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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

Gene

Ndufaf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
Alternative name(s):
Protein 2P1
Gene namesi
Name:Ndufaf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1913956. Ndufaf3.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002811551 – 185NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3Add BLAST185

Proteomic databases

EPDiQ9JKL4.
MaxQBiQ9JKL4.
PaxDbiQ9JKL4.
PeptideAtlasiQ9JKL4.
PRIDEiQ9JKL4.

PTM databases

PhosphoSitePlusiQ9JKL4.

Expressioni

Tissue specificityi

Strongly expressed in testis and weakly expressed in the epididymis. Expressed in spermatocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000070283.
CleanExiMM_4733401H18RIK.
ExpressionAtlasiQ9JKL4. baseline and differential.
GenevisibleiQ9JKL4. MM.

Interactioni

Subunit structurei

Interacts with NDUFAF4, NDUFS2 and NDUFS3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073832.

Structurei

3D structure databases

ProteinModelPortaliQ9JKL4.
SMRiQ9JKL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3363. Eukaryota.
ENOG4111J7F. LUCA.
GeneTreeiENSGT00390000018312.
HOGENOMiHOG000261143.
InParanoidiQ9JKL4.
KOiK09008.
OMAiSKAYDHD.
OrthoDBiEOG091G0O8P.
PhylomeDBiQ9JKL4.
TreeFamiTF321072.

Family and domain databases

CDDicd05125. Mth938_2P1-like. 1 hit.
Gene3Di3.40.1230.10. 1 hit.
InterProiView protein in InterPro
IPR034095. NDUF3.
IPR007523. NDUFAF3/AAMDC.
PANTHERiPTHR21192. PTHR21192. 1 hit.
PfamiView protein in Pfam
PF04430. DUF498. 1 hit.
SUPFAMiSSF64076. SSF64076. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JKL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATALGFRCL FRTRPAPLCR HVDRLWRNPR RGHRLSPADD ELYQRTRISL
60 70 80 90 100
LQSEFPQAVY IDSYSSRGFT ICGNRVFGPC VLLPQTVVQW NVGSHQDITE
110 120 130 140 150
ESFSLFWMLE PRIEIVVVGT GNKTERLHPQ VLQAMRQRGI AVEVQDTPNA
160 170 180
CATFNFLCHE GRVTGAALIP PPGETALASL GQASE
Length:185
Mass (Da):20,734
Last modified:October 1, 2000 - v1
Checksum:iEB2095864254B757
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89Q → H in AAH27513 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235017 mRNA. Translation: AAF61723.1.
AK005252 mRNA. Translation: BAB23907.1.
AK014634 mRNA. Translation: BAB29477.1.
BC027513 mRNA. Translation: AAH27513.1.
CCDSiCCDS23531.1.
RefSeqiNP_075736.1. NM_023247.1.
UniGeneiMm.29471.

Genome annotation databases

EnsembliENSMUST00000074208; ENSMUSP00000073832; ENSMUSG00000070283.
GeneIDi66706.
KEGGimmu:66706.
UCSCiuc009rqh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF235017 mRNA. Translation: AAF61723.1.
AK005252 mRNA. Translation: BAB23907.1.
AK014634 mRNA. Translation: BAB29477.1.
BC027513 mRNA. Translation: AAH27513.1.
CCDSiCCDS23531.1.
RefSeqiNP_075736.1. NM_023247.1.
UniGeneiMm.29471.

3D structure databases

ProteinModelPortaliQ9JKL4.
SMRiQ9JKL4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073832.

PTM databases

PhosphoSitePlusiQ9JKL4.

Proteomic databases

EPDiQ9JKL4.
MaxQBiQ9JKL4.
PaxDbiQ9JKL4.
PeptideAtlasiQ9JKL4.
PRIDEiQ9JKL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074208; ENSMUSP00000073832; ENSMUSG00000070283.
GeneIDi66706.
KEGGimmu:66706.
UCSCiuc009rqh.1. mouse.

Organism-specific databases

CTDi25915.
MGIiMGI:1913956. Ndufaf3.

Phylogenomic databases

eggNOGiKOG3363. Eukaryota.
ENOG4111J7F. LUCA.
GeneTreeiENSGT00390000018312.
HOGENOMiHOG000261143.
InParanoidiQ9JKL4.
KOiK09008.
OMAiSKAYDHD.
OrthoDBiEOG091G0O8P.
PhylomeDBiQ9JKL4.
TreeFamiTF321072.

Enzyme and pathway databases

ReactomeiR-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

ChiTaRSiNdufaf3. mouse.
PROiQ9JKL4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070283.
CleanExiMM_4733401H18RIK.
ExpressionAtlasiQ9JKL4. baseline and differential.
GenevisibleiQ9JKL4. MM.

Family and domain databases

CDDicd05125. Mth938_2P1-like. 1 hit.
Gene3Di3.40.1230.10. 1 hit.
InterProiView protein in InterPro
IPR034095. NDUF3.
IPR007523. NDUFAF3/AAMDC.
PANTHERiPTHR21192. PTHR21192. 1 hit.
PfamiView protein in Pfam
PF04430. DUF498. 1 hit.
SUPFAMiSSF64076. SSF64076. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUF3_MOUSE
AccessioniPrimary (citable) accession number: Q9JKL4
Secondary accession number(s): Q8K1A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2000
Last modified: March 15, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.