Q9JKL8 (ADNP_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Activity-dependent neuroprotector homeobox protein

Alternative name(s):
Activity-dependent neuroprotective protein

Gene names

Name:

Adnp

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	823 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.
Subcellular location	Nucleus Potential.
Induction	By the neuroprotective peptide VIP.
Sequence similarities	Contains 5 C2H2-type zinc fingers. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of protein kinase activity Inferred from direct assay PubMed 19047645. Source: RGD cellular response to extracellular stimulus Inferred from expression pattern PubMed 15518891. Source: RGD estrous cycle phase Inferred from expression pattern PubMed 16023261. Source: RGD negative regulation of gene expression Inferred from direct assay PubMed 15314252. Source: RGD negative regulation of neuron apoptotic process Inferred from direct assay PubMed 16938277. Source: RGD negative regulation of protein binding Inferred from direct assay PubMed 14706557. Source: RGD negative regulation of synaptic transmission Inferred from mutant phenotype PubMed 15963648. Source: RGD nitric oxide homeostasis Inferred from direct assay PubMed 16938277. Source: RGD positive regulation of axon extension Inferred from direct assay PubMed 19047645. Source: RGD positive regulation of cGMP biosynthetic process Inferred from direct assay PubMed 11438390. Source: RGD positive regulation of neuron projection development Inferred from direct assay PubMed 15800376. Source: RGD positive regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay PubMed 19047645. Source: RGD positive regulation of synapse assembly Inferred from direct assay PubMed 15800376. Source: RGD regulation of protein ADP-ribosylation Inferred from direct assay PubMed 16093393. Source: RGD response to carbohydrate stimulus Inferred from expression pattern PubMed 19130308. Source: RGD response to inorganic substance Inferred from expression pattern PubMed 18571851. Source: RGD short-term memory Inferred from direct assay PubMed 12212775. Source: RGD transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	axon Inferred from direct assay PubMed 18072088. Source: RGD cytoplasm Inferred from direct assay PubMed 19130308. Source: RGD dendrite Inferred from direct assay PubMed 19130308. Source: RGD extracellular space Inferred from direct assay PubMed 16845437. Source: RGD neuronal cell body Inferred from direct assay PubMed 19130308. Source: RGD nucleus Inferred from direct assay PubMed 16845437. Source: RGD
Molecular_function	copper ion binding Inferred from direct assay PubMed 14706557. Source: RGD peptide binding Inferred from direct assay PubMed 14706557. Source: RGD sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 823	823	Activity-dependent neuroprotector homeobox protein		PRO_0000048809
Regions
	Zinc finger	167 – 189	23	C2H2-type 1; atypical
	Zinc finger	209 – 230	22	C2H2-type 2
	Zinc finger	232 – 255	24	C2H2-type 3
	Zinc finger	342 – 367	26	C2H2-type 4; atypical
	Zinc finger	382 – 406	25	C2H2-type 5; atypical
	DNA binding	474 – 534	61	Homeobox
Amino acid modifications
	Modified residue	129	1	Phosphoserine By similarity
	Modified residue	133	1	Phosphoserine By similarity
	Modified residue	429	1	Phosphoserine By similarity
	Modified residue	525	1	Phosphoserine By similarity
	Modified residue	596	1	Phosphoserine By similarity
	Modified residue	598	1	Phosphoserine By similarity
	Modified residue	674	1	Phosphoserine By similarity
	Modified residue	676	1	Phosphoserine By similarity
	Modified residue	756	1	N6-acetyllysine By similarity
	Modified residue	763	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9JKL8 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: A4C4BC616052DBDF	FASTA	823	91,335
	10 20 30 40 50 60 MGLPPRISSL ASGNVRSLPS QQMVNRLSIP KPNLNSTGVN MMSNVHLQQN NYGVKSVGQS 70 80 90 100 110 120 YGVGQSVRLG LGGNAPVSIP QQSQSVKQLL PSGNGRSYGL GAEQRPPAAA RYSLQTANTS 130 140 150 160 170 180 SLPPGQVKSP SVSQSQASRV LGQSSSKPPP AATGPPPSNH CATQKWKICT ICNELFPENV 190 200 210 220 230 240 YSVHFEKEHK AEKVPAVANY IMKIHNFTSK CLYCNRYLAT DTLLNHMLIH GLSCPYCRST 250 260 270 280 290 300 FNDVEKMAAH MRMVHIDEEM GPKTDSTLSF DLTLQQGSHT NIHLLVTTYN LRDAPAESVA 310 320 330 340 350 360 YHAQNNAPVP PKPQPKVQEK ADVPVKSSPQ AAVPYKKDVG KTLCPLCFSI LKGPISDALA 370 380 390 400 410 420 HHLRERHQVI QTVHPVEKKL TYKCIHCLGV YTSNMTASTI TLHLVHCRGV GKTQNGQDKT 430 440 450 460 470 480 NAPSRLNQSP GLAPVKRTYE QMEFPLLKKR KLEDENDSPG CFEEKPEEPV VLALDPKGHE 490 500 510 520 530 540 DDSYEARKSF LTKYFNKQPY PTRREIEKLA ASLWLWKSDI ASHFSNKRKK CVRDCEKYKP 550 560 570 580 590 600 GVLLGFNMKE LNKVKHEMDF DAEWLFENHD EKASRVNASK TVDKKHNLGK EDDSFSDSFE 610 620 630 640 650 660 HLEEESNGSG GPFDPVFEVE PKIPSDNAEE PVPKVIPEGA LESEKLDQKE EEDGSKYETI 670 680 690 700 710 720 HLTEERAKLM HDASDSEVDQ DDVVEWKDGA SPSESGPGSR QVSDFEDNTC EMKPGTWSDE 730 740 750 760 770 780 SSQSEDARSS KPAAKKKATV QDDTEQLKWK NSSYGKVEGF WSKDQSQWEN ASENAERLPN 790 800 810 820 PQIEWQNSTI DSEDGEQFDS MTDGVADPMH GSLTGVKLSS QQA

References

[1]	"Complete sequence of a rat protein containing a femtomolar-activity-dependent neuroprotective peptide." Dong M., Xu K., Du Y. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF234680 mRNA. Translation: AAF40431.1.
IPI	IPI00202761.
UniGene	Rn.48777.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000014595.
PTM databases
PhosphoSite	Q9JKL8.
Proteomic databases
PaxDb	Q9JKL8.
PRIDE	Q9JKL8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	71030. Adnp.
Phylogenomic databases
eggNOG	NOG41028.
HOGENOM	HOG000232088.
HOVERGEN	HBG024319.
InParanoid	Q9JKL8.
OrthoDB	EOG4VHK5N.
Gene expression databases
Genevestigator	Q9JKL8.
GermOnline	ENSRNOG00000010975. Rattus norvegicus.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. SM00355. ZnF_C2H2. 4 hits. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. False negative. PS50071. HOMEOBOX_2. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 1 hit. PS50157. ZINC_FINGER_C2H2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADNP_RAT

Accession

Primary (citable) accession number: Q9JKL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program