETI HLTEERAKLM
960 970 980 990 1000
HDASDSEVDQ DDVVEWKDGA SPSESGPGSR QVSDFEDNTC EMKPGTWSDE
1010 1020 1030 1040 1050
SSQSEDARSS KPAAKKKATV QDDTEQLKWK NSSYGKVEGF WSKDQSQWEN
1060 1070 1080 1090 1100
ASENAERLPN PQIEWQNSTI DSEDGEQFDS MTDGVADPMH GSLTGVKLSS

QQA
Length:1,103
Mass (Da):123,626
Last modified:October 14, 2015 - v2
Checksum:i91B6D9AD8D62D620
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti499P → A in AAF40431 (Ref. 3) Curated1
Sequence conflicti866L → H in AAF40431 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054626 Genomic DNA. No translation available.
AABR07054627 Genomic DNA. No translation available.
AABR07054628 Genomic DNA. No translation available.
CH474005 Genomic DNA. Translation: EDL96377.1.
AF234680 mRNA. Translation: AAF40431.1.
RefSeqiNP_001334461.1. NM_001347532.1.
UniGeneiRn.48777.

Genome annotation databases

EnsembliENSRNOT00000014595; ENSRNOP00000014595; ENSRNOG00000010975.
GeneIDi64622.
KEGGirno:64622.

Similar proteinsi

Entry informationi

Entry nameiADNP_RAT
AccessioniPrimary (citable) accession number: Q9JKL8
Secondary accession number(s): G3V7G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 14, 2015
Last modified: September 27, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome